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Items: 1 to 50 of 107

1.

An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.

Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori MA, Tangy F, Stavru F, Bessonov S, Dessen A, Muchardt C, Lebreton A, Komarova AV, Cossart P.

Cell Host Microbe. 2019 Nov 4. pii: S1931-3128(19)30528-1. doi: 10.1016/j.chom.2019.10.004. [Epub ahead of print]

2.

Complex Formation between Mur Enzymes from Streptococcus pneumoniae.

Miyachiro MM, Granato D, Trindade DM, Ebel C, Paes Leme AF, Dessen A.

Biochemistry. 2019 Jul 30;58(30):3314-3324. doi: 10.1021/acs.biochem.9b00277. Epub 2019 Jul 15.

PMID:
31264408
3.

Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.

Howard SP, Estrozi LF, Bertrand Q, Contreras-Martel C, Strozen T, Job V, Martins A, Fenel D, Schoehn G, Dessen A.

PLoS Pathog. 2019 May 13;15(5):e1007731. doi: 10.1371/journal.ppat.1007731. eCollection 2019 May.

4.

Structural and Functional Characterization of the Type Three Secretion System (T3SS) Needle of Pseudomonas aeruginosa.

Lombardi C, Tolchard J, Bouillot S, Signor L, Gebus C, Liebl D, Fenel D, Teulon JM, Brock J, Habenstein B, Pellequer JL, Faudry E, Loquet A, Attrée I, Dessen A, Job V.

Front Microbiol. 2019 Mar 29;10:573. doi: 10.3389/fmicb.2019.00573. eCollection 2019.

5.

The MurG glycosyltransferase provides an oligomeric scaffold for the cytoplasmic steps of peptidoglycan biosynthesis in the human pathogen Bordetella pertussis.

Laddomada F, Miyachiro MM, Jessop M, Patin D, Job V, Mengin-Lecreulx D, Le Roy A, Ebel C, Breyton C, Gutsche I, Dessen A.

Sci Rep. 2019 Mar 15;9(1):4656. doi: 10.1038/s41598-019-40966-z.

6.

Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome.

Dortet L, Lombardi C, Cretin F, Dessen A, Filloux A.

Nat Microbiol. 2018 Mar;3(3):378-386. doi: 10.1038/s41564-018-0109-7. Epub 2018 Feb 5.

7.

Assembly of an atypical α-macroglobulin complex from Pseudomonas aeruginosa.

Zouhir S, Robert-Genthon M, Trindade DM, Job V, Nedeljković M, Breyton C, Ebel C, Attrée I, Dessen A.

Sci Rep. 2018 Jan 11;8(1):527. doi: 10.1038/s41598-017-18083-6.

8.

Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex.

Contreras-Martel C, Martins A, Ecobichon C, Trindade DM, Matteï PJ, Hicham S, Hardouin P, Ghachi ME, Boneca IG, Dessen A.

Nat Commun. 2017 Oct 3;8(1):776. doi: 10.1038/s41467-017-00783-2.

9.

New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus.

Assis LM, Nedeljković M, Dessen A.

Drug Resist Updat. 2017 Mar;31:1-14. doi: 10.1016/j.drup.2017.03.001. Epub 2017 Apr 6. Review.

PMID:
28867240
10.

A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness.

Pritchard MF, Powell LC, Jack AA, Powell K, Beck K, Florance H, Forton J, Rye PD, Dessen A, Hill KE, Thomas DW.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00762-17. doi: 10.1128/AAC.00762-17. Print 2017 Sep.

11.

OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium.

Ermund A, Recktenwald CV, Skjåk-Braek G, Meiss LN, Onsøyen E, Rye PD, Dessen A, Myrset AH, Hansson GC.

Clin Exp Pharmacol Physiol. 2017 Jun;44(6):639-647. doi: 10.1111/1440-1681.12744.

PMID:
28261854
12.

A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice.

Vitko M, Valerio DM, Rye PD, Onsøyen E, Myrset AH, Dessen A, Drumm ML, Hodges CA.

