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Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms.

Lee J, Minden MD, Chen WC, Streck E, Chen B, Kang H, Arruda A, Ly D, Der SD, Kang S, Achita P, D'Souza C, Li Y, Childs RW, Dick JE, Zhang L.

Clin Cancer Res. 2018 Jan 15;24(2):370-382. doi: 10.1158/1078-0432.CCR-17-2228. Epub 2017 Oct 26.


A Cost-Effectiveness Analysis of Using the JBR.10-Based 15-Gene Expression Signature to Guide Adjuvant Chemotherapy in Early Stage Non-Small-Cell Lung Cancer.

Wong KM, Ding K, Li S, Bradbury P, Tsao MS, Der SD, Shepherd FA, Chung C, Ng R, Seymour L, Leighl NB.

Clin Lung Cancer. 2017 Jan;18(1):e41-e47. doi: 10.1016/j.cllc.2016.06.009. Epub 2016 Jul 9.


Corrosion and mechanical performance of AZ91 exposed to simulated inflammatory conditions.

Brooks EK, Der S, Ehrensberger MT.

Mater Sci Eng C Mater Biol Appl. 2016 Mar;60:427-436. doi: 10.1016/j.msec.2015.11.059. Epub 2015 Dec 2.


Predicting Prognosis of Early-Stage Non-Small Cell Lung Cancer Using the GeneFx® Lung Signature.

Der S, Zhu CQ, Brower S, Uihlein A.

PLoS Curr. 2015 Oct 26;7. pii: ecurrents.eogt.49eb4408c48237b8a8d4ed2060951083. doi: 10.1371/currents.eogt.49eb4408c48237b8a8d4ed2060951083.


Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers.

Dodbiba L, Teichman J, Fleet A, Thai H, Starmans MH, Navab R, Chen Z, Girgis H, Eng L, Espin-Garcia O, Shen X, Bandarchi B, Schwock J, Tsao MS, El-Zimaity H, Der SD, Xu W, Bristow RG, Darling GE, Boutros PC, Ailles LE, Liu G.

PLoS One. 2015 Mar 31;10(3):e0121872. doi: 10.1371/journal.pone.0121872. eCollection 2015.


Integrating RAS status into prognostic signatures for adenocarcinomas of the lung.

Starmans MH, Pintilie M, Chan-Seng-Yue M, Moon NC, Haider S, Nguyen F, Lau SK, Liu N, Kasprzyk A, Wouters BG, Der SD, Shepherd FA, Jurisica I, Penn LZ, Tsao MS, Lambin P, Boutros PC.

Clin Cancer Res. 2015 Mar 15;21(6):1477-86. doi: 10.1158/1078-0432.CCR-14-1749. Epub 2015 Jan 21.


Two BRM promoter insertion polymorphisms increase the risk of early-stage upper aerodigestive tract cancers.

Wong KM, Qiu X, Cheng D, Azad AK, Habbous S, Palepu P, Mirshams M, Patel D, Chen Z, Roberts H, Knox J, Marquez S, Wong R, Darling G, Waldron J, Goldstein D, Leighl N, Shepherd FA, Tsao M, Der S, Reisman D, Liu G.

Cancer Med. 2014 Apr;3(2):426-33. doi: 10.1002/cam4.201. Epub 2014 Feb 12.


Resistance to bleomycin in cancer cell lines is characterized by prolonged doubling time, reduced DNA damage and evasion of G2/M arrest and apoptosis.

Wang Q, Cui K, Espin-Garcia O, Cheng D, Qiu X, Chen Z, Moore M, Bristow RG, Xu W, Der S, Liu G.

PLoS One. 2013 Dec 4;8(12):e82363. doi: 10.1371/journal.pone.0082363. eCollection 2013.


Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage IA patients.

Der SD, Sykes J, Pintilie M, Zhu CQ, Strumpf D, Liu N, Jurisica I, Shepherd FA, Tsao MS.

J Thorac Oncol. 2014 Jan;9(1):59-64. doi: 10.1097/JTO.0000000000000042.


NKG2D regulates production of soluble TRAIL by ex vivo expanded human γδ T cells.

Dokouhaki P, Schuh NW, Joe B, Allen CA, Der SD, Tsao MS, Zhang L.

Eur J Immunol. 2013 Dec;43(12):3175-82. doi: 10.1002/eji.201243150. Epub 2013 Sep 10.


Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies.

Starmans MH, Pintilie M, John T, Der SD, Shepherd FA, Jurisica I, Lambin P, Tsao MS, Boutros PC.

Genome Med. 2012 Nov 12;4(11):84. doi: 10.1186/gm385. eCollection 2012.


Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue.

Fehringer G, Liu G, Pintilie M, Sykes J, Cheng D, Liu N, Chen Z, Seymour L, Der SD, Shepherd FA, Tsao MS, Hung RJ.

Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1097-104. doi: 10.1158/1055-9965.EPI-11-1123-T. Epub 2012 Apr 26.


Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events.

Kim H, Gillis LC, Jarvis JD, Yang S, Huang K, Der S, Barber DL.

