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Items: 1 to 50 of 115

1.

CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke.

Faustino J, Chip S, Derugin N, Jullienne A, Hamer M, Haddad E, Butovsky O, Obenaus A, Vexler ZS.

J Cereb Blood Flow Metab. 2019 Jan 10:271678X18817663. doi: 10.1177/0271678X18817663. [Epub ahead of print]

PMID:
30628839
2.

Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke.

Chip S, Fernández-López D, Li F, Faustino J, Derugin N, Vexler ZS.

Brain Behav Immun. 2017 Feb;60:270-281. doi: 10.1016/j.bbi.2016.11.005. Epub 2016 Nov 9.

PMID:
27836669
3.

Brain tissue oxygen tension and its response to physiological manipulations: influence of distance from injury site in a swine model of traumatic brain injury.

Hawryluk GW, Phan N, Ferguson AR, Morabito D, Derugin N, Stewart CL, Knudson MM, Manley G, Rosenthal G.

J Neurosurg. 2016 Nov;125(5):1217-1228. Epub 2016 Feb 5.

PMID:
26848909
4.

Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats.

van Velthoven CT, Dzietko M, Wendland MF, Derugin N, Faustino J, Heijnen CJ, Ferriero DM, Vexler ZS.

J Neurosci Res. 2017 May;95(5):1225-1236. doi: 10.1002/jnr.23954. Epub 2016 Oct 26.

5.

Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.

Fernández-López D, Faustino J, Klibanov AL, Derugin N, Blanchard E, Simon F, Leib SL, Vexler ZS.

J Neurosci. 2016 Mar 9;36(10):2881-93. doi: 10.1523/JNEUROSCI.0140-15.2016.

6.

Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke.

Li F, Faustino J, Woo MS, Derugin N, Vexler ZS.

J Neurochem. 2015 Nov;135(3):445-52. doi: 10.1111/jnc.13239. Epub 2015 Sep 3.

7.

LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.

Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R.

J Cell Biol. 2015 Mar 16;208(6):703-11. doi: 10.1083/jcb.201410131. Epub 2015 Mar 9.

8.

Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent.

Nejadnik H, Ye D, Lenkov OD, Donig JS, Martin JE, Castillo R, Derugin N, Sennino B, Rao J, Daldrup-Link H.

ACS Nano. 2015 Feb 24;9(2):1150-60. doi: 10.1021/nn504494c. Epub 2015 Jan 26.

9.

Improved approach for chondrogenic differentiation of human induced pluripotent stem cells.

Nejadnik H, Diecke S, Lenkov OD, Chapelin F, Donig J, Tong X, Derugin N, Chan RC, Gaur A, Yang F, Wu JC, Daldrup-Link HE.

Stem Cell Rev. 2015 Apr;11(2):242-53. doi: 10.1007/s12015-014-9581-5.

10.

Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia.

Yao X, Derugin N, Manley GT, Verkman AS.

Neurosci Lett. 2015 Jan 1;584:368-72. doi: 10.1016/j.neulet.2014.10.040. Epub 2014 Nov 1.

11.

MRI blood-brain barrier permeability measurements to predict hemorrhagic transformation in a rat model of ischemic stroke.

Hoffmann A, Bredno J, Wendland MF, Derugin N, Hom J, Schuster T, Zimmer C, Su H, Ohara PT, Young WL, Wintermark M.

Transl Stroke Res. 2012 Dec;3(4):508-16. doi: 10.1007/s12975-012-0212-7. Epub 2012 Sep 16.

PMID:
24323835
12.

Delayed VEGF treatment enhances angiogenesis and recovery after neonatal focal rodent stroke.

Dzietko M, Derugin N, Wendland MF, Vexler ZS, Ferriero DM.

Transl Stroke Res. 2013 Apr;4(2):189-200. doi: 10.1007/s12975-012-0221-6.

13.

