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Items: 1 to 50 of 83

1.

Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense.

Chandrakar P, Parmar N, Descoteaux A, Kar S.

J Immunol. 2020 Feb 1;204(3):596-610. doi: 10.4049/jimmunol.1900412. Epub 2019 Dec 27.

PMID:
31882519
2.

Leishmania braziliensis: Strain-Specific Modulation of Phagosome Maturation.

da Silva Vieira T, Arango Duque G, Ory K, Gontijo CM, Soares RP, Descoteaux A.

Front Cell Infect Microbiol. 2019 Sep 6;9:319. doi: 10.3389/fcimb.2019.00319. eCollection 2019.

3.

The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole.

Arango Duque G, Jardim A, Gagnon É, Fukuda M, Descoteaux A.

PLoS Pathog. 2019 Jul 29;15(7):e1007982. doi: 10.1371/journal.ppat.1007982. eCollection 2019 Jul.

4.

Intraspecies Polymorphisms in the Lipophosphoglycan of L. braziliensis Differentially Modulate Macrophage Activation via TLR4.

Vieira TDS, Rugani JN, Nogueira PM, Torrecilhas AC, Gontijo CMF, Descoteaux A, Soares RP.

Front Cell Infect Microbiol. 2019 Jul 10;9:240. doi: 10.3389/fcimb.2019.00240. eCollection 2019.

5.

Proportion of US Hospitalized Medically Ill Patients Who May Qualify for Extended Thromboprophylaxis.

Miao B, Chalupadi B, Clark B, Descoteaux A, Huang D, Ilham S, Ly B, Spyropoulos AC, Coleman CI.

Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619850897. doi: 10.1177/1076029619850897.

6.

Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.

Chaparro V, Leroux LP, Zimmermann A, Jardim A, Johnston B, Descoteaux A, Jaramillo M.

Infect Immun. 2019 Apr 23;87(5). pii: e00064-19. doi: 10.1128/IAI.00064-19. Print 2019 Mar.

7.

Leishmania donovani Induces Autophagy in Human Blood-Derived Neutrophils.

Pitale DM, Gendalur NS, Descoteaux A, Shaha C.

J Immunol. 2019 Feb 15;202(4):1163-1175. doi: 10.4049/jimmunol.1801053. Epub 2019 Jan 11.

PMID:
30635391
8.

Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System.

Borrelli EP, Lee EY, Descoteaux AM, Kogut SJ, Caffrey AR.

Epilepsia. 2018 Dec;59(12):2318-2324. doi: 10.1111/epi.14591. Epub 2018 Nov 5.

9.

Fragment-Based Phenotypic Lead Discovery: Cell-Based Assay to Target Leishmaniasis.

Ayotte Y, Bilodeau F, Descoteaux A, LaPlante SR.

ChemMedChem. 2018 Jul 18;13(14):1377-1386. doi: 10.1002/cmdc.201800161. Epub 2018 May 30.

PMID:
29722149
10.

Leishmania infantum Lipophosphoglycan-Deficient Mutants: A Tool to Study Host Cell-Parasite Interplay.

Lázaro-Souza M, Matte C, Lima JB, Arango Duque G, Quintela-Carvalho G, de Carvalho Vivarini Á, Moura-Pontes S, Figueira CP, Jesus-Santos FH, Gazos Lopes U, Farias LP, Araújo-Santos T, Descoteaux A, Borges VM.

Front Microbiol. 2018 Apr 5;9:626. doi: 10.3389/fmicb.2018.00626. eCollection 2018.

11.

Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.

Gomez CP, Descoteaux A.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1964-1971. doi: 10.1016/j.bbrc.2017.12.061. Epub 2017 Dec 13.

PMID:
29247647
12.

Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2.

Lima JB, Araújo-Santos T, Lázaro-Souza M, Carneiro AB, Ibraim IC, Jesus-Santos FH, Luz NF, Pontes SM, Entringer PF, Descoteaux A, Bozza PT, Soares RP, Borges VM.

Sci Rep. 2017 Oct 30;7(1):14321. doi: 10.1038/s41598-017-14229-8.

13.

Macrophages Tell the Non-Professionals What to Do.

Arango Duque G, Descoteaux A.

Dev Cell. 2016 Dec 19;39(6):633-635. doi: 10.1016/j.devcel.2016.12.009.

14.

Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process.

Matte C, Descoteaux A.

PLoS Pathog. 2016 Dec 8;12(12):e1005962. doi: 10.1371/journal.ppat.1005962. eCollection 2016 Dec. Review. No abstract available.

