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Items: 1 to 50 of 174

1.

PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues.

Blanchard PG, Moreira RJ, Castro É, Caron A, Côté M, Andrade ML, Oliveira TE, Ortiz-Silva M, Peixoto AS, Dias FA, Gélinas Y, Guerra-Sá R, Deshaies Y, Festuccia WT.

Metabolism. 2018 Dec;89:27-38. doi: 10.1016/j.metabol.2018.09.007. Epub 2018 Oct 11.

PMID:
30316815
2.

Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure.

Carter S, Miard S, Caron A, Sallé-Lefort S, St-Pierre P, Anhê FF, Lavoie-Charland E, Blais-Lecours P, Drolet MC, Lefebvre JS, Lacombe J, Deshaies Y, Couet J, Laplante M, Ferron M, Bossé Y, Marette A, Richard D, Marsolais D, Picard F.

Diabetes. 2018 Jul;67(7):1285-1296. doi: 10.2337/db17-0558. Epub 2018 Mar 1.

3.

Genetic regulation of differentially methylated genes in visceral adipose tissue of severely obese men discordant for the metabolic syndrome.

Guénard F, Tchernof A, Deshaies Y, Biron S, Lescelleur O, Biertho L, Marceau S, Pérusse L, Vohl MC.

Transl Res. 2017 Jun;184:1-11.e2. doi: 10.1016/j.trsl.2017.01.002. Epub 2017 Feb 2.

PMID:
28219716
4.

A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.

de Toro-Martín J, Guénard F, Tchernof A, Deshaies Y, Pérusse L, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC.

Obes Sci Pract. 2016 Dec;2(4):407-414. doi: 10.1002/osp4.74. Epub 2016 Oct 21.

5.

Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects.

de Toro-Martín J, Guénard F, Tchernof A, Deshaies Y, Pérusse L, Hould FS, Lebel S, Marceau P, Vohl MC.

Diabetol Metab Syndr. 2016 Jul 29;8:55. doi: 10.1186/s13098-016-0171-3. eCollection 2016.

6.

Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptor γ.

Bolsoni-Lopes A, Deshaies Y, Festuccia WT.

Temperature (Austin). 2015 Mar 19;2(4):476-82. doi: 10.1080/23328940.2015.1011564. eCollection 2015 Oct-Dec. Review.

7.

A CpG-SNP Located within the ARPC3 Gene Promoter Is Associated with Hypertriglyceridemia in Severely Obese Patients.

de Toro-Martín J, Guénard F, Tchernof A, Deshaies Y, Pérusse L, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC.

Ann Nutr Metab. 2016;68(3):203-12. doi: 10.1159/000445358. Epub 2016 Apr 8.

PMID:
27055012
8.

Peroxisome proliferator-activated receptor γ activation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes.

Blanchard PG, Turcotte V, Côté M, Gélinas Y, Nilsson S, Olivecrona G, Deshaies Y, Festuccia WT.

Acta Physiol (Oxf). 2016 Jul;217(3):227-39. doi: 10.1111/apha.12665. Epub 2016 Mar 12.

PMID:
26918671
9.

Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action.

Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo RL, Isserlin R, Bader GD, Tungtrongchitr R, Deshaies Y, Xu A, Sweeney G.

Biochem J. 2015 Jul 1;469(1):71-82. doi: 10.1042/BJ20141455. Epub 2015 Apr 27.

10.

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions.

Belchior T, Paschoal VA, Magdalon J, Chimin P, Farias TM, Chaves-Filho AB, Gorjão R, St-Pierre P, Miyamoto S, Kang JX, Deshaies Y, Marette A, Festuccia W.

Mol Nutr Food Res. 2015 May;59(5):957-67. doi: 10.1002/mnfr.201400914. Epub 2015 Mar 16.

PMID:
25641959
11.

Influences of gestational obesity on associations between genotypes and gene expression levels in offspring following maternal gastrointestinal bypass surgery for obesity.

Guénard F, Lamontagne M, Bossé Y, Deshaies Y, Cianflone K, Kral JG, Marceau P, Vohl MC.