Iron administration before stem cell harvest enables MR imaging tracking after transplantation.

Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald DM, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE.

Radiology. 2013 Oct;269(1):186-97. doi: 10.1148/radiol.13130858. Epub 2013 Jul 12.

14.

Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat.

Fernández-López D, Faustino J, Derugin N, Vexler ZS.

Transl Stroke Res. 2013 Apr;4(2):179-88. doi: 10.1007/s12975-012-0214-5.

15.

Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.

van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM.

Stroke. 2013 May;44(5):1426-32. doi: 10.1161/STROKEAHA.111.000326. Epub 2013 Mar 28.

16.

Ferumoxytol: a new, clinically applicable label for stem-cell tracking in arthritic joints with MRI.

Khurana A, Nejadnik H, Chapelin F, Lenkov O, Gawande R, Lee S, Gupta SN, Aflakian N, Derugin N, Messing S, Lin G, Lue TF, Pisani L, Daldrup-Link HE.

Nanomedicine (Lond). 2013 Dec;8(12):1969-83. doi: 10.2217/nnm.12.198. Epub 2013 Mar 27.

17.

Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke.

Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM.

Stroke. 2013 Mar;44(3):753-8. doi: 10.1161/STROKEAHA.111.000104. Epub 2013 Feb 7.

18.

Genetic deletion of CD36 enhances injury after acute neonatal stroke.

Woo MS, Wang X, Faustino JV, Derugin N, Wendland MF, Zhou P, Iadecola C, Vexler ZS.

Ann Neurol. 2012 Dec;72(6):961-70. doi: 10.1002/ana.23727.

19.

Intravenous ferumoxytol allows noninvasive MR imaging monitoring of macrophage migration into stem cell transplants.

Khurana A, Nejadnik H, Gawande R, Lin G, Lee S, Messing S, Castaneda R, Derugin N, Pisani L, Lue TF, Daldrup-Link HE.

Radiology. 2012 Sep;264(3):803-11. doi: 10.1148/radiol.12112393. Epub 2012 Jul 19.

20.

Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat.

Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurosci. 2012 Jul 11;32(28):9588-600. doi: 10.1523/JNEUROSCI.5977-11.2012.

21.

Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations.

Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE.

Mol Imaging. 2012 Jun;11(3):197-209.

22.

Heparin-modified small-diameter nanofibrous vascular grafts.

Janairo RR, Henry JJ, Lee BL, Hashi CK, Derugin N, Lee R, Li S.

IEEE Trans Nanobioscience. 2012 Mar;11(1):22-7. doi: 10.1109/TNB.2012.2188926.

PMID:
22434651
23.

Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke.

Fernández-López D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro MA, Vexler ZS.

Neuroscience. 2012 Apr 5;207:307-15. doi: 10.1016/j.neuroscience.2012.01.008. Epub 2012 Jan 12.

24.

Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke.

Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler ZS.

J Neurosci. 2011 Sep 7;31(36):12992-3001. doi: 10.1523/JNEUROSCI.2102-11.2011.

25.

Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke.

Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS.

J Child Neurol. 2011 Sep;26(9):1145-53. doi: 10.1177/0883073811408308. Epub 2011 Jun 13.

26.

Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology.

Hoffmann A, Bredno J, Wendland MF, Derugin N, Hom J, Schuster T, Su H, Ohara PT, Young WL, Wintermark M.

Stroke. 2011 Jul;42(7):2054-60. doi: 10.1161/STROKEAHA.110.597997. Epub 2011 Jun 2.

27.

High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)-Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations.

Hoffmann A, Bredno J, Wendland M, Derugin N, Ohara P, Wintermark M.

Transl Stroke Res. 2011 Mar;2(1):106-11. doi: 10.1007/s12975-010-0049-x. Epub 2010 Nov 11.

28.

Antithrombogenic modification of small-diameter microfibrous vascular grafts.

