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Items: 1 to 50 of 60

1.

Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease.

Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R.

Kidney Int. 2019 Apr;95(4):797-814. doi: 10.1016/j.kint.2018.11.042.

PMID:
30904067
2.

New chief of cardiovascular medicine at Yale School of Medicine.

Desir GV, Churchwell KB.

Eur Heart J. 2018 May 14;39(19):1665. doi: 10.1093/eurheartj/ehy197. No abstract available.

PMID:
29762704
3.

The serum protein renalase reduces injury in experimental pancreatitis.

Kolodecik TR, Reed AM, Date K, Shugrue CA, Patel V, Chung SL, Desir GV, Gorelick FS.

J Biol Chem. 2017 Dec 22;292(51):21047-21059. doi: 10.1074/jbc.M117.789776. Epub 2017 Oct 17.

4.

Extracellular renalase protects cells and organs by outside-in signalling.

Wang Y, Safirstein R, Velazquez H, Guo XJ, Hollander L, Chang J, Chen TM, Mu JJ, Desir GV.

J Cell Mol Med. 2017 Jul;21(7):1260-1265. doi: 10.1111/jcmm.13062. Epub 2017 Feb 26. Review.

5.

A Remote Role for Renalase.

Giordano FJ, Wang Y, Desir GV.

EBioMedicine. 2016 Jul;9:27-28. doi: 10.1016/j.ebiom.2016.06.034. Epub 2016 Jun 25. No abstract available.

6.

Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism.

Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV.

Cancer Res. 2016 Jul 1;76(13):3884-94. doi: 10.1158/0008-5472.CAN-15-1524. Epub 2016 May 9.

7.

Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.

Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV.

Sci Rep. 2016 Mar 14;6:22996. doi: 10.1038/srep22996.

8.

Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD.

Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R.

J Am Soc Nephrol. 2016 Apr;27(4):1102-12. doi: 10.1681/ASN.2015010079. Epub 2015 Aug 24.

9.

Identification of a receptor for extracellular renalase.

Wang L, Velazquez H, Chang J, Safirstein R, Desir GV.

PLoS One. 2015 Apr 23;10(4):e0122932. doi: 10.1371/journal.pone.0122932. eCollection 2015.

10.

Renalase regulates peripheral and central dopaminergic activities.

Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M.

Am J Physiol Renal Physiol. 2015 Jan 15;308(2):F84-91. doi: 10.1152/ajprenal.00274.2014. Epub 2014 Nov 19.

11.

Renalase: its role as a cytokine, and an update on its association with type 1 diabetes and ischemic stroke.

Guo X, Wang L, Velazquez H, Safirstein R, Desir GV.

Curr Opin Nephrol Hypertens. 2014 Sep;23(5):513-8. doi: 10.1097/MNH.0000000000000044. Review.

12.

Renalase prevents AKI independent of amine oxidase activity.

Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV.

J Am Soc Nephrol. 2014 Jun;25(6):1226-35. doi: 10.1681/ASN.2013060665. Epub 2014 Feb 7.

13.

Renalase in hypertension and kidney disease.

Desir GV, Peixoto AJ.

Nephrol Dial Transplant. 2014 Jan;29(1):22-8. doi: 10.1093/ndt/gft083. Epub 2013 Oct 17. Review.

PMID:
24137013
14.

Renalase regulates renal dopamine and phosphate metabolism.

Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV.

Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F839-44. doi: 10.1152/ajprenal.00616.2012. Epub 2013 Jul 17.

15.

Renalase protects against ischemic AKI.

Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D'Agati VD, Desir GV.

J Am Soc Nephrol. 2013 Feb;24(3):445-55. doi: 10.1681/ASN.2012090943. Epub 2013 Feb 7.

16.

Does kidney disease cause hypertension?

Peixoto AJ, Orias M, Desir GV.

Curr Hypertens Rep. 2013 Apr;15(2):89-94. doi: 10.1007/s11906-013-0327-6. Review.

PMID:
23344662
17.

Renalase lowers ambulatory blood pressure by metabolizing circulating adrenaline.

Desir GV, Tang L, Wang P, Li G, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Velazquez H.

J Am Heart Assoc. 2012 Aug;1(4):e002634. doi: 10.1161/JAHA.112.002634. Epub 2012 Aug 24.

18.

Human renalase: a review of its biology, function, and implications for hypertension.

Desir GV, Wang L, Peixoto AJ.

J Am Soc Hypertens. 2012 Nov-Dec;6(6):417-26. doi: 10.1016/j.jash.2012.09.002. Epub 2012 Oct 26. Review.

PMID:
23107895
19.

Increased renal dopamine and acute renal adaptation to a high-phosphate diet.

Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S.

Am J Physiol Renal Physiol. 2011 May;300(5):F1123-9. doi: 10.1152/ajprenal.00744.2010. Epub 2011 Feb 16.

20.

Renalase deficiency aggravates ischemic myocardial damage.

Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV.

Kidney Int. 2011 Apr;79(8):853-60. doi: 10.1038/ki.2010.488. Epub 2010 Dec 22.

21.

Role of renalase in the regulation of blood pressure and the renal dopamine system.

Desir GV.

Curr Opin Nephrol Hypertens. 2011 Jan;20(1):31-6. doi: 10.1097/MNH.0b013e3283412721. Review.

