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Items: 1 to 50 of 53

1.

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC.

J Clin Invest. 2009 Sep;119(9):2550-63. doi: 10.1172/JCI33288. Epub 2009 Aug 3.

2.

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.

Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.

Nature. 2008 Apr 3;452(7187):654-8. doi: 10.1038/nature06663. Epub 2008 Feb 27.

PMID:
18305483
3.

Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation.

Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR.

BMC Physiol. 2007 Mar 30;7:4.

4.

Regulatory network of inflammation downstream of proteinase-activated receptors.

Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR.

BMC Physiol. 2007 Mar 30;7:3.

5.

Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Boñaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE.

Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25.

PMID:
17350261
6.

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.

Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, Xia P.

J Cell Biol. 2006 Apr 24;173(2):301-10.

7.

Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.

Leger AJ, Jacques SL, Badar J, Kaneider NC, Derian CK, Andrade-Gordon P, Covic L, Kuliopulos A.

Circulation. 2006 Mar 7;113(9):1244-54. Epub 2006 Feb 27.

PMID:
16505172
8.

Integrated expressional analysis: application to the drug discovery process.

Ilyin SE, Horowitz D, Belkowski SM, Xin H, Eckardt AJ, Darrow AL, Chen C, Maley D, D'Andrea M, Plata-Salamán CR, Derian CK.

Methods. 2005 Nov;37(3):280-8.

PMID:
16308157
9.

Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

Zhang HC, Derian CK, McComsey DF, White KB, Ye H, Hecker LR, Li J, Addo MF, Croll D, Eckardt AJ, Smith CE, Li Q, Cheung WM, Conway BR, Emanuel S, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE.

J Med Chem. 2005 Mar 24;48(6):1725-8.

PMID:
15771419
10.

A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.

de Garavilla L, Greco MN, Sukumar N, Chen ZW, Pineda AO, Mathews FS, Di Cera E, Giardino EC, Wells GI, Haertlein BJ, Kauffman JA, Corcoran TW, Derian CK, Eckardt AJ, Damiano BP, Andrade-Gordon P, Maryanoff BE.

J Biol Chem. 2005 May 6;280(18):18001-7. Epub 2005 Feb 28.

11.

Functional informatics: convergence and integration of automation and bioinformatics.

Ilyin SE, Bernal A, Horowitz D, Derian CK, Xin H.

Pharmacogenomics. 2004 Sep;5(6):721-30. Review.

PMID:
15335292
12.

Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1).

Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK.

Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):13-36. Review.

PMID:
15317288
13.

An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.

Roberts JL, Moretti PA, Darrow AL, Derian CK, Vadas MA, Pitson SM.

Anal Biochem. 2004 Aug 1;331(1):122-9.

PMID:
15246004
14.

High-throughput siRNA-based functional target validation.

Xin H, Bernal A, Amato FA, Pinhasov A, Kauffman J, Brenneman DE, Derian CK, Andrade-Gordon P, Plata-Salamán CR, Ilyin SE.

J Biomol Screen. 2004 Jun;9(4):286-93.

PMID:
15191645
15.

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Ye H, Conway BR, Derian CK, Addo MF, Kuo GH, Hecker LR, Croll DR, Li J, Westover L, Xu JZ, Look R, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3245-50.

PMID:
15149684
16.

Mer receptor tyrosine kinase signaling participates in platelet function.

Chen C, Li Q, Darrow AL, Wang Y, Derian CK, Yang J, de Garavilla L, Andrade-Gordon P, Damiano BP.

Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1118-23. Epub 2004 May 6.

PMID:
15130911
17.

Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4.

Quinton TM, Kim S, Derian CK, Jin J, Kunapuli SP.

J Biol Chem. 2004 Apr 30;279(18):18434-9. Epub 2004 Feb 18.

18.

RWJ-58259: a selective antagonist of protease activated receptor-1.

Damiano BP, Derian CK, Maryanoff BE, Zhang HC, Gordon PA.

Cardiovasc Drug Rev. 2003 Winter;21(4):313-26. Review.

PMID:
14647534
19.

Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.

Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkötter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.

FASEB J. 2003 Oct;17(13):1871-85.

PMID:
14519665
20.

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53.

PMID:
12941331
21.

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

Zhang HC, White KB, McComsey DF, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2199-203.

PMID:
12798334
22.

Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice.

Major CD, Santulli RJ, Derian CK, Andrade-Gordon P.

Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):931-9. Epub 2003 Apr 3. Review.

PMID:
12676802
23.

Therapeutic potential of protease-activated receptor-1 antagonists.

Derian CK, Maryanoff BE, Zhang HC, Andrade-Gordon P.

Expert Opin Investig Drugs. 2003 Feb;12(2):209-21. Review.

PMID:
12556215
24.

Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.

Derian CK, Damiano BP, Addo MF, Darrow AL, D'Andrea MR, Nedelman M, Zhang HC, Maryanoff BE, Andrade-Gordon P.

J Pharmacol Exp Ther. 2003 Feb;304(2):855-61. Erratum in: J Pharmacol Exp Ther. 2003 Apr;305(1):402.

PMID:
12538843
25.

The nucleotide-binding site of human sphingosine kinase 1.