Hashi CK, Derugin N, Janairo RR, Lee R, Schultz D, Lotz J, Li S.

Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1621-7. doi: 10.1161/ATVBAHA.110.208348. Epub 2010 May 13.

29.

Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke.

Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P.

Dev Neurosci. 2010 Jul;32(2):101-13. doi: 10.1159/000279654. Epub 2010 May 4.

30.

Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke.

Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM.

Stroke. 2010 Feb;41(2):343-9. doi: 10.1161/STROKEAHA.109.564229.

31.

Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds.

Wan JJ, Cohen MJ, Rosenthal G, Haitsma IK, Morabito DJ, Derugin N, Knudson MM, Manley GT.

J Trauma. 2009 Feb;66(2):353-7. doi: 10.1097/TA.0b013e318195e222.

PMID:
19204507
32.

Radiation arteriopathy in the transgenic arteriovenous fistula model.

Lawton MT, Arnold CM, Kim YJ, Bogarin EA, Stewart CL, Wulfstat AA, Derugin N, Deen D, Young WL.

Neurosurgery. 2008 May;62(5):1129-38; discussion 138-9. doi: 10.1227/01.neu.0000325875.82999.3c.

PMID:
18580811
33.

The ACTCellerate initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives.

West MD, Sargent RG, Long J, Brown C, Chu JS, Kessler S, Derugin N, Sampathkumar J, Burrows C, Vaziri H, Williams R, Chapman KB, Larocca D, Loring JF, Murai J.

Regen Med. 2008 May;3(3):287-308. doi: 10.2217/17460751.3.3.287.

34.

Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation.

Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, Knudson MM, Manley G.

J Neurosurg. 2008 Mar;108(3):575-87. doi: 10.3171/JNS/2008/108/3/0575.

PMID:
18312106
35.

Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke.

Denker SP, Ji S, Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurochem. 2007 Feb;100(4):893-904. Epub 2006 Dec 22.

36.

Controlled cortical impact in swine: pathophysiology and biomechanics.

Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS.

J Neurotrauma. 2006 Feb;23(2):128-39.

PMID:
16503797
37.

Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia.

Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS.

J Neurochem. 2006 Mar;96(5):1467-79. Epub 2006 Feb 8.

38.

Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model.

Derugin N, Dingman A, Wendland MF, Fox C, Bollen A, Vexler ZS.

Brain Res. 2005 Dec 20;1066(1-2):49-56. Epub 2005 Dec 5.

PMID:
16336947
39.

Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion.

Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, Ferriero DM, Vexler ZS.

J Cereb Blood Flow Metab. 2005 Sep;25(9):1138-49. Erratum in: J Cereb Blood Flow Metab. 2006 Mar;26(3):446.

40.

The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations.

Lawton MT, Stewart CL, Wulfstat AA, Derugin N, Hashimoto T, Young WL.

Neurosurgery. 2004 Jun;54(6):1463-71; discussion 1471.

PMID:
15157304
41.

Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation.

Manley GT, Hemphill JC, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM.

Adv Exp Med Biol. 2003;530:311-7.

PMID:
14562727
42.
43.
44.

Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain.

Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS.

Stroke. 2003 Jan;34(1):207-13.

45.

Rat forebrain neurogenesis and striatal neuron replacement after focal stroke.

Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM.

Ann Neurol. 2002 Dec;52(6):802-13.

46.

Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.

Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley GT.

Acad Emerg Med. 2002 Oct;9(10):969-76.

47.
48.

Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen.

Hemphill JC 3rd, Knudson MM, Derugin N, Morabito D, Manley GT.

Neurosurgery. 2001 Feb;48(2):377-83; discussion 383-4.

PMID:
11220382
49.
50.

Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats.

Derugin N, Wendland M, Muramatsu K, Roberts TP, Gregory G, Ferriero DM, Vexler ZS.

Stroke. 2000 Jul;31(7):1752-61.

PMID:
10884483

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