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Items: 1 to 50 of 140

1.

Review: Chemosensing of nutrients and non-nutrients in the human and porcine gastrointestinal tract.

Roura E, Depoortere I, Navarro M.

Animal. 2019 Nov;13(11):2714-2726. doi: 10.1017/S1751731119001794. Epub 2019 Aug 7.

PMID:
31387651
2.

Influence of subliminal intragastric fatty acid infusion on subjective and physiological responses to positive emotion induction in healthy women: A randomized trial.

Zhao D, Boey L, Weltens N, Biesiekierski JR, Iven J, Depoortere I, Tack J, Van Oudenhove L.

Psychoneuroendocrinology. 2019 Oct;108:43-52. doi: 10.1016/j.psyneuen.2019.06.010. Epub 2019 Jun 13.

PMID:
31226660
3.
4.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, Sprangers B, Himmelreich U, Soenen S, Guilliams M, Vanden Berghe P, Jones E, Lambrechts D, Boeckxstaens G.

Cell. 2019 Jan 24;176(3):676. doi: 10.1016/j.cell.2019.01.010. No abstract available.

PMID:
30682373
5.

Motilin: from gastric motility stimulation to hunger signalling.

Deloose E, Verbeure W, Depoortere I, Tack J.

Nat Rev Endocrinol. 2019 Apr;15(4):238-250. doi: 10.1038/s41574-019-0155-0. Review.

PMID:
30675023
6.

Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut.

Wang Q, Liszt KI, Deloose E, Canovai E, Thijs T, Farré R, Ceulemans LJ, Lannoo M, Tack J, Depoortere I.

FASEB J. 2019 Apr;33(4):4907-4920. doi: 10.1096/fj.201801661RR. Epub 2019 Jan 10.

PMID:
30629462
7.

Therapeutic potential of ectopic olfactory and taste receptors.

Lee SJ, Depoortere I, Hatt H.

Nat Rev Drug Discov. 2019 Feb;18(2):116-138. doi: 10.1038/s41573-018-0002-3. Review.

PMID:
30504792
8.

The circadian clock regulates the diurnal levels of microbial short-chain fatty acids and their rhythmic effects on colon contractility in mice.

Segers A, Desmet L, Thijs T, Verbeke K, Tack J, Depoortere I.

Acta Physiol (Oxf). 2019 Mar;225(3):e13193. doi: 10.1111/apha.13193. Epub 2018 Oct 22.

PMID:
30269420
9.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, Sprangers B, Himmelreich U, Soenen S, Guilliams M, Vanden Berghe P, Jones E, Lambrechts D, Boeckxstaens G.

Cell. 2018 Oct 4;175(2):400-415.e13. doi: 10.1016/j.cell.2018.07.048. Epub 2018 Aug 30. Erratum in: Cell. 2019 Jan 24;176(3):676.

10.

Effects of caloric and noncaloric sweeteners on antroduodenal motility, gastrointestinal hormone secretion and appetite-related sensations in healthy subjects.

Meyer-Gerspach AC, Biesiekierski JR, Deloose E, Clevers E, Rotondo A, Rehfeld JF, Depoortere I, Van Oudenhove L, Tack J.

Am J Clin Nutr. 2018 May 1;107(5):707-716. doi: 10.1093/ajcn/nqy004.

PMID:
29722834
11.

Effect of motilin receptor activation on food intake and food timing.

Deloose E, Biesiekierski JR, Vanheel H, Depoortere I, Tack J.

Am J Clin Nutr. 2018 Apr 1;107(4):537-543. doi: 10.1093/ajcn/nqx044.

PMID:
29635488
12.

Intragastric quinine administration decreases hedonic eating in healthy women through peptide-mediated gut-brain signaling mechanisms.

Iven J, Biesiekierski JR, Zhao D, Deloose E, O'Daly OG, Depoortere I, Tack J, Van Oudenhove L.

Nutr Neurosci. 2019 Dec;22(12):850-862. doi: 10.1080/1028415X.2018.1457841. Epub 2018 Apr 2.

