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Items: 1 to 50 of 60

1.

Mutant voltage-gated Na+ channels can exert a dominant negative effect through coupled gating.

Clatot J, Zheng Y, Girardeau A, Liu H, Laurita KR, Marionneau C, Deschênes I.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1250-H1257. doi: 10.1152/ajpheart.00721.2017. Epub 2018 Aug 17.

PMID:
30351229
2.

Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy.

Li J, Gresham KS, Mamidi R, Doh CY, Wan X, Deschenes I, Stelzer JE.

Int J Cardiol. 2018 Dec 15;273:168-176. doi: 10.1016/j.ijcard.2018.09.073. Epub 2018 Sep 21.

PMID:
30279005
3.

Mutant voltage-gated Na+ channels can exert a dominant negative effect through coupled gating.

Clatot J, Zheng Y, Girardeau A, Liu H, Laurita KR, Marionneau C, Deschênes I.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1250-H1257. doi: 10.1152/ajpheart.00721.2017. Epub 2018 Aug 17.

PMID:
30118344
4.

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.

Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG.

Elife. 2018 Aug 14;7. pii: e37610. doi: 10.7554/eLife.37610.

5.

The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation.

Chatterjee S, Vyas R, Chalamalasetti SV, Sahu ID, Clatot J, Wan X, Lorigan GA, Deschênes I, Chakrapani S.

J Gen Physiol. 2018 Sep 3;150(9):1333-1347. doi: 10.1085/jgp.201812118. Epub 2018 Aug 6.

6.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.

Staudacher I, Illg C, Chai S, Deschenes I, Seehausen S, Gramlich D, Müller ME, Wieder T, Rahm AK, Mayer C, Schweizer PA, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1119-1131. doi: 10.1007/s00210-018-1535-z. Epub 2018 Jul 14.

PMID:
30008082
7.

S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit.

Bektik E, Dennis A, Pawlowski G, Zhou C, Maleski D, Takahashi S, Laurita KR, Deschênes I, Fu JD.

Int J Mol Sci. 2018 May 4;19(5). pii: E1364. doi: 10.3390/ijms19051364.

8.

Strategically targeting calcium: Altering activation sequence to reverse remodel the failing ventricle.

Wilson LD, Deschenes I.

Heart Rhythm. 2018 Oct;15(10):1550-1551. doi: 10.1016/j.hrthm.2018.04.023. Epub 2018 Apr 22. No abstract available.

PMID:
29689310
9.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I.

J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12.

10.

Voltage-gated sodium channels assemble and gate as dimers.

Clatot J, Hoshi M, Wan X, Liu H, Jain A, Shinlapawittayatorn K, Marionneau C, Ficker E, Ha T, Deschênes I.

Nat Commun. 2017 Dec 12;8(1):2077. doi: 10.1038/s41467-017-02262-0.

11.

T-Wave Morphology Analysis to Detect High Risk in Long-QT Syndrome.

Kaufman ES, Deschênes I.

Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: e005920. doi: 10.1161/CIRCEP.117.005920. No abstract available.

PMID:
29141847
12.

A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current.

Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD.

Stem Cell Rev. 2017 Oct;13(5):631-643. doi: 10.1007/s12015-017-9745-1.

13.

KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity.

Nassal DM, Wan X, Liu H, Laurita KR, Deschênes I.

PLoS One. 2017 Apr 6;12(4):e0175221. doi: 10.1371/journal.pone.0175221. eCollection 2017.

14.

Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes.

Chai S, Wan X, Nassal DM, Liu H, Moravec CS, Ramirez-Navarro A, Deschênes I.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1144-H1153. doi: 10.1152/ajpheart.00107.2017. Epub 2017 Mar 24.

15.

Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function.

Nassal MMJ, Wan X, Dale Z, Deschênes I, Wilson LD, Piktel JS.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H886-H895. doi: 10.1152/ajpheart.00298.2016. Epub 2017 Mar 10.

16.

KChIP2 is a core transcriptional regulator of cardiac excitability.

Nassal DM, Wan X, Liu H, Maleski D, Ramirez-Navarro A, Moravec CS, Ficker E, Laurita KR, Deschênes I.

Elife. 2017 Mar 6;6. pii: e17304. doi: 10.7554/eLife.17304.

17.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.

Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM.

J Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. Epub 2017 Jan 5. Review.

18.

Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway.

