Sort by
Items per page

Send to

Choose Destination

Search results

Items: 39


Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.

Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung BH, Hwang D, Kim MS, Park KS, Macedo MP, White M, Jones J, Kim YB.

J Clin Invest. 2018 Dec 3;128(12):5335-5350. doi: 10.1172/JCI63562. Epub 2018 Oct 29.


Measurement of TLR4 and CD14 Receptor Endocytosis Using Flow Cytometry.

Schappe MS, Desai BN.

Bio Protoc. 2018 Jul 20;8(14). pii: e2926. doi: 10.21769/BioProtoc.2926.


Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.

Serbulea V, Upchurch CM, Schappe MS, Voigt P, DeWeese DE, Desai BN, Meher AK, Leitinger N.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263. doi: 10.1073/pnas.1800544115. Epub 2018 Jun 11.


Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

Schappe MS, Szteyn K, Stremska ME, Mendu SK, Downs TK, Seegren PV, Mahoney MA, Dixit S, Krupa JK, Stipes EJ, Rogers JS, Adamson SE, Leitinger N, Desai BN.

Immunity. 2018 Jan 16;48(1):59-74.e5. doi: 10.1016/j.immuni.2017.11.026.


Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.

Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13.


Revisiting multimodal activation and channel properties of Pannexin 1.

Chiu YH, Schappe MS, Desai BN, Bayliss DA.

J Gen Physiol. 2018 Jan 2;150(1):19-39. doi: 10.1085/jgp.201711888. Epub 2017 Dec 12. Review.


Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.

Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E.

Mol Metab. 2017 Nov;6(11):1395-1406. doi: 10.1016/j.molmet.2017.08.004. Epub 2017 Aug 19.


A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.

Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT.

Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z.


Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice.

Douris N, Desai BN, Fisher FM, Cisu T, Fowler AJ, Zarebidaki E, Nguyen NLT, Morgan DA, Bartness TJ, Rahmouni K, Flier JS, Maratos-Flier E.

Mol Metab. 2017 Jun 6;6(8):854-862. doi: 10.1016/j.molmet.2017.05.017. eCollection 2017 Aug.


Hematopoietic pannexin 1 function is critical for neuropathic pain.

Weaver JL, Arandjelovic S, Brown G, K Mendu S, S Schappe M, Buckley MW, Chiu YH, Shu S, Kim JK, Chung J, Krupa J, Jevtovic-Todorovic V, Desai BN, Ravichandran KS, Bayliss DA.

Sci Rep. 2017 Feb 14;7:42550. doi: 10.1038/srep42550.


Fourth-ventricle leptin infusions dose-dependently activate hypothalamic signal transducer and activator of transcription 3.

Harris RB, Desai BN.

Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E939-E948. doi: 10.1152/ajpendo.00343.2016. Epub 2016 Nov 1.


Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus.

Desai BN, Harris RB.

Am J Physiol Endocrinol Metab. 2015 Mar 1;308(5):E351-61. doi: 10.1152/ajpendo.00501.2014. Epub 2014 Dec 30.


Purinergic and calcium signaling in macrophage function and plasticity.

Desai BN, Leitinger N.

Front Immunol. 2014 Nov 27;5:580. doi: 10.3389/fimmu.2014.00580. eCollection 2014. Review.


An acute method to test leptin responsiveness in rats.

Desai BN, Harris RB.

Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1;306(11):R852-60. doi: 10.1152/ajpregu.00548.2013. Epub 2014 Mar 26.


Caspase-11 controls interleukin-1β release through degradation of TRPC1.

Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J.

Cell Rep. 2014 Mar 27;6(6):1122-1128. doi: 10.1016/j.celrep.2014.02.015. Epub 2014 Mar 13.


Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain.

Vaill MI, Desai BN, Harris RB.

Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E414-23. doi: 10.1152/ajpendo.00661.2013. Epub 2013 Dec 17.


Integrated effects of leptin in the forebrain and hindbrain of male rats.

Desai BN, Harris RB.

Endocrinology. 2013 Aug;154(8):2663-75. doi: 10.1210/en.2013-1099. Epub 2013 May 22.


Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons.

Scott EL, Zhang QG, Han D, Desai BN, Brann DW.