PMID:
29607741
13.

The motilin agonist erythromycin increases hunger by modulating homeostatic and hedonic brain circuits in healthy women: a randomized, placebo-controlled study.

Zhao D, Meyer-Gerspach AC, Deloose E, Iven J, Weltens N, Depoortere I, O'daly O, Tack J, Van Oudenhove L.

Sci Rep. 2018 Jan 29;8(1):1819. doi: 10.1038/s41598-018-19444-5.

14.

Obesity Impairs Oligopeptide/Amino Acid-Induced Ghrelin Release and Smooth Muscle Contractions in the Human Proximal Stomach.

Vancleef L, Thijs T, Baert F, Ceulemans LJ, Canovai E, Wang Q, Steensels S, Segers A, Farré R, Pirenne J, Lannoo M, Tack J, Depoortere I.

Mol Nutr Food Res. 2018 Mar;62(5). doi: 10.1002/mnfr.201700804. Epub 2018 Feb 12.

PMID:
29323774
15.

Chemoreceptors in the Gut.

Steensels S, Depoortere I.

Annu Rev Physiol. 2018 Feb 10;80:117-141. doi: 10.1146/annurev-physiol-021317-121332. Epub 2017 Oct 13. Review.

PMID:
29029594
16.

Manometric evaluation of the motilin receptor agonist camicinal (GSK962040) in humans.

Deloose E, Depoortere I, de Hoon J, Van Hecken A, Dewit OE, Vasist Johnson LS, Barton ME, Dukes GE, Tack J.

Neurogastroenterol Motil. 2018 Jan;30(1). doi: 10.1111/nmo.13173. Epub 2017 Aug 6.

PMID:
28782145
17.

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers.

Deloose E, Corsetti M, Van Oudenhove L, Depoortere I, Tack J.

Neurogastroenterol Motil. 2018 Jan;30(1). doi: 10.1111/nmo.13171. Epub 2017 Aug 4.

PMID:
28776826
18.

Abdominal vagus nerve stimulation as a new therapeutic approach to prevent postoperative ileus.

Stakenborg N, Wolthuis AM, Gomez-Pinilla PJ, Farro G, Di Giovangiulio M, Bosmans G, Labeeuw E, Verhaegen M, Depoortere I, D'Hoore A, Matteoli G, Boeckxstaens GE.

Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13075. Epub 2017 Apr 21.

PMID:
28429863
19.

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

Deloose E, Janssen P, Corsetti M, Biesiekierski J, Masuy I, Rotondo A, Van Oudenhove L, Depoortere I, Tack J.

Am J Clin Nutr. 2017 Mar;105(3):580-588. doi: 10.3945/ajcn.116.138297. Epub 2017 Feb 1.

PMID:
28148502
20.

The role of nutrient sensing in the metabolic changes after gastric bypass surgery.

Steensels S, Lannoo M, Avau B, Laermans J, Vancleef L, Farré R, Verbeke K, Depoortere I.

J Endocrinol. 2017 Mar;232(3):363-376. doi: 10.1530/JOE-16-0541. Epub 2016 Dec 15.

PMID:
27980002
21.

The Sweetener-Sensing Mechanisms of the Ghrelin Cell.

Steensels S, Vancleef L, Depoortere I.

Nutrients. 2016 Dec 7;8(12). pii: E795.

22.

Supplementation of oligofructose, but not sucralose, decreases high-fat diet induced body weight gain in mice independent of gustducin-mediated gut hormone release.

Steensels S, Cools L, Avau B, Vancleef L, Farré R, Verbeke K, Depoortere I.

Mol Nutr Food Res. 2017 Mar;61(3). doi: 10.1002/mnfr.201600716. Epub 2016 Dec 2.

PMID:
27800650
23.

Differential brain responses to gradual intragastric nutrient infusion and gastric balloon distension: A role for gut peptides?

Ly HG, Dupont P, Van Laere K, Depoortere I, Tack J, Van Oudenhove L.

