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Items: 1 to 50 of 154

1.

Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11.

Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Perez C, Yang Y, Peng J, Cohen SM, Chou TF, Hilton ST, Deshaies RJ.

Cell Chem Biol. 2018 Nov 15;25(11):1350-1358.e9. doi: 10.1016/j.chembiol.2018.07.012. Epub 2018 Aug 23.

PMID:
30146242
2.

Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.

Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP, Deshaies RJ, Arshavsky VY.

Nat Commun. 2018 Apr 30;9(1):1738. doi: 10.1038/s41467-018-04117-8.

3.

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes.

Verma R, Reichermeier KM, Burroughs AM, Oania RS, Reitsma JM, Aravind L, Deshaies RJ.

Nature. 2018 May;557(7705):446-451. doi: 10.1038/s41586-018-0022-5. Epub 2018 Apr 9.

4.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2018 Mar 15;37(6). pii: e99170. doi: 10.15252/embj.201899170. No abstract available.

5.

Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.

Liu X, Reitsma JM, Mamrosh JL, Zhang Y, Straube R, Deshaies RJ.

Mol Cell. 2018 Mar 1;69(5):773-786.e6. doi: 10.1016/j.molcel.2018.01.038.

PMID:
29499133
6.

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Skrott Z, Mistrik M, Andersen KK, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Dzubak P, Vrobel I, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou QP, Olsen J, Hajduch M, Cvek B, Deshaies RJ, Bartek J.

Nature. 2017 Dec 14;552(7684):194-199. doi: 10.1038/nature25016. Epub 2017 Dec 6.

7.

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D.

Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. Epub 2017 Nov 16.

8.

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.

Reitsma JM, Liu X, Reichermeier KM, Moradian A, Sweredoski MJ, Hess S, Deshaies RJ.

Cell. 2017 Nov 30;171(6):1326-1339.e14. doi: 10.1016/j.cell.2017.10.016. Epub 2017 Nov 2.

9.

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.

Blythe EE, Olson KC, Chau V, Deshaies RJ.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4380-E4388. doi: 10.1073/pnas.1706205114. Epub 2017 May 16.

10.

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.

Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A.

Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1.

11.

Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Perez C, Li J, Parlati F, Rouffet M, Ma Y, Zhou HJ, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM.

J Med Chem. 2017 Apr 13;60(7):3217. doi: 10.1021/acs.jmedchem.7b00390. Epub 2017 Mar 22. No abstract available.

PMID:
28328205
12.

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.

Nguyen TV, Li J, Lu CJ, Mamrosh JL, Lu G, Cathers BE, Deshaies RJ.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3565-3571. doi: 10.1073/pnas.1700949114. Epub 2017 Mar 20.

13.

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Li J, Yakushi T, Parlati F, Mackinnon AL, Perez C, Ma Y, Carter KP, Colayco S, Magnuson G, Brown B, Nguyen K, Vasile S, Suyama E, Smith LH, Sergienko E, Pinkerton AB, Chung TDY, Palmer AE, Pass I, Hess S, Cohen SM, Deshaies RJ.

Nat Chem Biol. 2017 May;13(5):486-493. doi: 10.1038/nchembio.2326. Epub 2017 Feb 28.

14.

Discovery of an Inhibitor of the Proteasome Subunit Rpn11.

Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM.

J Med Chem. 2017 Feb 23;60(4):1343-1361. doi: 10.1021/acs.jmedchem.6b01379. Epub 2017 Feb 13. Erratum in: J Med Chem. 2017 Apr 13;60(7):3217.

15.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2017 Feb 1;36(3):260-273. doi: 10.15252/embj.201694795. Epub 2016 Dec 22. Erratum in: EMBO J. 2018 Mar 15;37(6):.

16.

Nrf1 can be processed and activated in a proteasome-independent manner.

Vangala JR, Sotzny F, Krüger E, Deshaies RJ, Radhakrishnan SK.

Curr Biol. 2016 Sep 26;26(18):R834-R835. doi: 10.1016/j.cub.2016.08.008.

17.

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.

Sung MK, Porras-Yakushi TR, Reitsma JM, Huber FM, Sweredoski MJ, Hoelz A, Hess S, Deshaies RJ.

Elife. 2016 Aug 23;5. pii: e19105. doi: 10.7554/eLife.19105.

18.

Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor.

Xue L, Blythe EE, Freiberger EC, Mamrosh JL, Hebert AS, Reitsma JM, Hess S, Coon JJ, Deshaies RJ.

Mol Cell Proteomics. 2016 Sep;15(9):2970-86. doi: 10.1074/mcp.M116.061036. Epub 2016 Jul 12.

19.

Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system.

Sung MK, Reitsma JM, Sweredoski MJ, Hess S, Deshaies RJ.

Mol Biol Cell. 2016 Sep 1;27(17):2642-52. doi: 10.1091/mbc.E16-05-0290. Epub 2016 Jul 6.

20.

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.

Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, Enchev RI.

Elife. 2016 Mar 31;5. pii: e12102. doi: 10.7554/eLife.12102.

21.

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.

Nguyen TV, Lee JE, Sweredoski MJ, Yang SJ, Jeon SJ, Harrison JS, Yim JH, Lee SG, Handa H, Kuhlman B, Jeong JS, Reitsma JM, Park CS, Hess S, Deshaies RJ.

Mol Cell. 2016 Mar 17;61(6):809-20. doi: 10.1016/j.molcel.2016.02.032.

22.

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM.

ACS Med Chem Lett. 2015 Dec 22;7(2):182-7. doi: 10.1021/acsmedchemlett.5b00396. eCollection 2016 Feb 11.

23.

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S.

Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28.