Sattayaprasert P, Nassal DM, Wan X, Deschenes I, Laurita KR.

J Mol Cell Cardiol. 2016 Sep;98:138-45. doi: 10.1016/j.yjmcc.2016.05.014. Epub 2016 May 26.

19.

Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.

Nassal DM, Wan X, Liu H, Deschênes I.

PLoS One. 2016 Jan 14;11(1):e0146561. doi: 10.1371/journal.pone.0146561. eCollection 2016.

20.

Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress.

Nassal MM, Werdich AA, Wan X, Hoshi M, Deschênes I, Rosenbaum DS, Donahue JK.

J Cardiovasc Electrophysiol. 2016 Jan;27(1):110-9. doi: 10.1111/jce.12833. Epub 2015 Oct 13.

21.

Polygenic Case of Long QT Syndrome Confirmed through Functional Characterization Informs the Interpretation of Genetic Screening Results.

Hoshi M, Liu H, Kaufman ES, Deschênes I.

HeartRhythm Case Rep. 2015 Jul 1;1(4):201-205. No abstract available.

22.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

23.

Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction.

Plummer BN, Liu H, Wan X, Deschênes I, Laurita KR.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):165-73. doi: 10.1161/CIRCEP.114.001789. Epub 2014 Dec 9.

24.

A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation.

Ziyadeh-Isleem A, Clatot J, Duchatelet S, Gandjbakhch E, Denjoy I, Hidden-Lucet F, Hatem S, Deschênes I, Coulombe A, Neyroud N, Guicheney P.

Heart Rhythm. 2014 Jun;11(6):1015-1023. doi: 10.1016/j.hrthm.2014.02.021. Epub 2014 Feb 25.

25.

Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations.

Hoshi M, Du XX, Shinlapawittayatorn K, Liu H, Chai S, Wan X, Ficker E, Deschênes I.

Circ Cardiovasc Genet. 2014 Apr;7(2):123-31. doi: 10.1161/CIRCGENETICS.113.000292. Epub 2014 Feb 26.

26.

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR.

J Clin Invest. 2014 Mar;124(3):1057-68. doi: 10.1172/JCI71863. Epub 2014 Feb 17.

27.

Ionic bases for electrical remodeling of the canine cardiac ventricle.

Jeyaraj D, Wan X, Ficker E, Stelzer JE, Deschenes I, Liu H, Wilson LD, Decker KF, Said TH, Jain MK, Rudy Y, Rosenbaum DS.

Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H410-9. doi: 10.1152/ajpheart.00213.2013. Epub 2013 May 24.

28.

Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart.

Cutler MJ, Plummer BN, Wan X, Sun QA, Hess D, Liu H, Deschenes I, Rosenbaum DS, Stamler JS, Laurita KR.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18186-91. doi: 10.1073/pnas.1210565109. Epub 2012 Oct 15.

29.

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.

Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2013 Mar;168(5):1215-29. doi: 10.1111/bph.12002.

30.

Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.

Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR, Hajjar RJ, Rosenbaum DS.

Circulation. 2012 Oct 23;126(17):2095-104. doi: 10.1161/CIRCULATIONAHA.111.071480. Epub 2012 Sep 27.

31.

Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits.

Clatot J, Ziyadeh-Isleem A, Maugenre S, Denjoy I, Liu H, Dilanian G, Hatem SN, Deschênes I, Coulombe A, Guicheney P, Neyroud N.

Cardiovasc Res. 2012 Oct 1;96(1):53-63. doi: 10.1093/cvr/cvs211. Epub 2012 Jun 27.

32.

Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Dennis AT, Wang L, Wan H, Nassal D, Deschenes I, Ficker E.

Mol Pharmacol. 2012 Feb;81(2):198-209. doi: 10.1124/mol.111.075135. Epub 2011 Nov 1.

33.

Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.

Abu Jawdeh BG, Khan S, Deschênes I, Hoshi M, Goel M, Lock JT, Shinlapawittayatorn K, Babcock G, Lakhe-Reddy S, DeCaro G, Yadav SP, Mohan ML, Naga Prasad SV, Schilling WP, Ficker E, Schelling JR.

J Biol Chem. 2011 Dec 9;286(49):42435-45. doi: 10.1074/jbc.M110.212845. Epub 2011 Oct 21.

34.

A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations.

Shinlapawittayatorn K, Dudash LA, Du XX, Heller L, Poelzing S, Ficker E, Deschênes I.