J Cyst Fibros. 2016 Nov;15(6):745-751. doi: 10.1016/j.jcf.2016.06.005. Epub 2016 Jun 21.

13.

Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis.

Laddomada F, Miyachiro MM, Dessen A.

Antibiotics (Basel). 2016 Apr 28;5(2). pii: E14. doi: 10.3390/antibiotics5020014. Review.

14.

Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited.

Šink R, Kotnik M, Zega A, Barreteau H, Gobec S, Blanot D, Dessen A, Contreras-Martel C.

PLoS One. 2016 Mar 31;11(3):e0152075. doi: 10.1371/journal.pone.0152075. eCollection 2016.

15.

Structural Basis of Lipid Targeting and Destruction by the Type V Secretion System of Pseudomonas aeruginosa.

da Mata Madeira PV, Zouhir S, Basso P, Neves D, Laubier A, Salacha R, Bleves S, Faudry E, Contreras-Martel C, Dessen A.

J Mol Biol. 2016 May 8;428(9 Pt A):1790-803. doi: 10.1016/j.jmb.2016.03.012. Epub 2016 Mar 21.

PMID:
27012424
16.

A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease.

Pritchard MF, Powell LC, Menzies GE, Lewis PD, Hawkins K, Wright C, Doull I, Walsh TR, Onsøyen E, Dessen A, Myrvold R, Rye PD, Myrset AH, Stevens HN, Hodges LA, MacGregor G, Neilly JB, Hill KE, Thomas DW.

Mol Pharm. 2016 Mar 7;13(3):863-72. doi: 10.1021/acs.molpharmaceut.5b00794. Epub 2016 Feb 16.

PMID:
26833139
17.

A structural snapshot of type II pilus formation in Streptococcus pneumoniae.

Shaik MM, Lombardi C, Maragno Trindade D, Fenel D, Schoehn G, Di Guilmi AM, Dessen A.

J Biol Chem. 2015 Sep 11;290(37):22581-92. doi: 10.1074/jbc.M115.647834. Epub 2015 Jul 21.

18.

FtsZ filament capping by MciZ, a developmental regulator of bacterial division.

Bisson-Filho AW, Discola KF, Castellen P, Blasios V, Martins A, Sforça ML, Garcia W, Zeri AC, Erickson HP, Dessen A, Gueiros-Filho FJ.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2130-8. doi: 10.1073/pnas.1414242112. Epub 2015 Apr 6.

19.

Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity.

Wong SG, Dessen A.

Nat Commun. 2014 Sep 15;5:4917. doi: 10.1038/ncomms5917.

PMID:
25221932
20.

Structural similarity of secretins from type II and type III secretion systems.

Tosi T, Estrozi LF, Job V, Guilvout I, Pugsley AP, Schoehn G, Dessen A.

Structure. 2014 Sep 2;22(9):1348-1355. doi: 10.1016/j.str.2014.07.005. Epub 2014 Aug 21.

21.

Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae.

Shaik MM, Maccagni A, Tourcier G, Di Guilmi AM, Dessen A.

J Biol Chem. 2014 Jun 13;289(24):16988-97. doi: 10.1074/jbc.M114.555854. Epub 2014 Apr 21.

22.

Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.

Lebreton A, Job V, Ragon M, Le Monnier A, Dessen A, Cossart P, Bierne H.

MBio. 2014 Jan 21;5(1):e00775-13. doi: 10.1128/mBio.00775-13.

23.

Resistance to antibiotics targeted to the bacterial cell wall.

Nikolaidis I, Favini-Stabile S, Dessen A.

Protein Sci. 2014 Mar;23(3):243-59. doi: 10.1002/pro.2414. Epub 2014 Jan 17. Review.

24.

Membrane and chaperone recognition by the major translocator protein PopB of the type III secretion system of Pseudomonas aeruginosa.

Discola KF, Förster A, Boulay F, Simorre JP, Attree I, Dessen A, Job V.

