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Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors.

Nocentini A, Moi D, Deplano A, Osman SM, AlOthman ZA, Balboni G, Supuran CT, Onnis V.

Eur J Med Chem. 2019 Nov 21:111896. doi: 10.1016/j.ejmech.2019.111896. [Epub ahead of print]


Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation.

Moi D, Nocentini A, Deplano A, Balboni G, Supuran CT, Onnis V.

Eur J Med Chem. 2019 Nov 15;182:111638. doi: 10.1016/j.ejmech.2019.111638. Epub 2019 Aug 22.


Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors.

Moi D, Foster PA, Rimmer LG, Jaffri A, Deplano A, Balboni G, Onnis V, Potter BVL.

Eur J Med Chem. 2019 Nov 15;182:111614. doi: 10.1016/j.ejmech.2019.111614. Epub 2019 Aug 12.


Detection of optrA-positive enterococci clinical isolates in Belgium.

Argudín MA, Youzaga S, Dodémont M, Heinrichs A, Roisin S, Deplano A, Nonhoff C, Hallin M.

Eur J Clin Microbiol Infect Dis. 2019 May;38(5):985-987. doi: 10.1007/s10096-019-03504-3. Epub 2019 Feb 15. No abstract available.


Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors.

Deplano A, Cipriano M, Moraca F, Novellino E, Catalanotti B, Fowler CJ, Onnis V.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):562-576. doi: 10.1080/14756366.2018.1532418.


Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis.

Lee JYH, Monk IR, Gonçalves da Silva A, Seemann T, Chua KYL, Kearns A, Hill R, Woodford N, Bartels MD, Strommenger B, Laurent F, Dodémont M, Deplano A, Patel R, Larsen AR, Korman TM, Stinear TP, Howden BP.

Nat Microbiol. 2018 Oct;3(10):1175-1185. doi: 10.1038/s41564-018-0230-7. Epub 2018 Sep 3.


European external quality assessments for identification, molecular typing and characterization of Staphylococcus aureus.

Deplano A, Dodémont M, Denis O, Westh H, Gumpert H, Larsen AR, Larsen J, Kearns A, Pichon B, Layer F, Schulte B, Wolz C, Spiliopoulou I, Brennan G, Empel J, Hryniewicz W, de Lencastre H, Faria NA, Codita I, Sabat AJ, Friedrich AW, Deurenberg RH, Tristan A, Laurent F, Vandenesch F.

J Antimicrob Chemother. 2018 Oct 1;73(10):2662-2666. doi: 10.1093/jac/dky260.


An Outpatient Clinic as a Potential Site of Transmission for an Outbreak of New Delhi Metallo-β-Lactamase-producing Klebsiella pneumoniae Sequence Type 716: A Study Using Whole-genome Sequencing.

Heinrichs A, Argudín MA, De Mendonça R, Deplano A, Roisin S, Dodémont M, Coussement J, Filippin L, Dombrecht J, De Bruyne K, Huang TD, Supply P, Byl B, Glupczynski Y, Denis O.

Clin Infect Dis. 2019 Mar 5;68(6):993-1000. doi: 10.1093/cid/ciy581.


Development and Validation of Molecular Overlays Derived from Three-Dimensional Hydrophobic Similarity with PharmScreen.

Vázquez J, Deplano A, Herrero A, Ginex T, Gibert E, Rabal O, Oyarzabal J, Herrero E, Luque FJ.

J Chem Inf Model. 2018 Aug 27;58(8):1596-1609. doi: 10.1021/acs.jcim.8b00216. Epub 2018 Jul 30.


Emergence of livestock-associated MRSA isolated from cystic fibrosis patients: Result of a Belgian national survey.

Dodémont M, Argudín MA, Willekens J, Vanderhelst E, Pierard D, Miendje Deyi VY, Hanssens L, Franckx H, Schelstraete P, Leroux-Roels I, Nonhoff C, Deplano A, Knoop C, Malfroot A, Denis O.