Circ Cardiovasc Genet. 2011 Oct;4(5):500-9. doi: 10.1161/CIRCGENETICS.111.960633. Epub 2011 Aug 12.

35.

Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.

Dennis AT, Nassal D, Deschenes I, Thomas D, Ficker E.

J Biol Chem. 2011 Sep 30;286(39):34413-25. doi: 10.1074/jbc.M111.254367. Epub 2011 Aug 9.

36.

A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations.

Shinlapawittayatorn K, Du XX, Liu H, Ficker E, Kaufman ES, Deschênes I.

Heart Rhythm. 2011 Mar;8(3):455-62. doi: 10.1016/j.hrthm.2010.11.034. Epub 2010 Nov 23.

37.

Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release.

Hsu K, Han J, Shinlapawittayatorn K, Deschenes I, Marbán E.

Biophys J. 2010 Sep 22;99(6):1718-25. doi: 10.1016/j.bpj.2010.07.027.

38.

Alteration of tyrosine kinase signaling: another player in the arrhythmogenesis of atrial fibrillation?

Shinlapawittayatorn K, Deschênes I.

Heart Rhythm. 2010 Sep;7(9):1253-4. doi: 10.1016/j.hrthm.2010.06.021. Epub 2010 Jun 17. No abstract available.

PMID:
20601156
39.

A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.

Christé G, Thériault O, Chahine M, Millat G, Rodriguez-Lafrasse C, Rousson R, Deschênes I, Ficker E, Chevalier P.

Heart Rhythm. 2008 Nov;5(11):1577-86. doi: 10.1016/j.hrthm.2008.08.031. Epub 2008 Aug 31.

40.

Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents.

Deschênes I, Armoundas AA, Jones SP, Tomaselli GF.

J Mol Cell Cardiol. 2008 Sep;45(3):336-46. doi: 10.1016/j.yjmcc.2008.05.001. Epub 2008 May 12.

41.

Calmodulin regulation of Nav1.4 current: role of binding to the carboxyl terminus.

Biswas S, Deschênes I, Disilvestre D, Tian Y, Halperin VL, Tomaselli GF.

J Gen Physiol. 2008 Mar;131(3):197-209. doi: 10.1085/jgp.200709863. Epub 2008 Feb 11.

42.

Stretch the heart: get memory.

Jeyaraj D, Wilson LD, Deschênes I.

Heart Rhythm. 2008 Jan;5(1):114-5. Epub 2007 Oct 9. No abstract available.

PMID:
18065282
43.

Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans.

Kjølbye AL, Dikshteyn M, Eloff BC, Deschênes I, Rosenbaum DS.

Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H41-9. Epub 2007 Nov 2.

44.

Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.

Jeyaraj D, Wilson LD, Zhong J, Flask C, Saffitz JE, Deschênes I, Yu X, Rosenbaum DS.

Circulation. 2007 Jun 26;115(25):3145-55. Epub 2007 Jun 11.

PMID:
17562957
45.

How can a single mutation cause such arrhythmic havoc?

Deschênes I, Laurita KR.

Heart Rhythm. 2007 Feb;4(2):198-9. Epub 2006 Nov 17. No abstract available.

46.

SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene.

Poelzing S, Forleo C, Samodell M, Dudash L, Sorrentino S, Anaclerio M, Troccoli R, Iacoviello M, Romito R, Guida P, Chahine M, Pitzalis M, Deschênes I.

Circulation. 2006 Aug 1;114(5):368-76. Epub 2006 Jul 24.

PMID:
16864729
47.

Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.

Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V 3rd, Houser SR, Tomaselli GF.

Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H602-9. Epub 2003 Oct 2.

48.

Kaposi's sarcoma following immune suppressive therapy for Wegener's granulomatosis.

Deschênes I, Dion L, Beauchesne C, de Brum-Fernandes A.

J Rheumatol. 2003 Mar;30(3):622-4.

PMID:
12610826
49.

Somatic gene transfer of tagged K+ channel fragments to probe trafficking and electrical function in epithelial cells and cardiac myocytes.

Neyroud N, Deschênes I, Akao M, Nuss HB, Marbán E.

J Membr Biol. 2002 Nov 15;190(2):133-44.

PMID:
12474078
50.

Modulation of Kv4.3 current by accessory subunits.

Deschênes I, Tomaselli GF.

FEBS Lett. 2002 Sep 25;528(1-3):183-8.

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