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Nanometric targeting of type 9 adenylyl cyclase in heart.

Marsden AN, Dessauer CW.

Biochem Soc Trans. 2019 Nov 26. pii: BST20190227. doi: 10.1042/BST20190227. [Epub ahead of print]


Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening.

Doyle TB, Muntean BS, Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ.

Cells. 2019 Nov 19;8(11). pii: E1468. doi: 10.3390/cells8111468.



Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2019 Dec;176 Suppl 1:S297-S396. doi: 10.1111/bph.14752.


Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase.

Li Y, Hof T, Baldwin TA, Chen L, Kass RS, Dessauer CW.

Cells. 2019 Aug 27;8(9). pii: E981. doi: 10.3390/cells8090981.


Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9.

Baldwin TA, Li Y, Brand CS, Watts VJ, Dessauer CW.

Mol Pharmacol. 2019 Apr;95(4):349-360. doi: 10.1124/mol.118.114595. Epub 2019 Jan 29.


Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain.

Odem MA, Bavencoffe AG, Cassidy RM, Lopez ER, Tian J, Dessauer CW, Walters ET.

Pain. 2018 Nov;159(11):2347-2362. doi: 10.1097/j.pain.0000000000001341.


Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.


Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Navarro G, Cordomí A, Casadó-Anguera V, Moreno E, Cai NS, Cortés A, Canela EI, Dessauer CW, Casadó V, Pardo L, Lluís C, Ferré S.

Nat Commun. 2018 Mar 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.


Function of Adenylyl Cyclase in Heart: the AKAP Connection.

Baldwin TA, Dessauer CW.

J Cardiovasc Dev Dis. 2018 Jan 16;5(1). pii: E2. doi: 10.3390/jcdd5010002. Review.


Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain.

Luo J, Bavencoffe A, Yang P, Feng J, Yin S, Qian A, Yu W, Liu S, Gong X, Cai T, Walters ET, Dessauer CW, Hu H.

J Neurosci. 2018 Jan 10;38(2):474-483. doi: 10.1523/JNEUROSCI.1816-17.2017. Epub 2017 Nov 30.


Shining a light on GPCR complexes.

Dessauer CW.

J Biol Chem. 2017 Aug 25;292(34):14290-14291. doi: 10.1074/jbc.H117.797100.


Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction.

Li Y, Baldwin TA, Wang Y, Subramaniam J, Carbajal AG, Brand CS, Cunha SR, Dessauer CW.

Sci Rep. 2017 Jul 17;7(1):5522. doi: 10.1038/s41598-017-05816-w.


International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R.

Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078. Review.


Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ.

Sci Signal. 2017 Feb 21;10(467). pii: eaah5381. doi: 10.1126/scisignal.aah5381.


Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.

Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW.

J Neurosci. 2016 Feb 3;36(5):1660-8. doi: 10.1523/JNEUROSCI.0895-15.2016.


Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling.

Xie K, Masuho I, Shih CC, Cao Y, Sasaki K, Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA.

Elife. 2015 Nov 27;4. pii: e10451. doi: 10.7554/eLife.10451.


A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015 Nov.


Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.

Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW.

Mol Pharmacol. 2015 Oct;88(4):758-67. doi: 10.1124/mol.115.099556. Epub 2015 Jul 23.


Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2014 Dec 15;592(24):5373-90. doi: 10.1113/jphysiol.2014.283218. Epub 2014 Nov 10.


Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂.

Dvir M, Strulovich R, Sachyani D, Ben-Tal Cohen I, Haitin Y, Dessauer C, Pongs O, Kass R, Hirsch JA, Attali B.

J Cell Sci. 2014 Sep 15;127(Pt 18):3943-55. doi: 10.1242/jcs.147033. Epub 2014 Jul 18.

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