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Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells.

Budi EH, Hoffman S, Gao S, Zhang YE, Derynck R.

Sci Rep. 2019 Nov 18;9(1):16992. doi: 10.1038/s41598-019-53490-x.


EMT and Cancer: More Than Meets the Eye.

Derynck R, Weinberg RA.

Dev Cell. 2019 May 6;49(3):313-316. doi: 10.1016/j.devcel.2019.04.026. Review.


Transforming growth factor-β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response.

Duan D, Derynck R.

J Biol Chem. 2019 May 24;294(21):8490-8504. doi: 10.1074/jbc.RA118.005763. Epub 2019 Apr 4.


Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.

Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R.

Sci Signal. 2019 Feb 26;12(570). pii: eaau8544. doi: 10.1126/scisignal.aau8544.


Specificity, versatility, and control of TGF-β family signaling.

Derynck R, Budi EH.

Sci Signal. 2019 Feb 26;12(570). pii: eaav5183. doi: 10.1126/scisignal.aav5183. Review.


Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells.

Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R.

iScience. 2019 Jan 25;11:474-491. doi: 10.1016/j.isci.2018.12.038. Epub 2019 Jan 3.


Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation.

Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R.

J Biol Chem. 2018 Aug 24;293(34):13059-13072. doi: 10.1074/jbc.RA118.002027. Epub 2018 Jun 15.


Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition.

Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R.

EMBO Rep. 2018 Jan;19(1):135-155. doi: 10.15252/embr.201744250. Epub 2017 Dec 12.


Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.

Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA.

J Clin Invest. 2017 Oct 2;127(10):3675-3688. doi: 10.1172/JCI94624. Epub 2017 Sep 5.


Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility.

Budi EH, Duan D, Derynck R.

Trends Cell Biol. 2017 Sep;27(9):658-672. doi: 10.1016/j.tcb.2017.04.005. Epub 2017 May 25. Review.


Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.

Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12478-12483. Epub 2016 Oct 13.


The Discovery and Early Days of TGF-β: A Historical Perspective.

Moses HL, Roberts AB, Derynck R.

Cold Spring Harb Perspect Biol. 2016 Jul 1;8(7). pii: a021865. doi: 10.1101/cshperspect.a021865. Review.


TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology.

Morikawa M, Derynck R, Miyazono K.

Cold Spring Harb Perspect Biol. 2016 May 2;8(5). pii: a021873. doi: 10.1101/cshperspect.a021873. Review.


ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.

Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R.

PLoS Biol. 2015 Dec 17;13(12):e1002325. doi: 10.1371/journal.pbio.1002325. eCollection 2015 Dec.


Regulation of TGF-β Receptors.

Budi EH, Xu J, Derynck R.

Methods Mol Biol. 2016;1344:1-33. doi: 10.1007/978-1-4939-2966-5_1.


The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors.

Budi EH, Muthusamy BP, Derynck R.

Sci Signal. 2015 Sep 29;8(396):ra96. doi: 10.1126/scisignal.aaa9432.


Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.

Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R.

Mol Cell. 2014 Dec 18;56(6):723-37. doi: 10.1016/j.molcel.2014.11.027.


Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition.

Derynck R, Muthusamy BP, Saeteurn KY.

Curr Opin Cell Biol. 2014 Dec;31:56-66. doi: 10.1016/ Epub 2014 Sep 18. Review.


Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050.

Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS.

J Immunol. 2014 Apr 1;192(7):2939-52. No abstract available.


Does Smad6 methylation control BMP signaling in cancer?

Xu J, Derynck R.

Cell Cycle. 2014;13(8):1209-10. doi: 10.4161/cc.28380. Epub 2014 Mar 5. No abstract available.


Molecular mechanisms of epithelial-mesenchymal transition.

Lamouille S, Xu J, Derynck R.

Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96. doi: 10.1038/nrm3758. Review.


BMP-9 balances endothelial cell fate.

Derynck R, Akhurst RJ.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18746-7. doi: 10.1073/pnas.1318346110. Epub 2013 Nov 12. No abstract available.


Arginine Methylation Initiates BMP-Induced Smad Signaling.

Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R.

Mol Cell. 2013 Jul 11;51(1):5-19. doi: 10.1016/j.molcel.2013.05.004. Epub 2013 Jun 6.


Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.

Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R.

J Biol Chem. 2013 Jun 21;288(25):18546-60. doi: 10.1074/jbc.M112.446591. Epub 2013 May 6.


Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

Lamouille S, Subramanyam D, Blelloch R, Derynck R.

Curr Opin Cell Biol. 2013 Apr;25(2):200-7. doi: 10.1016/ Epub 2013 Feb 20. Review.


