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Sequence specific suppression of androgen receptor-DNA binding in vivo by a Py-Im polyamide.

Kurmis AA, Dervan PB.

Nucleic Acids Res. 2019 May 7;47(8):3828-3835. doi: 10.1093/nar/gkz153.


Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.

Diaz-Perez S, Kane N, Kurmis AA, Yang F, Kummer NT, Dervan PB, Nickols NG.

PLoS One. 2018 May 1;13(5):e0196803. doi: 10.1371/journal.pone.0196803. eCollection 2018.


Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.

Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D.

Nature. 2017 Nov 30;551(7682):653-657. doi: 10.1038/nature24658. Epub 2017 Nov 22.


A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer.

Kurmis AA, Yang F, Welch TR, Nickols NG, Dervan PB.

Cancer Res. 2017 May 1;77(9):2207-2212. doi: 10.1158/0008-5472.CAN-16-2503. Epub 2017 Mar 30.


RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.

Xu L, Wang W, Gotte D, Yang F, Hare AA, Welch TR, Li BC, Shin JH, Chong J, Strathern JN, Dervan PB, Wang D.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12426-12431. Epub 2016 Oct 17.


Ahmed H. Zewail (1946-2016).

Dervan PB.

Science. 2016 Sep 9;353(6304):1103. doi: 10.1126/science.aai8466. No abstract available.


Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells.

Gerhardt J, Bhalla AD, Butler JS, Puckett JW, Dervan PB, Rosenwaks Z, Napierala M.

Cell Rep. 2016 Aug 2;16(5):1218-1227. doi: 10.1016/j.celrep.2016.06.075. Epub 2016 Jul 14.


A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.

Mysore VS, Szablowski J, Dervan PB, Frost PJ.

Mol Cancer Res. 2016 Mar;14(3):253-66. doi: 10.1158/1541-7786.MCR-15-0361. Epub 2016 Jan 22.


An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors.

Szablowski JO, Raskatov JA, Dervan PB.

Mol Cancer Ther. 2016 Apr;15(4):608-17. doi: 10.1158/1535-7163.MCT-15-0719. Epub 2015 Dec 30.


Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.

Hargrove AE, Martinez TF, Hare AA, Kurmis AA, Phillips JW, Sud S, Pienta KJ, Dervan PB.

PLoS One. 2015 Nov 16;10(11):e0143161. doi: 10.1371/journal.pone.0143161. eCollection 2015.


Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.

Martínez TF, Phillips JW, Karanja KK, Polaczek P, Wang CM, Li BC, Campbell JL, Dervan PB.

Nucleic Acids Res. 2014 Oct;42(18):11546-59. doi: 10.1093/nar/gku866. Epub 2014 Sep 23.


Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted.

Raskatov JA, Szablowski JO, Dervan PB.

J Med Chem. 2014 Oct 23;57(20):8471-6. doi: 10.1021/jm500964c. Epub 2014 Oct 1.


A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.

Raskatov JA, Puckett JW, Dervan PB.

Bioorg Med Chem. 2014 Aug 15;22(16):4371-5. doi: 10.1016/j.bmc.2014.04.010. Epub 2014 Apr 16.


Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition.

Kang JS, Meier JL, Dervan PB.

J Am Chem Soc. 2014 Mar 5;136(9):3687-94. doi: 10.1021/ja500211z. Epub 2014 Feb 19.


Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.

Yang F, Nickols NG, Li BC, Szablowski JO, Hamilton SR, Meier JL, Wang CM, Dervan PB.

J Med Chem. 2013 Sep 26;56(18):7449-57. doi: 10.1021/jm401100s. Epub 2013 Sep 9.


Activity of a Py-Im polyamide targeted to the estrogen response element.

Nickols NG, Szablowski JO, Hargrove AE, Li BC, Raskatov JA, Dervan PB.

Mol Cancer Ther. 2013 May;12(5):675-84. doi: 10.1158/1535-7163.MCT-12-1040. Epub 2013 Feb 26.


Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.

Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK 3rd, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2804-9. doi: 10.1073/pnas.1219701110. Epub 2013 Jan 28.


Antitumor activity of a pyrrole-imidazole polyamide.

Yang F, Nickols NG, Li BC, Marinov GK, Said JW, Dervan PB.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1863-8. doi: 10.1073/pnas.1222035110. Epub 2013 Jan 14.


Synthesis of cyclic Py-Im polyamide libraries.

Li BC, Montgomery DC, Puckett JW, Dervan PB.

J Org Chem. 2013 Jan 4;78(1):124-33. doi: 10.1021/jo302053v. Epub 2012 Nov 2.


Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing.

Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB.

J Am Chem Soc. 2012 Oct 24;134(42):17814-22. doi: 10.1021/ja308888c. Epub 2012 Oct 10.


Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.

Raskatov JA, Nickols NG, Hargrove AE, Marinov GK, Wold B, Dervan PB.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16041-5. doi: 10.1073/pnas.1214267109. Epub 2012 Sep 17.


Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

Chenoweth DM, Meier JL, Dervan PB.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):415-8. doi: 10.1002/anie.201205775. Epub 2012 Sep 14.


Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.

Synold TW, Xi B, Wu J, Yen Y, Li BC, Yang F, Phillips JW, Nickols NG, Dervan PB.