15.

Leishmania, the phagosome, and host responses: The journey of a parasite.

Séguin O, Descoteaux A.

Cell Immunol. 2016 Nov;309:1-6. doi: 10.1016/j.cellimm.2016.08.004. Epub 2016 Aug 8. Review.

PMID:
27531526
16.

Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63.

Matte C, Casgrain PA, Séguin O, Moradin N, Hong WJ, Descoteaux A.

PLoS Pathog. 2016 Jun 9;12(6):e1005690. doi: 10.1371/journal.ppat.1005690. eCollection 2016 Jun.

17.

Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia.

Silva-Barrios S, Smans M, Duerr CU, Qureshi ST, Fritz JH, Descoteaux A, Stäger S.

Cell Rep. 2016 Jun 14;15(11):2427-37. doi: 10.1016/j.celrep.2016.05.028. Epub 2016 Jun 2.

18.

Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression.

Casgrain PA, Martel C, McMaster WR, Mottram JC, Olivier M, Descoteaux A.

PLoS Pathog. 2016 May 18;12(5):e1005658. doi: 10.1371/journal.ppat.1005658. eCollection 2016 May.

19.

Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection.

Rabhi S, Rabhi I, Trentin B, Piquemal D, Regnault B, Goyard S, Lang T, Descoteaux A, Enninga J, Guizani-Tabbane L.

PLoS One. 2016 Feb 12;11(2):e0148640. doi: 10.1371/journal.pone.0148640. eCollection 2016.

20.

Leishmania survival in the macrophage: where the ends justify the means.

Arango Duque G, Descoteaux A.

Curr Opin Microbiol. 2015 Aug;26:32-40. doi: 10.1016/j.mib.2015.04.007. Epub 2015 May 17. Review.

PMID:
25988701
21.

Leishmania and the macrophage: a multifaceted interaction.

Podinovskaia M, Descoteaux A.

Future Microbiol. 2015;10(1):111-29. doi: 10.2217/fmb.14.103. Review.

PMID:
25598341
22.

Dok proteins are recruited to the phagosome and degraded in a GP63-dependent manner during Leishmania major infection.

Álvarez de Celis H, Gómez CP, Descoteaux A, Duplay P.

Microbes Infect. 2015 Apr;17(4):285-94. doi: 10.1016/j.micinf.2014.12.011. Epub 2014 Dec 30.

PMID:
25554486
23.

Macrophage cytokines: involvement in immunity and infectious diseases.

Arango Duque G, Descoteaux A.

Front Immunol. 2014 Oct 7;5:491. doi: 10.3389/fimmu.2014.00491. eCollection 2014. Review.

24.

Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.

Arango Duque G, Fukuda M, Turco SJ, Stäger S, Descoteaux A.

J Immunol. 2014 Sep 1;193(5):2363-72. doi: 10.4049/jimmunol.1303043. Epub 2014 Jul 25.

25.

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.

Dacher M, Morales MA, Pescher P, Leclercq O, Rachidi N, Prina E, Cayla M, Descoteaux A, Späth GF.

Mol Microbiol. 2014 Jul;93(1):146-66. doi: 10.1111/mmi.12648. Epub 2014 Jun 3.

26.

Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.

Matheoud D, Moradin N, Bellemare-Pelletier A, Shio MT, Hong WJ, Olivier M, Gagnon E, Desjardins M, Descoteaux A.

Cell Host Microbe. 2013 Jul 17;14(1):15-25. doi: 10.1016/j.chom.2013.06.003.

27.

Leishmania dices away cholesterol for survival.

Descoteaux A, Moradin N, Arango Duque G.

Cell Host Microbe. 2013 Mar 13;13(3):245-7. doi: 10.1016/j.chom.2013.02.018.

28.

Synaptotagmin XI regulates phagocytosis and cytokine secretion in macrophages.

Arango Duque G, Fukuda M, Descoteaux A.

J Immunol. 2013 Feb 15;190(4):1737-45. doi: 10.4049/jimmunol.1202500. Epub 2013 Jan 9.

29.

Leishmania promastigotes: building a safe niche within macrophages.

Moradin N, Descoteaux A.

Front Cell Infect Microbiol. 2012 Sep 19;2:121. doi: 10.3389/fcimb.2012.00121. eCollection 2012. Review.

30.

Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.

