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RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV.

Sci Signal. 2018 Oct 30;11(554). pii: eaar3924. doi: 10.1126/scisignal.aar3924.


The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.

Radwańska MJ, Jaskółowski M, Davydova E, Derewenda U, Miyake T, Engel DA, Kossiakoff AA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):681-689. doi: 10.1107/S2059798318007878. Epub 2018 Jun 27.


Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain.

Bukrejewska M, Derewenda U, Radwanska M, Engel DA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2017 Sep 1;73(Pt 9):767-774. doi: 10.1107/S2059798317010737. Epub 2017 Aug 15.


Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2).

Utepbergenov D, Hennig PM, Derewenda U, Artamonov MV, Somlyo AV, Derewenda ZS.

PLoS One. 2016 Oct 12;11(10):e0164343. doi: 10.1371/journal.pone.0164343. eCollection 2016.



Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR.

J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967. Epub 2016 Aug 1.


Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.

Baker LE, Ellena JF, Handing KB, Derewenda U, Utepbergenov D, Engel DA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):49-58. doi: 10.1107/S2059798315021439. Epub 2016 Jan 1.


The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein.

Dziubańska PJ, Derewenda U, Ellena JF, Engel DA, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2420-9. doi: 10.1107/S1399004714014710. Epub 2014 Aug 29.


Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV.

J Biol Chem. 2013 Nov 22;288(47):34030-40. doi: 10.1074/jbc.M113.514596. Epub 2013 Oct 8.


Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

Yeh TY, Kowalska AK, Scipioni BR, Cheong FK, Zheng M, Derewenda U, Derewenda ZS, Schroer TA.

EMBO J. 2013 Apr 3;32(7):1023-35. doi: 10.1038/emboj.2013.30. Epub 2013 Mar 1.


Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.

Derewenda U, Artamonov M, Szukalska G, Utepbergenov D, Olekhnovich N, Parikh HI, Kellogg GE, Somlyo AV, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):266-75. doi: 10.1107/S0907444912045520. Epub 2013 Jan 19.


Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.

Utepbergenov D, Derewenda U, Olekhnovich N, Szukalska G, Banerjee B, Hilinski MK, Lannigan DA, Stukenberg PT, Derewenda ZS.

Biochemistry. 2012 Aug 21;51(33):6499-510. doi: 10.1021/bi300620c. Epub 2012 Aug 6.


p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.

Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV.

Circ Res. 2011 Oct 14;109(9):993-1002. doi: 10.1161/CIRCRESAHA.111.248898. Epub 2011 Sep 1.


Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.


Structural features and chaperone activity of the NudC protein family.

Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PŁ, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS.

J Mol Biol. 2011 Jun 24;409(5):722-41. doi: 10.1016/j.jmb.2011.04.018. Epub 2011 Apr 21.


The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein.

Zyłkiewicz E, Kijańska M, Choi WC, Derewenda U, Derewenda ZS, Stukenberg PT.

J Cell Biol. 2011 Feb 7;192(3):433-45. doi: 10.1083/jcb.201011142. Epub 2011 Jan 31.


Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.

Guergnon J, Derewenda U, Edelson JR, Brautigan DL.

BMC Biochem. 2009 Oct 16;10:24. doi: 10.1186/1471-2091-10-24.


The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS.

Protein Sci. 2009 Oct;18(10):2067-79. doi: 10.1002/pro.219.


Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif .

Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, Joachimiak A, Raines RT, Derewenda ZS.

Biochemistry. 2009 Sep 15;48(36):8664-71. doi: 10.1021/bi900437z.


On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS.

BMC Struct Biol. 2009 May 21;9:36. doi: 10.1186/1472-6807-9-36.


Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains.

Zheng M, Cooper DR, Grossoehme NE, Yu M, Hung LW, Cieslik M, Derewenda U, Lesley SA, Wilson IA, Giedroc DP, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2009 Apr;65(Pt 4):356-65. doi: 10.1107/S0907444909004727. Epub 2009 Mar 19.


Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

Smietana K, Kasztura M, Paduch M, Derewenda U, Derewenda ZS, Otlewski J.

Acta Biochim Pol. 2008;55(2):269-80. Epub 2008 Jun 7.


The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.

Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS.

Structure. 2007 Nov;15(11):1467-81.


The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.

Oleksy A, Opaliński Ł, Derewenda U, Derewenda ZS, Otlewski J.

J Biol Chem. 2006 Oct 27;281(43):32891-7. Epub 2006 Sep 5.


