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Items: 1 to 50 of 53

1.

Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma.

Hilf N, Kuttruff-Coqui S, Frenzel K, Bukur V, Stevanović S, Gouttefangeas C, Platten M, Tabatabai G, Dutoit V, van der Burg SH, Straten PT, Martinez-Ricarte F, Ponsati B, Okada H, Lassen U, Admon A, Ottensmeier CH, Ulges A, Kreiter S, von Deimling A, Skardelly M, Migliorini D, Kroep JR, Idorn M, Rodon J, Piro J, Poulsen HS, Shraibman B, McCann K, Mendrzyk R, Lower M, Stieglbauer M, Britten CM, Capper D, Welters MJP, Sahuquillo J, Kiesel K, Derhovanessian E, Rusch E, Bunse L, Song C, Heesch S, Wagner C, Kemmer-Bruck A, Ludwig J, Castle JC, Schoor O, Tadmor AD, Green E, Fritsche J, Meyer M, Pawlowski N, Dorner S, Hoffgaard F, Rossler B, Maurer D, Weinschenk T, Reinhardt C, Huber C, Rammensee HG, Singh-Jasuja H, Sahin U, Dietrich PY, Wick W.

Nature. 2019 Feb;566(7745):E13. doi: 10.1038/s41586-019-0959-z.

PMID:
30733620
2.

Actively personalized vaccination trial for newly diagnosed glioblastoma.

Hilf N, Kuttruff-Coqui S, Frenzel K, Bukur V, Stevanović S, Gouttefangeas C, Platten M, Tabatabai G, Dutoit V, van der Burg SH, Thor Straten P, Martínez-Ricarte F, Ponsati B, Okada H, Lassen U, Admon A, Ottensmeier CH, Ulges A, Kreiter S, von Deimling A, Skardelly M, Migliorini D, Kroep JR, Idorn M, Rodon J, Piró J, Poulsen HS, Shraibman B, McCann K, Mendrzyk R, Löwer M, Stieglbauer M, Britten CM, Capper D, Welters MJP, Sahuquillo J, Kiesel K, Derhovanessian E, Rusch E, Bunse L, Song C, Heesch S, Wagner C, Kemmer-Brück A, Ludwig J, Castle JC, Schoor O, Tadmor AD, Green E, Fritsche J, Meyer M, Pawlowski N, Dorner S, Hoffgaard F, Rössler B, Maurer D, Weinschenk T, Reinhardt C, Huber C, Rammensee HG, Singh-Jasuja H, Sahin U, Dietrich PY, Wick W.

Nature. 2019 Jan;565(7738):240-245. doi: 10.1038/s41586-018-0810-y. Epub 2018 Dec 19. Erratum in: Nature. 2019 Feb;566(7745):E13.

PMID:
30568303
3.

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.

Sahin U, Derhovanessian E, Miller M, Kloke BP, Simon P, Löwer M, Bukur V, Tadmor AD, Luxemburger U, Schrörs B, Omokoko T, Vormehr M, Albrecht C, Paruzynski A, Kuhn AN, Buck J, Heesch S, Schreeb KH, Müller F, Ortseifer I, Vogler I, Godehardt E, Attig S, Rae R, Breitkreuz A, Tolliver C, Suchan M, Martic G, Hohberger A, Sorn P, Diekmann J, Ciesla J, Waksmann O, Brück AK, Witt M, Zillgen M, Rothermel A, Kasemann B, Langer D, Bolte S, Diken M, Kreiter S, Nemecek R, Gebhardt C, Grabbe S, Höller C, Utikal J, Huber C, Loquai C, Türeci Ö.

Nature. 2017 Jul 13;547(7662):222-226. doi: 10.1038/nature23003. Epub 2017 Jul 5.

PMID:
28678784
4.

CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study.

Adriaensen W, Pawelec G, Vaes B, Hamprecht K, Derhovanessian E, van Pottelbergh G, Degryse JM, Matheï C.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1155-1162. doi: 10.1093/gerona/glw215.

PMID:
27927759
5.

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.

Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Hüsemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Türeci Ö, Sahin U.