PLoS One. 2015 Jan 20;10(1):e0117011. doi: 10.1371/journal.pone.0117011. eCollection 2015.

12.

Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides.

Carter S, Li Z, Lemieux I, Alméras N, Tremblay A, Bergeron J, Poirier P, Deshaies Y, Després JP, Picard F.

Atherosclerosis. 2014 Dec;237(2):645-51. doi: 10.1016/j.atherosclerosis.2014.09.022. Epub 2014 Oct 2.

13.

Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

Le Quang K, Bouchareb R, Lachance D, Laplante MA, El Husseini D, Boulanger MC, Fournier D, Fang XP, Avramoglu RK, Pibarot P, Deshaies Y, Sweeney G, Mathieu P, Marette A.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2283-91. doi: 10.1161/ATVBAHA.114.304205. Epub 2014 Aug 14.

PMID:
25231636
14.

PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.

Festuccia WT, Blanchard PG, Belchior T, Chimin P, Paschoal VA, Magdalon J, Hirabara SM, Simões D, St-Pierre P, Carpinelli A, Marette A, Deshaies Y.

Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1046-54. doi: 10.1152/ajpendo.00683.2013. Epub 2014 Mar 11.

15.

The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations.

Kohen Avramoglu R, Laplante MA, Le Quang K, Deshaies Y, Després JP, Larose E, Mathieu P, Poirier P, Pérusse L, Vohl MC, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A.

Can J Diabetes. 2013 Oct;37(5):351-8. doi: 10.1016/j.jcjd.2013.08.262. Review.

PMID:
24500564
16.

Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances.

Guénard F, Tchernof A, Deshaies Y, Pérusse L, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC.

Physiol Genomics. 2014 Mar 15;46(6):216-22. doi: 10.1152/physiolgenomics.00160.2013. Epub 2014 Feb 4.

PMID:
24495915
17.

DUSP1 Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression.

Guénard F, Bouchard L, Tchernof A, Deshaies Y, Hould FS, Lebel S, Marceau P, Pérusse L, Vohl MC.

Int J Genomics. 2013;2013:609748. doi: 10.1155/2013/609748. Epub 2013 Aug 6.

18.

Methylation and expression of immune and inflammatory genes in the offspring of bariatric bypass surgery patients.

Guénard F, Tchernof A, Deshaies Y, Cianflone K, Kral JG, Marceau P, Vohl MC.

J Obes. 2013;2013:492170. doi: 10.1155/2013/492170. Epub 2013 Jun 11.

19.

Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E573-84. doi: 10.1152/ajpendo.00122.2013. Epub 2013 Jul 2.

20.

Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery.

Guénard F, Deshaies Y, Cianflone K, Kral JG, Marceau P, Vohl MC.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11439-44. doi: 10.1073/pnas.1216959110. Epub 2013 May 28.

21.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

22.

Comparison of the dipeptidyl peptidase-4 gene methylation levels between severely obese subjects with and without the metabolic syndrome.

Turcot V, Tchernof A, Deshaies Y, Pérusse L, Bélisle A, Marceau P, Hould FS, Lebel S, Vohl MC.

Diabetol Metab Syndr. 2013 Feb 4;5(1):4. doi: 10.1186/1758-5996-5-4.

23.

Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis.

Liu Y, Turdi S, Park T, Morris NJ, Deshaies Y, Xu A, Sweeney G.

Diabetes. 2013 Mar;62(3):743-52. doi: 10.2337/db12-0687. Epub 2012 Dec 13.

24.

Inflammation, ectopic fat and lipid metabolism: view from the chair.

Picard F, Deshaies Y.

Int J Obes Suppl. 2012 Dec;2(Suppl 2):S29-S30.

25.

PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2.

Festuccia WT, Blanchard PG, Oliveira TB, Magdalon J, Paschoal VA, Richard D, Deshaies Y.

Am J Physiol Regul Integr Comp Physiol. 2012 Dec 15;303(12):R1277-85. doi: 10.1152/ajpregu.00299.2012. Epub 2012 Oct 24. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2016 Apr 1;310(7):R670-1.