Steroids. 2013 Jun;78(6):624-32. doi: 10.1016/j.steroids.2012.11.004. Epub 2012 Nov 22.


Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.

Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE.

Dev Cell. 2012 Jun 12;22(6):1149-62. doi: 10.1016/j.devcel.2012.04.006.


Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model.

Desai BN, Maharjan RH, Nampoothiri LP.

Pharmacognosy Res. 2012 Apr;4(2):109-15. doi: 10.4103/0974-8490.94736.


Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.

Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE.

Science. 2008 Oct 31;322(5902):756-60. doi: 10.1126/science.1163493.


Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.

Nagarajan SR, Lu HF, Gasiecki AF, Khanna IK, Parikh MD, Desai BN, Rogers TE, Clare M, Chen BB, Russell MA, Keene JL, Duffin T, Engleman VW, Finn MB, Freeman SK, Klover JA, Nickols GA, Nickols MA, Shannon KE, Steininger CA, Westlin WF, Westlin MM, Williams ML.

Bioorg Med Chem. 2007 May 15;15(10):3390-412. Epub 2007 Mar 13.


Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists.

Boys ML, Schretzman LA, Chandrakumar NS, Tollefson MB, Mohler SB, Downs VL, Penning TD, Russell MA, Wendt JA, Chen BB, Stenmark HG, Wu H, Spangler DP, Clare M, Desai BN, Khanna IK, Nguyen MN, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Steininger CN, Westlin M, Westlin W, Yu YX, Wang Y, Dalton CR, Norring SA.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):839-44. Epub 2005 Nov 17.


TRP channels and mice deficient in TRP channels.

Desai BN, Clapham DE.

Pflugers Arch. 2005 Oct;451(1):11-8. Epub 2005 Aug 3. Review.


Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists.

Penning TD, Russell MA, Chen BB, Chen HY, Desai BN, Docter SH, Edwards DJ, Gesicki GJ, Liang CD, Malecha JW, Yu SS, Engleman VW, Freeman SK, Hanneke ML, Shannon KE, Westlin MM, Nickols GA.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1471-6.


Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1137-9.


Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Liang CD, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3383-6.


ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint.

Nghiem P, Park PK, Kim Ys YS, Desai BN, Schreiber SL.

J Biol Chem. 2002 Feb 8;277(6):4428-34. Epub 2001 Nov 15.


Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM, Russell MA, Yu SS, Corley DG, Durley RC, Kilpatrick BF, Parnas BL, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Krivi GG, Villani-Price D, Pyla EY, Smith WG.

J Med Chem. 2000 Feb 24;43(4):721-35.


Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein.

Peterson RT, Desai BN, Hardwick JS, Schreiber SL.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4438-42.


Unusual presentation of gastroesophageal reflux with corpus callosum agenesis, cleft palate and mental retardation.

Desai BN, Joshi SM, Malik S, Mittal S, Dandge VP.

Indian Pediatr. 1991 Nov;28(11):1328-30. No abstract available.


Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: monobasic derivatives of disobutamide.

Desai BN, Fowler KW, Chorvat RJ, Frederick LG, Hatley FR, Rorig KJ, Garthwaite SM.

J Med Chem. 1988 Nov;31(11):2158-64.


22-Hydroxycholesterol derivatives as HMG CoA reductase suppressors and serum cholesterol lowering agents.

Chorvat RJ, Desai BN, Radak SE, McLaughlin KT, Miller JE, Jett C, Rohrbacher E.

J Med Chem. 1985 Feb;28(2):194-200.


Priority health problems of children in an urban community.

Jinabhai CC, Supersad V, Desai BN.

S Afr Med J. 1983 Dec 3;64(24):929-33.


Synthesis, benzodiazepine receptor binding, and anticonvulsant activity of 2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitriles.

Chorvat RJ, Desai BN, Radak SE, Bloss J, Hirsch J, Tenen S.

J Med Chem. 1983 Jun;26(6):845-50.


Effect of 23-methyl-21-norcholest-5-ene-3 beta, 23,25-triol on hepatic cholesterol 7 alpha-hydroxylase activity in the rat.

Nicholson N, Flanders L, Desai BN, Chinn L.

J Steroid Biochem. 1979 Jun;10(6):709-10. No abstract available.


Supplemental Content

Loading ...
Support Center