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Items: 1 to 50 of 63

1.

In Vitro Assays to Monitor the Enzymatic Activities of zDHHC Protein Acyltransferases.

Mitchell DA, Pendleton LC, Deschenes RJ.

Methods Mol Biol. 2019;2009:169-177. doi: 10.1007/978-1-4939-9532-5_13.

PMID:
31152403
2.

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome.

Beard RS Jr, Yang X, Meegan JE, Overstreet JW, Yang CG, Elliott JA, Reynolds JJ, Cha BJ, Pivetti CD, Mitchell DA, Wu MH, Deschenes RJ, Yuan SY.

Nat Commun. 2016 Sep 22;7:12823. doi: 10.1038/ncomms12823.

3.

Physicochemical sequence characteristics that influence S-palmitoylation propensity.

Reddy KD, Malipeddi J, DeForte S, Pejaver V, Radivojac P, Uversky VN, Deschenes RJ.

J Biomol Struct Dyn. 2017 Aug;35(11):2337-2350. doi: 10.1080/07391102.2016.1217275. Epub 2016 Aug 7.

PMID:
27498722
4.

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library.

Hamel LD, Lenhart BJ, Mitchell DA, Santos RG, Giulianotti MA, Deschenes RJ.

Comb Chem High Throughput Screen. 2016;19(4):262-74.

5.

Middle mesial canals in mandibular molars: incidence and related factors.

Nosrat A, Deschenes RJ, Tordik PA, Hicks ML, Fouad AF.

J Endod. 2015 Jan;41(1):28-32. doi: 10.1016/j.joen.2014.08.004. Epub 2014 Sep 27.

PMID:
25266468
6.

A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening.

Hamel LD, Deschenes RJ, Mitchell DA.

Anal Biochem. 2014 Sep 1;460:1-8. doi: 10.1016/j.ab.2014.05.013. Epub 2014 May 27.

7.

Mutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms.

Mitchell DA, Hamel LD, Reddy KD, Farh L, Rettew LM, Sanchez PR, Deschenes RJ.

J Biol Chem. 2014 Jun 27;289(26):18582-92. doi: 10.1074/jbc.M114.567420. Epub 2014 May 8.

8.

The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate.

Mitchell DA, Hamel LD, Ishizuka K, Mitchell G, Schaefer LM, Deschenes RJ.

J Biol Chem. 2012 Oct 5;287(41):34337-48. doi: 10.1074/jbc.M112.379297. Epub 2012 Aug 16.

9.

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

Pedram A, Razandi M, Deschenes RJ, Levin ER.

Mol Biol Cell. 2012 Jan;23(1):188-99. doi: 10.1091/mbc.E11-07-0638. Epub 2011 Oct 26.

10.

Mutational analysis of Saccharomyces cerevisiae Erf2 reveals a two-step reaction mechanism for protein palmitoylation by DHHC enzymes.

Mitchell DA, Mitchell G, Ling Y, Budde C, Deschenes RJ.

J Biol Chem. 2010 Dec 3;285(49):38104-14. doi: 10.1074/jbc.M110.169102. Epub 2010 Sep 17.

11.

Analysis of the diffusion of Ras2 in Saccharomyces cerevisiae using fluorescence recovery after photobleaching.

Vinnakota KC, Mitchell DA, Deschenes RJ, Wakatsuki T, Beard DA.

Phys Biol. 2010 Jun 4;7(2):026011. doi: 10.1088/1478-3975/7/2/026011.

12.

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro.

Jennings BC, Nadolski MJ, Ling Y, Baker MB, Harrison ML, Deschenes RJ, Linder ME.

J Lipid Res. 2009 Feb;50(2):233-42. doi: 10.1194/jlr.M800270-JLR200. Epub 2008 Sep 30.

13.

Modulation of yeast Sln1 kinase activity by the CCW12 cell wall protein.

Shankarnarayan S, Malone CL, Deschenes RJ, Fassler JS.

J Biol Chem. 2008 Jan 25;283(4):1962-73. Epub 2007 Nov 28. Erratum in: J Biol Chem. 2008 Aug 22;283(34):23496. Narang, Sandhya S [corrected to Shankarnarayan, Sandhya].

14.

Palmitoylation: policing protein stability and traffic.

Linder ME, Deschenes RJ.

Nat Rev Mol Cell Biol. 2007 Jan;8(1):74-84. Review.

PMID:
17183362
15.

Purification and characterization of recombinant protein acyltransferases.

Budde C, Schoenfish MJ, Linder ME, Deschenes RJ.

Methods. 2006 Oct;40(2):143-50. Review.

16.

