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Items: 43


Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space.

Leone P, Roche J, Vincent MS, Tran QH, Desmyter A, Cascales E, Kellenberger C, Cambillau C, Roussel A.

Nat Commun. 2018 Jan 30;9(1):429. doi: 10.1038/s41467-017-02784-7.


Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics.

Douzi B, Trinh NTT, Michel-Souzy S, Desmyter A, Ball G, Barbier P, Kosta A, Durand E, Forest KT, Cambillau C, Roussel A, Voulhoux R.

mBio. 2017 Oct 17;8(5). pii: e01185-17. doi: 10.1128/mBio.01185-17.


Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.

Desmyter A, Spinelli S, Boutton C, Saunders M, Blachetot C, de Haard H, Denecker G, Van Roy M, Cambillau C, Rommelaere H.

Front Immunol. 2017 Aug 21;8:884. doi: 10.3389/fimmu.2017.00884. eCollection 2017.


Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.

Beirnaert E, Desmyter A, Spinelli S, Lauwereys M, Aarden L, Dreier T, Loris R, Silence K, Pollet C, Cambillau C, de Haard H.

Front Immunol. 2017 Jul 31;8:867. doi: 10.3389/fimmu.2017.00867. eCollection 2017.


Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor.

Hassaïne G, Deluz C, Grasso L, Wyss R, Hovius R, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Peclinovska L, Minniberger S, Mebarki L, Li XD, Vogel H, Nury H.

Methods Mol Biol. 2017;1635:139-168. doi: 10.1007/978-1-4939-7151-0_8.


Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.

Nguyen VS, Logger L, Spinelli S, Legrand P, Huyen Pham TT, Nhung Trinh TT, Cherrak Y, Zoued A, Desmyter A, Durand E, Roussel A, Kellenberger C, Cascales E, Cambillau C.

Nat Microbiol. 2017 Jun 26;2:17103. doi: 10.1038/nmicrobiol.2017.103.


Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis.

Duhoo Y, Roche J, Trinh TTN, Desmyter A, Gaubert A, Kellenberger C, Cambillau C, Roussel A, Leone P.

Acta Crystallogr F Struct Biol Commun. 2017 May 1;73(Pt 5):286-293. doi: 10.1107/S2053230X17005969. Epub 2017 Apr 26.


Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.

Blanchetot C, De Jonge N, Desmyter A, Ongenae N, Hofman E, Klarenbeek A, Sadi A, Hultberg A, Kretz-Rommel A, Spinelli S, Loris R, Cambillau C, de Haard H.

J Biol Chem. 2016 Jun 24;291(26):13846-54. doi: 10.1074/jbc.M115.695528. Epub 2016 Apr 27.


Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics.

Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-Rommel A, Dreier T, De Haard HJ, Roovers RC.

Protein Eng Des Sel. 2016 Apr;29(4):123-33. doi: 10.1093/protein/gzw003. Epub 2016 Mar 5.


The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules.

Legrand P, Collins B, Blangy S, Murphy J, Spinelli S, Gutierrez C, Richet N, Kellenberger C, Desmyter A, Mahony J, van Sinderen D, Cambillau C.

mBio. 2016 Jan 26;7(1):e01781-15. doi: 10.1128/mBio.01781-15.


Biogenesis and structure of a type VI secretion membrane core complex.

Durand E, Nguyen VS, Zoued A, Logger L, Péhau-Arnaudet G, Aschtgen MS, Spinelli S, Desmyter A, Bardiaux B, Dujeancourt A, Roussel A, Cambillau C, Cascales E, Fronzes R.

Nature. 2015 Jul 30;523(7562):555-60. doi: 10.1038/nature14667. Epub 2015 Jul 22.


Signalment, clinical features, echocardiographic findings, and outcome of dogs and cats with ventricular septal defects: 109 cases (1992-2013).

Bomassi E, Misbach C, Tissier R, Gouni V, Trehiou-Sechi E, Petit AM, Desmyter A, Damoiseaux C, Pouchelon JL, Chetboul V.

J Am Vet Med Assoc. 2015 Jul 15;247(2):166-75. doi: 10.2460/javma.247.2.166.


Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.

Klarenbeek A, El Mazouari K, Desmyter A, Blanchetot C, Hultberg A, de Jonge N, Roovers RC, Cambillau C, Spinelli S, Del-Favero J, Verrips T, de Haard HJ, Achour I.

