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Items: 26


The immune system profoundly restricts intratumor genetic heterogeneity.

Milo I, Bedora-Faure M, Garcia Z, Thibaut R, Périé L, Shakhar G, Deriano L, Bousso P.

Sci Immunol. 2018 Nov 23;3(29). pii: eaat1435. doi: 10.1126/sciimmunol.aat1435.


Chromosomal Translocation Formation Is Sufficient to Produce Fusion Circular RNAs Specific to Patient Tumor Cells.

Babin L, Piganeau M, Renouf B, Lamribet K, Thirant C, Deriano L, Mercher T, Giovannangeli C, Brunet EC.

iScience. 2018 Jul 27;5:19-29. doi: 10.1016/j.isci.2018.06.007. Epub 2018 Jun 19.


Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP.

Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18.


Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.

Lenden Hasse H, Lescale C, Bianchi JJ, Yu W, Bedora-Faure M, Deriano L.

J Immunol Methods. 2017 Dec;451:71-77. doi: 10.1016/j.jim.2017.08.007. Epub 2017 Sep 4.


[Paralogy and redundancy: maintaining genome integrity during V(D)J recombination].

Lescale C, Lenden Hasse H, Deriano L.

Med Sci (Paris). 2017 May;33(5):474-477. doi: 10.1051/medsci/20173305005. Epub 2017 Jun 14. French. No abstract available.


The RAG recombinase: Beyond breaking.

Lescale C, Deriano L.

Mech Ageing Dev. 2017 Jul;165(Pt A):3-9. doi: 10.1016/j.mad.2016.11.003. Epub 2016 Nov 15. Review.


Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP.

Genes Dev. 2016 Oct 1;30(19):2152-2157.


Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale C, Lenden Hasse H, Blackford AN, Balmus G, Bianchi JJ, Yu W, Bacoccina L, Jarade A, Clouin C, Sivapalan R, Reina-San-Martin B, Jackson SP, Deriano L.

Cell Rep. 2016 Sep 13;16(11):2967-2979. doi: 10.1016/j.celrep.2016.08.069. Epub 2016 Sep 2.


RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.

Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L.

Nat Commun. 2016 Feb 2;7:10529. doi: 10.1038/ncomms10529.


Listeria monocytogenes dampens the DNA damage response.

Samba-Louaka A, Pereira JM, Nahori MA, Villiers V, Deriano L, Hamon MA, Cossart P.

PLoS Pathog. 2014 Oct 23;10(10):e1004470. doi: 10.1371/journal.ppat.1004470. eCollection 2014 Oct.


RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.

Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB.

Nucleic Acids Res. 2014 Jun;42(10):6352-64. doi: 10.1093/nar/gku295. Epub 2014 Apr 20.


Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage.

Deriano L, Roth DB.

Annu Rev Genet. 2013;47:433-55. doi: 10.1146/annurev-genet-110711-155540. Epub 2013 Sep 11. Review.


RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.

Coussens MA, Wendland RL, Deriano L, Lindsay CR, Arnal SM, Roth DB.

Cell Rep. 2013 Sep 12;4(5):870-8. doi: 10.1016/j.celrep.2013.07.041. Epub 2013 Aug 29.


The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA.

Nat Commun. 2013;4:2231. doi: 10.1038/ncomms3231.


Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.

Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA.

Cell Rep. 2013 Feb 21;3(2):359-70. doi: 10.1016/j.celrep.2013.01.024. Epub 2013 Feb 14.


A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing.

Mijušković M, Brown SM, Tang Z, Lindsay CR, Efstathiadis E, Deriano L, Roth DB.

PLoS One. 2012;7(10):e48314. doi: 10.1371/journal.pone.0048314. Epub 2012 Oct 29.


The RAG2 C terminus suppresses genomic instability and lymphomagenesis.

Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko AV, Chang S, Skok JA, Roth DB.

Nature. 2011 Mar 3;471(7336):119-23. doi: 10.1038/nature09755.


Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB.

Mol Cell. 2009 Apr 10;34(1):13-25. doi: 10.1016/j.molcel.2009.03.009.


Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.


Rag mutations reveal robust alternative end joining.

Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB.

Nature. 2007 Sep 27;449(7161):483-6.


Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination.

Delacôte F, Deriano L, Lambert S, Bertrand P, Saintigny Y, Lopez BS.

Mutat Res. 2007 Feb 3;615(1-2):125-33. Epub 2006 Dec 15.


New molecular markers in resistant B-CLL.

Bouley J, Deriano L, Delic J, Merle-Béral H.

Leuk Lymphoma. 2006 May;47(5):791-801. Review.


Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells.

Deriano L, Merle-Béral H, Guipaud O, Sabatier L, Delic J.

Br J Haematol. 2006 Jun;133(5):520-5.


Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.

Deriano L, Guipaud O, Merle-Béral H, Binet JL, Ricoul M, Potocki-Veronese G, Favaudon V, Maciorowski Z, Muller C, Salles B, Sabatier L, Delic J.

Blood. 2005 Jun 15;105(12):4776-83. Epub 2005 Feb 17.


B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features.

Guipaud O, Deriano L, Salin H, Vallat L, Sabatier L, Merle-Béral H, Delic J.

Lancet Oncol. 2003 Aug;4(8):505-14. Review.


IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes.

Pombo I, Martin-Verdeaux S, Iannascoli B, Le Mao J, Deriano L, Rivera J, Blank U.

J Biol Chem. 2001 Nov 16;276(46):42893-900. Epub 2001 Sep 12.

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