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Items: 46


Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.


Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.

Lueck SC, Russ AC, Botzenhardt U, Schlenk RF, Zobel K, Deshayes K, Vucic D, Döhner H, Döhner K, Fulda S, Bullinger L.

Oncotarget. 2016 Aug 2;7(31):49539-49551. doi: 10.18632/oncotarget.10390.


Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.

Zhai Q, He M, Song A, Deshayes K, Dixit VM, Carter PJ.

J Mol Biol. 2016 Feb 13;428(3):603-617. doi: 10.1016/j.jmb.2016.01.006. Epub 2016 Jan 14.


Development of orthogonally protected hypusine for solid-phase peptide synthesis.

Song A, Tom J, Yu Z, Pham V, Tan D, Zhang D, Fang G, Yu T, Deshayes K.

J Org Chem. 2015 Apr 3;80(7):3677-81. doi: 10.1021/acs.joc.5b00110. Epub 2015 Mar 24.


By any means necessary: discovering a Bcl-xL specific domain.

Deshayes KD.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1239-1240. doi: 10.1016/j.jmb.2014.12.016. Epub 2014 Dec 31. No abstract available.


Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Tao ZF, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MF, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW, Souers AJ.

ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93. doi: 10.1021/ml5001867. eCollection 2014 Oct 9.


Further insights into the effects of pre-organizing the BimBH3 helix.

Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.

ACS Chem Biol. 2014 Mar 21;9(3):838-9. doi: 10.1021/cb400638p. Epub 2014 Feb 18. No abstract available.


Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG.

Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21.


OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22.


Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.

ACS Chem Biol. 2013 Feb 15;8(2):297-302. doi: 10.1021/cb3005403. Epub 2012 Dec 10.


Characterization of ML-IAP protein stability and physiological role in vivo.

Varfolomeev E, Moradi E, Dynek JN, Zha J, Fedorova AV, Deshayes K, Fairbrother WJ, Newton K, Le Couter J, Vucic D.

Biochem J. 2012 Nov 1;447(3):427-36. doi: 10.1042/BJ20121103.


Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S.

Oncogene. 2013 Feb 21;32(8):988-97. doi: 10.1038/onc.2012.108. Epub 2012 Apr 2.


Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D.

Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878.


Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ.

J Med Chem. 2012 May 10;55(9):4101-13. doi: 10.1021/jm300060k. Epub 2012 Mar 28.


Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis.

Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D, Debatin KM, Fulda S.

Neoplasia. 2011 Dec;13(12):1162-70.


Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S, Zobel K, Deshayes K, Vucic D, Jeremias I, Bertrand MJ, Vandenabeele P, Fulda S.

Neoplasia. 2011 Oct;13(10):971-9.


Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.

Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ.

Science. 2011 Oct 21;334(6054):376-80. doi: 10.1126/science.1207862.


The development of peptide-based tools for the analysis of angiogenesis.

Fedorova A, Zobel K, Gill HS, Ogasawara A, Flores JE, Tinianow JN, Vanderbilt AN, Wu P, Meng YG, Williams SP, Wiesmann C, Murray J, Marik J, Deshayes K.

Chem Biol. 2011 Jul 29;18(7):839-45. doi: 10.1016/j.chembiol.2011.05.011.


c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D.

EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26.


cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production.

Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ.

Cell Death Differ. 2011 Apr;18(4):656-65. doi: 10.1038/cdd.2010.138. Epub 2010 Nov 5.


Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.

Phu L, Izrael-Tomasevic A, Matsumoto ML, Bustos D, Dynek JN, Fedorova AV, Bakalarski CE, Arnott D, Deshayes K, Dixit VM, Kelley RF, Vucic D, Kirkpatrick DS.

Mol Cell Proteomics. 2011 May;10(5):M110.003756. doi: 10.1074/mcp.M110.003756. Epub 2010 Nov 3.


Electrostatic docking of a supramolecular host-guest assembly to cytochrome c probed by bidirectional photoinduced electron transfer.

