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Items: 49

1.

Alterations in Striatal microRNA-mRNA Networks Contribute to Neuroinflammation in Multiple System Atrophy.

Kim T, Valera E, Desplats P.

Mol Neurobiol. 2019 Apr 9. doi: 10.1007/s12035-019-1577-3. [Epub ahead of print]

PMID:
30968343
2.

DNA methylation changes associated with Parkinson's disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood.

Henderson-Smith A, Fisch KM, Hua J, Liu G, Ricciardelli E, Jepsen K, Huentelman M, Stalberg G, Edland SD, Scherzer CR, Dunckley T, Desplats P.

Epigenetics. 2019 Apr;14(4):365-382. doi: 10.1080/15592294.2019.1588682. Epub 2019 Mar 14.

PMID:
30871403
3.

Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy.

Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P.

J Neurochem. 2018 Dec;147(6):784-802. doi: 10.1111/jnc.14582. Epub 2018 Nov 26.

PMID:
30152135
4.

Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis.

Frasch MG, Lobmaier SM, Stampalija T, Desplats P, Pallarés ME, Pastor V, Brocco MA, Wu HT, Schulkin J, Herry CL, Seely AJE, Metz GAS, Louzoun Y, Antonelli MC.

Neurosci Biobehav Rev. 2018 May 30. pii: S0149-7634(18)30054-X. doi: 10.1016/j.neubiorev.2018.05.026. [Epub ahead of print] Review.

PMID:
29859198
5.

Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples.

Spencer B, Rank L, Metcalf J, Desplats P.

Sci Rep. 2018 Mar 6;8(1):4070. doi: 10.1038/s41598-018-22434-2.

6.

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy.

Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E, Desplats P.

Front Mol Neurosci. 2017 Oct 17;10:329. doi: 10.3389/fnmol.2017.00329. eCollection 2017.

7.

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.

Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E.

Acta Neuropathol Commun. 2017 Jan 5;5(1):2. doi: 10.1186/s40478-016-0409-1.

8.

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.

Cronin P, McCarthy MJ, Lim ASP, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P.

Alzheimers Dement. 2017 Jun;13(6):689-700. doi: 10.1016/j.jalz.2016.10.003. Epub 2016 Nov 22.

9.

A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.

Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E.

Brain. 2016 Dec;139(Pt 12):3217-3236. Epub 2016 Sep 27.

10.

Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.

Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E.

J Neurosci. 2016 Jul 27;36(30):7971-84. doi: 10.1523/JNEUROSCI.0775-16.2016.

11.

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.

Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E.

J Neuroinflammation. 2016 May 24;13(1):120. doi: 10.1186/s12974-016-0585-8.

12.

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.

Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, Adame A, Lee SJ, Desplats P, Masliah E.

Hum Mol Genet. 2016 Mar 15;25(6):1100-15. doi: 10.1093/hmg/ddv633. Epub 2016 Jan 5.

13.

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease.

Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E.

J Neuroinflammation. 2015 Dec 18;12:236. doi: 10.1186/s12974-015-0455-9.

14.

Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease.

Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E.

Stem Cell Res. 2015 Jul;15(1):54-67. doi: 10.1016/j.scr.2015.04.008. Epub 2015 May 9.

15.

Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease.

Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Moessler H, Masliah E.

J Exp Neurosci. 2016 Jul 7;9(Suppl 2):131-40. doi: 10.4137/JEN.S25521. eCollection 2015.

16.

Perinatal programming of neurodevelopment: epigenetic mechanisms and the prenatal shaping of the brain.

Desplats PA.

Adv Neurobiol. 2015;10:335-61. doi: 10.1007/978-1-4939-1372-5_16.

PMID:
25287548
17.

Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence.

Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, Smith D, Masliah E, Grant I.

PLoS One. 2014 Jul 23;9(7):e102555. doi: 10.1371/journal.pone.0102555. eCollection 2014.

18.

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E.

Mol Ther. 2014 Oct;22(10):1753-67. doi: 10.1038/mt.2014.129. Epub 2014 Jul 10.

19.

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.

Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E.

Mol Neurodegener. 2014 May 19;9:18. doi: 10.1186/1750-1326-9-18.

20.

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.

Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E.

J Biol Chem. 2014 Jun 20;289(25):17917-31. doi: 10.1074/jbc.M114.557439. Epub 2014 May 13.

21.

Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation.

Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E.

J Alzheimers Dis. 2014;39(3):583-600. doi: 10.3233/JAD-131589.

22.

Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes.

Masliah E, Dumaop W, Galasko D, Desplats P.

Epigenetics. 2013 Oct;8(10):1030-8. doi: 10.4161/epi.25865. Epub 2013 Aug 1.

23.

TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.

Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E.

PLoS One. 2013 Apr 23;8(4):e62277. doi: 10.1371/journal.pone.0062277. Print 2013.

24.

Molecular and pathologic insights from latent HIV-1 infection in the human brain.

Desplats P, Dumaop W, Smith D, Adame A, Everall I, Letendre S, Ellis R, Cherner M, Grant I, Masliah E.

