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Items: 1 to 50 of 180


Human intestinal spheroids cultured using Sacrificial Micromolding as a model system for studying drug transport.

Samy KE, Levy ES, Phong K, Demaree B, Abate AR, Desai TA.

Sci Rep. 2019 Jul 9;9(1):9936. doi: 10.1038/s41598-019-46408-0.


Recent advances in intraocular sustained-release drug delivery devices.

Cao Y, Samy KE, Bernards DA, Desai TA.

Drug Discov Today. 2019 Jun 4. pii: S1359-6446(18)30384-2. doi: 10.1016/j.drudis.2019.05.031. [Epub ahead of print] Review.


Bottom-Up Fabrication of Multilayer Enteric Devices for the Oral Delivery of Peptides.

Nemeth CL, Lykins WR, Tran H, ElSayed MEH, Desai TA.

Pharm Res. 2019 Apr 19;36(6):89. doi: 10.1007/s11095-019-2618-3.


Hang on tight: reprogramming the cell with microstructural cues.

Le LV, Mkrtschjan MA, Russell B, Desai TA.

Biomed Microdevices. 2019 Apr 6;21(2):43. doi: 10.1007/s10544-019-0394-9.


Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery.

Schlesinger EB, Bernards DA, Chen HH, Feindt J, Cao J, Dix D, Romano C, Bhisitkul RB, Desai TA.

Bioeng Transl Med. 2018 Dec 3;4(1):152-163. doi: 10.1002/btm2.10121. eCollection 2019 Jan.


Co-Delivery of Timolol and Brimonidine with a Polymer Thin-Film Intraocular Device.

Samy KE, Cao Y, Kim J, Konichi da Silva NR, Phone A, Bloomer MM, Bhisitkul RB, Desai TA.

J Ocul Pharmacol Ther. 2019 Mar;35(2):124-131. doi: 10.1089/jop.2018.0096. Epub 2019 Jan 7.


Islet encapsulation therapy - racing towards the finish line?

Desai TA, Tang Q.

Nat Rev Endocrinol. 2018 Nov;14(11):630-632. doi: 10.1038/s41574-018-0100-7. No abstract available.


Pro-resolving lipid mediators in vascular disease.

Conte MS, Desai TA, Wu B, Schaller M, Werlin E.

J Clin Invest. 2018 Aug 31;128(9):3727-3735. doi: 10.1172/JCI97947. Epub 2018 Aug 31. Review.


Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model.

Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS.

J Vasc Surg. 2018 Dec;68(6S):188S-200S.e4. doi: 10.1016/j.jvs.2018.05.206. Epub 2018 Jul 29.


The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.


Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction.

Le LV, Mohindra P, Fang Q, Sievers RE, Mkrtschjan MA, Solis C, Safranek CW, Russell B, Lee RJ, Desai TA.

Biomaterials. 2018 Jul;169:11-21. doi: 10.1016/j.biomaterials.2018.03.042. Epub 2018 Mar 24.


Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.

Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S.

ACS Biomater Sci Eng. 2017 Jun 12;3(6):1051-1061. doi: 10.1021/acsbiomaterials.6b00814. Epub 2017 Apr 11.


Long-term intraocular pressure reduction with intracameral polycaprolactone glaucoma devices that deliver a novel anti-glaucoma agent.

Kim J, Kudisch M, da Silva NRK, Asada H, Aya-Shibuya E, Bloomer MM, Mudumba S, Bhisitkul RB, Desai TA.

J Control Release. 2018 Jan 10;269:45-51. doi: 10.1016/j.jconrel.2017.11.008. Epub 2017 Nov 7.


Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators.

Zamecnik CR, Lowe MM, Patterson DM, Rosenblum MD, Desai TA.

ACS Nano. 2017 Nov 28;11(11):11433-11440. doi: 10.1021/acsnano.7b06094. Epub 2017 Nov 15.


Lipid signaling affects primary fibroblast collective migration and anchorage in response to stiffness and microtopography.

Mkrtschjan MA, Gaikwad SB, Kappenman KJ, Solís C, Dommaraju S, Le LV, Desai TA, Russell B.