PMID:
21099685
22.

A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study.

Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA.

PLoS One. 2010 Oct 20;5(10):e13496. doi: 10.1371/journal.pone.0013496.

23.

The evidence-based use of thiazide diuretics in hypertension and nephrolithiasis.

Reilly RF, Peixoto AJ, Desir GV.

Clin J Am Soc Nephrol. 2010 Oct;5(10):1893-903. doi: 10.2215/CJN.04670510. Epub 2010 Aug 26. Review.

24.

A case of extreme hemodynamic lability and hypocalcemia.

Knauf F, Desir GV, Perazella MA.

Am J Med Sci. 2009 Sep;338(3):241-4. doi: 10.1097/MAJ.0b013e3181a66af1.

PMID:
19590425
25.

Regulation of blood pressure and cardiovascular function by renalase.

Desir GV.

Kidney Int. 2009 Aug;76(4):366-70. doi: 10.1038/ki.2009.169. Epub 2009 May 27. Review.

26.

Catecholamines regulate the activity, secretion, and synthesis of renalase.

Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV.

Circulation. 2008 Mar 11;117(10):1277-82. doi: 10.1161/CIRCULATIONAHA.107.732032. Epub 2008 Feb 25.

PMID:
18299506
27.

Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease.

Desir GV.

Curr Opin Nephrol Hypertens. 2008 Mar;17(2):181-5. doi: 10.1097/MNH.0b013e3282f521ba. Review.

PMID:
18277152
28.

Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII.

Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV.

Biochem Biophys Res Commun. 2007 Oct 26;362(3):658-64. Epub 2007 Aug 15.

29.

Renalase, a new renal hormone: its role in health and disease.

Xu J, Desir GV.

Curr Opin Nephrol Hypertens. 2007 Jul;16(4):373-8. Review.

PMID:
17565281
30.

Renalase is a novel renal hormone that regulates cardiovascular function.

Desir GV.

J Am Soc Hypertens. 2007 Mar-Apr;1(2):99-103. doi: 10.1016/j.jash.2006.12.001.

PMID:
20409839
31.
32.

Kv1.3 potassium channel blockade as an approach to insulin resistance.

Desir GV.

Expert Opin Ther Targets. 2005 Jun;9(3):571-9. Review.

PMID:
15948674
33.

Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV.

J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7.

34.

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.

Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3112-7. Epub 2004 Feb 23.

35.

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of Pharmacology.

Pharmacol Rev. 2003 Dec;55(4):583-6.

PMID:
14657415
36.

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight.

Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV.

Hum Mol Genet. 2003 Mar 1;12(5):551-9.

PMID:
12588802
37.

Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.

Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV.

J Am Soc Nephrol. 2002 Dec;13(12):2831-9.

38.

On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport.

Segal AS, Hayslett JP, Desir GV.

Am J Physiol Renal Physiol. 2002 Oct;283(4):F765-70.

39.

Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.

Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV.

Am J Physiol Renal Physiol. 2002 Jul;283(1):F142-9.

40.

The distal convoluted tubule of rabbit kidney does not express a functional sodium channel.

Velázquez H, Silva T, Andújar E, Desir GV, Ellison DH, Greger R.

Am J Physiol Renal Physiol. 2001 Mar;280(3):F530-9.

41.

Close association of the N terminus of Kv1.3 with the pore region.

Yao X, Liu W, Tian S, Rafi H, Segal AS, Desir GV.

J Biol Chem. 2000 Apr 14;275(15):10859-63.

42.

KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.

Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV.

Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21.

43.

Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome.

Kunchaparty S, Palcso M, Berkman J, Velázquez H, Desir GV, Bernstein P, Reilly RF, Ellison DH.

Am J Physiol. 1999 Oct;277(4):F643-9. doi: 10.1152/ajprenal.1999.277.4.F643.

PMID:
10516289
44.

The T0 domain of rabbit KV1.3 regulates steady state channel protein level.

Segal AS, Yao X, Desir GV.

Biochem Biophys Res Commun. 1999 Jan 8;254(1):54-64.

PMID:
9920732
45.

Rabbit distal convoluted tubule coexpresses NaCl cotransporter and 11 beta-hydroxysteroid dehydrogenase II mRNA.

Velázquez H, Náray-Fejes-Tóth A, Silva T, Andújar E, Reilly RF, Desir GV, Ellison DH.

Kidney Int. 1998 Aug;54(2):464-72.

46.

Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments.

Orias M, Velázquez H, Tung F, Lee G, Desir GV.

Am J Physiol. 1997 Oct;273(4):F663-6. doi: 10.1152/ajprenal.1997.273.4.F663.

PMID:
9362344
47.

Genomic localization of the human gene for KCNA10, a cGMP-activated K channel.

Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV.

Genomics. 1997 May 15;42(1):33-7.

PMID:
9177773
48.

Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel.

Yao X, Liu Y, Tung F, Desir GV.

Am J Physiol. 1996 Jul;271(1 Pt 2):F37-41.

PMID:
8760241
49.

Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney.

Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV.

J Clin Invest. 1996 Jun 1;97(11):2525-33.

50.

Primary structure and functional expression of a cGMP-gated potassium channel.

Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11711-5.

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