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Items: 42

1.

Cell-Specific Deletion of PGC-1α from Medium Spiny Neurons Causes Transcriptional Alterations and Age-Related Motor Impairment.

McMeekin LJ, Li Y, Fox SN, Rowe GC, Crossman DK, Day JJ, Li Y, Detloff PJ, Cowell RM.

J Neurosci. 2018 Mar 28;38(13):3273-3286. doi: 10.1523/JNEUROSCI.0848-17.2018. Epub 2018 Feb 28.

2.

Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.

Cao JK, Detloff PJ, Gardner RG, Stella N.

Behav Brain Res. 2018 Jan 30;337:34-45. doi: 10.1016/j.bbr.2017.09.026. Epub 2017 Sep 18.

3.

Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington's disease.

Garland H, Wood NI, Skillings EA, Detloff PJ, Morton AJ, Grant RA.

J Neurosci Methods. 2018 Apr 15;300:103-111. doi: 10.1016/j.jneumeth.2017.04.020. Epub 2017 May 1.

PMID:
28472678
4.

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, Van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ.

Hum Mol Genet. 2016 Apr 15;25(8):1619-36. doi: 10.1093/hmg/ddw040. Epub 2016 Feb 14.

5.

Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease.

Ciamei A, Detloff PJ, Morton AJ.

Behav Brain Res. 2015 Sep 15;291:140-146. doi: 10.1016/j.bbr.2015.05.010. Epub 2015 May 16.

PMID:
25986402
6.

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.

Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W.

Hum Mol Genet. 2015 May 1;24(9):2508-27. doi: 10.1093/hmg/ddv016. Epub 2015 Jan 21.

7.

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22.

8.

Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington disease.

Dougherty SE, Reeves JL, Lesort M, Detloff PJ, Cowell RM.

Exp Neurol. 2013 Feb;240:96-102. doi: 10.1016/j.expneurol.2012.11.015. Epub 2012 Nov 26.

9.

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease.

Kumar A, Kneynsberg A, Tucholski J, Perry G, van Groen T, Detloff PJ, Lesort M.

Exp Neurol. 2012 Sep;237(1):78-89. doi: 10.1016/j.expneurol.2012.05.015. Epub 2012 Jun 12.

10.

Early alterations of autophagy in Huntington disease-like mice.

Heng MY, Detloff PJ, Paulson HL, Albin RL.

Autophagy. 2010 Nov;6(8):1206-8. Epub 2010 Nov 16.

11.

Early autophagic response in a novel knock-in model of Huntington disease.

Heng MY, Duong DK, Albin RL, Tallaksen-Greene SJ, Hunter JM, Lesort MJ, Osmand A, Paulson HL, Detloff PJ.

Hum Mol Genet. 2010 Oct 1;19(19):3702-20. doi: 10.1093/hmg/ddq285. Epub 2010 Jul 8.

12.

Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease.

Perry GM, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff PJ, Albin RL, Lesort M.

Hum Mol Genet. 2010 Sep 1;19(17):3354-71. doi: 10.1093/hmg/ddq247. Epub 2010 Jun 17.

13.

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

Heng MY, Detloff PJ, Wang PL, Tsien JZ, Albin RL.

J Neurosci. 2009 Mar 11;29(10):3200-5. doi: 10.1523/JNEUROSCI.5599-08.2009.

14.

Rodent genetic models of Huntington disease.

Heng MY, Detloff PJ, Albin RL.

Neurobiol Dis. 2008 Oct;32(1):1-9. doi: 10.1016/j.nbd.2008.06.005. Epub 2008 Jun 26. Review.

PMID:
18638556
15.

DNA instability in postmitotic neurons.

Gonitel R, Moffitt H, Sathasivam K, Woodman B, Detloff PJ, Faull RL, Bates GP.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3467-72. doi: 10.1073/pnas.0800048105. Epub 2008 Feb 25.