J Cyst Fibros. 2019 Jan;18(1):86-93. doi: 10.1016/j.jcf.2018.04.008. Epub 2018 May 24.


Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes.

Argudín MA, Roisin S, Nienhaus L, Dodémont M, de Mendonça R, Nonhoff C, Deplano A, Denis O.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00091-18. doi: 10.1128/AAC.00091-18. Print 2018 Jul.


In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals.

Argudín MA, Dodémont M, Taguemount M, Roisin S, de Mendonça R, Deplano A, Nonhoff C, Denis O.

J Antimicrob Chemother. 2018 Jul 1;73(7):2001. doi: 10.1093/jac/dky140. No abstract available.


CC398 Staphylococcus aureus subpopulations in Belgian patients.

Argudín MA, Deplano A, Vandendriessche S, Dodémont M, Nonhoff C, Denis O, Roisin S.

Eur J Clin Microbiol Infect Dis. 2018 May;37(5):911-916. doi: 10.1007/s10096-018-3205-y. Epub 2018 Feb 15.


Neuroinvasive Infection from O117:K52:H-Escherichia coli following Acute Pyelonephritis.

Cromlin H, Rodriguez-Villalobos H, Deplano A, Duprez T, Hantson P.

Case Rep Infect Dis. 2017;2017:8976754. doi: 10.1155/2017/8976754. Epub 2017 Nov 26.


Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline.

Argudín MA, Roisin S, Dodémont M, Nonhoff C, Deplano A, Denis O.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01852-17. doi: 10.1128/AAC.01852-17. Print 2018 Jan.


Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.

Corona A, Onnis V, Deplano A, Bianco G, Demurtas M, Distinto S, Cheng YC, Alcaro S, Esposito F, Tramontano E.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx078.


Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.

Argudín MA, Deplano A, Meghraoui A, Dodémont M, Heinrichs A, Denis O, Nonhoff C, Roisin S.

Antibiotics (Basel). 2017 Jun 6;6(2). pii: E12. doi: 10.3390/antibiotics6020012. Review.


Novel propanamides as fatty acid amide hydrolase inhibitors.

Deplano A, Morgillo CM, Demurtas M, Björklund E, Cipriano M, Svensson M, Hashemian S, Smaldone G, Pedone E, Luque FJ, Cabiddu MG, Novellino E, Fowler CJ, Catalanotti B, Onnis V.

Eur J Med Chem. 2017 Aug 18;136:523-542. doi: 10.1016/j.ejmech.2017.05.033. Epub 2017 May 12.


Characterisation of Staphylococcus aureus isolates from bloodstream infections, Democratic Republic of the Congo.

Vandendriessche S, De Boeck H, Deplano A, Phoba MF, Lunguya O, Falay D, Dauly N, Verhaegen J, Denis O, Jacobs J.

Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1163-1171. doi: 10.1007/s10096-017-2904-0. Epub 2017 Jan 23.


Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy.

Costanzi S, Skorski M, Deplano A, Habermehl B, Mendoza M, Wang K, Biederman M, Dawson J, Gao J.

J Mol Graph Model. 2016 Nov;70:140-152. doi: 10.1016/j.jmgm.2016.10.004. Epub 2016 Oct 4.


In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals.

Argudín MA, Dodémont M, Taguemount M, Roisin S, de Mendonça R, Deplano A, Nonhoff C, Denis O.

J Antimicrob Chemother. 2017 Jan;72(1):56-59. Epub 2016 Sep 15. Erratum in: J Antimicrob Chemother. 2018 Jul 1;73(7):2001.


Antimicrobial Susceptibility of Pseudomonas aeruginosa Isolated from Cystic Fibrosis Patients in Northern Europe.