26.

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes.

Turcot V, Tchernof A, Deshaies Y, Pérusse L, Bélisle A, Marceau S, Biron S, Lescelleur O, Biertho L, Vohl MC.

Clin Epigenetics. 2012 Jul 2;4(1):10. doi: 10.1186/1868-7083-4-10.

27.

Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease.

Chechi K, Blanchard PG, Mathieu P, Deshaies Y, Richard D.

Int J Cardiol. 2013 Sep 1;167(5):2264-70. doi: 10.1016/j.ijcard.2012.06.008. Epub 2012 Jun 22.

PMID:
22727960
28.

Validation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue.

Chechi K, Gelinas Y, Mathieu P, Deshaies Y, Richard D.

PLoS One. 2012;7(4):e32265. doi: 10.1371/journal.pone.0032265. Epub 2012 Apr 12.

29.

Lack of "immunological fitness" during fasting in metabolically challenged animals.

Asterholm IW, McDonald J, Blanchard PG, Sinha M, Xiao Q, Mistry J, Rutkowski JM, Deshaies Y, Brekken RA, Scherer PE.

J Lipid Res. 2012 Jul;53(7):1254-67. doi: 10.1194/jlr.M021725. Epub 2012 Apr 13.

30.

Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion.

Blanchard PG, Festuccia WT, Houde VP, St-Pierre P, Brûlé S, Turcotte V, Côté M, Bellmann K, Marette A, Deshaies Y.

J Lipid Res. 2012 Jun;53(6):1117-25. doi: 10.1194/jlr.M021485. Epub 2012 Mar 30.

31.

Association of LIPA gene polymorphisms with obesity-related metabolic complications among severely obese patients.

Guénard F, Houde A, Bouchard L, Tchernof A, Deshaies Y, Biron S, Lescelleur O, Biertho L, Marceau S, Pérusse L, Vohl MC.

Obesity (Silver Spring). 2012 Oct;20(10):2075-82. doi: 10.1038/oby.2012.52. Epub 2012 Mar 7.

32.

Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesity.

Turcot V, Bouchard L, Faucher G, Garneau V, Tchernof A, Deshaies Y, Pérusse L, Marceau S, Biron S, Lescelleur O, Biertho L, Vohl MC.

Clin Sci (Lond). 2012 Jul;123(2):99-109. doi: 10.1042/CS20110584. Erratum in: Clin Sci (Lond). 2012 Aug 1;123(4):271.

PMID:
22304237
33.

Genetic contribution to C-reactive protein levels in severe obesity.

Faucher G, Guénard F, Bouchard L, Garneau V, Turcot V, Houde A, Tchernof A, Bergeron J, Deshaies Y, Hould FS, Lebel S, Marceau P, Vohl MC.

Mol Genet Metab. 2012 Mar;105(3):494-501. doi: 10.1016/j.ymgme.2011.11.198. Epub 2011 Dec 2.

PMID:
22178353
34.

A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals.

Turcot V, Bouchard L, Faucher G, Tchernof A, Deshaies Y, Pérusse L, Marceau P, Hould FS, Lebel S, Vohl MC.

Hum Genet. 2012 Jan;131(1):57-66. doi: 10.1007/s00439-011-1043-4. Epub 2011 Jun 24.

PMID:
21701784
35.

[Novel adipokines: links between obesity and atherosclerosis].

Gauvreau D, Villeneuve N, Deshaies Y, Cianflone K.

Ann Endocrinol (Paris). 2011 Jun;72(3):224-31. doi: 10.1016/j.ando.2010.02.025. Epub 2011 May 17. French.

PMID:
21592454
36.

Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ.

Festuccia WT, Blanchard PG, Deshaies Y.

Front Endocrinol (Lausanne). 2011 Dec 21;2:84. doi: 10.3389/fendo.2011.00084. eCollection 2011.

37.

Physiology of BAT thermogenesis: a view from the chair.

Picard F, Deshaies Y.

Int J Obes (Lond). 2010 Oct;34 Suppl 1:S34-5. doi: 10.1038/ijo.2010.181. No abstract available.

