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Items: 1 to 50 of 64

1.

Bnip3 Regulates Airway Smooth Muscle Cell Focal Adhesion and Proliferation.

Pan S, Shah SD, Panettieri RA Jr, Deshpande DA.

Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11. doi: 10.1152/ajplung.00224.2019. [Epub ahead of print]

PMID:
31509440
2.

Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?

Nayak AP, Villalba D, Deshpande DA.

Curr Allergy Asthma Rep. 2019 Sep 5;19(10):48. doi: 10.1007/s11882-019-0876-0. Review.

PMID:
31486942
3.

Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.

Singh BK, Lu W, Schmidt Paustian AM, Ge MQ, Koziol-White CJ, Flayer CH, Killingbeck SS, Wang N, Dong X, Riese MJ, Deshpande DA, Panettieri RA Jr, Haczku A, Kambayashi T.

Sci Signal. 2019 Sep 3;12(597). pii: eaax3332. doi: 10.1126/scisignal.aax3332.

PMID:
31481522
4.

Bitter Taste Receptors for Asthma Therapeutics.

Nayak AP, Shah SD, Michael JV, Deshpande DA.

Front Physiol. 2019 Jul 16;10:884. doi: 10.3389/fphys.2019.00884. eCollection 2019.

5.

Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation.

Defnet AE, Huang W, Polischak S, Yadav SK, Kane MA, Shapiro P, Deshpande DA.

FASEB J. 2019 Jul 26:fj201900680R. doi: 10.1096/fj.201900680R. [Epub ahead of print]

PMID:
31266368
6.

Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle.

Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB.

FASEB J. 2019 Aug;33(8):9008-9016. doi: 10.1096/fj.201900323R. Epub 2019 May 1.

PMID:
31042404
7.

Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling.

Nayak AP, Pera T, Deshpande DA, Michael JV, Liberato JR, Pan S, Tompkins E, Morelli HP, Yi R, Wang N, Penn RB.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L894-L902. doi: 10.1152/ajplung.00426.2018. Epub 2019 Feb 6.

PMID:
30724097
8.

NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy.

Thangavel C, Gomes CM, Zderic SA, Javed E, Addya S, Singh J, Das S, Birbe R, Den RB, Rattan S, Deshpande DA, Penn RB, Chacko S, Boopathi E.

Am J Pathol. 2019 Apr;189(4):847-867. doi: 10.1016/j.ajpath.2018.12.013. Epub 2019 Jan 30.

PMID:
30707892
9.

Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases.

Pan S, Conaway S Jr, Deshpande DA.

Arch Biochem Biophys. 2019 Mar 15;663:109-119. doi: 10.1016/j.abb.2019.01.002. Epub 2019 Jan 8. Review.

PMID:
30629957
10.

Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle.

Michael JV, Gavrila A, Nayak AP, Pera T, Liberato JR, Polischak SR, Shah SD, Deshpande DA, Penn RB.

FASEB J. 2019 Apr;33(4):4780-4789. doi: 10.1096/fj.201801959R. Epub 2019 Jan 2.

PMID:
30601680
11.

Autophagy Activation in Asthma Airways Remodeling.

McAlinden KD, Deshpande DA, Ghavami S, Xenaki D, Sohal SS, Oliver BG, Haghi M, Sharma P.

Am J Respir Cell Mol Biol. 2019 May;60(5):541-553. doi: 10.1165/rcmb.2018-0169OC.

PMID:
30383396
12.

Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.

Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P.

Clin Sci (Lond). 2018 Jul 31;132(14):1615-1627. doi: 10.1042/CS20180398. Print 2018 Jul 31.

13.

New targets for resolution of airway remodeling in obstructive lung diseases.

Nayak AP, Deshpande DA, Penn RB.

F1000Res. 2018 May 30;7. pii: F1000 Faculty Rev-680. doi: 10.12688/f1000research.14581.1. eCollection 2018. Review.

14.

Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen Nanoparticle.

Thangavel C, Perepelyuk M, Boopathi E, Liu Y, Polischak S, Deshpande DA, Rafiq K, Dicker AP, Knudsen KE, Shoyele SA, Den RB.