Pitson SM, Moretti PA, Zebol JR, Zareie R, Derian CK, Darrow AL, Qi J, D'Andrea RJ, Bagley CJ, Vadas MA, Wattenberg BW.

J Biol Chem. 2002 Dec 20;277(51):49545-53. Epub 2002 Oct 18.

26.

Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4.

Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P.

J Immunol. 2002 Aug 1;169(3):1467-73.

27.

Thrombin regulation of cell function through protease-activated receptors: implications for therapeutic intervention.

Derian CK, Damiano BP, D'Andrea MR, Andrade-Gordon P.

Biochemistry (Mosc). 2002 Jan;67(1):56-64. Review.

28.

Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.

Zhang HC, McComsey DF, White KB, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2105-9.

PMID:
11514149
29.

Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2.

Elliott JT, Hoekstra WJ, Derian CK, Addo MF, Maryanoff BE, Ahern DG, Prestwich GD.

J Pept Res. 2001 Jun;57(6):494-506.

PMID:
11437953
30.

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.

Andrade-Gordon P, Derian CK, Maryanoff BE, Zhang HC, Addo MF, Cheung Wm, Damiano BP, D'Andrea MR, Darrow AL, de Garavilla L, Eckardt AJ, Giardino EC, Haertlein BJ, McComsey DF.

J Pharmacol Exp Ther. 2001 Jul;298(1):34-42.

PMID:
11408522
31.
32.

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

Zhang HC, Derian CK, Andrade-Gordon P, Hoekstra WJ, McComsey DF, White KB, Poulter BL, Addo MF, Cheung WM, Damiano BP, Oksenberg D, Reynolds EE, Pandey A, Scarborough RM, Maryanoff BE.

J Med Chem. 2001 Mar 29;44(7):1021-4. No abstract available.

PMID:
11297447
33.

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.

Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.

34.

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.

Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, de Garavilla L, Andrade-Gordon P.

J Pharmacol Exp Ther. 1999 Feb;288(2):671-8.

PMID:
9918574
35.

Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo.

Cheung WM, Andrade-Gordon P, Derian CK, Damiano BP.

Can J Physiol Pharmacol. 1998 Jan;76(1):16-25.

PMID:
9564545
36.

Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues.

D'Andrea MR, Derian CK, Leturcq D, Baker SM, Brunmark A, Ling P, Darrow AL, Santulli RJ, Brass LF, Andrade-Gordon P.

J Histochem Cytochem. 1998 Feb;46(2):157-64.

PMID:
9446822
37.
38.
39.
40.

Biological consequences of thrombin receptor deficiency in mice.

Darrow AL, Fung-Leung WP, Ye RD, Santulli RJ, Cheung WM, Derian CK, Burns CL, Damiano BP, Zhou L, Keenan CM, Peterson PA, Andrade-Gordon P.

Thromb Haemost. 1996 Dec;76(6):860-6.

PMID:
8972001
41.

N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor.

Higgins JD 3rd, Bridger GJ, Derian CK, Beblavy MJ, Hernandez PE, Gaul FE, Abrams MJ, Pike MC, Solomon HF.

J Med Chem. 1996 Mar 1;39(5):1013-5. No abstract available.

PMID:
8676333
42.

Selective inhibition of N-formylpeptide-induced neutrophil activation by carbamate-modified peptide analogues.

Derian CK, Solomon HF, Higgins JD 3rd, Beblavy MJ, Santulli RJ, Bridger GJ, Pike MC, Kroon DJ, Fischman AJ.

Biochemistry. 1996 Jan 30;35(4):1265-9.

PMID:
8573582
43.

Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes.

Santulli RJ, Derian CK, Darrow AL, Tomko KA, Eckardt AJ, Seiberg M, Scarborough RM, Andrade-Gordon P.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9151-5.

44.

Species differences in platelet responses to thrombin and SFLLRN. receptor-mediated calcium mobilization and aggregation, and regulation by protein kinases.

Derian CK, Santulli RJ, Tomko KA, Haertlein BJ, Andrade-Gordon P.

Thromb Res. 1995 Jun 15;78(6):505-19.

PMID:
15714752
45.

Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.

Derian CK, Santulli RJ, Rao PE, Solomon HF, Barrett JA.

J Immunol. 1995 Jan 1;154(1):308-17.

PMID:
7995950
46.

The role of the neutrophil and formed elements of the blood in an in vitro model of reperfusion injury.

Barrett JA, Derian CK, Swillo RS, Woltmann RF, Perrone MH.

Mediators Inflamm. 1993;2(1):85-92.

47.
48.

Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.

Derian CK, Gould RJ, Friedman PA.

Thromb Res. 1990 Feb 1;57(3):393-403.

PMID:
2156349
49.

Inhibitors of 2-ketoglutarate-dependent dioxygenases block aspartyl beta-hydroxylation of recombinant human factor IX in several mammalian expression systems.

Derian CK, VanDusen W, Przysiecki CT, Walsh PN, Berkner KL, Kaufman RJ, Friedman PA.

J Biol Chem. 1989 Apr 25;264(12):6615-8.

50.

Effect of ticlopidine ex vivo on platelet intracellular calcium mobilization.

Derian CK, Friedman PA.

Thromb Res. 1988 Apr 1;50(1):65-76.

PMID:
3400086

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