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EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury.

Berkey SC, Herrera JJ, Odem MA, Rahman S, Cheruvu SS, Cheng X, Walters ET, Dessauer CW, Bavencoffe AG.

Neurobiol Pain. 2019 Dec 4;7:100040. doi: 10.1016/j.ynpai.2019.100040. eCollection 2020 Jan-Jul.


Nanometric targeting of type 9 adenylyl cyclase in heart.

Marsden AN, Dessauer CW.

Biochem Soc Trans. 2019 Dec 20;47(6):1749-1756. doi: 10.1042/BST20190227.


Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening.

Doyle TB, Muntean BS, Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ.

Cells. 2019 Nov 19;8(11). pii: E1468. doi: 10.3390/cells8111468.


Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase.

Li Y, Hof T, Baldwin TA, Chen L, Kass RS, Dessauer CW.

Cells. 2019 Aug 27;8(9). pii: E981. doi: 10.3390/cells8090981.


Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9.

Baldwin TA, Li Y, Brand CS, Watts VJ, Dessauer CW.

Mol Pharmacol. 2019 Apr;95(4):349-360. doi: 10.1124/mol.118.114595. Epub 2019 Jan 29.


Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain.

Odem MA, Bavencoffe AG, Cassidy RM, Lopez ER, Tian J, Dessauer CW, Walters ET.

Pain. 2018 Nov;159(11):2347-2362. doi: 10.1097/j.pain.0000000000001341.


Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.


Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S.

Nat Commun. 2018 Mar 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.


Function of Adenylyl Cyclase in Heart: the AKAP Connection.

Baldwin TA, Dessauer CW.

J Cardiovasc Dev Dis. 2018 Jan 16;5(1). pii: E2. doi: 10.3390/jcdd5010002. Review.


Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain.

Luo J, Bavencoffe A, Yang P, Feng J, Yin S, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H.

J Neurosci. 2018 Jan 10;38(2):474-483. doi: 10.1523/JNEUROSCI.1816-17.2017. Epub 2017 Nov 30.


Shining a light on GPCR complexes.

Dessauer CW.

J Biol Chem. 2017 Aug 25;292(34):14290-14291. doi: 10.1074/jbc.H117.797100.


Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction.

Li Y, Baldwin TA, Wang Y, Subramaniam J, Carbajal AG, Brand CS, Cunha SR, Dessauer CW.

Sci Rep. 2017 Jul 17;7(1):5522. doi: 10.1038/s41598-017-05816-w.


International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R.

Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078. Review.


Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ.

Sci Signal. 2017 Feb 21;10(467). pii: eaah5381. doi: 10.1126/scisignal.aah5381.


Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.

Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW.

J Neurosci. 2016 Feb 3;36(5):1660-8. doi: 10.1523/JNEUROSCI.0895-15.2016.


Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling.

Xie K, Masuho I, Shih CC, Cao Y, Sasaki K, Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA.

Elife. 2015 Nov 27;4. pii: e10451. doi: 10.7554/eLife.10451.


A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015 Nov.


Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.

Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW.

Mol Pharmacol. 2015 Oct;88(4):758-67. doi: 10.1124/mol.115.099556. Epub 2015 Jul 23.


Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2014 Dec 15;592(24):5373-90. doi: 10.1113/jphysiol.2014.283218. Epub 2014 Nov 10.


Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.

Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5018-23. doi: 10.1073/pnas.1316425111. Epub 2014 Mar 17.


Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ.

J Pharmacol Exp Ther. 2013 Nov;347(2):276-87. doi: 10.1124/jpet.113.207449. Epub 2013 Sep 5.


Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds.

Brand CS, Hocker HJ, Gorfe AA, Cavasotto CN, Dessauer CW.

J Pharmacol Exp Ther. 2013 Nov;347(2):265-75. doi: 10.1124/jpet.113.208157. Epub 2013 Sep 4.


Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

Efendiev R, Bavencoffe A, Hu H, Zhu MX, Dessauer CW.

J Biol Chem. 2013 Feb 8;288(6):3929-37. doi: 10.1074/jbc.M112.428144. Epub 2012 Dec 21.


Creating order from chaos: cellular regulation by kinase anchoring.

Scott JD, Dessauer CW, Taskén K.

Annu Rev Pharmacol Toxicol. 2013;53:187-210. doi: 10.1146/annurev-pharmtox-011112-140204. Epub 2012 Oct 8. Review.


The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.

Xie K, Masuho I, Brand C, Dessauer CW, Martemyanov KA.

Sci Signal. 2012 Aug 28;5(239):ra63. doi: 10.1126/scisignal.2002922.


The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.

Li Y, Chen L, Kass RS, Dessauer CW.

J Biol Chem. 2012 Aug 24;287(35):29815-24. doi: 10.1074/jbc.M112.380568. Epub 2012 Jul 9.


Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production.