Mol Pharm. 2018 May 7;15(5):1778-1790. doi: 10.1021/acs.molpharmaceut.7b01024. Epub 2018 Apr 4.

15.

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.

Deshpande DA, Guedes AGP, Graeff R, Dogan S, Subramanian S, Walseth TF, Kannan MS.

Mediators Inflamm. 2018 Feb 7;2018:8942042. doi: 10.1155/2018/8942042. eCollection 2018. Review.

16.

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB.

FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4.

17.

Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells.

Pan S, Sharma P, Shah SD, Deshpande DA.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L154-L165. doi: 10.1152/ajplung.00106.2017. Epub 2017 Apr 27.

18.

Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice.

Sharma P, Yi R, Nayak AP, Wang N, Tang F, Knight MJ, Pan S, Oliver B, Deshpande DA.

Sci Rep. 2017 Apr 11;7:46166. doi: 10.1038/srep46166.

19.

Autophagy and airway fibrosis: Is there a link?

Kota A, Deshpande DA, Haghi M, Oliver B, Sharma P.

Version 2. F1000Res. 2017 Apr 3 [revised 2018 Jan 1];6:409. doi: 10.12688/f1000research.11236.2. eCollection 2017. Review.

20.

CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets.

Deshpande DA, Guedes AGP, Lund FE, Subramanian S, Walseth TF, Kannan MS.

Pharmacol Ther. 2017 Apr;172:116-126. doi: 10.1016/j.pharmthera.2016.12.002. Epub 2016 Dec 7. Review.

21.

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.

Sharma P, Panebra A, Pera T, Tiegs BC, Hershfeld A, Kenyon LC, Deshpande DA.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L365-76. doi: 10.1152/ajplung.00373.2015. Epub 2015 Dec 18.

22.

MicroRNA Regulation of Airway Inflammation and Airway Smooth Muscle Function: Relevance to Asthma.

Deshpande DA, Dileepan M, Walseth TF, Subramanian S, Kannan MS.

Drug Dev Res. 2015 Sep;76(6):286-95. doi: 10.1002/ddr.21267. Epub 2015 Aug 26. Review.

PMID:
26587803
23.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL.

Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699. Epub 2015 Nov 9.

24.

Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells.

Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB.

PLoS One. 2015 Jun 29;10(6):e0131582. doi: 10.1371/journal.pone.0131582. eCollection 2015.

25.

Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.

Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB.

FASEB J. 2015 Oct;29(10):4227-35. doi: 10.1096/fj.15-273094. Epub 2015 Jun 23.

26.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L129-38. doi: 10.1152/ajplung.00288.2014. Epub 2015 May 22.

27.

Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors.

Lakkaraju SK, Yu W, Raman EP, Hershfeld AV, Fang L, Deshpande DA, MacKerell AD Jr.

J Chem Inf Model. 2015 Mar 23;55(3):700-8. doi: 10.1021/ci500729k. Epub 2015 Feb 25.

28.

CD38 and airway hyper-responsiveness: studies on human airway smooth muscle cells and mouse models.

Guedes AG, Deshpande DA, Dileepan M, Walseth TF, Panettieri RA Jr, Subramanian S, Kannan MS.

Can J Physiol Pharmacol. 2015 Feb;93(2):145-53. doi: 10.1139/cjpp-2014-0410. Epub 2014 Dec 9. Review.

29.

β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.

Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB.

J Biol Chem. 2014 Aug 15;289(33):23065-74. doi: 10.1074/jbc.M114.557652. Epub 2014 Jun 27.

30.

Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle.

Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB.

FASEB J. 2014 Feb;28(2):956-65. doi: 10.1096/fj.13-240226. Epub 2013 Oct 16.

31.

A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle.

Horvat SJ, Deshpande DA, Yan H, Panettieri RA, Codina J, DuBose TD Jr, Xin W, Rich TC, Penn RB.

FASEB J. 2012 Sep;26(9):3670-9. doi: 10.1096/fj.11-201020. Epub 2012 May 30.

32.

Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation.

An SS, Robinett KS, Deshpande DA, Wang WC, Liggett SB.

Nat Med. 2012 May 4;18(5):650-1. doi: 10.1038/nm.2734. No abstract available.

33.

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH.

