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Items: 36


Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.


Review: Structure and Activation Mechanisms of CRAC Channels.

Butorac C, Krizova A, Derler I.

Adv Exp Med Biol. 2020;1131:547-604. doi: 10.1007/978-3-030-12457-1_23. Review.


STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and I CRAC.

Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, Salido GM, Smani T, Rosado JA, Redondo PC.

J Cell Sci. 2019 May 15;132(10). pii: jcs226019. doi: 10.1242/jcs.226019.


Critical parameters maintaining authentic CRAC channel hallmarks.

Krizova A, Maltan L, Derler I.

Eur Biophys J. 2019 Jul;48(5):425-445. doi: 10.1007/s00249-019-01355-6. Epub 2019 Mar 21. Review.


A novel STIM1-Orai1 gating interface essential for CRAC channel activation.

Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A, Lindinger S, Schober R, Frischauf I, Bhardwaj R, Hediger MA, Groschner K, Romanin C.

Cell Calcium. 2019 May;79:57-67. doi: 10.1016/j.ceca.2019.02.009. Epub 2019 Feb 23.


Rapid NMR-scale purification of 15N,13C isotope-labeled recombinant human STIM1 coiled coil fragments.

Rathner P, Stadlbauer M, Romanin C, Fahrner M, Derler I, Müller N.

Protein Expr Purif. 2018 Jun;146:45-50. doi: 10.1016/j.pep.2018.01.013.


Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.

Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C.

J Biol Chem. 2018 Jan 26;293(4):1259-1270. doi: 10.1074/jbc.M117.812206. Epub 2017 Dec 13.


Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.


The STIM-Orai Pathway: The Interactions Between STIM and Orai.

Fahrner M, Schindl R, Muik M, Derler I, Romanin C.

Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. Review.


Molecular mechanisms of STIM/Orai communication.

Derler I, Jardin I, Romanin C.

Am J Physiol Cell Physiol. 2016 Apr 15;310(8):C643-62. doi: 10.1152/ajpcell.00007.2016. Epub 2016 Jan 28. Review.


Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.


A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.

Frischauf I, Zayats V, Deix M, Hochreiter A, Jardin I, Muik M, Lackner B, Svobodová B, Pammer T, Litviňuková M, Sridhar AA, Derler I, Bogeski I, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2015 Dec 22;8(408):ra131. doi: 10.1126/scisignal.aab1901.


The STIM1/Orai signaling machinery.

Fahrner M, Derler I, Jardin I, Romanin C.

Channels (Austin). 2013 Sep-Oct;7(5):330-43. doi: 10.4161/chan.26742. Epub 2013 Oct 9. Review.


The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.


The action of selective CRAC channel blockers is affected by the Orai pore geometry.

Derler I, Schindl R, Fritsch R, Heftberger P, Riedl MC, Begg M, House D, Romanin C.

Cell Calcium. 2013 Feb;53(2):139-51. doi: 10.1016/j.ceca.2012.11.005. Epub 2012 Dec 5.


Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.

Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K.

Br J Pharmacol. 2012 Dec;167(8):1712-22. doi: 10.1111/j.1476-5381.2012.02126.x.


Structure, regulation and biophysics of I(CRAC), STIM/Orai1.

Derler I, Madl J, Schütz G, Romanin C.

Adv Exp Med Biol. 2012;740:383-410. doi: 10.1007/978-94-007-2888-2_16. Review.


Gating and permeation of Orai channels.

Derler I, Schindl R, Fritsch R, Romanin C.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1304-22. Review.


Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.


STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.


Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.


Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ.

J Biol Chem. 2010 Dec 24;285(52):41135-42. doi: 10.1074/jbc.M110.177881. Epub 2010 Oct 20.


Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

Schindl R, Frischauf I, Bergsmann J, Muik M, Derler I, Lackner B, Groschner K, Romanin C.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19623-8. doi: 10.1073/pnas.0907714106. Epub 2009 Nov 3.


Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.


Recent progress on STIM1 domains controlling Orai activation.

Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C.

Cell Calcium. 2009 Oct;46(4):227-32. doi: 10.1016/j.ceca.2009.08.003. Epub 2009 Sep 4. Review.


A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083. Epub 2009 Jul 21.


Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Aug 7;284(32):21696-706. doi: 10.1074/jbc.M109.018408. Epub 2009 Jun 8.


Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.

J Biol Chem. 2009 Jun 5;284(23):15903-15. doi: 10.1074/jbc.M808312200. Epub 2009 Apr 14.


A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.

Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.

J Biol Chem. 2009 Mar 27;284(13):8421-6. doi: 10.1074/jbc.C800229200. Epub 2009 Feb 3.


The STIM/Orai coupling machinery.

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.

Channels (Austin). 2008 Jul-Aug;2(4):261-8. Epub 2008 Jul 21. Review.


CRAC inhibitors: identification and potential.

Derler I, Fritsch R, Schindl R, Romanin C.

Expert Opin Drug Discov. 2008 Jul;3(7):787-800. doi: 10.1517/17460441.3.7.787.


2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.

J Biol Chem. 2008 Jul 18;283(29):20261-7. doi: 10.1074/jbc.M803101200. Epub 2008 May 21.


Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.


The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C.

Cell Calcium. 2008 Mar;43(3):260-9. Epub 2007 Jul 12.


Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.

Derler I, Hofbauer M, Kahr H, Fritsch R, Muik M, Kepplinger K, Hack ME, Moritz S, Schindl R, Groschner K, Romanin C.

J Physiol. 2006 Nov 15;577(Pt 1):31-44. Epub 2006 Sep 7.


TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.

Poteser M, Graziani A, Rosker C, Eder P, Derler I, Kahr H, Zhu MX, Romanin C, Groschner K.

J Biol Chem. 2006 May 12;281(19):13588-95. Epub 2006 Mar 13.

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