Pulliainen AT, Pieles K, Brand CS, Hauert B, Böhm A, Quebatte M, Wepf A, Gstaiger M, Aebersold R, Dessauer CW, Dehio C.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9581-6. doi: 10.1073/pnas.1117651109. Epub 2012 May 25.


Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly.

Ejendal KF, Dessauer CW, Hébert TE, Watts VJ.

J Signal Transduct. 2012;2012:210324. doi: 10.1155/2012/210324. Epub 2012 Mar 12.


A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.

Efendiev R, Dessauer CW.

J Cardiovasc Pharmacol. 2011 Oct;58(4):339-44. doi: 10.1097/FJC.0b013e31821bc3f0. Review.


Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N.

J Biol Chem. 2011 Sep 23;286(38):33223-35. doi: 10.1074/jbc.M111.271056. Epub 2011 Jul 27.


Stargazin modulates neuronal voltage-dependent Ca(2+) channel Ca(v)2.2 by a Gbetagamma-dependent mechanism.

Tselnicker I, Tsemakhovich VA, Dessauer CW, Dascal N.

J Biol Chem. 2010 Jul 2;285(27):20462-71. doi: 10.1074/jbc.M110.121277. Epub 2010 Apr 30.


AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors.

Efendiev R, Samelson BK, Nguyen BT, Phatarpekar PV, Baameur F, Scott JD, Dessauer CW.

J Biol Chem. 2010 May 7;285(19):14450-8. doi: 10.1074/jbc.M110.109769. Epub 2010 Mar 15.


Quantitative modeling of GRK-mediated beta2AR regulation.

Vayttaden SJ, Friedman J, Tran TM, Rich TC, Dessauer CW, Clark RB.

PLoS Comput Biol. 2010 Jan 22;6(1):e1000647. doi: 10.1371/journal.pcbi.1000647.


G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK).

Berlin S, Keren-Raifman T, Castel R, Rubinstein M, Dessauer CW, Ivanina T, Dascal N.

J Biol Chem. 2010 Feb 26;285(9):6179-85. doi: 10.1074/jbc.M109.085944. Epub 2009 Dec 16.


N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.

Sadana R, Dascal N, Dessauer CW.

Mol Pharmacol. 2009 Dec;76(6):1256-64. doi: 10.1124/mol.109.058370. Epub 2009 Sep 25.


Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.

Dessauer CW.

Mol Pharmacol. 2009 Nov;76(5):935-41. doi: 10.1124/mol.109.059345. Epub 2009 Aug 14. Review.


An adenylyl cyclase-mAKAPbeta signaling complex regulates cAMP levels in cardiac myocytes.

Kapiloff MS, Piggott LA, Sadana R, Li J, Heredia LA, Henson E, Efendiev R, Dessauer CW.

J Biol Chem. 2009 Aug 28;284(35):23540-6. doi: 10.1074/jbc.M109.030072. Epub 2009 Jul 1.


Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma.

Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2009 Jul 15;587(Pt 14):3473-91. doi: 10.1113/jphysiol.2009.173229. Epub 2009 May 26.


Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.

Sadana R, Dessauer CW.

Neurosignals. 2009;17(1):5-22. doi: 10.1159/000166277. Epub 2008 Oct 24. Review.


The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain.

Piggott LA, Bauman AL, Scott JD, Dessauer CW.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13835-40. doi: 10.1073/pnas.0712100105. Epub 2008 Sep 4.


Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels.

Yakubovich D, Rishal I, Dessauer CW, Dascal N.

J Mol Neurosci. 2009 Mar;37(3):201-11. doi: 10.1007/s12031-008-9117-z. Epub 2008 Jul 12.


Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.

Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP.

Mol Pharmacol. 2008 Jan;73(1):1-11. Epub 2007 Sep 27.


Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

Gao X, Sadana R, Dessauer CW, Patel TB.

J Biol Chem. 2007 Jan 5;282(1):294-302. Epub 2006 Nov 16.


Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.

Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD.

Mol Cell. 2006 Sep 15;23(6):925-31.


Soluble adenylyl cyclase reveals the significance of cAMP compartmentation on pulmonary microvascular endothelial cell barrier.

Sayner SL, Alexeyev M, Dessauer CW, Stevens T.

Circ Res. 2006 Mar 17;98(5):675-81. Epub 2006 Feb 9.


Relaxin stimulates protein kinase C zeta translocation: requirement for cyclic adenosine 3',5'-monophosphate production.

Nguyen BT, Dessauer CW.

Mol Endocrinol. 2005 Apr;19(4):1012-23. Epub 2004 Dec 16.


Modeling of Galpha(s) and Galpha(i) regulation of human type V and VI adenylyl cyclase.

Chen-Goodspeed M, Lukan AN, Dessauer CW.

J Biol Chem. 2005 Jan 21;280(3):1808-16. Epub 2004 Nov 15.


Analysis of the interaction between RGS2 and adenylyl cyclase.

Salim S, Dessauer CW.

Methods Enzymol. 2004;390:83-99.


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