Saxena H, Deshpande DA, Tiegs BC, Yan H, Battafarano RJ, Burrows WM, Damera G, Panettieri RA, Dubose TD Jr, An SS, Penn RB.

Br J Pharmacol. 2012 Jun;166(3):981-90. doi: 10.1111/j.1476-5381.2011.01807.x.

34.

Bronchodilator activity of bitter tastants in human tissue.

Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB.

Nat Med. 2011 Jul 7;17(7):776-8. doi: 10.1038/nm0711-776b. No abstract available.

35.

Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.

Robinett KS, Deshpande DA, Malone MM, Liggett SB.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1069-74. doi: 10.1165/rcmb.2011-0061OC. Epub 2011 Jun 3.

36.

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB.

Nat Med. 2010 Nov;16(11):1299-304. doi: 10.1038/nm.2237. Epub 2010 Oct 24.

37.

Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.

Yan H, Deshpande DA, Misior AM, Miles MC, Saxena H, Riemer EC, Pascual RM, Panettieri RA, Penn RB.

FASEB J. 2011 Jan;25(1):389-97. doi: 10.1096/fj.10-164798. Epub 2010 Aug 30.

38.

Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle.

Misior AM, Deshpande DA, Loza MJ, Pascual RM, Hipp JD, Penn RB.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):24-39. doi: 10.1165/rcmb.2008-0266OC. Epub 2008 Dec 4.

39.

Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization.

Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB.

Biochemistry. 2008 Sep 2;47(35):9279-88. doi: 10.1021/bi801056w. Epub 2008 Aug 9.

40.

Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.

Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL.

J Allergy Clin Immunol. 2008 Jul;122(1):107-13, 113.e1-7. doi: 10.1016/j.jaci.2008.03.026. Epub 2008 May 9.

41.

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.

Deshpande DA, Theriot BS, Penn RB, Walker JK.

FASEB J. 2008 Jul;22(7):2134-41. doi: 10.1096/fj.07-102459. Epub 2008 Mar 12.

42.

Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors.

Misior AM, Yan H, Pascual RM, Deshpande DA, Panettieri RA, Penn RB.

Mol Pharmacol. 2008 Feb;73(2):566-74. Epub 2007 Nov 9.

PMID:
17993511
43.

Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice.

Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L25-32. Epub 2007 Apr 27.

44.

PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation.

Deshpande DA, Pascual RM, Wang SW, Eckman DM, Riemer EC, Funk CD, Penn RB.

FASEB J. 2007 Aug;21(10):2335-42. Epub 2007 Mar 28.

PMID:
17392478
45.

Targeting G protein-coupled receptor signaling in asthma.

Deshpande DA, Penn RB.

Cell Signal. 2006 Dec;18(12):2105-20. Epub 2006 Jul 7. Review.

PMID:
16828259
46.

Transcriptional regulation of CD38 expression by tumor necrosis factor-alpha in human airway smooth muscle cells: role of NF-kappaB and sensitivity to glucocorticoids.

Kang BN, Tirumurugaan KG, Deshpande DA, Amrani Y, Panettieri RA, Walseth TF, Kannan MS.

FASEB J. 2006 May;20(7):1000-2. Epub 2006 Mar 29.

PMID:
16571778
47.

Regulation of CD 38 expression and function by steroid hormones in myometrium.

Dogan S, Deshpande DA, White TA, Walseth TF, Kannan MS.

Mol Cell Endocrinol. 2006 Feb 26;246(1-2):101-6. Epub 2006 Jan 4. Review.

PMID:
16388888
48.

Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells.

Kang BN, Deshpande DA, Tirumurugaan KG, Panettieri RA, Walseth TF, Kannan MS.

Can J Physiol Pharmacol. 2005 Aug-Sep;83(8-9):799-804.

PMID:
16333382
49.

Enhanced photocatalytic inactivation of bacterial spores on surfaces in air.

Vohra A, Goswami DY, Deshpande DA, Block SS.

J Ind Microbiol Biotechnol. 2005 Aug;32(8):364-70. Epub 2005 Sep 29.

PMID:
16044291
50.

CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle.

Deshpande DA, White TA, Dogan S, Walseth TF, Panettieri RA, Kannan MS.

Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L773-88. Review.

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