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Items: 12


Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication.

Escobar TM, Oksuz O, Saldaña-Meyer R, Descostes N, Bonasio R, Reinberg D.

Cell. 2019 Oct 31;179(4):953-963.e11. doi: 10.1016/j.cell.2019.10.009.


LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.

LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai RA, Kara HO, Yu JR, Lee CH, Stafford J, Shilatifard A, Reinberg D.

Sci Adv. 2019 Oct 2;5(10):eaay3068. doi: 10.1126/sciadv.aay3068. eCollection 2019 Oct.


MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D.

Nucleic Acids Res. 2019 Jan 25;47(2):700-715. doi: 10.1093/nar/gky1148.


Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.

Stafford JM, Lee CH, Voigt P, Descostes N, Saldaña-Meyer R, Yu JR, Leroy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin NS, Placantonakis DG, Karajannis MA, Snuderl M, Ueberheide B, Reinberg D.

Sci Adv. 2018 Oct 31;4(10):eaau5935. doi: 10.1126/sciadv.aau5935. eCollection 2018 Oct.


Capturing the Onset of PRC2-Mediated Repressive Domain Formation.

Oksuz O, Narendra V, Lee CH, Descostes N, LeRoy G, Raviram R, Blumenberg L, Karch K, Rocha PP, Garcia BA, Skok JA, Reinberg D.

Mol Cell. 2018 Jun 21;70(6):1149-1162.e5. doi: 10.1016/j.molcel.2018.05.023.


ARS2 is a general suppressor of pervasive transcription.

Iasillo C, Schmid M, Yahia Y, Maqbool MA, Descostes N, Karadoulama E, Bertrand E, Andrau JC, Jensen TH.

Nucleic Acids Res. 2017 Sep 29;45(17):10229-10241. doi: 10.1093/nar/gkx647.


Pasha: a versatile R package for piling chromatin HTS data.

Fenouil R, Descostes N, Spinelli L, Koch F, Maqbool MA, Benoukraf T, Cauchy P, Innocenti C, Ferrier P, Andrau JC.

Bioinformatics. 2016 Aug 15;32(16):2528-30. doi: 10.1093/bioinformatics/btw206. Epub 2016 Apr 22.


Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.

Voss K, Forné I, Descostes N, Hintermair C, Schüller R, Maqbool MA, Heidemann M, Flatley A, Imhof A, Gut M, Gut I, Kremmer E, Andrau JC, Eick D.

Transcription. 2015;6(5):91-101. doi: 10.1080/21541264.2015.1114983.


Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells.

Descostes N, Heidemann M, Spinelli L, Schüller R, Maqbool MA, Fenouil R, Koch F, Innocenti C, Gut M, Gut I, Eick D, Andrau JC.

Elife. 2014 May 9;3:e02105. doi: 10.7554/eLife.02105.


CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters.

Fenouil R, Cauchy P, Koch F, Descostes N, Cabeza JZ, Innocenti C, Ferrier P, Spicuglia S, Gut M, Gut I, Andrau JC.

Genome Res. 2012 Dec;22(12):2399-408. doi: 10.1101/gr.138776.112. Epub 2012 Oct 25.


Argonaute proteins couple chromatin silencing to alternative splicing.

Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E, Harel-Bellan A.

Nat Struct Mol Biol. 2012 Oct;19(10):998-1004. doi: 10.1038/nsmb.2373. Epub 2012 Sep 9.


Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.

Hintermair C, Heidemann M, Koch F, Descostes N, Gut M, Gut I, Fenouil R, Ferrier P, Flatley A, Kremmer E, Chapman RD, Andrau JC, Eick D.

EMBO J. 2012 Jun 13;31(12):2784-97. doi: 10.1038/emboj.2012.123. Epub 2012 May 1.

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