Mustafa MH, Chalhoub H, Denis O, Deplano A, Vergison A, Rodriguez-Villalobos H, Tunney MM, Elborn JS, Kahl BC, Traore H, Vanderbist F, Tulkens PM, Van Bambeke F.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6735-6741. doi: 10.1128/AAC.01046-16. Print 2016 Nov.


MALDI-TOF MS typing of a nosocomial methicillin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit.

Steensels D, Deplano A, Denis O, Simon A, Verroken A.

Acta Clin Belg. 2017 Aug;72(4):219-225. doi: 10.1080/17843286.2016.1198521. Epub 2016 Jun 24.


Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita.

Eloh K, Demurtas M, Mura MG, Deplano A, Onnis V, Sasanelli N, Maxia A, Caboni P.

J Agric Food Chem. 2016 Jun 22;64(24):4876-81. doi: 10.1021/acs.jafc.6b02250. Epub 2016 Jun 9.


Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones.

Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J.

Molecules. 2016 Apr 30;21(5). pii: E579. doi: 10.3390/molecules21050579.


National surveillance of Staphylococcus epidermidis recovered from bloodstream infections in Belgian hospitals.

Deplano A, Vandendriessche S, Nonhoff C, Dodémont M, Roisin S, Denis O.

J Antimicrob Chemother. 2016 Jul;71(7):1815-9. doi: 10.1093/jac/dkw086. Epub 2016 Apr 26.


Low occurrence of the new species Staphylococcus argenteus in a Staphylococcus aureus collection of human isolates from Belgium.

Argudín MA, Dodémont M, Vandendriessche S, Rottiers S, Tribes C, Roisin S, de Mendonça R, Nonhoff C, Deplano A, Denis O.

Eur J Clin Microbiol Infect Dis. 2016 Jun;35(6):1017-22. doi: 10.1007/s10096-016-2632-x. Epub 2016 Apr 4.


Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.

Karlsson J, Morgillo CM, Deplano A, Smaldone G, Pedone E, Luque FJ, Svensson M, Novellino E, Congiu C, Onnis V, Catalanotti B, Fowler CJ.

PLoS One. 2015 Nov 13;10(11):e0142711. doi: 10.1371/journal.pone.0142711. eCollection 2015.


In vitro nematicidal activity of aryl hydrazones and comparative GC-MS metabolomics analysis.

Eloh K, Demurtas M, Deplano A, Ngoutane Mfopa A, Murgia A, Maxia A, Onnis V, Caboni P.

J Agric Food Chem. 2015 Nov 18;63(45):9970-6. doi: 10.1021/acs.jafc.5b04815. Epub 2015 Nov 10.


Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

Gouveia-Figueira S, Karlsson J, Deplano A, Hashemian S, Svensson M, Fredriksson Sundbom M, Congiu C, Onnis V, Fowler CJ.

PLoS One. 2015 Sep 25;10(9):e0139212. doi: 10.1371/journal.pone.0139212. eCollection 2015.


Low prevalence of mupirocin resistance in Belgian Staphylococcus aureus isolates collected during a 10 year nationwide surveillance.

Nagant C, Deplano A, Nonhoff C, De Mendonça R, Roisin S, Dodémont M, Denis O.

J Antimicrob Chemother. 2016 Jan;71(1):266-7. doi: 10.1093/jac/dkv286. Epub 2015 Sep 16. No abstract available.


Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.

Congiu C, Onnis V, Deplano A, Balboni G, Ceruso M, Supuran CT.

Bioorg Med Chem. 2015 Sep 1;23(17):5619-25. doi: 10.1016/j.bmc.2015.07.024. Epub 2015 Jul 21.


Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.

Congiu C, Onnis V, Deplano A, Balboni G, Dedeoglu N, Supuran CT.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3850-3. doi: 10.1016/j.bmcl.2015.07.060. Epub 2015 Jul 26.


Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

De Petrocellis L, Schiano Moriello A, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Di Marzo V.