The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.

Cierpicki T, Kim MH, Cooper DR, Derewenda U, Bushweller JH, Derewenda ZS.

Proteins. 2006 Sep 1;64(4):874-82.


The binding of the PDZ tandem of syntenin to target proteins.

Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS.

Biochemistry. 2006 Mar 21;45(11):3674-83.


B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes.

Bielnicki J, Devedjiev Y, Derewenda U, Dauter Z, Joachimiak A, Derewenda ZS.

Proteins. 2006 Jan 1;62(1):144-51.


The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.

Derewenda U, Oleksy A, Stevenson AS, Korczynska J, Dauter Z, Somlyo AP, Otlewski J, Somlyo AV, Derewenda ZS.

Structure. 2004 Nov;12(11):1955-65.


The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism.

Janda I, Devedjiev Y, Derewenda U, Dauter Z, Bielnicki J, Cooper DR, Graf PC, Joachimiak A, Jakob U, Derewenda ZS.

Structure. 2004 Oct;12(10):1901-7.


The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins.

Devedjiev Y, Surendranath Y, Derewenda U, Gabrys A, Cooper DR, Zhang RG, Lezondra L, Joachimiak A, Derewenda ZS.

J Mol Biol. 2004 Oct 15;343(2):395-406.


The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.

Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS.

Structure. 2004 Jun;12(6):987-98.


Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution.

Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys A, Minor W, Joachimiak A, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1101-7. Epub 2004 May 21.


The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography.

Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS.

J Mol Biol. 2004 Apr 30;338(3):483-93. Erratum in: J Mol Biol. 2004 Jun 25;340(1):191.


Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

Oleksy A, Barton H, Devedjiev Y, Purdy M, Derewenda U, Otlewski J, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):740-2. Epub 2004 Mar 23.


The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague.

Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS.

Structure. 2004 Feb;12(2):301-6.


The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI.

Czepas J, Devedjiev Y, Krowarsch D, Derewenda U, Otlewski J, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):275-80. Epub 2004 Jan 23.


Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.

Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS.

Structure. 2003 Jul;11(7):845-53.


The DCX-domain tandems of doublecortin and doublecortin-like kinase.

Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS.

Nat Struct Biol. 2003 May;10(5):324-33.


PDZ tandem of human syntenin: crystal structure and functional properties.

Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS.

Structure. 2003 Apr;11(4):459-68.


Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.

Kim MH, Derewenda U, Devedjiev Y, Dauter Z, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):502-5. Epub 2003 Feb 21.


Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.

Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U.

Structure. 2002 Jul;10(7):933-42.


The crystal structure of a major dust mite allergen Der p 2, and its biological implications.

Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC.

J Mol Biol. 2002 Apr 19;318(1):189-97.


The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product.

Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):381-91. Epub 2002 Feb 21.


Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.

Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS.

Protein Eng. 2001 Jul;14(7):513-9.


The molecular basis of antigenic cross-reactivity between the group 2 mite allergens.

Smith AM, Benjamin DC, Hozic N, Derewenda U, Smith WA, Thomas WR, Gafvelin G, van Hage-Hamsten M, Chapman MD.

J Allergy Clin Immunol. 2001 Jun;107(6):977-84.


Sequence polymorphisms and antibody binding to the group 2 dust mite allergens.

Smith AM, Benjamin DC, Derewenda U, Smith WA, Thomas WR, Chapman MD.

Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):61-3.


Structure of the BH domain from graf and its implications for Rho GTPase recognition.

Longenecker KL, Zhang B, Derewenda U, Sheffield PJ, Dauter Z, Parsons JT, Zheng Y, Derewenda ZS.

J Biol Chem. 2000 Dec 8;275(49):38605-10.


Substrate specificity in glycoside hydrolase family 10. Structural and kinetic analysis of the Streptomyces lividans xylanase 10A.

Ducros V, Charnock SJ, Derewenda U, Derewenda ZS, Dauter Z, Dupont C, Shareck F, Morosoli R, Kluepfel D, Davies GJ.

J Biol Chem. 2000 Jul 28;275(30):23020-6.


Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme.

Li J, Derewenda U, Dauter Z, Smith S, Derewenda ZS.

Nat Struct Biol. 2000 Jul;7(7):555-9.


Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome.

Sheffield PJ, Garrard S, Caspi M, Aoki J, Arai H, Derewenda U, Inoue K, Suter B, Reiner O, Derewenda ZS.

Proteins. 2000 Apr 1;39(1):1-8.


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