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Items: 1 to 50 of 56

1.

Molecular basis of action of a small molecule positive allosteric modulator (PAM)-agonist at the type 1 cholecystokinin holoreceptor.

Desai AJ, Mechin I, Nagarajan K, Valant C, Wootten D, Lam PCH, Orry A, Abagyan R, Nair A, Sexton PM, Christopoulos A, Miller LJ.

Mol Pharmacol. 2018 Dec 27. pii: mol.118.114082. doi: 10.1124/mol.118.114082. [Epub ahead of print]

2.

'The silicone siphon' - A safe and simple method of removing silicone implant and content from the breast.

Chukwulobelu R, Seetharam S, Desai AJ, Ragoowansi R.

J Plast Reconstr Aesthet Surg. 2018 Sep;71(9):1362-1380. doi: 10.1016/j.bjps.2018.05.044. Epub 2018 Jun 8. No abstract available.

PMID:
30007537
3.

Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function.

Desai AJ, Miller LJ.

Br J Pharmacol. 2018 Nov;175(21):4009-4025. doi: 10.1111/bph.13943. Epub 2017 Aug 3. Review.

PMID:
28691227
4.

Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor.

Desai AJ, Dong M, Harikumar KG, Miller LJ.

Int J Obes Suppl. 2016 Dec;6(Suppl 1):S22-S27. doi: 10.1038/ijosup.2016.5. Epub 2016 Nov 16. Review.

5.

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

Desai AJ, Dong M, Langlais BT, Dueck AC, Miller LJ.

Am J Clin Nutr. 2017 Aug;106(2):447-456. doi: 10.3945/ajcn.117.156943. Epub 2017 Jun 7.

6.

Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target.

Miller LJ, Desai AJ.

Trends Endocrinol Metab. 2016 Sep;27(9):609-619. doi: 10.1016/j.tem.2016.04.002. Epub 2016 May 4. Review.

7.

Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol.

Desai AJ, Dong M, Miller LJ.

Clin Nutr. 2016 Dec;35(6):1374-1379. doi: 10.1016/j.clnu.2016.03.003. Epub 2016 Mar 15.

8.

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.

Desai AJ, Lam PC, Orry A, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Med Chem. 2015 Dec 24;58(24):9562-77. doi: 10.1021/acs.jmedchem.5b01110. Epub 2015 Dec 10.

9.

Characterization and Application of Biosurfactant Produced by Bacillus licheniformis R2.

Joshi SJ, Geetha SJ, Desai AJ.

Appl Biochem Biotechnol. 2015 Sep;177(2):346-61. doi: 10.1007/s12010-015-1746-4. Epub 2015 Jul 18.

PMID:
26186955
10.

Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.

Desai AJ, Dong M, Harikumar KG, Miller LJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G377-86. doi: 10.1152/ajpgi.00173.2015. Epub 2015 Jul 2.

11.

Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.

Desai AJ, Henke BR, Miller LJ.

Bioorg Med Chem Lett. 2015 May 1;25(9):1849-55. doi: 10.1016/j.bmcl.2015.03.051. Epub 2015 Mar 24.

12.

In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response.

Hurvitz SA, Kalous O, Conklin D, Desai AJ, Dering J, Anderson L, O'Brien NA, Kolarova T, Finn RS, Linnartz R, Chen D, Slamon DJ.

Breast Cancer Res Treat. 2015 Feb;149(3):669-80. doi: 10.1007/s10549-015-3282-x. Epub 2015 Feb 8.

PMID:
25663547
13.

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.

Desai AJ, Harikumar KG, Miller LJ.

J Biol Chem. 2014 Jun 27;289(26):18314-26. doi: 10.1074/jbc.M114.570200. Epub 2014 May 13.

14.

Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.

Desai AJ, Roberts DJ, Richards GO, Skerry TM.

PLoS One. 2014 Jan 13;9(1):e85237. doi: 10.1371/journal.pone.0085237. eCollection 2014.

15.

AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.

Kalous O, Conklin D, Desai AJ, Dering J, Goldstein J, Ginther C, Anderson L, Lu M, Kolarova T, Eckardt MA, Langerød A, Børresen-Dale AL, Slamon DJ, Finn RS.

Breast Cancer Res Treat. 2013 Oct;141(3):397-408. doi: 10.1007/s10549-013-2702-z. Epub 2013 Oct 5.

PMID:
24091768
16.

PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.

Logan JE, Mostofizadeh N, Desai AJ, VON Euw E, Conklin D, Konkankit V, Hamidi H, Eckardt M, Anderson L, Chen HW, Ginther C, Taschereau E, Bui PH, Christensen JG, Belldegrun AS, Slamon DJ, Kabbinavar FF.

