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Items: 11


Circumventing senescence is associated with stem cell properties and metformin sensitivity.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G.

Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6.


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


Cellular senescence and protein degradation: breaking down cancer.

Deschênes-Simard X, Lessard F, Gaumont-Leclerc MF, Bardeesy N, Ferbeyre G.

Cell Cycle. 2014;13(12):1840-58. doi: 10.4161/cc.29335. Epub 2014 May 27.


ERKs in cancer: friends or foes?

Deschênes-Simard X, Kottakis F, Meloche S, Ferbeyre G.

Cancer Res. 2014 Jan 15;74(2):412-9. doi: 10.1158/0008-5472.CAN-13-2381. Epub 2014 Jan 9. Review.


Macrophages in pancreatic cancer: starting things off on the wrong track.

Deschênes-Simard X, Mizukami Y, Bardeesy N.

J Cell Biol. 2013 Aug 5;202(3):403-5. doi: 10.1083/jcb.201307066.


Metformin, aging and cancer.

Moiseeva O, Deschênes-Simard X, Pollak M, Ferbeyre G.

Aging (Albany NY). 2013 May;5(5):330-1. No abstract available.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

Moiseeva O, Deschênes-Simard X, St-Germain E, Igelmann S, Huot G, Cadar AE, Bourdeau V, Pollak MN, Ferbeyre G.

Aging Cell. 2013 Jun;12(3):489-98. doi: 10.1111/acel.12075. Epub 2013 Apr 23.


Metformin reduces endogenous reactive oxygen species and associated DNA damage.

Algire C, Moiseeva O, Deschênes-Simard X, Amrein L, Petruccelli L, Birman E, Viollet B, Ferbeyre G, Pollak MN.

Cancer Prev Res (Phila). 2012 Apr;5(4):536-43. doi: 10.1158/1940-6207.CAPR-11-0536. Epub 2012 Jan 18.


SOCS1 links cytokine signaling to p53 and senescence.

Calabrese V, Mallette FA, Deschênes-Simard X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G.

Mol Cell. 2009 Dec 11;36(5):754-67. doi: 10.1016/j.molcel.2009.09.044.


Mitochondrial dysfunction contributes to oncogene-induced senescence.

Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G.

Mol Cell Biol. 2009 Aug;29(16):4495-507. doi: 10.1128/MCB.01868-08. Epub 2009 Jun 15.

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