TGF-β signaling and epithelial-mesenchymal transition in cancer progression.

Katsuno Y, Lamouille S, Derynck R.

Curr Opin Oncol. 2013 Jan;25(1):76-84. doi: 10.1097/CCO.0b013e32835b6371. Review.


TGF-β family signaling in stem cells.

Sakaki-Yumoto M, Katsuno Y, Derynck R.

Biochim Biophys Acta. 2013 Feb;1830(2):2280-96. doi: 10.1016/j.bbagen.2012.08.008. Epub 2012 Aug 16. Review.


Post-translational regulation of TGF-β receptor and Smad signaling.

Xu P, Liu J, Derynck R.

FEBS Lett. 2012 Jul 4;586(14):1871-84. doi: 10.1016/j.febslet.2012.05.010. Epub 2012 May 19. Review.


TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.

Xu P, Liu J, Sakaki-Yumoto M, Derynck R.

Sci Signal. 2012 May 1;5(222):ra34. doi: 10.1126/scisignal.2002689.


TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.

Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R.

J Cell Sci. 2012 Mar 1;125(Pt 5):1259-73. doi: 10.1242/jcs.095299. Epub 2012 Mar 7.


Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.

Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7820-5. doi: 10.1073/pnas.1103441108. Epub 2011 Apr 25.


Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.

Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R.

Nat Biotechnol. 2011 May;29(5):443-8. doi: 10.1038/nbt.1862. Epub 2011 Apr 13.


Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition.

Lamouille S, Derynck R.

Cells Tissues Organs. 2011;193(1-2):8-22. doi: 10.1159/000320172. Epub 2010 Nov 2. Review.


Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.

Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T.

EMBO Rep. 2010 Oct;11(10):765-71. doi: 10.1038/embor.2010.135. Epub 2010 Sep 17.


Oncogene and tumour suppressor: the two faces of SnoN.

Lamouille S, Derynck R.

EMBO J. 2009 Nov 18;28(22):3459-60. doi: 10.1038/emboj.2009.311.


TGFbeta family signaling: novel insights in development and disease.

Wharton K, Derynck R.

Development. 2009 Nov;136(22):3691-7. doi: 10.1242/dev.040584.


Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter.

Piscopo DM, Johansen EB, Derynck R.

J Biol Chem. 2009 Nov 13;284(46):31690-703. doi: 10.1074/jbc.M109.052316. Epub 2009 Sep 15.


New regulatory mechanisms of TGF-beta receptor function.

Kang JS, Liu C, Derynck R.

Trends Cell Biol. 2009 Aug;19(8):385-94. doi: 10.1016/j.tcb.2009.05.008. Epub 2009 Aug 3. Review.


Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.

Wu L, Derynck R.

Dev Cell. 2009 Jul;17(1):35-48. doi: 10.1016/j.devcel.2009.05.010.


TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.

Liu C, Xu P, Lamouille S, Xu J, Derynck R.

Mol Cell. 2009 Jul 10;35(1):26-36. doi: 10.1016/j.molcel.2009.06.018.


Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.

Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T.

PLoS One. 2009;4(4):e5275. doi: 10.1371/journal.pone.0005275. Epub 2008 Apr 16.


TGF-beta-induced epithelial to mesenchymal transition.

Xu J, Lamouille S, Derynck R.

Cell Res. 2009 Feb;19(2):156-72. doi: 10.1038/cr.2009.5. Review.


TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.

Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF.

EMBO J. 2009 Jan 21;28(2):88-98. doi: 10.1038/emboj.2008.266. Epub 2008 Dec 18.


Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization.

Imhof I, Gasper WJ, Derynck R.

J Cell Sci. 2008 Jul 1;121(Pt 13):2265-74. doi: 10.1242/jcs.021717. Epub 2008 Jun 10.


The type I TGF-beta receptor is covalently modified and regulated by sumoylation.

Kang JS, Saunier EF, Akhurst RJ, Derynck R.

Nat Cell Biol. 2008 Jun;10(6):654-64. doi: 10.1038/ncb1728. Epub 2008 May 11.


Differentiation plasticity regulated by TGF-beta family proteins in development and disease.

Derynck R, Akhurst RJ.

Nat Cell Biol. 2007 Sep;9(9):1000-4.


TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.

Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R.

EMBO J. 2007 Sep 5;26(17):3957-67. Epub 2007 Aug 2.


Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells.

Castro CP, Piscopo D, Nakagawa T, Derynck R.

J Cell Sci. 2007 Jul 15;120(Pt 14):2454-66.

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