J Biol Chem. 2014 Feb 7;289(6):3591-601. doi: 10.1074/jbc.M113.517920. Epub 2013 Dec 2.

25.

Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI.

J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24.

26.

Structure of internalin InlK from the human pathogen Listeria monocytogenes.

Neves D, Job V, Dortet L, Cossart P, Dessen A.

J Mol Biol. 2013 Nov 15;425(22):4520-9. doi: 10.1016/j.jmb.2013.08.010. Epub 2013 Aug 16.

PMID:
23958637
27.

Unique features of a Pseudomonas aeruginosa α2-macroglobulin homolog.

Robert-Genthon M, Casabona MG, Neves D, Couté Y, Cicéron F, Elsen S, Dessen A, Attrée I.

MBio. 2013 Aug 6;4(4). pii: e00309-13. doi: 10.1128/mBio.00309-13.

28.

MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis.

Favini-Stabile S, Contreras-Martel C, Thielens N, Dessen A.

Environ Microbiol. 2013 Dec;15(12):3218-28. doi: 10.1111/1462-2920.12171. Epub 2013 Jul 4.

PMID:
23826965
29.

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21.

PMID:
23786712
30.

Structural basis of eukaryotic cell targeting by type III secretion system (T3SS) effectors.

Tosi T, Pflug A, Discola KF, Neves D, Dessen A.

Res Microbiol. 2013 Jul-Aug;164(6):605-19. doi: 10.1016/j.resmic.2013.03.019. Epub 2013 Mar 26. Review.

PMID:
23541478
31.

Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.

Tomašić T, Sink R, Zidar N, Fic A, Contreras-Martel C, Dessen A, Patin D, Blanot D, Müller-Premru M, Gobec S, Zega A, Kikelj D, Mašič LP.

ACS Med Chem Lett. 2012 Jun 27;3(8):626-30. doi: 10.1021/ml300047h. eCollection 2012 Aug 9.

32.

Microbiology: sensing stability.

Neves D, Dessen A.

Nat Chem Biol. 2012 Jul 18;8(8):681-2. doi: 10.1038/nchembio.1026. No abstract available.

PMID:
22810772
33.

Conformational states of a bacterial α2-macroglobulin resemble those of human complement C3.

Neves D, Estrozi LF, Job V, Gabel F, Schoehn G, Dessen A.

PLoS One. 2012;7(4):e35384. doi: 10.1371/journal.pone.0035384. Epub 2012 Apr 17.

34.

Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa.

Gendrin C, Contreras-Martel C, Bouillot S, Elsen S, Lemaire D, Skoufias DA, Huber P, Attree I, Dessen A.

PLoS Pathog. 2012;8(4):e1002637. doi: 10.1371/journal.ppat.1002637. Epub 2012 Apr 5.

35.

Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa.

Nikolaidis I, Izoré T, Job V, Thielens N, Breukink E, Dessen A.

Microb Drug Resist. 2012 Jun;18(3):298-305. doi: 10.1089/mdr.2012.0006. Epub 2012 Mar 20.

PMID:
22432706
36.

Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca.

Tosi T, Nickerson NN, Mollica L, Jensen MR, Blackledge M, Baron B, England P, Pugsley AP, Dessen A.

Mol Microbiol. 2011 Dec;82(6):1422-32. doi: 10.1111/j.1365-2958.2011.07896.x. Epub 2011 Nov 21.

37.

The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fibre-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization.

El Mortaji L, Contreras-Martel C, Moschioni M, Ferlenghi I, Manzano C, Vernet T, Dessen A, Di Guilmi AM.

Biochem J. 2012 Feb 1;441(3):833-41. doi: 10.1042/BJ20111397.

PMID:
22013894
38.

New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.

Zidar N, Tomašić T, Šink R, Kovač A, Patin D, Blanot D, Contreras-Martel C, Dessen A, Premru MM, Zega A, Gobec S, Mašič LP, Kikelj D.