Nature. 2016 Jun 16;534(7607):396-401. doi: 10.1038/nature18300. Epub 2016 Jun 1.

PMID:
27281205
6.

Income and Markers of Immunological Cellular Aging.

Aiello AE, Feinstein L, Dowd JB, Pawelec G, Derhovanessian E, Galea S, Uddin M, Wildman DE, Simanek AM.

Psychosom Med. 2016 Jul-Aug;78(6):657-66. doi: 10.1097/PSY.0000000000000320.

7.

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection.

Goldeck D, Larsen LA, Christiansen L, Christensen K, Hamprecht K, Pawelec G, Derhovanessian E.

J Gerontol A Biol Sci Med Sci. 2016 Dec;71(12):1537-1543. Epub 2016 Jan 11.

PMID:
26755680
8.

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young.

Janssen N, Derhovanessian E, Demuth I, Arnaout F, Steinhagen-Thiessen E, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1117-23. doi: 10.1093/gerona/glv119. Epub 2015 Nov 27.

PMID:
26615178
9.

IL7R gene expression network associates with human healthy ageing.

Passtoors WM, van den Akker EB, Deelen J, Maier AB, van der Breggen R, Jansen R, Trompet S, van Heemst D, Derhovanessian E, Pawelec G, van Ommen GJ, Slagboom PE, Beekman M.

Immun Ageing. 2015 Nov 11;12:21. doi: 10.1186/s12979-015-0048-6. eCollection 2015.

10.

Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients.

Bailur JK, Derhovanessian E, Gueckel B, Pawelec G.

J Immunother Cancer. 2015 Oct 20;3:45. doi: 10.1186/s40425-015-0090-0. eCollection 2015.

11.

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival.

Derhovanessian E, Chen S, Maier AB, Hähnel K, de Craen AJ, Roelofs H, Westendorp R, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):917-23. doi: 10.1093/gerona/glu128. Epub 2015 Apr 7.

PMID:
25852090
12.
13.

Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study.

Di Benedetto S, Derhovanessian E, Steinhagen-Thiessen E, Goldeck D, Müller L, Pawelec G.

Biogerontology. 2015 Oct;16(5):631-43. doi: 10.1007/s10522-015-9563-2. Epub 2015 Mar 3.

PMID:
25732234
14.

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly.

Derhovanessian E, Maier AB, Hähnel K, McElhaney JE, Slagboom EP, Pawelec G.

J Immunol. 2014 Oct 1;193(7):3624-31. doi: 10.4049/jimmunol.1303361. Epub 2014 Sep 3.

15.

Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma.

Zelba H, Weide B, Martens A, Derhovanessian E, Bailur JK, Kyzirakos C, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries J, Sucker A, Schadendorf D, Büttner P, Garbe C, Pawelec G.

Clin Cancer Res. 2014 Aug 15;20(16):4390-9. doi: 10.1158/1078-0432.CCR-14-1015. Epub 2014 Jun 17.

16.

Inflammation, ageing and chronic disease.

Pawelec G, Goldeck D, Derhovanessian E.

Curr Opin Immunol. 2014 Aug;29:23-8. doi: 10.1016/j.coi.2014.03.007. Epub 2014 Apr 22. Review.

PMID:
24762450
17.

OMIP-020: phenotypic characterization of human γδ T-cells by multicolor flow cytometry.

Wistuba-Hamprecht K, Pawelec G, Derhovanessian E.

Cytometry A. 2014 Jun;85(6):522-4. doi: 10.1002/cyto.a.22470. Epub 2014 Apr 22. No abstract available.

18.

New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.

19.

CD4:8 ratio >5 is associated with a dominant naive T-cell phenotype and impaired physical functioning in CMV-seropositive very elderly people: results from the BELFRAIL study.

Adriaensen W, Derhovanessian E, Vaes B, Van Pottelbergh G, Degryse JM, Pawelec G, Hamprecht K, Theeten H, Matheï C.

J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):143-54. doi: 10.1093/gerona/glu018. Epub 2014 Feb 25.

PMID:
24568932
20.

Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells.

Weide B, Martens A, Zelba H, Stutz C, Derhovanessian E, Di Giacomo AM, Maio M, Sucker A, Schilling B, Schadendorf D, Büttner P, Garbe C, Pawelec G.