Neuroimage. 2017 Jan 1;144(Pt A):101-112. doi: 10.1016/j.neuroimage.2016.09.032. Epub 2016 Sep 14.

PMID:
27639359
24.

Subchronic treatment with grape-seed phenolics inhibits ghrelin production despite a short-term stimulation of ghrelin secretion produced by bitter-sensing flavanols.

Serrano J, Casanova-Martí À, Depoortere I, Blay MT, Terra X, Pinent M, Ardévol A.

Mol Nutr Food Res. 2016 Dec;60(12):2554-2564. doi: 10.1002/mnfr.201600242. Epub 2016 Sep 26.

PMID:
27417519
25.
26.

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus.

Farro G, Gomez-Pinilla PJ, Di Giovangiulio M, Stakenborg N, Auteri M, Thijs T, Depoortere I, Matteoli G, Boeckxstaens GE.

Neurogastroenterol Motil. 2016 Jun;28(6):934-47. doi: 10.1111/nmo.12796. Epub 2016 Feb 18.

PMID:
26891411
27.

The motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway.

Deloose E, Vos R, Janssen P, Van den Bergh O, Van Oudenhove L, Depoortere I, Tack J.

Am J Clin Nutr. 2016 Mar;103(3):730-7. doi: 10.3945/ajcn.115.113456. Epub 2016 Jan 27.

PMID:
26817505
28.

Chronobesity: role of the circadian system in the obesity epidemic.

Laermans J, Depoortere I.

Obes Rev. 2016 Feb;17(2):108-25. doi: 10.1111/obr.12351. Epub 2015 Dec 23. Review.

PMID:
26693661
29.

The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice.

Avau B, Bauters D, Steensels S, Vancleef L, Laermans J, Lesuisse J, Buyse J, Lijnen HR, Tack J, Depoortere I.

PLoS One. 2015 Dec 21;10(12):e0145538. doi: 10.1371/journal.pone.0145538. eCollection 2015.

30.

Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system.

Laermans J, Vancleef L, Tack J, Depoortere I.

Sci Rep. 2015 Nov 18;5:16748. doi: 10.1038/srep16748.

31.

Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation.

Avau B, Rotondo A, Thijs T, Andrews CN, Janssen P, Tack J, Depoortere I.

Sci Rep. 2015 Nov 6;5:15985. doi: 10.1038/srep15985.

32.

Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell.

Vancleef L, Van Den Broeck T, Thijs T, Steensels S, Briand L, Tack J, Depoortere I.

Sci Rep. 2015 Oct 29;5:15725. doi: 10.1038/srep15725.

33.

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity.

Avau B, Depoortere I.

Acta Physiol (Oxf). 2016 Apr;216(4):407-20. doi: 10.1111/apha.12621. Epub 2015 Nov 16. Review.

PMID:
26493384
34.

Ghrelin receptor modulates T helper cells during intestinal inflammation.

Di Giovangiulio M, Stakenborg N, Bosmans G, Meroni E, Farro G, Gomez-Pinilla PJ, Depoortere I, Boeckxstaens GE, Matteoli G.

Neurogastroenterol Motil. 2015 Nov;27(11):1542-52. doi: 10.1111/nmo.12640. Epub 2015 Jul 30.

PMID:
26227790
35.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

36.

Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger.

Deloose E, Janssen P, Lannoo M, Van der Schueren B, Depoortere I, Tack J.

Gut. 2016 Jul;65(7):1110-8. doi: 10.1136/gutjnl-2015-309242. Epub 2015 May 18.

PMID:
25986945
37.

Taste receptors in the gut tune the release of peptides in response to nutrients.

Depoortere I.

Peptides. 2015 Apr;66:9-12. doi: 10.1016/j.peptides.2015.01.013. Epub 2015 Feb 13. No abstract available.

PMID:
25683908
38.

Motilin-induced gastric contractions signal hunger in man.

Tack J, Deloose E, Ang D, Scarpellini E, Vanuytsel T, Van Oudenhove L, Depoortere I.