MAbs. 2015;7(4):693-706. doi: 10.1080/19420862.2015.1046648.


Inhibition of type VI secretion by an anti-TssM llama nanobody.

Nguyen VS, Logger L, Spinelli S, Desmyter A, Le TT, Kellenberger C, Douzi B, Durand E, Roussel A, Cascales E, Cambillau C.

PLoS One. 2015 Mar 26;10(3):e0122187. doi: 10.1371/journal.pone.0122187. eCollection 2015.


Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid nanobody.

Nguyen VS, Spinelli S, Desmyter A, Le TT, Kellenberger C, Cascales E, Cambillau C, Roussel A.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):266-71. doi: 10.1107/S2053230X15000709. Epub 2015 Feb 19.


Camelid nanobodies: killing two birds with one stone.

Desmyter A, Spinelli S, Roussel A, Cambillau C.

Curr Opin Struct Biol. 2015 Jun;32:1-8. doi: 10.1016/ Epub 2015 Jan 19. Review.


X-ray structure of the mouse serotonin 5-HT3 receptor.

Hassaine G, Deluz C, Grasso L, Wyss R, Tol MB, Hovius R, Graff A, Stahlberg H, Tomizaki T, Desmyter A, Moreau C, Li XD, Poitevin F, Vogel H, Nury H.

Nature. 2014 Aug 21;512(7514):276-81. doi: 10.1038/nature13552. Epub 2014 Aug 3.


Viral infection modulation and neutralization by camelid nanobodies.

Desmyter A, Farenc C, Mahony J, Spinelli S, Bebeacua C, Blangy S, Veesler D, van Sinderen D, Cambillau C.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1371-9. doi: 10.1073/pnas.1301336110. Epub 2013 Mar 25.


Mammalian G protein-coupled receptor expression in Escherichia coli: II. Refolding and biophysical characterization of mouse cannabinoid receptor 1 and human parathyroid hormone receptor 1.

Michalke K, Huyghe C, Lichière J, Gravière ME, Siponen M, Sciara G, Lepaul I, Wagner R, Magg C, Rudolph R, Cambillau C, Desmyter A.

Anal Biochem. 2010 Jun 1;401(1):74-80. doi: 10.1016/j.ab.2010.02.017. Epub 2010 Feb 20.


Quantification of pulmonary to systemic flow ratio by a Doppler echocardiographic method in the normal dog: Repeatability, reproducibility, and reference ranges.

Serres F, Chetboul V, Tissier R, Gouni V, Desmyter A, Sampedrano CC, Pouchelon JL.

J Vet Cardiol. 2009 Jun;11(1):23-9. doi: 10.1016/j.jvc.2009.04.001. Epub 2009 May 24.


Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase.

Conrath K, Pereira AS, Martins CE, Timóteo CG, Tavares P, Spinelli S, Kinne J, Flaudrops C, Cambillau C, Muyldermans S, Moura I, Moura JJ, Tegoni M, Desmyter A.

Protein Sci. 2009 Mar;18(3):619-28. doi: 10.1002/pro.69.


Primary hyperparathyroidism and monoclonal gammopathy in a dog.

Benchekroun G, Desmyter A, Hidalgo A, Boulouis HJ, Gomes E, Garnier F, Escoffier L, Poujol L, de Fornel-Thibaud P, Maurey C, Rosenberg D.

J Vet Intern Med. 2009 Jan-Feb;23(1):211-4. doi: 10.1111/j.1939-1676.2008.0223.x. No abstract available.


Mammalian G-protein-coupled receptor expression in Escherichia coli: I. High-throughput large-scale production as inclusion bodies.

Michalke K, Gravière ME, Huyghe C, Vincentelli R, Wagner R, Pattus F, Schroeder K, Oschmann J, Rudolph R, Cambillau C, Desmyter A.

Anal Biochem. 2009 Mar 15;386(2):147-55. doi: 10.1016/j.ab.2008.12.016. Epub 2008 Dec 24.


Combining site-specific mutagenesis and seeding as a strategy to crystallize 'difficult' proteins: the case of Staphylococcus aureus thioredoxin.

Roos G, Brosens E, Wahni K, Desmyter A, Spinelli S, Wyns L, Messens J, Loris R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1255-8. Epub 2006 Nov 30.


Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems.

