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Items: 1 to 50 of 136

1.

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.

Wigger L, Casals-Casas C, Baruchet M, Trang KB, Pradervand S, Naldi A, Desvergne B.

PLoS One. 2019 Aug 22;14(8):e0220894. doi: 10.1371/journal.pone.0220894. eCollection 2019.

2.

Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility.

Gilardi F, Winkler C, Quignodon L, Diserens JG, Toffoli B, Schiffrin M, Sardella C, Preitner F, Desvergne B.

Metabolism. 2019 Jun;95:8-20. doi: 10.1016/j.metabol.2019.03.003. Epub 2019 Mar 13.

3.

Renal mineralocorticoid receptor expression is reduced in lipoatrophy.

Toffoli B, Bernardi S, Winkler C, Carrascosa C, Gilardi F, Desvergne B.

FEBS Open Bio. 2019 Jan 18;9(2):328-334. doi: 10.1002/2211-5463.12579. eCollection 2019 Feb.

4.

Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.

Wilson A, Fu H, Schiffrin M, Winkler C, Koufany M, Jouzeau JY, Bonnet N, Gilardi F, Renevey F, Luther SA, Moulin D, Desvergne B.

Front Immunol. 2018 Nov 13;9:2573. doi: 10.3389/fimmu.2018.02573. eCollection 2018.

5.

PPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle Regeneration.

Dammone G, Karaz S, Lukjanenko L, Winkler C, Sizzano F, Jacot G, Migliavacca E, Palini A, Desvergne B, Gilardi F, Feige JN.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2044. doi: 10.3390/ijms19072044.

6.

Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.

Toffoli B, Zennaro C, Winkler C, Giordano Attianese GMP, Bernardi S, Carraro M, Gilardi F, Desvergne B.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1154-F1165. doi: 10.1152/ajprenal.00198.2017. Epub 2018 Feb 28.

7.

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.

Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F.

J Invest Dermatol. 2018 Mar;138(3):500-510. doi: 10.1016/j.jid.2017.09.024. Epub 2017 Sep 28.

8.

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M.

Nat Commun. 2017 Jul 21;8(1):93. doi: 10.1038/s41467-017-00182-7.

9.

From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions.

Caputo T, Gilardi F, Desvergne B.

FEBS Lett. 2017 Oct;591(19):3061-3088. doi: 10.1002/1873-3468.12742. Epub 2017 Jul 25. Review.

10.

Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system.

Toffoli B, Gilardi F, Winkler C, Soderberg M, Kowalczuk L, Arsenijevic Y, Bamberg K, Bonny O, Desvergne B.

PLoS One. 2017 Feb 9;12(2):e0171474. doi: 10.1371/journal.pone.0171474. eCollection 2017.

11.

PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.

Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ, Alfaidy N.

Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E357-69. doi: 10.1152/ajpendo.00093.2015. Epub 2015 Jun 16.

12.

Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function.

Giordano Attianese GM, Desvergne B.

Nucl Recept Signal. 2015 Apr 27;13:e001. doi: 10.1621/nrs.13001. eCollection 2015. Review.

13.

Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F.

Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24.

PMID:
25497132
14.

Impaired musculoskeletal response to age and exercise in PPARβ(-/-) diabetic mice.

Fu H, Desvergne B, Ferrari S, Bonnet N.

Endocrinology. 2014 Dec;155(12):4686-96. doi: 10.1210/en.2014-1585. Epub 2014 Oct 3.

15.

RXRs: collegial partners.

Gilardi F, Desvergne B.

Subcell Biochem. 2014;70:75-102. doi: 10.1007/978-94-017-9050-5_5. Review.

PMID:
24962882
16.

Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals.

Gilardi F, Migliavacca E, Naldi A, Baruchet M, Canella D, Le Martelot G, Guex N, Desvergne B; CycliX Consortium.

PLoS Genet. 2014 Mar 6;10(3):e1004155. doi: 10.1371/journal.pgen.1004155. eCollection 2014 Mar.

17.

SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.

Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, Chevriaux A, Rébé C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L.

Cancer Res. 2013 Jun 15;73(12):3578-90. doi: 10.1158/0008-5472.CAN-12-4018. Epub 2013 Apr 25.

18.

PPARβ/δ governs Wnt signaling and bone turnover.

Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G.

Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31.

PMID:
23542786
19.

Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles.