Anticancer Res. 2013 Aug;33(8):2997-3004.

PMID:
23898052
17.

The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.

Garon EB, Finn RS, Hamidi H, Dering J, Pitts S, Kamranpour N, Desai AJ, Hosmer W, Ide S, Avsar E, Jensen MR, Quadt C, Liu M, Dubinett SM, Slamon DJ.

Mol Cancer Ther. 2013 Jun;12(6):890-900. doi: 10.1158/1535-7163.MCT-12-0998. Epub 2013 Mar 14.

18.

Pre-operative ultrasound for breast tumour measurements: is there potential for mismanagement?

Doddi S, Singhal T, Maghsoudi S, Sinha P, Desai AJ.

G Chir. 2013 Jan-Feb;34(1-2):6-10.

PMID:
23463924
19.

Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer.

Garon EB, Pietras RJ, Finn RS, Kamranpour N, Pitts S, Márquez-Garbán DC, Desai AJ, Dering J, Hosmer W, von Euw EM, Dubinett SM, Slamon DJ.

J Thorac Oncol. 2013 Mar;8(3):270-8. doi: 10.1097/JTO.0b013e31827d525c.

20.

Inhibition of HSP90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer.

Wainberg ZA, Anghel A, Rogers AM, Desai AJ, Kalous O, Conklin D, Ayala R, O'Brien NA, Quadt C, Akimov M, Slamon DJ, Finn RS.

Mol Cancer Ther. 2013 Apr;12(4):509-19. doi: 10.1158/1535-7163.MCT-12-0507. Epub 2013 Feb 8.

21.

Sensitivity of cholecystokinin receptors to membrane cholesterol content.

Desai AJ, Miller LJ.

Front Endocrinol (Lausanne). 2012 Oct 18;3:123. doi: 10.3389/fendo.2012.00123. eCollection 2012.

22.

Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to trastuzumab and lapatinib.

Kalous O, Conklin D, Desai AJ, O'Brien NA, Ginther C, Anderson L, Cohen DJ, Britten CD, Taylor I, Christensen JG, Slamon DJ, Finn RS.

Mol Cancer Ther. 2012 Sep;11(9):1978-87. doi: 10.1158/1535-7163.MCT-11-0730. Epub 2012 Jul 3.

23.

Biosurfactant's role in bioremediation of NAPL and fermentative production.

Joshi SJ, Desai AJ.

Adv Exp Med Biol. 2010;672:222-35. Review.

PMID:
20545286
24.

Catalytic and thermodynamic characterization of protease from Halobacterium sp. SP1(1).

Akolkar AV, Desai AJ.

Res Microbiol. 2010 Jun;161(5):355-62. doi: 10.1016/j.resmic.2010.04.005. Epub 2010 May 15.

PMID:
20438836
25.

Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo.

Wainberg ZA, Anghel A, Desai AJ, Ayala R, Luo T, Safran B, Fejzo MS, Hecht JR, Slamon DJ, Finn RS.

Clin Cancer Res. 2010 Mar 1;16(5):1509-19. doi: 10.1158/1078-0432.CCR-09-1112. Epub 2010 Feb 23.

26.

Halobacterium sp. SP1(1) as a starter culture for accelerating fish sauce fermentation.

Akolkar AV, Durai D, Desai AJ.

J Appl Microbiol. 2010 Jul;109(1):44-53. doi: 10.1111/j.1365-2672.2009.04626.x. Epub 2009 Nov 14.

27.

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro.

Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ, Ginther C, Atefi M, Chen I, Fowst C, Los G, Slamon DJ.

Breast Cancer Res. 2009;11(5):R77. doi: 10.1186/bcr2419.

28.

Organic solvent tolerance of Halobacterium sp. SP1(1) and its extracellular protease.

Akolkar AV, Deshpande GM, Raval KN, Durai D, Nerurkar AS, Desai AJ.

J Basic Microbiol. 2008 Oct;48(5):421-5. doi: 10.1002/jobm.200800012.

PMID:
18759223
29.

Statistical optimization of medium components for the production of biosurfactant by Bacillus licheniformis K51.

Joshi S, Yadav S, Nerurkar A, Desai AJ.

J Microbiol Biotechnol. 2007 Feb;17(2):313-9.

30.

Enhanced PHB production and scale up studies using cheese whey in fed batch culture of Methylobacterium sp. ZP24.

Nath A, Dixit M, Bandiya A, Chavda S, Desai AJ.

Bioresour Technol. 2008 Sep;99(13):5749-55. Epub 2007 Nov 26.

PMID:
18032031
31.

Bone marrow cells for myocardial repair-a new therapeutic concept.