16.

Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.

Heng MY, Tallaksen-Greene SJ, Detloff PJ, Albin RL.

J Neurosci. 2007 Aug 22;27(34):8989-98.

17.

Intraflagellar transport is essential for endochondral bone formation.

Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK.

Development. 2007 Jan;134(2):307-16. Epub 2006 Dec 13.

18.

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.

Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M.

Neurobiol Dis. 2006 May;22(2):346-56. Epub 2006 Jan 19.

PMID:
16423528
19.
20.

Verification of somatic CAG repeat expansion by pre-PCR fractionation.

Hunter JM, Crouse AB, Lesort M, Johnson GV, Detloff PJ.

J Neurosci Methods. 2005 May 15;144(1):11-7. Epub 2004 Nov 28.

PMID:
15848234
21.

Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice.

Tallaksen-Greene SJ, Crouse AB, Hunter JM, Detloff PJ, Albin RL.

Neuroscience. 2005;131(4):843-52.

PMID:
15749339
22.

Mouse Huntington's disease homolog mRNA levels: variation and allele effects.

Dixon KT, Cearley JA, Hunter JM, Detloff PJ.

Gene Expr. 2004;11(5-6):221-31.

23.

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release.

Choo YS, Johnson GV, MacDonald M, Detloff PJ, Lesort M.

Hum Mol Genet. 2004 Jul 15;13(14):1407-20. Epub 2004 May 26.

PMID:
15163634
24.
25.

Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis.

Kennedy L, Evans E, Chen CM, Craven L, Detloff PJ, Ennis M, Shelbourne PF.

Hum Mol Genet. 2003 Dec 15;12(24):3359-67. Epub 2003 Oct 21.

PMID:
14570710
27.
29.

Neurological abnormalities in a knock-in mouse model of Huntington's disease.

Lin CH, Tallaksen-Greene S, Chien WM, Cearley JA, Jackson WS, Crouse AB, Ren S, Li XJ, Albin RL, Detloff PJ.

Hum Mol Genet. 2001 Jan 15;10(2):137-44.

PMID:
11152661
30.
31.

CAG-polyglutamine-repeat mutations: independence from gene context.

Ordway JM, Cearley JA, Detloff PJ.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1083-8. Review.

32.

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

Ordway JM, Tallaksen-Greene S, Gutekunst CA, Bernstein EM, Cearley JA, Wiener HW, Dure LS 4th, Lindsey R, Hersch SM, Jope RS, Albin RL, Detloff PJ.

Cell. 1997 Dec 12;91(6):753-63.

33.

In vitro synthesis and cloning of long CAG repeats.

Ordway JM, Detloff PJ.

Biotechniques. 1996 Oct;21(4):609-10, 612. No abstract available.

34.

Gene modification via "plug and socket" gene targeting.

Lewis J, Yang B, Detloff P, Smithies O.

J Clin Invest. 1996 Jan 1;97(1):3-5. Review. No abstract available.

35.

A mouse model for beta 0-thalassemia.

Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11608-12.

36.

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.

Detloff PJ, Lewis J, John SW, Shehee WR, Langenbach R, Maeda N, Smithies O.

Mol Cell Biol. 1994 Oct;14(10):6936-43.

37.

Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae.

Detloff P, White MA, Petes TD.

Genetics. 1992 Sep;132(1):113-23.

38.
39.

A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast.

White MA, Detloff P, Strand M, Petes TD.

Curr Genet. 1992 Feb;21(2):109-16.

PMID:
1568254
40.

DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.

White MA, Wierdl M, Detloff P, Petes TD.

Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9755-9.

41.
42.

Recombination in yeast and the recombinant DNA technology.

Petes TD, Detloff P, Jinks-Robertson S, Judd SR, Kupiec M, Nag D, Stapleton A, Symington LS, Vincent A, White M.

Genome. 1989;31(2):536-40. Review.

PMID:
2698829

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