Le Martelot G, Canella D, Symul L, Migliavacca E, Gilardi F, Liechti R, Martin O, Harshman K, Delorenzi M, Desvergne B, Herr W, Deplancke B, Schibler U, Rougemont J, Guex N, Hernandez N, Naef F; CycliX Consortium.

PLoS Biol. 2012;10(11):e1001442. doi: 10.1371/journal.pbio.1001442. Epub 2012 Nov 27.

20.

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.

Nadra K, Médard JJ, Mul JD, Han GS, Grès S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R.

Mol Cell Biol. 2012 Dec;32(23):4794-810. doi: 10.1128/MCB.00512-12. Epub 2012 Oct 1.

21.

Epineurial adipocytes are dispensable for Schwann cell myelination.

Nadra K, Médard JJ, Quignodon L, Verheijen MH, Desvergne B, Chrast R.

J Neurochem. 2012 Dec;123(5):662-7. doi: 10.1111/j.1471-4159.2012.07896.x. Epub 2012 Oct 10.

22.

Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin.

Brunner JM, Plattet P, Doucey MA, Rosso L, Curie T, Montagner A, Wittek R, Vandelvelde M, Zurbriggen A, Hirling H, Desvergne B.

PLoS One. 2012;7(3):e32803. doi: 10.1371/journal.pone.0032803. Epub 2012 Mar 5.

23.

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J.

Cell. 2011 Nov 11;147(4):827-39. doi: 10.1016/j.cell.2011.10.017.

24.

Endocrine disruptors: from endocrine to metabolic disruption.

Casals-Casas C, Desvergne B.

Annu Rev Physiol. 2011;73:135-62. doi: 10.1146/annurev-physiol-012110-142200. Review.

PMID:
21054169
25.

PPARgamma in placental angiogenesis.

Nadra K, Quignodon L, Sardella C, Joye E, Mucciolo A, Chrast R, Desvergne B.

Endocrinology. 2010 Oct;151(10):4969-81. doi: 10.1210/en.2010-0131. Epub 2010 Sep 1.

PMID:
20810566
26.

Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.

Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NS, Sepodes B, Castiglia S, Fantozzi R, Bishop-Bailey D, Mota-Filipe H, Yaqoob MM, Suzuki K, Bahrami S, Desvergne B, Mitchell JA, Thiemermann C.

Am J Respir Crit Care Med. 2010 Dec 15;182(12):1506-15. doi: 10.1164/rccm.201002-0240OC. Epub 2010 Aug 6.

PMID:
20693380
27.

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.

Peyrin-Biroulet L, Beisner J, Wang G, Nuding S, Oommen ST, Kelly D, Parmentier-Decrucq E, Dessein R, Merour E, Chavatte P, Grandjean T, Bressenot A, Desreumaux P, Colombel JF, Desvergne B, Stange EF, Wehkamp J, Chamaillard M.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8772-7. doi: 10.1073/pnas.0905745107. Epub 2010 Apr 26.

28.

Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress.

Georgiadi A, Lichtenstein L, Degenhardt T, Boekschoten MV, van Bilsen M, Desvergne B, Müller M, Kersten S.

Circ Res. 2010 Jun 11;106(11):1712-21. doi: 10.1161/CIRCRESAHA.110.217380. Epub 2010 Apr 8.

PMID:
20378851
29.

The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension.

Harrington LS, Moreno L, Reed A, Wort SJ, Desvergne B, Garland C, Zhao L, Mitchell JA.

PLoS One. 2010 Mar 4;5(3):e9526. doi: 10.1371/journal.pone.0009526.

30.

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.

Feige JN, Gerber A, Casals-Casas C, Yang Q, Winkler C, Bedu E, Bueno M, Gelman L, Auwerx J, Gonzalez FJ, Desvergne B.

Environ Health Perspect. 2010 Feb;118(2):234-41. doi: 10.1289/ehp.0901217.

31.

Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver.

Sanderson LM, Boekschoten MV, Desvergne B, Müller M, Kersten S.

Physiol Genomics. 2010 Mar 3;41(1):42-52. doi: 10.1152/physiolgenomics.00127.2009. Epub 2009 Dec 15. Erratum in: Physiol Genomics. 2010 Jul 7;42(2):317.

PMID:
20009009
32.

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver.

Sanderson LM, Degenhardt T, Koppen A, Kalkhoven E, Desvergne B, Müller M, Kersten S.