24.

Corrigendum: Protein degradation: Prime time for PROTACs.

Deshaies RJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887b. No abstract available.

PMID:
26485081
25.

Protein degradation: Prime time for PROTACs.

Deshaies RJ.

Nat Chem Biol. 2015 Sep;11(9):634-5. doi: 10.1038/nchembio.1887. No abstract available. Erratum in: Nat Chem Biol. 2015 Nov;11(11):887.

PMID:
26284668
26.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J.

Oncotarget. 2015 Jun 20;6(17):14796-813.

27.

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.

Deshaies RJ.

BMC Biol. 2014 Nov 11;12:94. doi: 10.1186/s12915-014-0094-0. Review.

28.

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.

Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T.

Nat Cell Biol. 2014 Dec;16(12):1227-37. doi: 10.1038/ncb3054. Epub 2014 Oct 26.

29.

Structural biology: Corralling a protein-degradation regulator.

Deshaies RJ.

Nature. 2014 Aug 14;512(7513):145-6. doi: 10.1038/nature13644. Epub 2014 Jul 16. No abstract available.

PMID:
25043034
30.

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR.

J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27.

31.

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

Chan NC, den Besten W, Sweredoski MJ, Hess S, Deshaies RJ, Chan DC.

J Biol Chem. 2014 Jul 11;289(28):19789-98. doi: 10.1074/jbc.M114.569392. Epub 2014 May 22.

32.

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan SK, den Besten W, Deshaies RJ.

Elife. 2014;3:e01856. doi: 10.7554/eLife.01856. Epub 2014 Jan 21.

33.

F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.

Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ.

Mol Cell Proteomics. 2014 Mar;13(3):780-91. doi: 10.1074/mcp.M113.031765. Epub 2014 Jan 5.

34.

Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.

Kolawa N, Sweredoski MJ, Graham RL, Oania R, Hess S, Deshaies RJ.

Mol Cell Proteomics. 2013 Oct;12(10):2791-803. doi: 10.1074/mcp.M113.030163. Epub 2013 Jun 22.

35.

Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.

Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X.

Mol Cell Biol. 2013 Aug;33(16):3330-42. doi: 10.1128/MCB.00082-13. Epub 2013 Jun 17.

36.

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ.

Cell. 2013 Mar 28;153(1):206-15. doi: 10.1016/j.cell.2013.02.024. Epub 2013 Feb 28.

37.

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.

Verma R, Oania RS, Kolawa NJ, Deshaies RJ.

Elife. 2013 Jan 22;2:e00308. doi: 10.7554/eLife.00308.

38.

Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.

Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ.

ChemMedChem. 2013 Feb;8(2):297-312. doi: 10.1002/cmdc.201200520. Epub 2013 Jan 11.

39.

Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.

Emberley ED, Mosadeghi R, Deshaies RJ.

J Biol Chem. 2012 Aug 24;287(35):29679-89. doi: 10.1074/jbc.M112.352484. Epub 2012 Jul 5.

40.

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ.

Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1. doi: 10.1038/nsmb.2269.

41.

Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions.

Sohn CH, Agnew HD, Lee JE, Sweredoski MJ, Graham RL, Smith GT, Hess S, Czerwieniec G, Loo JA, Heath JR, Deshaies RJ, Beauchamp JL.

Anal Chem. 2012 Mar 20;84(6):2662-9. doi: 10.1021/ac202637n. Epub 2012 Mar 5.

42.

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

Haines DS, Lee JE, Beauparlant SL, Kyle DB, den Besten W, Sweredoski MJ, Graham RL, Hess S, Deshaies RJ.

Mol Cell Proteomics. 2012 Jun;11(6):M111.016444. doi: 10.1074/mcp.M111.016444. Epub 2012 Feb 14.

43.

Click chemistry facilitates formation of reporter ions and simplified synthesis of amine-reactive multiplexed isobaric tags for protein quantification.

Sohn CH, Lee JE, Sweredoski MJ, Graham RL, Smith GT, Hess S, Czerwieniec G, Loo JA, Deshaies RJ, Beauchamp JL.

J Am Chem Soc. 2012 Feb 8;134(5):2672-80. doi: 10.1021/ja2099003. Epub 2012 Jan 27.

44.

The TFIIH subunit Tfb3 regulates cullin neddylation.

Rabut G, Le Dez G, Verma R, Makhnevych T, Knebel A, Kurz T, Boone C, Deshaies RJ, Peter M.

Mol Cell. 2011 Aug 5;43(3):488-95. doi: 10.1016/j.molcel.2011.05.032.

45.

Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1.

Gomez TA, Kolawa N, Gee M, Sweredoski MJ, Deshaies RJ.

BMC Biol. 2011 May 31;9:33. doi: 10.1186/1741-7007-9-33.

46.

Development of p97 AAA ATPase inhibitors.

Chou TF, Deshaies RJ.

Autophagy. 2011 Sep;7(9):1091-2. Epub 2011 Sep 1.

47.

Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

Saha A, Lewis S, Kleiger G, Kuhlman B, Deshaies RJ.

Mol Cell. 2011 Apr 8;42(1):75-83. doi: 10.1016/j.molcel.2011.03.016.

48.

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7.

49.

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system.

Chou TF, Deshaies RJ.

J Biol Chem. 2011 May 13;286(19):16546-54. doi: 10.1074/jbc.M110.215319. Epub 2011 Feb 22.

50.

Control of cullin-ring ubiquitin ligase activity by nedd8.

Deshaies RJ, Emberley ED, Saha A.

Subcell Biochem. 2010;54:41-56. doi: 10.1007/978-1-4419-6676-6_4. Review.

PMID:
21222272

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