Gut. 2016 Feb;65(2):214-24. doi: 10.1136/gutjnl-2014-308472. Epub 2014 Dec 24.

PMID:
25539673
39.

Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man.

Deloose E, Vos R, Corsetti M, Depoortere I, Tack J.

Neurogastroenterol Motil. 2015 Jan;27(1):63-71. doi: 10.1111/nmo.12470. Epub 2014 Nov 13.

PMID:
25393165
40.

Shifting the circadian rhythm of feeding in mice induces gastrointestinal, metabolic and immune alterations which are influenced by ghrelin and the core clock gene Bmal1.

Laermans J, Broers C, Beckers K, Vancleef L, Steensels S, Thijs T, Tack J, Depoortere I.

PLoS One. 2014 Oct 16;9(10):e110176. doi: 10.1371/journal.pone.0110176. eCollection 2014.

41.

Taste receptors of the gut: emerging roles in health and disease.

Depoortere I.

Gut. 2014 Jan;63(1):179-90. doi: 10.1136/gutjnl-2013-305112. Epub 2013 Oct 16. Review.

PMID:
24131638
42.

Ghrelin signaling in the gut, its physiological properties, and therapeutic potential.

Avau B, Carbone F, Tack J, Depoortere I.

Neurogastroenterol Motil. 2013 Sep;25(9):720-32. doi: 10.1111/nmo.12193. Review.

PMID:
23910374
43.

Ghrelin is involved in the paracrine communication between neurons and glial cells.

Avau B, De Smet B, Thijs T, Geuzens A, Tack J, Vanden Berghe P, Depoortere I.

Neurogastroenterol Motil. 2013 Sep;25(9):e599-608. doi: 10.1111/nmo.12171. Epub 2013 Jun 19.

PMID:
23781841
44.

Systemic inflammation with enhanced brain activation contributes to more severe delay in postoperative ileus.

van Bree SH, Cailotto C, Di Giovangiulio M, Jansen E, van der Vliet J, Costes L, Depoortere I, Gomez-Pinilla PJ, Matteoli G, Boeckxstaens GE.

Neurogastroenterol Motil. 2013 Aug;25(8):e540-9. doi: 10.1111/nmo.12157. Epub 2013 May 27.

PMID:
23711101
45.

Neurotransmitters involved in fast excitatory neurotransmission directly activate enteric glial cells.

Boesmans W, Cirillo C, Van den Abbeel V, Van den Haute C, Depoortere I, Tack J, Vanden Berghe P.

Neurogastroenterol Motil. 2013 Feb;25(2):e151-60. doi: 10.1111/nmo.12065. Epub 2013 Jan 2.

PMID:
23279281
46.

Nutrient sensing in the gut: new roads to therapeutics?

Janssen S, Depoortere I.

Trends Endocrinol Metab. 2013 Feb;24(2):92-100. doi: 10.1016/j.tem.2012.11.006. Epub 2012 Dec 21. Review.

PMID:
23266105
47.

GI functions of GPR39: novel biology.

Depoortere I.

Curr Opin Pharmacol. 2012 Dec;12(6):647-52. doi: 10.1016/j.coph.2012.07.019. Epub 2012 Aug 10. Review.

PMID:
22884904
48.

Ghrelin's second life: from appetite stimulator to glucose regulator.

Verhulst PJ, Depoortere I.

World J Gastroenterol. 2012 Jul 7;18(25):3183-95. doi: 10.3748/wjg.v18.i25.3183. Review.

49.

Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein.

Janssen S, Laermans J, Iwakura H, Tack J, Depoortere I.

PLoS One. 2012;7(6):e40168. doi: 10.1371/journal.pone.0040168. Epub 2012 Jun 29.

50.

Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity.

Roosen L, Boesmans W, Dondeyne M, Depoortere I, Tack J, Vanden Berghe P.

J Physiol. 2012 Sep 1;590(17):4321-33. doi: 10.1113/jphysiol.2012.231134. Epub 2012 Jun 18.

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