Jankowska KI, Pagba CV, Piatnitski Chekler EL, Deshayes K, Piotrowiak P.

J Am Chem Soc. 2010 Nov 24;132(46):16423-31. doi: 10.1021/ja102188e. Epub 2010 Nov 1.


Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

Lamkanfi M, Mueller JL, Vitari AC, Misaghi S, Fedorova A, Deshayes K, Lee WP, Hoffman HM, Dixit VM.

J Cell Biol. 2009 Oct 5;187(1):61-70. doi: 10.1083/jcb.200903124.


Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.

Lee EF, Fedorova A, Zobel K, Boyle MJ, Yang H, Perugini MA, Colman PM, Huang DC, Deshayes K, Fairlie WD.

J Biol Chem. 2009 Nov 6;284(45):31315-26. doi: 10.1074/jbc.M109.048009. Epub 2009 Sep 10.


Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D.

ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m.


Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D.

Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885.


c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D.

J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11.


IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D.

Cell. 2007 Nov 16;131(4):669-81.


Evaluation of assay technologies for the identification of protein-Peptide interaction antagonists.

Kadkhodayan S, Elliott LO, Mausisa G, Wallweber HA, Deshayes K, Feng B, Fairbrother WJ.

Assay Drug Dev Technol. 2007 Aug;5(4):501-13.


Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.

Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD.

Cell Death Differ. 2007 Sep;14(9):1711-3. Epub 2007 Jun 15. No abstract available.


Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K.

ACS Chem Biol. 2006 Sep 19;1(8):525-33. Erratum in: ACS Chem Biol. 2006 Oct 20;1(9):601.


Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ.

Biochem J. 2005 Jan 1;385(Pt 1):11-20.


Hybrid photoactive assemblies: electron injection from host-guest complexes into semiconductor nanoparticles.

Pagba C, Zordan G, Galoppini E, Piatnitski EL, Hore S, Deshayes K, Piotrowiak P.

J Am Chem Soc. 2004 Aug 18;126(32):9888-9.


Bacteriophage that display small molecules.

Fellouse F, Deshayes K.

Chem Biol. 2003 Sep;10(9):783-4.


Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I.

Schaffer ML, Deshayes K, Nakamura G, Sidhu S, Skelton NJ.

Biochemistry. 2003 Aug 12;42(31):9324-34.


Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ.

Biochemistry. 2003 Jul 15;42(27):8223-31.


Exploring protein-protein interactions with phage display.

Sidhu SS, Fairbrother WJ, Deshayes K.

Chembiochem. 2003 Jan 3;4(1):14-25. Review.


Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.

Deshayes K, Schaffer ML, Skelton NJ, Nakamura GR, Kadkhodayan S, Sidhu SS.

Chem Biol. 2002 Apr;9(4):495-505.


The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.

Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA.

J Biol Chem. 2002 Apr 12;277(15):12906-14. Epub 2002 Jan 30.


SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).

Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM.

J Biol Chem. 2002 Apr 5;277(14):12275-9. Epub 2002 Jan 18.


Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.

Vajdos FF, Ultsch M, Schaffer ML, Deshayes KD, Liu J, Skelton NJ, de Vos AM.

Biochemistry. 2001 Sep 18;40(37):11022-9.


Remote intermolecular "heavy-atom effect": spin-orbit coupling across the wall of a hemicarcerand.

Romanova ZS, Deshayes K, Piotrowiak P.

J Am Chem Soc. 2001 Mar 14;123(10):2444-5. No abstract available.


Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1.

Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB.

Biochemistry. 2001 Jul 24;40(29):8487-98.


Hemicarceplexes That Release Guests upon Irradiation.

Piatnitski EL, Deshayes KD.

Angew Chem Int Ed Engl. 1998 Apr 20;37(7):970-972. doi: 10.1002/(SICI)1521-3773(19980420)37:7<970::AID-ANIE970>3.0.CO;2-4.


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