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Items: 1 to 50 of 52

1.

Polyploidy in liver development, homeostasis and disease.

Donne R, Saroul-Aïnama M, Cordier P, Celton-Morizur S, Desdouets C.

Nat Rev Gastroenterol Hepatol. 2020 Apr 2. doi: 10.1038/s41575-020-0284-x. [Epub ahead of print] Review.

PMID:
32242122
2.

Hepatospecific ablation of p38α MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury.

Fortier M, Cadoux M, Boussetta N, Pham S, Donné R, Couty JP, Desdouets C, Celton-Morizur S.

Sci Rep. 2019 Oct 10;9(1):14614. doi: 10.1038/s41598-019-51175-z.

3.

[Hepatic polyploidy: Dr Jekyll or Mr Hyde].

Donné R, Saroul M, Maillet V, Celton-Morizur S, Desdouets C.

Med Sci (Paris). 2019 Jun-Jul;35(6-7):519-526. doi: 10.1051/medsci/2019094. Epub 2019 Jul 5. Review. French.

PMID:
31274081
4.

Polyploidy spectrum: a new marker in HCC classification.

Bou-Nader M, Caruso S, Donne R, Celton-Morizur S, Calderaro J, Gentric G, Cadoux M, L'Hermitte A, Klein C, Guilbert T, Albuquerque M, Couchy G, Paradis V, Couty JP, Zucman-Rossi J, Desdouets C.

Gut. 2020 Feb;69(2):355-364. doi: 10.1136/gutjnl-2018-318021. Epub 2019 Apr 12.

5.

Histone stress: an unexplored source of chromosomal instability in cancer?

Miles DM, Desdouets C, Géli V.

Curr Genet. 2019 Oct;65(5):1081-1088. doi: 10.1007/s00294-019-00967-x. Epub 2019 Apr 11. Review.

PMID:
30976832
6.

Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.

Manco R, Clerbaux LA, Verhulst S, Bou Nader M, Sempoux C, Ambroise J, Bearzatto B, Gala JL, Horsmans Y, van Grunsven L, Desdouets C, Leclercq I.

J Hepatol. 2019 Jun;70(6):1180-1191. doi: 10.1016/j.jhep.2019.02.003. Epub 2019 Feb 20.

PMID:
30794890
7.

Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation.

Ahodantin J, Bou-Nader M, Cordier C, Mégret J, Soussan P, Desdouets C, Kremsdorf D.

Oncogene. 2019 Apr;38(14):2645-2657. doi: 10.1038/s41388-018-0607-3. Epub 2018 Dec 11.

PMID:
30538294
8.

Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma.

L'Hermitte A, Pham S, Cadoux M, Couchy G, Caruso S, Anson M, Crain-Denoyelle AM, Celton-Morizur S, Yamagoe S, Zucman-Rossi J, Desdouets C, Couty JP.

Hepatology. 2019 Jan;69(1):160-178. doi: 10.1002/hep.30140. Epub 2018 Dec 22.

PMID:
30070727
9.

Inhibiting Cytokinesis in the Liver: A New Way to Reduce Tumor Development.

Desdouets C, Avila MA.

Gastroenterology. 2018 Apr;154(5):1229-1231. doi: 10.1053/j.gastro.2018.03.006. Epub 2018 Mar 3. No abstract available.

PMID:
29510129
10.

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.

Maillet V, Boussetta N, Leclerc J, Fauveau V, Foretz M, Viollet B, Couty JP, Celton-Morizur S, Perret C, Desdouets C.

Cell Rep. 2018 Feb 20;22(8):1994-2005. doi: 10.1016/j.celrep.2018.01.086.

11.

Liver physiological polyploidization: MicroRNA-122 a key regulator.

Celton-Morizur S, Desdouets C.

Clin Res Hepatol Gastroenterol. 2017 Mar;41(2):123-125. doi: 10.1016/j.clinre.2016.07.006. Epub 2017 Jan 27.

PMID:
28139382
12.

Incomplete cytokinesis/binucleation in mammals: The powerful system of hepatocytes.

Fortier M, Celton-Morizur S, Desdouets C.

Methods Cell Biol. 2017;137:119-142. doi: 10.1016/bs.mcb.2016.04.006. Epub 2016 May 6.

PMID:
28065301
13.

Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma.

Morzyglod L, Caüzac M, Popineau L, Denechaud PD, Fajas L, Ragazzon B, Fauveau V, Planchais J, Vasseur-Cognet M, Fartoux L, Scatton O, Rosmorduc O, Guilmeau S, Postic C, Desdouets C, Desbois-Mouthon C, Burnol AF.