Lundstrom K, Wagner R, Reinhart C, Desmyter A, Cherouati N, Magnin T, Zeder-Lutz G, Courtot M, Prual C, André N, Hassaine G, Michel H, Cambillau C, Pattus F.

J Struct Funct Genomics. 2006 Jun;7(2):77-91. Epub 2006 Nov 22.


Receptor-binding protein of Lactococcus lactis phages: identification and characterization of the saccharide receptor-binding site.

Tremblay DM, Tegoni M, Spinelli S, Campanacci V, Blangy S, Huyghe C, Desmyter A, Labrie S, Moineau S, Cambillau C.

J Bacteriol. 2006 Apr;188(7):2400-10.


Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses.

Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C.

Nat Struct Mol Biol. 2006 Jan;13(1):85-9. Epub 2005 Dec 4.


Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet structure.

Spinelli S, Desmyter A, Frenken L, Verrips T, Tegoni M, Cambillau C.

FEBS Lett. 2004 Apr 23;564(1-2):35-40.


A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.

Dumoulin M, Last AM, Desmyter A, Decanniere K, Canet D, Larsson G, Spencer A, Archer DB, Sasse J, Muyldermans S, Wyns L, Redfield C, Matagne A, Robinson CV, Dobson CM.

Nature. 2003 Aug 14;424(6950):783-8.


All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade.

Messens J, Martins JC, Van Belle K, Brosens E, Desmyter A, De Gieter M, Wieruszeski JM, Willem R, Wyns L, Zegers I.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8506-11. Epub 2002 Jun 18.


Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.

Desmyter A, Spinelli S, Payan F, Lauwereys M, Wyns L, Muyldermans S, Cambillau C.

J Biol Chem. 2002 Jun 28;277(26):23645-50. Epub 2002 Apr 17.


Functional heavy-chain antibodies in Camelidae.

Nguyen VK, Desmyter A, Muyldermans S.

Adv Immunol. 2001;79:261-96. Review. No abstract available.


Degenerate interfaces in antigen-antibody complexes.

Decanniere K, Transue TR, Desmyter A, Maes D, Muyldermans S, Wyns L.

J Mol Biol. 2001 Oct 26;313(3):473-8.


Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.

Desmyter A, Decanniere K, Muyldermans S, Wyns L.

J Biol Chem. 2001 Jul 13;276(28):26285-90. Epub 2001 May 7.


The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus.

Messens J, Hayburn G, Desmyter A, Laus G, Wyns L.

Biochemistry. 1999 Dec 21;38(51):16857-65.


A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.

Decanniere K, Desmyter A, Lauwereys M, Ghahroudi MA, Muyldermans S, Wyns L.

Structure. 1999 Apr 15;7(4):361-70.


Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.

Lauwereys M, Arbabi Ghahroudi M, Desmyter A, Kinne J, Hölzer W, De Genst E, Wyns L, Muyldermans S.

EMBO J. 1998 Jul 1;17(13):3512-20.


Selection and identification of single domain antibody fragments from camel heavy-chain antibodies.

Arbabi Ghahroudi M, Desmyter A, Wyns L, Hamers R, Muyldermans S.

FEBS Lett. 1997 Sep 15;414(3):521-6.


Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.

Desmyter A, Transue TR, Ghahroudi MA, Thi MH, Poortmans F, Hamers R, Muyldermans S, Wyns L.

Nat Struct Biol. 1996 Sep;3(9):803-11.


[Phenotypic and genotypic properties of 4 virulence plasmids of Salmonella typhimurium].

Pohl P, Lintermans P, Bex F, Desmyter A, Dreze P, Fonteyne PA, Couturier M.

Ann Inst Pasteur Microbiol. 1987 Sep-Oct;138(5):523-8. French.


Mini-F E protein: the carboxy-terminal end is essential for E gene repression and mini-F copy number control.

Bex F, Piérard P, Desmyter A, Drèze P, Colet M, Couturier M.

J Mol Biol. 1986 May 20;189(2):293-303.


Inversion and deletion mutants in Bacillus subtilis bacteriophage SPP1 as a consequence of cloning.

Desmyter A, Reeve JN, Morelli G, Trautner TA.

Mol Gen Genet. 1985;198(3):537-9.


Construction in vitro of "phage-plasmid" chimerae: a new tool to analyse the mechanism of plasmid maintenance.

Couturier M, Janssens J, Bex F, Desmyter A, Bonnevalle I.

Mol Gen Genet. 1979 Jan 16;169(1):113-6.


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