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RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV.

Sci Signal. 2018 Oct 30;11(554). pii: eaar3924. doi: 10.1126/scisignal.aar3924.


The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.

Radwańska MJ, Jaskółowski M, Davydova E, Derewenda U, Miyake T, Engel DA, Kossiakoff AA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):681-689. doi: 10.1107/S2059798318007878. Epub 2018 Jun 27.


Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain.

Bukrejewska M, Derewenda U, Radwanska M, Engel DA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2017 Sep 1;73(Pt 9):767-774. doi: 10.1107/S2059798317010737. Epub 2017 Aug 15.


The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.

Derewenda ZS, Godzik A.

Methods Mol Biol. 2017;1607:77-115. doi: 10.1007/978-1-4939-7000-1_4. Review.


Adventures in cooperativity.

Derewenda ZS.

Postepy Biochem. 2016;62(3):286-297. Review.


Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2).

Utepbergenov D, Hennig PM, Derewenda U, Artamonov MV, Somlyo AV, Derewenda ZS.

PLoS One. 2016 Oct 12;11(10):e0164343. doi: 10.1371/journal.pone.0164343. eCollection 2016.


Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.

Baker LE, Ellena JF, Handing KB, Derewenda U, Utepbergenov D, Engel DA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):49-58. doi: 10.1107/S2059798315021439. Epub 2016 Jan 1.


The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein.

Dziubańska PJ, Derewenda U, Ellena JF, Engel DA, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2420-9. doi: 10.1107/S1399004714014710. Epub 2014 Aug 29.


Salvage or recovery of failed targets by mutagenesis to reduce surface entropy.

Goldschmidt L, Eisenberg D, Derewenda ZS.

Methods Mol Biol. 2014;1140:201-9. doi: 10.1007/978-1-4939-0354-2_16.


Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV.

J Biol Chem. 2013 Nov 22;288(47):34030-40. doi: 10.1074/jbc.M113.514596. Epub 2013 Oct 8.


The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.

Utepbergenov D, Derewenda ZS.

Biochim Biophys Acta. 2013 Jul;1834(7):1285-91. doi: 10.1016/j.bbapap.2013.03.018. Epub 2013 Mar 27. Review.


The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility.

Artamonov M, Momotani K, Utepbergenov D, Franke A, Khromov A, Derewenda ZS, Somlyo AV.

PLoS One. 2013;8(3):e58703. doi: 10.1371/journal.pone.0058703. Epub 2013 Mar 13.


Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

Yeh TY, Kowalska AK, Scipioni BR, Cheong FK, Zheng M, Derewenda U, Derewenda ZS, Schroer TA.

EMBO J. 2013 Apr 3;32(7):1023-35. doi: 10.1038/emboj.2013.30. Epub 2013 Mar 1.


Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.

Derewenda U, Artamonov M, Szukalska G, Utepbergenov D, Olekhnovich N, Parikh HI, Kellogg GE, Somlyo AV, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):266-75. doi: 10.1107/S0907444912045520. Epub 2013 Jan 19.


Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.

Utepbergenov D, Derewenda U, Olekhnovich N, Szukalska G, Banerjee B, Hilinski MK, Lannigan DA, Stukenberg PT, Derewenda ZS.

Biochemistry. 2012 Aug 21;51(33):6499-510. doi: 10.1021/bi300620c. Epub 2012 Aug 6.


Abstractions, algorithms and data structures for structural bioinformatics in PyCogent.

Cieślik M, Derewenda ZS, Mura C.

J Appl Crystallogr. 2011 Apr 1;44(Pt 2):424-428. Epub 2011 Feb 11.


p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.

Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV.

Circ Res. 2011 Oct 14;109(9):993-1002. doi: 10.1161/CIRCRESAHA.111.248898. Epub 2011 Sep 1.


Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.


Structural features and chaperone activity of the NudC protein family.

Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PŁ, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS.

J Mol Biol. 2011 Jun 24;409(5):722-41. doi: 10.1016/j.jmb.2011.04.018. Epub 2011 Apr 21.


It's all in the crystals….

Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):243-8. doi: 10.1107/S0907444911007797. Epub 2011 Mar 18.


The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein.

Zyłkiewicz E, Kijańska M, Choi WC, Derewenda U, Derewenda ZS, Stukenberg PT.

J Cell Biol. 2011 Feb 7;192(3):433-45. doi: 10.1083/jcb.201011142. Epub 2011 Jan 31.


Application of protein engineering to enhance crystallizability and improve crystal properties.

Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2010 May;66(Pt 5):604-15. doi: 10.1107/S090744491000644X. Epub 2010 Apr 21.


The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily.

Cooper DR, Grelewska K, Kim CY, Joachimiak A, Derewenda ZS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):219-24. doi: 10.1107/S1744309109053913. Epub 2010 Feb 23.


The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS.

Protein Sci. 2009 Oct;18(10):2067-79. doi: 10.1002/pro.219.


Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif .

Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, Joachimiak A, Raines RT, Derewenda ZS.

Biochemistry. 2009 Sep 15;48(36):8664-71. doi: 10.1021/bi900437z.


On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS.

BMC Struct Biol. 2009 May 21;9:36. doi: 10.1186/1472-6807-9-36.


The role of entropy and polarity in intermolecular contacts in protein crystals.

Cieślik M, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):500-9. doi: 10.1107/S0907444909009500. Epub 2009 Apr 18.


Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.

Zheng M, Cooper DR, Grossoehme NE, Yu M, Hung LW, Cieslik M, Derewenda U, Lesley SA, Wilson IA, Giedroc DP, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):356-65. doi: 10.1107/S0907444909004727. Epub 2009 Mar 19.


Dissecting the thermodynamics of GAP-RhoA interactions.

Jelen F, Lachowicz P, Apostoluk W, Mateja A, Derewenda ZS, Otlewski J.

J Struct Biol. 2009 Jan;165(1):10-8. doi: 10.1016/j.jsb.2008.09.007. Epub 2008 Oct 2.


Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

Smietana K, Kasztura M, Paduch M, Derewenda U, Derewenda ZS, Otlewski J.

Acta Biochim Pol. 2008;55(2):269-80. Epub 2008 Jun 7.


On wine, chirality and crystallography.

Derewenda ZS.

Acta Crystallogr A. 2008 Jan;64(Pt 1):246-58. Epub 2007 Dec 21.


Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state.

Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1269-73. Epub 2007 Nov 16.


The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.

Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS.

Structure. 2007 Nov;15(11):1467-81.


Protein crystallization in drug design: towards a rational approach.

Derewenda ZS.

Expert Opin Drug Discov. 2007 Oct;2(10):1329-40. doi: 10.1517/17460441.2.10.1329.


Toward rational protein crystallization: A Web server for the design of crystallizable protein variants.

Goldschmidt L, Cooper DR, Derewenda ZS, Eisenberg D.

Protein Sci. 2007 Aug;16(8):1569-76.


Bivalent peptides as models for multimeric targets of PDZ domains.

Paduch M, Biernat M, Stefanowicz P, Derewenda ZS, Szewczuk Z, Otlewski J.

Chembiochem. 2007 Mar 5;8(4):443-52.


The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.

Oleksy A, Opaliński Ł, Derewenda U, Derewenda ZS, Otlewski J.

J Biol Chem. 2006 Oct 27;281(43):32891-7. Epub 2006 Sep 5.


The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.

Cierpicki T, Kim MH, Cooper DR, Derewenda U, Bushweller JH, Derewenda ZS.

Proteins. 2006 Sep 1;64(4):874-82.


The binding of the PDZ tandem of syntenin to target proteins.

Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS.

Biochemistry. 2006 Mar 21;45(11):3674-83.


The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif.

Mateja A, Cierpicki T, Paduch M, Derewenda ZS, Otlewski J.

J Mol Biol. 2006 Mar 24;357(2):621-31. Epub 2006 Jan 19.


Entropy and surface engineering in protein crystallization.

Derewenda ZS, Vekilov PG.

Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):116-24. Epub 2005 Dec 14. Review.


The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase.

Kim MH, Choi WC, Kang HO, Lee JS, Kang BS, Kim KJ, Derewenda ZS, Oh TK, Lee CH, Lee JK.

Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17606-11. Epub 2005 Nov 28.


B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes.

Bielnicki J, Devedjiev Y, Derewenda U, Dauter Z, Joachimiak A, Derewenda ZS.

Proteins. 2006 Jan 1;62(1):144-51.


Probing the supramodular architecture of a multidomain protein: the structure of syntenin in solution.

Cierpicki T, Bushweller JH, Derewenda ZS.

Structure. 2005 Feb;13(2):319-27.


Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.

Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A.

Neuron. 2004 Dec 2;44(5):809-21.


The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.

Derewenda U, Oleksy A, Stevenson AS, Korczynska J, Dauter Z, Somlyo AP, Otlewski J, Somlyo AV, Derewenda ZS.

Structure. 2004 Nov;12(11):1955-65.


The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism.

Janda I, Devedjiev Y, Derewenda U, Dauter Z, Bielnicki J, Cooper DR, Graf PC, Joachimiak A, Jakob U, Derewenda ZS.

Structure. 2004 Oct;12(10):1901-7.


The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins.

Devedjiev Y, Surendranath Y, Derewenda U, Gabrys A, Cooper DR, Zhang RG, Lezondra L, Joachimiak A, Derewenda ZS.

J Mol Biol. 2004 Oct 15;343(2):395-406.


The use of recombinant methods and molecular engineering in protein crystallization.

Derewenda ZS.

Methods. 2004 Nov;34(3):354-63. Review.


The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.

Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS.

Structure. 2004 Jun;12(6):987-98.

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