Hepatology. 2017 Apr;65(4):1352-1368. doi: 10.1002/hep.28972. Epub 2017 Feb 21.

PMID:
27981611
14.

Liver polyploidy: Dr Jekyll or Mr Hide?

Gentric G, Desdouets C.

Oncotarget. 2015 Apr 20;6(11):8430-1. No abstract available.

15.

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease.

Gentric G, Maillet V, Paradis V, Couton D, L'Hermitte A, Panasyuk G, Fromenty B, Celton-Morizur S, Desdouets C.

J Clin Invest. 2015 Mar 2;125(3):981-92. doi: 10.1172/JCI73957. Epub 2015 Jan 26.

16.

Polyploidization in liver tissue.

Gentric G, Desdouets C.

Am J Pathol. 2014 Feb;184(2):322-31. doi: 10.1016/j.ajpath.2013.06.035. Epub 2013 Oct 17. Review.

17.

AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression.

Merlen G, Gentric G, Celton-Morizur S, Foretz M, Guidotti JE, Fauveau V, Leclerc J, Viollet B, Desdouets C.

J Hepatol. 2014 Jan;60(1):152-9. doi: 10.1016/j.jhep.2013.08.025. Epub 2013 Sep 6.

PMID:
24012615
18.

Auditory hair cell centrioles undergo confined Brownian motion throughout the developmental migration of the kinocilium.

Lepelletier L, de Monvel JB, Buisson J, Desdouets C, Petit C.

Biophys J. 2013 Jul 2;105(1):48-58. doi: 10.1016/j.bpj.2013.05.009.

19.

Regulation of the hepatocyte cell cycle: signaling pathways and protein kinases.

Loyer P, Corlu A, Desdouets C.

Int J Hepatol. 2012;2012:592354. doi: 10.1155/2012/592354. Epub 2012 Dec 26. No abstract available.

20.

Polyploidization without mitosis improves in vivo liver transduction with lentiviral vectors.

Pichard V, Couton D, Desdouets C, Ferry N.

Hum Gene Ther. 2013 Feb;24(2):143-51. doi: 10.1089/hum.2011.227. Epub 2013 Jan 30.

21.

Hepatocytes polyploidization and cell cycle control in liver physiopathology.

Gentric G, Desdouets C, Celton-Morizur S.

Int J Hepatol. 2012;2012:282430. doi: 10.1155/2012/282430. Epub 2012 Oct 22.

22.

KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.

Gasnereau I, Boissan M, Margall-Ducos G, Couchy G, Wendum D, Bourgain-Guglielmetti F, Desdouets C, Lacombe ML, Zucman-Rossi J, Sobczak-Thépot J.

Am J Pathol. 2012 Jan;180(1):131-40. doi: 10.1016/j.ajpath.2011.09.040. Epub 2011 Nov 1.

PMID:
22056911
23.

Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.

Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM.

Immunity. 2011 Sep 23;35(3):361-74. doi: 10.1016/j.immuni.2011.07.008. Epub 2011 Aug 4.

24.

Polyploidy and liver proliferation.

Gentric G, Celton-Morizur S, Desdouets C.

Clin Res Hepatol Gastroenterol. 2012 Feb;36(1):29-34. doi: 10.1016/j.clinre.2011.05.011. Epub 2011 Jul 21. Review.

PMID:
21778131
25.

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

Espeillac C, Mitchell C, Celton-Morizur S, Chauvin C, Koka V, Gillet C, Albrecht JH, Desdouets C, Pende M.

J Clin Invest. 2011 Jul;121(7):2821-32. doi: 10.1172/JCI44203.

26.

Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse.

Pulecio J, Petrovic J, Prete F, Chiaruttini G, Lennon-Dumenil AM, Desdouets C, Gasman S, Burrone OR, Benvenuti F.

J Exp Med. 2010 Nov 22;207(12):2719-32. doi: 10.1084/jem.20100007. Epub 2010 Nov 8.

27.

Polyploidization of liver cells.

Celton-Morizur S, Desdouets C.

Adv Exp Med Biol. 2010;676:123-35. Review.

PMID:
20687473
28.

Polyploidy and liver proliferation: central role of insulin signaling.

Celton-Morizur S, Merlen G, Couton D, Desdouets C.

Cell Cycle. 2010 Feb 1;9(3):460-6. Epub 2010 Feb 6.

PMID:
20090410
29.

Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.

Beck L, Leroy C, Salaün C, Margall-Ducos G, Desdouets C, Friedlander G.

