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Items: 13

1.

Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist.

Conlon K, De Maeyer JH, Bruce C, Schuurkes JAJ, Christie L, McRedmond J, Derakhchan K, Wade PR.

J Pharmacol Exp Ther. 2018 Feb;364(2):156-169. doi: 10.1124/jpet.117.244079. Epub 2017 Nov 27.

PMID:
29180358
2.

Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

Epstein O, Bryan MC, Cheng AC, Derakhchan K, Dineen TA, Hickman D, Hua Z, Human JB, Kreiman C, Marx IE, Weiss MM, Wahl RC, Wen PH, Whittington DA, Wood S, Zheng XM, Fremeau RT Jr, White RD, Patel VF.

J Med Chem. 2014 Dec 11;57(23):9796-810. doi: 10.1021/jm501266w. Epub 2014 Nov 12.

PMID:
25389560
3.

Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).

Dineen TA, Chen K, Cheng AC, Derakhchan K, Epstein O, Esmay J, Hickman D, Kreiman CE, Marx IE, Wahl RC, Wen PH, Weiss MM, Whittington DA, Wood S, Fremeau RT Jr, White RD, Patel VF.

J Med Chem. 2014 Dec 11;57(23):9811-31. doi: 10.1021/jm5012676. Epub 2014 Nov 14.

PMID:
25363711
4.

Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Derakhchan K, Chui RW, Stevens D, Gu W, Vargas HM.

Br J Pharmacol. 2014 Jan;171(2):509-22. doi: 10.1111/bph.12484.

5.

Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period.

Chui RW, Derakhchan K, Vargas HM.

J Pharmacol Toxicol Methods. 2012 Sep;66(2):84-91. doi: 10.1016/j.vascn.2012.05.002. Epub 2012 May 14.

PMID:
22613062
6.

Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects.

Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S.

Br J Pharmacol. 2004 Aug;142(8):1300-8. Epub 2004 Jul 26.

7.

Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy.

Shinagawa K, Derakhchan K, Nattel S.

Pacing Clin Electrophysiol. 2003 Mar;26(3):752-64. Review.

PMID:
12698678
8.

Atrial ischemia promotes atrial fibrillation in dogs.

Sinno H, Derakhchan K, Libersan D, Merhi Y, Leung TK, Nattel S.

Circulation. 2003 Apr 15;107(14):1930-6. Epub 2003 Mar 31.

9.

Method for simultaneous epicardial and endocardial mapping of in vivo canine heart: application to atrial conduction properties and arrhythmia mechanisms.

Derakhchan K, Li D, Courtemanche M, Smith B, Brouillette J, Pagé PL, Nattel S.

J Cardiovasc Electrophysiol. 2001 May;12(5):548-55.

PMID:
11386516
10.
11.
12.

Effects of procainamide and propafenone on the composition of the excitable gap in canine atrial reentry tachycardia.

Derakhchan K, Pagé P, Lambert C, Kus T.

J Pharmacol Exp Ther. 1994 Jul;270(1):47-54.

PMID:
8035342
13.

Effects of procainamide on refractoriness, conduction, and excitable gap in canine atrial reentrant tachycardia.

Kus T, Derakhchan K, Bouchard C, Pagé P.

Pacing Clin Electrophysiol. 1991 Nov;14(11 Pt 2):1707-13.

PMID:
1721162

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