Neurology. 2013 Apr 9;80(15):1415-23. doi: 10.1212/WNL.0b013e31828c2e9e. Epub 2013 Mar 13.

25.

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.

Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M, Masliah E.

Mol Neurodegener. 2012 Sep 28;7:49. doi: 10.1186/1750-1326-7-49.

26.

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.

Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ.

J Neurosci. 2012 Sep 26;32(39):13454-69.

27.

α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.

Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E.

J Biol Chem. 2012 Sep 14;287(38):31691-702. doi: 10.1074/jbc.M112.354522. Epub 2012 Jul 25.

28.

In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.

Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E.

J Neurosci. 2012 Jul 18;32(29):9992-8. doi: 10.1523/JNEUROSCI.1270-12.2012.

29.

Cell-to-cell transmission of α-synuclein aggregates.

Lee SJ, Desplats P, Lee HJ, Spencer B, Masliah E.

Methods Mol Biol. 2012;849:347-59. doi: 10.1007/978-1-61779-551-0_23.

30.

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease.

Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA.

Hum Mol Genet. 2012 Jul 15;21(14):3097-111. doi: 10.1093/hmg/dds132. Epub 2012 Apr 6.

31.

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E.

FEBS J. 2012 Mar;279(6):1000-13. doi: 10.1111/j.1742-4658.2012.08489.x. Epub 2012 Feb 27.

32.

Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine.

Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E.

Am J Pathol. 2011 Apr;178(4):1646-61. doi: 10.1016/j.ajpath.2010.12.033.

33.

In vivo demonstration that alpha-synuclein oligomers are toxic.

Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. doi: 10.1073/pnas.1100976108. Epub 2011 Feb 15.

34.

Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.

Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E.

J Biol Chem. 2011 Mar 18;286(11):9031-7. doi: 10.1074/jbc.C110.212589. Epub 2011 Feb 4.

35.

Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.

Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E.

PLoS One. 2010 Nov 16;5(11):e14020. doi: 10.1371/journal.pone.0014020.

36.

Cell-to-cell transmission of non-prion protein aggregates.

Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E.

Nat Rev Neurol. 2010 Dec;6(12):702-6. doi: 10.1038/nrneurol.2010.145. Epub 2010 Oct 12. Review. Erratum in: Nat Rev Neurol. 2011 Jan;7(1):5.

37.

Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease.

Denny CA, Desplats PA, Thomas EA, Seyfried TN.

J Neurochem. 2010 Nov;115(3):748-58. doi: 10.1111/j.1471-4159.2010.06964.x. Epub 2010 Sep 27.

38.

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E.

PLoS One. 2010 Feb 19;5(2):e9313. doi: 10.1371/journal.pone.0009313.

39.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5. doi: 10.1073/pnas.0903691106. Epub 2009 Jul 27. Erratum in: Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17606.

40.

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model.

Winner B, Desplats P, Hagl C, Klucken J, Aigner R, Ploetz S, Laemke J, Karl A, Aigner L, Masliah E, Buerger E, Winkler J.

Exp Neurol. 2009 Oct;219(2):543-52. doi: 10.1016/j.expneurol.2009.07.013. Epub 2009 Jul 18.

41.

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. doi: 10.1073/pnas.0804249105. Epub 2008 Sep 30.

42.

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E.

PLoS One. 2008 Sep 4;3(9):e3135. doi: 10.1371/journal.pone.0003135.

43.

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease.

Desplats PA, Lambert JR, Thomas EA.

Neurobiol Dis. 2008 Sep;31(3):298-308. doi: 10.1016/j.nbd.2008.05.005. Epub 2008 May 22.

44.

Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.

Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E.

J Neurosci. 2008 Apr 16;28(16):4250-60. doi: 10.1523/JNEUROSCI.0066-08.2008.

45.

Glycolipid and ganglioside metabolism imbalances in Huntington's disease.

Desplats PA, Denny CA, Kass KE, Gilmartin T, Head SR, Sutcliffe JG, Seyfried TN, Thomas EA.

Neurobiol Dis. 2007 Sep;27(3):265-77. Epub 2007 May 22.

46.

Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

Desplats PA, Kass KE, Gilmartin T, Stanwood GD, Woodward EL, Head SR, Sutcliffe JG, Thomas EA.

J Neurochem. 2006 Feb;96(3):743-57. Epub 2006 Jan 9.

47.

Sucrose may play an additional role to that of an osmolyte in Synechocystis sp. PCC 6803 salt-shocked cells.

Desplats P, Folco E, Salerno GL.

Plant Physiol Biochem. 2005 Feb;43(2):133-8.

PMID:
15820660
48.

Chemotaxis of Silicibacter sp. strain TM1040 toward dinoflagellate products.

Miller TR, Hnilicka K, Dziedzic A, Desplats P, Belas R.

Appl Environ Microbiol. 2004 Aug;70(8):4692-701.

49.

Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli.

Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G.

J Bacteriol. 1998 Dec;180(24):6776-9.

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