BMC Cancer. 2011 Dec 28;11:528. doi: 10.1186/1471-2407-11-528.


Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer.

Navab R, Strumpf D, Bandarchi B, Zhu CQ, Pintilie M, Ramnarine VR, Ibrahimov E, Radulovich N, Leung L, Barczyk M, Panchal D, To C, Yun JJ, Der S, Shepherd FA, Jurisica I, Tsao MS.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7160-5. doi: 10.1073/pnas.1014506108. Epub 2011 Apr 7.


Re: Gene expression-based prognostic signatures in lung cancer: ready for clinical use?

Boutros PC, Pintilie M, John T, Starmans MH, Der SD, Shepherd FA, Tsao MS, Jurisica I.

J Natl Cancer Inst. 2010 Nov 3;102(21):1677-8; author reply 1678-9. doi: 10.1093/jnci/djq385. Epub 2010 Oct 4. No abstract available.


Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.

Zhou L, Picard D, Ra YS, Li M, Northcott PA, Hu Y, Stearns D, Hawkins C, Taylor MD, Rutka J, Der SD, Huang A.

Cancer Res. 2010 Oct 15;70(20):8199-210. doi: 10.1158/0008-5472.CAN-09-4562. Epub 2010 Sep 28.


Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer.

Zhu CQ, Ding K, Strumpf D, Weir BA, Meyerson M, Pennell N, Thomas RK, Naoki K, Ladd-Acosta C, Liu N, Pintilie M, Der S, Seymour L, Jurisica I, Shepherd FA, Tsao MS.

J Clin Oncol. 2010 Oct 10;28(29):4417-24. doi: 10.1200/JCO.2009.26.4325. Epub 2010 Sep 7. Erratum in: J Clin Oncol. 2010 Dec 1;28(34):5126. J Clin Oncol. 2014 Feb 1;32(4):365.


Prognostic gene expression signature for squamous cell carcinoma of lung.

Zhu CQ, Strumpf D, Li CY, Li Q, Liu N, Der S, Shepherd FA, Tsao MS, Jurisica I.

Clin Cancer Res. 2010 Oct 15;16(20):5038-47. doi: 10.1158/1078-0432.CCR-10-0612. Epub 2010 Aug 25.


Immune activation and neuropsychiatric symptoms in HIV infection.

Warriner EM, Rourke SB, Rourke BP, Rubenstein S, Millikin C, Buchanan L, Connelly P, Hyrcza M, Ostrowski M, Der S, Gough K.

J Neuropsychiatry Clin Neurosci. 2010 Summer;22(3):321-8. doi: 10.1176/appi.neuropsych.22.3.321.


Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus.

Roos FC, Roberts AM, Hwang II, Moriyama EH, Evans AJ, Sybingco S, Watson IR, Carneiro LA, Gedye C, Girardin SE, Ailles LE, Jewett MA, Milosevic M, Wilson BC, Bell JC, Der SD, Ohh M.

EMBO Mol Med. 2010 Jul;2(7):275-88. doi: 10.1002/emmm.201000081.


Understanding prognostic gene expression signatures in lung cancer.

Zhu CQ, Pintilie M, John T, Strumpf D, Shepherd FA, Der SD, Jurisica I, Tsao MS.

Clin Lung Cancer. 2009 Sep;10(5):331-40. doi: 10.3816/CLC.2009.n.045. Review.


Prognostic gene signatures for non-small-cell lung cancer.

Boutros PC, Lau SK, Pintilie M, Liu N, Shepherd FA, Der SD, Tsao MS, Penn LZ, Jurisica I.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2824-8. doi: 10.1073/pnas.0809444106. Epub 2009 Feb 5.


CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.

Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA.

J Exp Med. 2009 Feb 16;206(2):421-34. doi: 10.1084/jem.20081811. Epub 2009 Feb 2. Erratum in: J Exp Med. 2009 Mar 16;206(3):721.


Chilaiditi's sign or Chilaiditi's syndrome in the emergency department.

Hivert B, Der SG, Claessens YE, Randone B, Afanou G, Allo JC.

BMJ Case Rep. 2009;2009:bcr2007046417. doi: 10.1136/bcr.2007.046417. Epub 2009 Jan 8. No abstract available.


Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment.

Walker E, Ohishi M, Davey RE, Zhang W, Cassar PA, Tanaka TS, Der SD, Morris Q, Hughes TR, Zandstra PW, Stanford WL.

Cell Stem Cell. 2007 Jun 7;1(1):71-86. doi: 10.1016/j.stem.2007.04.002.


Virulizin induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors.

Benatar T, Cao MY, Lee Y, Li H, Feng N, Gu X, Lee V, Jin H, Wang M, Der S, Lightfoot J, Wright JA, Young AH.

Cancer Immunol Immunother. 2008 Dec;57(12):1757-69. doi: 10.1007/s00262-008-0502-9. Epub 2008 Mar 20.


Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids.

Bikopoulos G, da Silva Pimenta A, Lee SC, Lakey JR, Der SD, Chan CB, Ceddia RB, Wheeler MB, Rozakis-Adcock M.