Eur J Med Chem. 2011 Nov;46(11):5512-23. doi: 10.1016/j.ejmech.2011.09.017. Epub 2011 Sep 17.

PMID:
21963114
39.

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases.

Inglis SR, Strieker M, Rydzik AM, Dessen A, Schofield CJ.

Anal Biochem. 2012 Jan 1;420(1):41-7. doi: 10.1016/j.ab.2011.08.036. Epub 2011 Aug 26.

PMID:
21925482
40.

Outer membrane targeting of secretin PulD protein relies on disordered domain recognition by a dedicated chaperone.

Nickerson NN, Tosi T, Dessen A, Baron B, Raynal B, England P, Pugsley AP.

J Biol Chem. 2011 Nov 11;286(45):38833-43. doi: 10.1074/jbc.M111.279851. Epub 2011 Aug 30.

41.

Structural characterization and membrane localization of ExsB from the type III secretion system (T3SS) of Pseudomonas aeruginosa.

Izoré T, Perdu C, Job V, Attree I, Faudry E, Dessen A.

J Mol Biol. 2011 Oct 14;413(1):236-46. doi: 10.1016/j.jmb.2011.07.043. Epub 2011 Aug 4.

PMID:
21839744
42.

Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori.

El Ghachi M, Matteï PJ, Ecobichon C, Martins A, Hoos S, Schmitt C, Colland F, Ebel C, Prévost MC, Gabel F, England P, Dessen A, Boneca IG.

Mol Microbiol. 2011 Oct;82(1):68-86. doi: 10.1111/j.1365-2958.2011.07791.x. Epub 2011 Sep 15.

43.

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).

Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A.

ACS Chem Biol. 2011 Sep 16;6(9):943-51. doi: 10.1021/cb2001846. Epub 2011 Aug 3.

PMID:
21732689
44.

Structure/function analysis of Neisseria meningitidis PilW, a conserved protein that plays multiple roles in type IV pilus biology.

Szeto TH, Dessen A, Pelicic V.

Infect Immun. 2011 Aug;79(8):3028-35. doi: 10.1128/IAI.05313-11. Epub 2011 Jun 6.

45.

Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).

Tomasić T, Zidar N, Sink R, Kovac A, Blanot D, Contreras-Martel C, Dessen A, Müller-Premru M, Zega A, Gobec S, Kikelj D, Masic LP.

J Med Chem. 2011 Jul 14;54(13):4600-10. doi: 10.1021/jm2002525. Epub 2011 Jun 3.

PMID:
21591605
46.

Biogenesis, regulation, and targeting of the type III secretion system.

Izoré T, Job V, Dessen A.

Structure. 2011 May 11;19(5):603-12. doi: 10.1016/j.str.2011.03.015. Review.

47.

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.

Sosič I, Barreteau H, Simčič M, Sink R, Cesar J, Zega A, Grdadolnik SG, Contreras-Martel C, Dessen A, Amoroso A, Joris B, Blanot D, Gobec S.

Eur J Med Chem. 2011 Jul;46(7):2880-94. doi: 10.1016/j.ejmech.2011.04.011. Epub 2011 Apr 9.

48.

A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H.

Science. 2011 Mar 11;331(6022):1319-21. doi: 10.1126/science.1200120. Epub 2011 Jan 20.

49.

Solution X-ray scattering study of a full-length class A penicillin-binding protein.

Macheboeuf P, Piuzzi M, Finet S, Bontems F, Pérez J, Dessen A, Vachette P.

Biochem Biophys Res Commun. 2011 Feb 4;405(1):107-11. doi: 10.1016/j.bbrc.2011.01.003. Epub 2011 Jan 7.

PMID:
21216228
50.

Membrane targeting and pore formation by the type III secretion system translocon.

Matteï PJ, Faudry E, Job V, Izoré T, Attree I, Dessen A.

FEBS J. 2011 Feb;278(3):414-26. doi: 10.1111/j.1742-4658.2010.07974.x. Epub 2010 Dec 23. Review.

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