PMID:
20935664
38.

DPP4 gene DNA methylation in the omentum is associated with its gene expression and plasma lipid profile in severe obesity.

Turcot V, Bouchard L, Faucher G, Tchernof A, Deshaies Y, Pérusse L, Bélisle A, Marceau S, Biron S, Lescelleur O, Biertho L, Vohl MC.

Obesity (Silver Spring). 2011 Feb;19(2):388-95. doi: 10.1038/oby.2010.198. Epub 2010 Sep 16.

39.

Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-gamma activation.

Festuccia WT, Blanchard PG, Richard D, Deshaies Y.

Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R159-67. doi: 10.1152/ajpregu.00821.2009. Epub 2010 Apr 14.

40.

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue.

Houde VP, Brûlé S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, Marette A.

Diabetes. 2010 Jun;59(6):1338-48. doi: 10.2337/db09-1324. Epub 2010 Mar 18.

41.

PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity.

Rudkowska I, Caron-Dorval D, Verreault M, Couture P, Deshaies Y, Barbier O, Vohl MC.

Mol Nutr Food Res. 2010 Apr;54(4):543-50. doi: 10.1002/mnfr.200900085.

PMID:
19937854
42.

Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet.

Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, Deshaies Y.

Metabolism. 2010 Jan;59(1):114-7. doi: 10.1016/j.metabol.2009.07.015. Epub 2009 Sep 18.

PMID:
19766266
43.

Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.

Festuccia WT, Laplante M, Brûlé S, Houde VP, Achouba A, Lachance D, Pedrosa ML, Silva ME, Guerra-Sá R, Couet J, Arsenault M, Marette A, Deshaies Y.

J Mol Cell Cardiol. 2009 Jul;47(1):85-95. doi: 10.1016/j.yjmcc.2009.04.011. Epub 2009 May 3.

PMID:
19397913
44.

Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity.

Bouchard L, Faucher G, Tchernof A, Deshaies Y, Marceau S, Lescelleur O, Biron S, Bouchard C, Pérusse L, Vohl MC.

Obesity (Silver Spring). 2009 Jul;17(7):1466-72. doi: 10.1038/oby.2009.71. Epub 2009 Mar 26.

45.

Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats.

Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, Deshaies Y.

Int J Obes (Lond). 2009 May;33(5):601-4. doi: 10.1038/ijo.2009.33. Epub 2009 Feb 17.

PMID:
19223847
46.

The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake.

Festuccia WT, Blanchard PG, Turcotte V, Laplante M, Sariahmetoglu M, Brindley DN, Richard D, Deshaies Y.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1327-35. doi: 10.1152/ajpregu.91012.2008. Epub 2009 Feb 11.

47.

Depot-specific effects of the PPARgamma agonist rosiglitazone on adipose tissue glucose uptake and metabolism.

Festuccia WT, Blanchard PG, Turcotte V, Laplante M, Sariahmetoglu M, Brindley DN, Deshaies Y.

J Lipid Res. 2009 Jun;50(6):1185-94. doi: 10.1194/jlr.M800620-JLR200. Epub 2009 Feb 5.

48.

Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat.

Laplante M, Festuccia WT, Soucy G, Blanchard PG, Renaud A, Berger JP, Olivecrona G, Deshaies Y.

Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R57-66. doi: 10.1152/ajpregu.90552.2008. Epub 2008 Oct 29.

49.

AMP kinase: heart, cancer and the CNS--view from the chair.

Deshaies Y.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S24-8. doi: 10.1038/ijo.2008.119. No abstract available.

PMID:
18719594
50.

Comprehensive genetic analysis of the dipeptidyl peptidase-4 gene and cardiovascular disease risk factors in obese individuals.

Bouchard L, Faucher G, Tchernof A, Deshaies Y, Lebel S, Hould FS, Marceau P, Vohl MC.

Acta Diabetol. 2009 Mar;46(1):13-21. doi: 10.1007/s00592-008-0049-4. Epub 2008 Aug 6.

PMID:
18682883

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