J Cell Physiol. 2018 Apr;233(4):3672-3683. doi: 10.1002/jcp.26236. Epub 2017 Nov 24.


Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.

Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA.

ACS Nano. 2017 Aug 22;11(8):7747-7757. doi: 10.1021/acsnano.7b01239. Epub 2017 Aug 7.


Long acting systemic HIV pre-exposure prophylaxis: an examination of the field.

Lykins WR, Luecke E, Johengen D, van der Straten A, Desai TA.

Drug Deliv Transl Res. 2017 Dec;7(6):805-816. doi: 10.1007/s13346-017-0391-6. Review.


Nanoengineered Stent Surface to Reduce In-Stent Restenosis in Vivo.

Nuhn H, Blanco CE, Desai TA.

ACS Appl Mater Interfaces. 2017 Jun 14;9(23):19677-19686. doi: 10.1021/acsami.7b04626. Epub 2017 Jun 2.


Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading.

Fox CB, Nemeth CL, Chevalier RW, Cantlon J, Bogdanoff DB, Hsiao JC, Desai TA.

Bioeng Transl Med. 2017 Mar;2(1):9-16. doi: 10.1002/btm2.10053. Epub 2017 Feb 3.


Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway.

Stewart T, Koval WT, Molina SA, Bock SM, Lillard JW Jr, Ross RF, Desai TA, Koval M.

Exp Cell Res. 2017 Jun 15;355(2):153-161. doi: 10.1016/j.yexcr.2017.03.065. Epub 2017 Apr 5.


Non-autonomous cell proliferation in the mammary gland and cancer.

Weber RJ, Desai TA, Gartner ZJ.

Curr Opin Cell Biol. 2017 Apr;45:55-61. doi: 10.1016/ Epub 2017 Mar 15. Review.


Nitinol-Based Nanotubular Arrays with Controlled Diameters Upregulate Human Vascular Cell ECM Production.

Lee PP, Desai TA.

ACS Biomater Sci Eng. 2016 Mar 14;2(3):409-414. Epub 2016 Feb 11.


Probing the luminal microenvironment of reconstituted epithelial microtissues.

Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA.

Sci Rep. 2016 Sep 13;6:33148. doi: 10.1038/srep33148.


Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma.

Kim J, Kudisch M, Mudumba S, Asada H, Aya-Shibuya E, Bhisitkul RB, Desai TA.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4341-6. doi: 10.1167/iovs.16-19585.


Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device.

Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS.

J Biomed Mater Res A. 2017 Jan;105(1):31-41. doi: 10.1002/jbm.a.35861. Epub 2016 Aug 23.


Fabrication of Sealed Nanostraw Microdevices for Oral Drug Delivery.

Fox CB, Cao Y, Nemeth CL, Chirra HD, Chevalier RW, Xu AM, Melosh NA, Desai TA.

ACS Nano. 2016 Jun 28;10(6):5873-81. doi: 10.1021/acsnano.6b00809. Epub 2016 Jun 13.


In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device.

Lance KD, Bernards DA, Ciaccio NA, Good SD, Mendes TS, Kudisch M, Chan E, Ishikiriyama M, Bhisitkul RB, Desai TA.

Drug Deliv Transl Res. 2016 Dec;6(6):771-780.


Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR.

Sci Rep. 2016 Apr 20;6:24726. doi: 10.1038/srep24726.


Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury.

Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS.

J Vasc Surg. 2017 Jan;65(1):207-217.e3. doi: 10.1016/j.jvs.2016.01.030. Epub 2016 Mar 29.


Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.

Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S.

Sci Rep. 2016 Mar 24;6:23679. doi: 10.1038/srep23679.


Approaching a cure for type 1 diabetes.

Tang Q, Desai TA.

Nat Med. 2016 Mar;22(3):236-7. doi: 10.1038/nm.4060. No abstract available.


In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device.

Lance KD, Good SD, Mendes TS, Ishikiriyama M, Chew P, Estes LS, Yamada K, Mudumba S, Bhisitkul RB, Desai TA.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7331-7. doi: 10.1167/iovs.15-17757.


Nanotopography applications in drug delivery.