Mol Cell Biol. 2009 Dec;29(23):6257-67. doi: 10.1128/MCB.00370-09. Epub 2009 Oct 5. Erratum in: Mol Cell Biol. 2010 Oct;30(20):4977.

33.

Steroid hormone pulsing drives cyclic gene expression.

Desvergne B, Héligon C.

Nat Cell Biol. 2009 Sep;11(9):1051-3. doi: 10.1038/ncb0909-1051.

PMID:
19724259
34.

PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report.

Ali FY, Hall MG, Desvergne B, Warner TD, Mitchell JA.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1871-3. doi: 10.1161/ATVBAHA.109.193367. Epub 2009 Aug 20.

PMID:
19696401
35.

PPAR-mediated activity of phthalates: A link to the obesity epidemic?

Desvergne B, Feige JN, Casals-Casas C.

Mol Cell Endocrinol. 2009 May 25;304(1-2):43-8. doi: 10.1016/j.mce.2009.02.017. Epub 2009 Mar 9. Review.

PMID:
19433246
36.

Interference of pollutants with PPARs: endocrine disruption meets metabolism.

Casals-Casas C, Feige JN, Desvergne B.

Int J Obes (Lond). 2008 Dec;32 Suppl 6:S53-61. doi: 10.1038/ijo.2008.207. Review.

PMID:
19079281
37.

Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis.

Hall MG, Quignodon L, Desvergne B.

PPAR Res. 2008;2008:780452. doi: 10.1155/2008/780452. Epub 2008 Nov 9.

38.

PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism.

Desvergne B.

Cell Metab. 2008 Jun;7(6):467-9. doi: 10.1016/j.cmet.2008.05.002. Review.

39.

Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.

Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK.

J Biol Chem. 2007 Dec 28;282(52):37770-82. Epub 2007 Oct 26.

40.

Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.

Anghel SI, Bedu E, Vivier CD, Descombes P, Desvergne B, Wahli W.

J Biol Chem. 2007 Oct 12;282(41):29946-57. Epub 2007 Aug 14.

41.

PPARs special issue: anchoring the present to explore the future.

Desvergne B.

Biochim Biophys Acta. 2007 Aug;1771(8):913-4. No abstract available.

PMID:
17689831
42.

Retinaldehyde: more than meets the eye.

Desvergne B.

Nat Med. 2007 Jun;13(6):671-3. No abstract available.

PMID:
17554331
43.

The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.

Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B.

J Biol Chem. 2007 Jun 29;282(26):19152-66. Epub 2007 Apr 27.

44.

Double gene deletion reveals the lack of cooperation between PPARalpha and PPARbeta in skeletal muscle.

Bedu E, Desplanches D, Pequignot J, Bordier B, Desvergne B.

Biochem Biophys Res Commun. 2007 Jun 15;357(4):877-81. Epub 2007 Apr 9.

PMID:
17466944
45.

Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes.

Gelman L, Feige JN, Desvergne B.

Biochim Biophys Acta. 2007 Aug;1771(8):1094-107. Epub 2007 Mar 16. Review.

PMID:
17459763
46.

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.

Berry A, Balard P, Coste A, Olagnier D, Lagane C, Authier H, Benoit-Vical F, Lepert JC, Séguéla JP, Magnaval JF, Chambon P, Metzger D, Desvergne B, Wahli W, Auwerx J, Pipy B.

Eur J Immunol. 2007 Jun;37(6):1642-52.

47.

MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.

Pialat JB, Cho TH, Beuf O, Joye E, Moucharrafie S, Langlois JB, Nemoz C, Janier M, Berthezene Y, Nighoghossian N, Desvergne B, Wiart M.

NMR Biomed. 2007 May;20(3):335-42. Erratum in: NMR Biomed. 2008 Mar;21(3):301. Moucharaffie, Samir [corrected to Moucharrafie, Samir].

PMID:
17451173
48.

Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

Mandard S, Stienstra R, Escher P, Tan NS, Kim I, Gonzalez FJ, Wahli W, Desvergne B, Müller M, Kersten S.

Cell Mol Life Sci. 2007 May;64(9):1145-57.

49.

RXR: from partnership to leadership in metabolic regulations.

Desvergne B.

Vitam Horm. 2007;75:1-32. Review.

PMID:
17368310
50.

Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.

Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P.

J Invest Dermatol. 2007 May;127(5):1250-60. Epub 2007 Feb 15.

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