Shah VK, Desai AJ, Vasvani JB, Desai MM, Shah BP, Lall TK, Mashru MR, Shalia KK, Tanavde V, Desai SS, Jankharia BJ.

Indian Heart J. 2007 Nov-Dec;59(6):482-90.

PMID:
19151463
32.

Production of biosurfactant and antifungal compound by fermented food isolate Bacillus subtilis 20B.

Joshi S, Bharucha C, Desai AJ.

Bioresour Technol. 2008 Jul;99(11):4603-8. Epub 2007 Sep 12.

PMID:
17855083
33.

Enhanced growth and nodulation of pigeon pea by co-inoculation of Bacillus strains with Rhizobium spp.

Rajendran G, Sing F, Desai AJ, Archana G.

Bioresour Technol. 2008 Jul;99(11):4544-50. Epub 2007 Sep 10.

PMID:
17826983
34.

Biosurfactant production using molasses and whey under thermophilic conditions.

Joshi S, Bharucha C, Jha S, Yadav S, Nerurkar A, Desai AJ.

Bioresour Technol. 2008 Jan;99(1):195-9. Epub 2007 Feb 26.

PMID:
17321739
35.
36.
37.

Patent foramen ovale and cerebrovascular diseases.

Desai AJ, Fuller CJ, Jesurum JT, Reisman M.

Nat Clin Pract Cardiovasc Med. 2006 Aug;3(8):446-55. Review.

PMID:
16874357
38.

Biodegradation of dimethylterephthalate by Comamonas acidovorans D-4.

Patel DS, Desai AJ, Desai JD.

Indian J Exp Biol. 1998 Mar;36(3):321-4.

PMID:
9754068
39.

An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers.

Taylor J, Lymboura M, Pace PE, A'hern RP, Desai AJ, Shousha S, Coombes RC, Ali S.

Int J Cancer. 1998 Aug 21;79(4):334-42.

40.

Bioremediation of crude oil contamination with Acinetobacter sp. A3.

Hanson KG, Nigam A, Kapadia M, Desai AJ.

Curr Microbiol. 1997 Sep;35(3):191-3.

PMID:
9236304
41.

Surface-active properties of rhamnolipids from Pseudomonas aeruginosa GS3.

Patel RM, Desai AJ.

J Basic Microbiol. 1997;37(4):281-6.

PMID:
9323868
42.

Presence of exon 5-deleted oestrogen receptor in human breast cancer: functional analysis and clinical significance.

Desai AJ, Luqmani YA, Walters JE, Coope RC, Dagg B, Gomm JJ, Pace PE, Rees CN, Thirunavukkarasu V, Shousha S, Groome NP, Coombes R, Ali S.

Br J Cancer. 1997;75(8):1173-84.

43.

Phaeochromocytoma in the organ of Zuckerkandl.

Desai JN, Desai AJ, Mehta PJ, Bichile SK, Nath AR, Lal SS, Phatak AP, Sanghavi BP, Patel VA.

J Assoc Physicians India. 1987 Feb;35(2):165-7. No abstract available.

PMID:
3693277
44.

Clinical profile of thalassemia syndromes in India.

Desai AJ, Bichile SK, Mehta NB, Nath AR.

Birth Defects Orig Artic Ser. 1987;23(5A):275-80. No abstract available.

PMID:
3689907
45.

Possible Involvement of Phage-Like Structures in Antagonism of Cowpea Rhizobia by Rhizobium trifolii.

Joseph MV, Desai JD, Desai AJ.

Appl Environ Microbiol. 1985 Feb;49(2):459-61.

46.

Primary hyperlipoproteinemia type I.

Rane HS, Garu R, Lahari KR, Desai AJ.

Indian J Pediatr. 1984 Mar-Apr;51(409):243-5. No abstract available.

PMID:
6500655
47.

Effect of biotin on alkaloid production during submerged cultivation of Claviceps sp. strain SD-58.

Desai JD, Desai AJ, Patel HC.

Appl Environ Microbiol. 1983 May;45(5):1694-6.

48.

Production of Antimicrobial and Bacteriocin-Like Substances by Rhizobium trifolii.

Joseph MV, Desai JD, Desai AJ.

Appl Environ Microbiol. 1983 Feb;45(2):532-5.

49.

A new method for isolation of saprophytic cultures of Claviceps fusiformis from sclerotia.

Desai JD, Desai AJ, Vaidya HC.

Folia Microbiol (Praha). 1982;27(3):182-5.

PMID:
7106661
50.

Possible congenital deficiency of factor X (Sturat-Prower): a case report.

Bhoweer AL, Shirwatkar LG, Desai AJ.

Ann Dent. 1977 Spring;36(1):1-7. No abstract available.

PMID:
266390

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