Clin Cancer Res. 2014 Mar 15;20(6):1601-9. doi: 10.1158/1078-0432.CCR-13-2508. Epub 2013 Dec 9.

21.

Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes.

Ioannou K, Derhovanessian E, Tsakiri E, Samara P, Kalbacher H, Voelter W, Trougakos IP, Pawelec G, Tsitsilonis OE.

BMC Immunol. 2013 Sep 22;14:43. doi: 10.1186/1471-2172-14-43.

22.

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus.

Wistuba-Hamprecht K, Frasca D, Blomberg B, Pawelec G, Derhovanessian E.

Immun Ageing. 2013 Jul 3;10(1):26. doi: 10.1186/1742-4933-10-26.

23.

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.

Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G.

Vaccine. 2013 Jan 11;31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041. Epub 2012 Nov 26.

PMID:
23196209
24.

CMV and Immunosenescence: from basics to clinics.

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.

Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.

25.

Gene expression analysis of mTOR pathway: association with human longevity.

Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE.

Aging Cell. 2013 Feb;12(1):24-31. doi: 10.1111/acel.12015. Epub 2012 Nov 23.

26.

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study.

Chen S, de Craen AJ, Raz Y, Derhovanessian E, Vossen AC, Westendorp RG, Pawelec G, Maier AB.

Immun Ageing. 2012 Aug 28;9(1):18. doi: 10.1186/1742-4933-9-18.

27.

Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters.

Shipp C, Weide B, Derhovanessian E, Pawelec G.

Cell Stress Chaperones. 2013 Mar;18(2):145-54. doi: 10.1007/s12192-012-0363-1. Epub 2012 Aug 8.

28.

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival.

Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J, Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H.

Nat Med. 2012 Aug;18(8):1254-61. doi: 10.1038/nm.2883. Epub 2012 Jul 29.

PMID:
22842478
29.

Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines.

Shipp C, Derhovanessian E, Pawelec G.

PLoS One. 2012;7(6):e37475. doi: 10.1371/journal.pone.0037475. Epub 2012 Jun 22.

30.

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.

Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G.

Age (Dordr). 2013 Aug;35(4):1387-99. doi: 10.1007/s11357-012-9425-7. Epub 2012 Jun 4.

31.

The impact of CMV infection on survival in older humans.

Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E.

Curr Opin Immunol. 2012 Aug;24(4):507-11. doi: 10.1016/j.coi.2012.04.002. Epub 2012 Apr 27. Review.

PMID:
22541724
32.

Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis.

Weide B, Zelba H, Derhovanessian E, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries IJ, Sucker A, Schadendorf D, Büttner P, Garbe C, Pawelec G.

J Clin Oncol. 2012 May 20;30(15):1835-41. doi: 10.1200/JCO.2011.40.2271. Epub 2012 Apr 23.

PMID:
22529253
33.

Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy.

Ioannou K, Samara P, Livaniou E, Derhovanessian E, Tsitsilonis OE.

Cancer Immunol Immunother. 2012 May;61(5):599-614. doi: 10.1007/s00262-012-1222-8. Epub 2012 Feb 26. Review.

PMID:
22366887
34.

Immune profiling of Alzheimer patients.

Pellicanò M, Larbi A, Goldeck D, Colonna-Romano G, Buffa S, Bulati M, Rubino G, Iemolo F, Candore G, Caruso C, Derhovanessian E, Pawelec G.

J Neuroimmunol. 2012 Jan 18;242(1-2):52-9. doi: 10.1016/j.jneuroim.2011.11.005. Epub 2011 Dec 6.

PMID:
22153977
35.

Vaccination in the elderly.

Derhovanessian E, Pawelec G.

Microb Biotechnol. 2012 Mar;5(2):226-32. doi: 10.1111/j.1751-7915.2011.00283.x. Epub 2011 Aug 31. Review.

36.

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans.

Derhovanessian E, Maier AB, Hähnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G.

J Gen Virol. 2011 Dec;92(Pt 12):2746-56. doi: 10.1099/vir.0.036004-0. Epub 2011 Aug 3.