Cancer Chemother Pharmacol. 2012 Oct;70(4):617-25. Epub 2012 Aug 21.


Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.

Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM.

J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13.


Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.

Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4068-71. doi: 10.1016/j.bmcl.2012.04.090. Epub 2012 Apr 25.


Characterization and solubilization of pyrrole-imidazole polyamide aggregates.

Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB.

J Med Chem. 2012 Jun 14;55(11):5425-32. doi: 10.1021/jm300380a. Epub 2012 May 24.


Microwave assisted synthesis of Py-Im polyamides.

Puckett JW, Green JT, Dervan PB.

Org Lett. 2012 Jun 1;14(11):2774-7. doi: 10.1021/ol3010003. Epub 2012 May 11.


Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.

Raskatov JA, Hargrove AE, So AY, Dervan PB.

J Am Chem Soc. 2012 May 9;134(18):7995-9. doi: 10.1021/ja302588v. Epub 2012 Apr 24.


Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders.

Raskatov JA, Meier JL, Puckett JW, Yang F, Ramakrishnan P, Dervan PB.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1023-8. doi: 10.1073/pnas.1118506109. Epub 2011 Dec 27.


Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.

Meier JL, Montgomery DC, Dervan PB.

Nucleic Acids Res. 2012 Mar;40(5):2345-56. doi: 10.1093/nar/gkr970. Epub 2011 Nov 12.


Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.

Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS.

Biochemistry. 2011 Dec 6;50(48):10431-41. doi: 10.1021/bi200962u. Epub 2011 Nov 10.


Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA.

Muzikar KA, Meier JL, Gubler DA, Raskatov JA, Dervan PB.

Org Lett. 2011 Oct 21;13(20):5612-5. doi: 10.1021/ol202285y. Epub 2011 Sep 29.


Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.

Chenoweth DM, Dervan PB.

J Am Chem Soc. 2010 Oct 20;132(41):14521-9. doi: 10.1021/ja105068b.


Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression.

Muzikar KA, Nickols NG, Dervan PB.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16598-603. doi: 10.1073/pnas.0909192106. Epub 2009 Sep 15.


Allosteric modulation of DNA by small molecules.

Chenoweth DM, Dervan PB.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13175-9. doi: 10.1073/pnas.0906532106. Epub 2009 Jul 30.


Oligomerization route to Py-Im polyamide macrocycles.

Chenoweth DM, Harki DA, Dervan PB.

Org Lett. 2009 Aug 20;11(16):3590-3. doi: 10.1021/ol901311m.


Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.

Jacobs CS, Dervan PB.

J Med Chem. 2009 Dec 10;52(23):7380-8. doi: 10.1021/jm900256f.


Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray.

Ho D, Dose C, Albrecht CH, Severin P, Falter K, Dervan PB, Gaub HE.

Biophys J. 2009 Jun 3;96(11):4661-71. doi: 10.1016/j.bpj.2009.02.059.


Solution-phase synthesis of pyrrole-imidazole polyamides.

Chenoweth DM, Harki DA, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7175-81. doi: 10.1021/ja901307m.


Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.

Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB.

J Am Chem Soc. 2009 May 27;131(20):7182-8. doi: 10.1021/ja901309z.


DNA sequence selectivity of hairpin polyamide turn units.

Farkas ME, Li BC, Dose C, Dervan PB.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3919-23. doi: 10.1016/j.bmcl.2009.03.072. Epub 2009 Mar 24.


In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.

Harki DA, Satyamurthy N, Stout DB, Phelps ME, Dervan PB.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13039-44. doi: 10.1073/pnas.0806308105. Epub 2008 Aug 27.


Completion of a Programmable DNA-Binding Small Molecule Library.

Hsu CF, Phillips JW, Trauger JW, Farkas ME, Belitsky JM, Heckel A, Olenyuk BZ, Puckett JW, Wang CC, Dervan PB.

Tetrahedron. 2007 Jul 2;63(27):6146-6151.


Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells.

Hsu CF, Dervan PB.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5851-5. doi: 10.1016/j.bmcl.2008.05.063. Epub 2008 May 20.


Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.

Dose C, Farkas ME, Chenoweth DM, Dervan PB.

J Am Chem Soc. 2008 May 28;130(21):6859-66. doi: 10.1021/ja800888d. Epub 2008 May 7.


Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly.

Moretti R, Donato LJ, Brezinski ML, Stafford RL, Hoff H, Thorson JS, Dervan PB, Ansari AZ.

ACS Chem Biol. 2008 Apr 18;3(4):220-9. doi: 10.1021/cb700258r.


Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.

Chou CJ, Farkas ME, Tsai SM, Alvarez D, Dervan PB, Gottesfeld JM.

Mol Cancer Ther. 2008 Apr;7(4):769-78. doi: 10.1158/1535-7163.MCT-08-0130.


Programming multiple protein patterns on a single DNA nanostructure.

Cohen JD, Sadowski JP, Dervan PB.

J Am Chem Soc. 2008 Jan 16;130(2):402-3. No abstract available.


The reach of linear protein-DNA dimerizers.

Stafford RL, Dervan PB.

J Am Chem Soc. 2007 Nov 14;129(45):14026-33. Epub 2007 Oct 20.

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