J Biol Chem. 2009 Nov 6;284(45):31363-74. doi: 10.1074/jbc.M109.053132. Epub 2009 Sep 2.

30.

The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.

Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C.

J Clin Invest. 2009 Jul;119(7):1880-7.

31.

[Cellular polyploidy in hepatic tissue: new role of insulin].

Celton-Morizur S, Desdouets C.

Med Sci (Paris). 2009 Jun-Jul;25(6-7):651-3. doi: 10.1051/medsci/2009256-7651. French. No abstract available.

32.

Liver tetraploidization is controlled by a new process of incomplete cytokinesis.

Margall-Ducos G, Celton-Morizur S, Couton D, Brégerie O, Desdouets C.

J Cell Sci. 2007 Oct 15;120(Pt 20):3633-9. Epub 2007 Sep 25.

33.

Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.

Michel C, Desdouets C, Slaoui M, Isaacs KR, Roberts RA, Boitier E.

Toxicol Sci. 2007 Sep;99(1):58-69. Epub 2007 Jun 30.

PMID:
17602206
34.

The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells.

Robert A, Margall-Ducos G, Guidotti JE, Brégerie O, Celati C, Bréchot C, Desdouets C.

J Cell Sci. 2007 Feb 15;120(Pt 4):628-37. Epub 2007 Jan 30. Erratum in: J Cell Sci. 2007 Mar 1;120(Pt 5):918.

35.
36.

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.

Wirth KG, Wutz G, Kudo NR, Desdouets C, Zetterberg A, Taghybeeglu S, Seznec J, Ducos GM, Ricci R, Firnberg N, Peters JM, Nasmyth K.

J Cell Biol. 2006 Mar 13;172(6):847-60.

37.
38.

Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis.

Toyoda H, Bregerie O, Vallet A, Nalpas B, Pivert G, Brechot C, Desdouets C.

Gut. 2005 Feb;54(2):297-302.

39.

Liver gene expression profiles of rats treated with clofibric acid: comparison of whole liver and laser capture microdissected liver.

Michel C, Desdouets C, Sacre-Salem B, Gautier JC, Roberts R, Boitier E.

Am J Pathol. 2003 Dec;163(6):2191-9.

40.

Liver cell polyploidization: a pivotal role for binuclear hepatocytes.

Guidotti JE, Brégerie O, Robert A, Debey P, Brechot C, Desdouets C.

J Biol Chem. 2003 May 23;278(21):19095-101. Epub 2003 Mar 7.

41.

Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation.

Witko-Sarsat V, Canteloup S, Durant S, Desdouets C, Chabernaud R, Lemarchand P, Descamps-Latscha B.

J Biol Chem. 2002 Dec 6;277(49):47338-47. Epub 2002 Sep 26.

42.
43.

p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.

Desdouets C, Bréchot C.

Pathol Biol (Paris). 2000 Apr;48(3):203-10. Review.

PMID:
10858954
44.

Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions.

McIntyre M, Desdouets C, Sénamaud-Beaufort C, Laurent-Winter C, Lamas E, Bréchot C.

Oncogene. 1999 Aug 12;18(32):4577-85.

45.

cAMP-dependent positive control of cyclin A2 expression during G1/S transition in primary hepatocytes.

Desdouets C, Thoresen GH, Senamaud-Beaufort C, Christoffersen T, Brechot C, Sobczak-Thepot J.

Biochem Biophys Res Commun. 1999 Jul 22;261(1):118-22.

PMID:
10405333
46.

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

Desdouets C, Santocanale C, Drury LS, Perkins G, Foiani M, Plevani P, Diffley JF.

EMBO J. 1998 Jul 15;17(14):4139-46.

47.

ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoter.

Desdouets C, Ory C, Matesic G, Soussi T, Bréchot C, Sobczak-Thépot J.

FEBS Lett. 1996 Apr 29;385(1-2):34-8.

48.

Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse.

Desdouets C, Fabre M, Gauthier F, Bréchot C, Sobczak-Thépot J.

J Hepatol. 1995 Nov;23(5):569-77.

PMID:
8583146
49.

Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM.

Desdouets C, Matesic G, Molina CA, Foulkes NS, Sassone-Corsi P, Brechot C, Sobczak-Thepot J.

Mol Cell Biol. 1995 Jun;15(6):3301-9.

50.

Cyclin A: function and expression during cell proliferation.

Desdouets C, Sobczak-Thépot J, Murphy M, Bréchot C.

Prog Cell Cycle Res. 1995;1:115-23. Review.

PMID:
9552357

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