Protein palmitoylation by a family of DHHC protein S-acyltransferases.

Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ.

J Lipid Res. 2006 Jun;47(6):1118-27. Epub 2006 Apr 1. Review.

18.

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME.

J Biol Chem. 2005 Sep 2;280(35):31141-8. Epub 2005 Jul 6.

19.
20.

Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting.

Babu P, Deschenes RJ, Robinson LC.

J Biol Chem. 2004 Jun 25;279(26):27138-47. Epub 2004 Apr 22.

21.

Model organisms lead the way to protein palmitoyltransferases.

Linder ME, Deschenes RJ.

J Cell Sci. 2004 Feb 1;117(Pt 4):521-6.

23.

Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae.

Dong X, Mitchell DA, Lobo S, Zhao L, Bartels DJ, Deschenes RJ.

Mol Cell Biol. 2003 Sep;23(18):6574-84.

24.

New insights into the mechanisms of protein palmitoylation.

Linder ME, Deschenes RJ.

Biochemistry. 2003 Apr 22;42(15):4311-20. Review.

PMID:
12693927
25.
26.

Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins.

Zhao L, Lobo S, Dong X, Ault AD, Deschenes RJ.

J Biol Chem. 2002 Dec 20;277(51):49352-9. Epub 2002 Oct 11.

27.

Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.

Lobo S, Greentree WK, Linder ME, Deschenes RJ.

J Biol Chem. 2002 Oct 25;277(43):41268-73. Epub 2002 Aug 21.

28.

A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1.

Tao W, Malone CL, Ault AD, Deschenes RJ, Fassler JS.

Mol Microbiol. 2002 Jan;43(2):459-73.

29.

The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p.

Li S, Dean S, Li Z, Horecka J, Deschenes RJ, Fassler JS.

Mol Biol Cell. 2002 Feb;13(2):412-24.

30.
31.

Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.

Bartels DJ, Mitchell DA, Dong X, Deschenes RJ.

Mol Cell Biol. 1999 Oct;19(10):6775-87.

32.

Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors.

Deschenes RJ, Lin H, Ault AD, Fassler JS.

Antimicrob Agents Chemother. 1999 Jul;43(7):1700-3.

33.
34.
35.

The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.

Li S, Ault A, Malone CL, Raitt D, Dean S, Johnston LH, Deschenes RJ, Fassler JS.

EMBO J. 1998 Dec 1;17(23):6952-62.

36.
38.

Activated alleles of yeast SLN1 increase Mcm1-dependent reporter gene expression and diminish signaling through the Hog1 osmosensing pathway.

Fassler JS, Gray WM, Malone CL, Tao W, Lin H, Deschenes RJ.

J Biol Chem. 1997 May 16;272(20):13365-71.

39.

An amino terminal prosequence is required for efficient synthesis of S. cerevisiae a-factor.

Quinby GE, Deschenes RJ.

Biochim Biophys Acta. 1997 Mar 27;1356(1):23-34.

40.
41.

Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway.

Farh L, Mitchell DA, Deschenes RJ.

Arch Biochem Biophys. 1995 Apr 1;318(1):113-21.

PMID:
7726551
42.

Characterization of protein prenylation in Saccharomyces cerevisiae.

Mitchell DA, Deschenes RJ.

Methods Enzymol. 1995;250:68-78. No abstract available.

PMID:
7651186
43.

A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiae.

Mitchell DA, Farh L, Marshall TK, Deschenes RJ.

J Biol Chem. 1994 Aug 26;269(34):21540-6.

44.

Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast.

Mitchell DA, Marshall TK, Deschenes RJ.

Yeast. 1993 Jul;9(7):715-22.

PMID:
8368005
45.

Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene.

Guan K, Farh L, Marshall TK, Deschenes RJ.

Curr Genet. 1993 Jul-Aug;24(1-2):141-8.

46.
47.

Cloning and expression of a yeast protein tyrosine phosphatase.

Guan KL, Deschenes RJ, Qiu H, Dixon JE.

J Biol Chem. 1991 Jul 15;266(20):12964-70.

48.

Acylation and prenylation of proteins.

Deschenes RJ, Resh MD, Broach JR.

Curr Opin Cell Biol. 1990 Dec;2(6):1108-13. Review. No abstract available.

PMID:
2099805
49.

Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein.

Stimmel JB, Deschenes RJ, Volker C, Stock J, Clarke S.

Biochemistry. 1990 Oct 16;29(41):9651-9.

PMID:
2271607
50.

SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

Fedor-Chaiken M, Deschenes RJ, Broach JR.

Cell. 1990 Apr 20;61(2):329-40.

PMID:
2158860

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