Rabhi I, Rabhi S, Ben-Othman R, Rasche A, Daskalaki A, Trentin B, Piquemal D, Regnault B, Descoteaux A, Guizani-Tabbane L; Sysco Consortium.

PLoS Negl Trop Dis. 2012;6(8):e1763. doi: 10.1371/journal.pntd.0001763. Epub 2012 Aug 21.

31.

The protein tyrosine phosphatase SHP-1 regulates phagolysosome biogenesis.

Gómez CP, Tiemi Shio M, Duplay P, Olivier M, Descoteaux A.

J Immunol. 2012 Sep 1;189(5):2203-10. doi: 10.4049/jimmunol.1103021. Epub 2012 Jul 23.

32.

Exclusion of synaptotagmin V at the phagocytic cup by Leishmania donovani lipophosphoglycan results in decreased promastigote internalization.

Vinet AF, Jananji S, Turco SJ, Fukuda M, Descoteaux A.

Microbiology. 2011 Sep;157(Pt 9):2619-2628. doi: 10.1099/mic.0.050252-0. Epub 2011 Jun 16.

PMID:
21680635
33.

Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps.

Gabriel C, McMaster WR, Girard D, Descoteaux A.

J Immunol. 2010 Oct 1;185(7):4319-27. doi: 10.4049/jimmunol.1000893. Epub 2010 Sep 8.

34.
35.

[Leishmania donovani delays phagolysosomal acidification].

Vinet AF, Descoteaux A.

Med Sci (Paris). 2010 Mar;26(3):227-8. doi: 10.1051/medsci/2010263227. French. No abstract available.

36.

Observed behaviours of pre-term children in a social play situation with classroom peers.

Nadeau L, Tessier R, Descôteaux A.

Dev Neurorehabil. 2009 Aug;12(4):201-6.

PMID:
19842819
37.

The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V.

Vinet AF, Fukuda M, Turco SJ, Descoteaux A.

PLoS Pathog. 2009 Oct;5(10):e1000628. doi: 10.1371/journal.ppat.1000628. Epub 2009 Oct 16.

38.

Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.

Hardy PO, Diallo TO, Matte C, Descoteaux A.

Immunology. 2009 Sep;128(1 Suppl):e652-60. doi: 10.1111/j.1365-2567.2009.03055.x. Epub 2009 Jan 23.

39.

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.

Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M.

PLoS Pathog. 2009 Aug;5(8):e1000559. doi: 10.1371/journal.ppat.1000559. Epub 2009 Aug 21. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/abca067d-b82b-4de6-93c5-0fcc38e3df05. Tiemi Shio, Marina [corrected to Shio, Marina Tiemi].

40.

Large scale phagosome preparation.

Vinet AF, Descoteaux A.

Methods Mol Biol. 2009;531:329-46. doi: 10.1007/978-1-59745-396-7_20.

PMID:
19347326
41.

Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts.

Winberg ME, Holm A, Särndahl E, Vinet AF, Descoteaux A, Magnusson KE, Rasmusson B, Lerm M.

Microbes Infect. 2009 Feb;11(2):215-22. doi: 10.1016/j.micinf.2008.11.007. Epub 2008 Dec 3.

PMID:
19070677
42.

The exocytosis regulator synaptotagmin V controls phagocytosis in macrophages.

Vinet AF, Fukuda M, Descoteaux A.

J Immunol. 2008 Oct 15;181(8):5289-95.

43.

Leishmania invasion and phagosome biogenesis.

Lodge R, Descoteaux A.

Subcell Biochem. 2008;47:174-81. Review.

PMID:
18512351
44.

Leishmania infantum promastigotes reduce entry of HIV-1 into macrophages through a lipophosphoglycan-mediated disruption of lipid rafts.

Garg R, Lodge R, Descoteaux A, Tremblay MJ.

J Infect Dis. 2008 Jun 15;197(12):1701-8. doi: 10.1086/588146.

PMID:
18422456
45.

Leishmania cysteine proteinases: virulence factors in quest of a function.

Descoteaux A.

Parasitol Today. 1998 Dec;14(6):220-1. No abstract available.

PMID:
17040763
46.
47.

Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane.

Lodge R, Diallo TO, Descoteaux A.

Cell Microbiol. 2006 Dec;8(12):1922-31. Epub 2006 Jul 11.

PMID:
16848789
48.

Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice.

Angers I, Sancho-Shimizu V, Descoteaux A, Gewirtz AT, Malo D.

Mamm Genome. 2006 May;17(5):385-97.

PMID:
16688529
50.

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