Walsh LA, Allen JL, Desai TA.

Expert Opin Drug Deliv. 2015;12(12):1823-7. doi: 10.1517/17425247.2015.1103734. Epub 2015 Oct 29.


Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design.

Schlesinger E, Ciaccio N, Desai TA.

Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:232-9. doi: 10.1016/j.msec.2015.07.027. Epub 2015 Aug 1.


Programmed synthesis of three-dimensional tissues.

Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ.

Nat Methods. 2015 Oct;12(10):975-81. doi: 10.1038/nmeth.3553. Epub 2015 Aug 31.


Micro/nanofabricated platforms for oral drug delivery.

Fox CB, Kim J, Le LV, Nemeth CL, Chirra HD, Desai TA.

J Control Release. 2015 Dec 10;219:431-444. doi: 10.1016/j.jconrel.2015.07.033. Epub 2015 Aug 2. Review.


Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices.

Nyitray CE, Chang R, Faleo G, Lance KD, Bernards DA, Tang Q, Desai TA.

ACS Nano. 2015 Jun 23;9(6):5675-82. doi: 10.1021/acsnano.5b00679. Epub 2015 May 14.


Intestinal absorption of fluorescently labeled nanoparticles.

Simovic S, Song Y, Nann T, Desai TA.

Nanomedicine. 2015 Jul;11(5):1169-78. doi: 10.1016/j.nano.2015.02.016. Epub 2015 Mar 16.


Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction.

Peña JR, Pinney JR, Ayala P, Desai TA, Goldspink PH.

Biomaterials. 2015 Apr;46:26-34. doi: 10.1016/j.biomaterials.2014.12.050. Epub 2015 Jan 16.


Fabrication of micropatterned polymeric nanowire arrays for high-resolution reagent localization and topographical cellular control.

Fox CB, Kim J, Schlesinger EB, Chirra HD, Desai TA.

Nano Lett. 2015 Mar 11;15(3):1540-6. doi: 10.1021/nl503872p. Epub 2015 Feb 5.


A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.

Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2287-92. doi: 10.1073/pnas.1410776112. Epub 2015 Jan 29.


Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding.

Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner ZJ.

Tissue Eng Part C Methods. 2015 Jun;21(6):541-7. doi: 10.1089/ten.TEC.2014.0450. Epub 2014 Dec 11.


Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly.

Weber RJ, Liang SI, Selden NS, Desai TA, Gartner ZJ.

Biomacromolecules. 2014 Dec 8;15(12):4621-6. doi: 10.1021/bm501467h. Epub 2014 Nov 20.


Planar bioadhesive microdevices: a new technology for oral drug delivery.

Fox CB, Chirra HD, Desai TA.

Curr Pharm Biotechnol. 2014;15(7):673-83. Review.


Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.

Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA.

Mol Ther. 2015 Jan;23(1):119-29. doi: 10.1038/mt.2014.155. Epub 2014 Aug 20.


Nitinol-based nanotubular coatings for the modulation of human vascular cell function.

Lee PP, Cerchiari A, Desai TA.

Nano Lett. 2014 Sep 10;14(9):5021-8. doi: 10.1021/nl501523v. Epub 2014 Aug 15.


Nanoparticulate drug delivery platforms for advancing bone infection therapies.

Uskoković V, Desai TA.

Expert Opin Drug Deliv. 2014 Dec;11(12):1899-912. doi: 10.1517/17425247.2014.944860. Epub 2014 Aug 11. Review.


Novel functionalization of discrete polymeric biomaterial microstructures for applications in imaging and three-dimensional manipulation.

Pinney JR, Melkus G, Cerchiari A, Hawkins J, Desai TA.

ACS Appl Mater Interfaces. 2014 Aug 27;6(16):14477-85. doi: 10.1021/am503778t. Epub 2014 Jul 28.


Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction.

Pinney JR, Du KT, Ayala P, Fang Q, Sievers RE, Chew P, Delrosario L, Lee RJ, Desai TA.

Biomaterials. 2014 Oct;35(31):8820-8828. doi: 10.1016/j.biomaterials.2014.07.005. Epub 2014 Jul 18.

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