PMID:
21813708
37.

Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins.

Mortensen LH, Maier AB, Slagbom PE, Pawelec G, Derhovanessian E, Petersen I, Jahn G, Westendorp RG, Christensen K.

Epidemiol Infect. 2012 May;140(5):835-41. doi: 10.1017/S0950268811001397. Epub 2011 Jul 25.

PMID:
21781370
38.

Role of CMV in immune senescence.

Pawelec G, Derhovanessian E.

Virus Res. 2011 May;157(2):175-9. doi: 10.1016/j.virusres.2010.09.010. Epub 2010 Oct 1. Review.

PMID:
20869407
39.

Hallmark features of immunosenescence are absent in familial longevity.

Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, de Craen AJ, Westendorp RG, Pawelec G.

J Immunol. 2010 Oct 15;185(8):4618-24. doi: 10.4049/jimmunol.1001629. Epub 2010 Sep 20.

40.

Immunosenescence and Cytomegalovirus: where do we stand after a decade?

Pawelec G, Akbar A, Beverley P, Caruso C, Derhovanessian E, Fülöp T, Griffiths P, Grubeck-Loebenstein B, Hamprecht K, Jahn G, Kern F, Koch SD, Larbi A, Maier AB, Macallan D, Moss P, Samson S, Strindhall J, Trannoy E, Wills M.

Immun Ageing. 2010 Sep 7;7:13. doi: 10.1186/1742-4933-7-13. No abstract available.

41.

Immunosenescence and cancer.

Pawelec G, Derhovanessian E, Larbi A.

Crit Rev Oncol Hematol. 2010 Aug;75(2):165-72. doi: 10.1016/j.critrevonc.2010.06.012. Review.

PMID:
20656212
42.

High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma.

Weide B, Derhovanessian E, Pflugfelder A, Eigentler TK, Radny P, Zelba H, Pföhler C, Pawelec G, Garbe C.

Cancer. 2010 Sep 1;116(17):4139-46. doi: 10.1002/cncr.25156.

43.

Senescence of the human immune system.

Pawelec G, Larbi A, Derhovanessian E.

J Comp Pathol. 2010 Jan;142 Suppl 1:S39-44. doi: 10.1016/j.jcpa.2009.09.005. Epub 2009 Nov 8. Review.

PMID:
19897208
44.

Impact of Cytomegalovirus infection on immune signatures in cancer patients.

Derhovanessian E.

Cancer Immunol Immunother. 2010 Feb;59(2):335-6; author reply 337. doi: 10.1007/s00262-009-0767-7. Epub 2009 Sep 17. No abstract available.

PMID:
19760219
45.

Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients.

Weide B, Pascolo S, Scheel B, Derhovanessian E, Pflugfelder A, Eigentler TK, Pawelec G, Hoerr I, Rammensee HG, Garbe C.

J Immunother. 2009 Jun;32(5):498-507. doi: 10.1097/CJI.0b013e3181a00068.

PMID:
19609242
46.

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection.

Derhovanessian E, Larbi A, Pawelec G.

Curr Opin Immunol. 2009 Aug;21(4):440-5. doi: 10.1016/j.coi.2009.05.012. Epub 2009 Jun 15. Review.

PMID:
19535233
47.

Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients.

Derhovanessian E, Adams V, Hähnel K, Groeger A, Pandha H, Ward S, Pawelec G.

Int J Cancer. 2009 Sep 15;125(6):1372-9. doi: 10.1002/ijc.24497.

48.

Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease.

Larbi A, Pawelec G, Witkowski JM, Schipper HM, Derhovanessian E, Goldeck D, Fulop T.

J Alzheimers Dis. 2009;17(1):91-103. doi: 10.3233/JAD-2009-1015.

PMID:
19494434
49.

Cytomegalovirus and human immunosenescence.

Pawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A.

Rev Med Virol. 2009 Jan;19(1):47-56. doi: 10.1002/rmv.598. Review.

PMID:
19035529
50.

Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner.

Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE.

Mol Immunol. 2009 Feb;46(5):784-92. doi: 10.1016/j.molimm.2008.09.014. Epub 2008 Oct 30.

PMID:
18976813

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