J Endocrinol. 2008 Mar;196(3):455-64. doi: 10.1677/JOE-07-0174.


Automatic target recognition using a feature-decomposition and data-decomposition modular neural network.

Wang LC, Der SZ, Nasrabadi NM.

IEEE Trans Image Process. 1998;7(8):1113-21. doi: 10.1109/83.704305.


Simulation of error in optical radar range measurements.

Der S, Redman B, Chellappa R.

Appl Opt. 1997 Sep 20;36(27):6869-74.


Model-based target recognition in pulsed ladar imagery.

Zheng Q, Der SZ, Mahmoud HI.

IEEE Trans Image Process. 2001;10(4):565-72. doi: 10.1109/83.913591.


Three-gene prognostic classifier for early-stage non small-cell lung cancer.

Lau SK, Boutros PC, Pintilie M, Blackhall FH, Zhu CQ, Strumpf D, Johnston MR, Darling G, Keshavjee S, Waddell TK, Liu N, Lau D, Penn LZ, Shepherd FA, Jurisica I, Der SD, Tsao MS.

J Clin Oncol. 2007 Dec 10;25(35):5562-9.


Virulizin, a novel immunotherapy agent, stimulates TNFalpha expression in monocytes/macrophages in vitro and in vivo.

Li H, Cao MY, Lee Y, Benatar T, Lee V, Feng N, Gu X, Liu P, Jin H, Wang M, Der S, Lightfoot J, Wright JA, Young AH.

Int Immunopharmacol. 2007 Oct;7(10):1350-9. Epub 2007 Jun 26.


The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P.

Nat Genet. 2007 Feb;39(2):168-77. Epub 2007 Jan 14.


Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.

Melichar HJ, Narayan K, Der SD, Hiraoka Y, Gardiol N, Jeannet G, Held W, Chambers CA, Kang J.

Science. 2007 Jan 12;315(5809):230-3.


Toll-like receptor and cytokine gene expression in the early phase of human lung transplantation.

Andrade CF, Kaneda H, Der S, Tsang M, Lodyga M, Chimisso Dos Santos C, Keshavjee S, Liu M.

J Heart Lung Transplant. 2006 Nov;25(11):1317-23.


Genomic DNA functions as a universal external standard in quantitative real-time PCR.

Yun JJ, Heisler LE, Hwang II, Wilkins O, Lau SK, Hyrcza M, Jayabalasingham B, Jin J, McLaurin J, Tsao MS, Der SD.

Nucleic Acids Res. 2006 Jul 13;34(12):e85. Erratum in: Nucleic Acids Res. 2006;34(22):6718.


CXCR5/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts.

Lee BP, Chen W, Shi H, Der SD, Förster R, Zhang L.

J Immunol. 2006 May 1;176(9):5276-83.


Apical role for BRG1 in cytokine-induced promoter assembly.

Ni Z, Karaskov E, Yu T, Callaghan SM, Der S, Park DS, Xu Z, Pattenden SG, Bremner R.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14611-6. Epub 2005 Sep 29.


A joint compression-discrimination neural transformation applied to target detection.

Chan AL, Der SZ, Nasrabadi NM.

IEEE Trans Syst Man Cybern B Cybern. 2005 Aug;35(4):670-81.


Transcriptional regulation of the one-carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p.

Subramanian M, Qiao WB, Khanam N, Wilkins O, Der SD, Lalich JD, Bognar AL.

Mol Microbiol. 2005 Jul;57(1):53-69.


CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome.

Heisler LE, Torti D, Boutros PC, Watson J, Chan C, Winegarden N, Takahashi M, Yau P, Huang TH, Farnham PJ, Jurisica I, Woodgett JR, Bremner R, Penn LZ, Der SD.

Nucleic Acids Res. 2005 May 23;33(9):2952-61. Print 2005.


Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages.

Li H, Cao MY, Lee Y, Lee V, Feng N, Benatar T, Jin H, Wang M, Der S, Wright JA, Young AH.

Cancer Immunol Immunother. 2005 Nov;54(11):1115-26. Epub 2005 May 13.


Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival.

Lee BP, Mansfield E, Hsieh SC, Hernandez-Boussard T, Chen W, Thomson CW, Ford MS, Bosinger SE, Der S, Zhang ZX, Zhang M, Kelvin DJ, Sarwal MM, Zhang L.

J Immunol. 2005 Apr 15;174(8):4535-44.


Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR.

Begum S, Emami N, Cheung A, Wilkins O, Der S, Hamel PA.

Oncogene. 2005 Mar 10;24(11):1860-72. Erratum in: Oncogene. 2008 Mar 13;27(12):1812. Emani, Nashmil [corrected to Emami, Nashmil].


Differentiation of human monocytic cell lines confers susceptibility to Bacillus anthracis lethal toxin.

Kassam A, Der SD, Mogridge J.

Cell Microbiol. 2005 Feb;7(2):281-92.


STAT5 is required for thymopoiesis in a development stage-specific manner.

Kang J, DiBenedetto B, Narayan K, Zhao H, Der SD, Chambers CA.

J Immunol. 2004 Aug 15;173(4):2307-14.

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