Pharmacol Res. 2015 Sep;99:362-9. doi: 10.1016/j.phrs.2015.07.009. Epub 2015 Jul 17.


Cognitive dysfunction and hepatitis C virus infection.

Solinas A, Piras MR, Deplano A.

World J Hepatol. 2015 May 8;7(7):922-5. doi: 10.4254/wjh.v7.i7.922.


Infection due to travel-related carbapenemase-producing Enterobacteriaceae, a largely underestimated phenomenon in Belgium.

Jans B, D Huang TD, Bauraing C, Berhin C, Bogaerts P, Deplano A, Denis O, Catry B, Glupczynski Y.

Acta Clin Belg. 2015 Jun;70(3):181-7. doi: 10.1179/2295333715Y.0000000001. Epub 2015 Mar 31.


Genetic characteristics and antimicrobial resistance of Staphylococcus epidermidis isolates from patients with catheter-related bloodstream infections and from colonized healthcare workers in a Belgian hospital.

Cherifi S, Byl B, Deplano A, Nagant C, Nonhoff C, Denis O, Hallin M.

Ann Clin Microbiol Antimicrob. 2014 Jun 4;13:20. doi: 10.1186/1476-0711-13-20.


A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists.

Congiu C, Onnis V, Deplano A, Salvadori S, Marconi V, Maftei D, Negri L, Lattanzi R, Balboni G.

Eur J Med Chem. 2014 Jun 23;81:334-40. doi: 10.1016/j.ejmech.2014.05.030. Epub 2014 May 14.


Genetic diversity among methicillin-resistant Staphylococcus aureus isolates carrying the mecC gene in Belgium.

Deplano A, Vandendriessche S, Nonhoff C, Denis O.

J Antimicrob Chemother. 2014 Jun;69(6):1457-60. doi: 10.1093/jac/dku020. Epub 2014 Feb 12.


Inhibition by EGTA of the formation of a biofilm by clinical strains of Staphylococcus aureus.

Liesse Iyamba JM, Seil M, Nagant C, Dulanto S, Deplano A, El Khattabi C, Takaisi Kikuni NB, Dehaye JP.

J Basic Microbiol. 2014 Jul;54(7):700-10. doi: 10.1002/jobm.201200511. Epub 2013 May 26.


Epidemiological investigation of a nosocomial outbreak of multidrug-resistant Corynebacterium striatum at one Belgian university hospital.

Verroken A, Bauraing C, Deplano A, Bogaerts P, Huang D, Wauters G, Glupczynski Y.

Clin Microbiol Infect. 2014 Jan;20(1):44-50. doi: 10.1111/1469-0691.12197. Epub 2013 Apr 15.


Dynamic pattern and genotypic diversity of Staphylococcus aureus nasopharyngeal carriage in healthy pre-school children.

Blumental S, Deplano A, Jourdain S, De Mendonça R, Hallin M, Nonhoff C, Rottiers S, Vergison A, Denis O.

J Antimicrob Chemother. 2013 Jul;68(7):1517-23. doi: 10.1093/jac/dkt080. Epub 2013 Mar 20.


Comparative epidemiology of Staphylococcus epidermidis isolates from patients with catheter-related bacteremia and from healthy volunteers.

Cherifi S, Byl B, Deplano A, Nonhoff C, Denis O, Hallin M.

J Clin Microbiol. 2013 May;51(5):1541-7. doi: 10.1128/JCM.03378-12. Epub 2013 Mar 13.


Staphylococcus aureus causing tropical pyomyositis, Amazon Basin, Peru.

García C, Hallin M, Deplano A, Denis O, Sihuincha M, de Groot R, Gotuzzo E, Jacobs J.

Emerg Infect Dis. 2013 Jan;19(1):123-5. doi: 10.3201/eid1901.120819.


Community-acquired methicillin-resistant Staphylococcus aureus clones circulating in Belgium from 2005 to 2009: changing epidemiology.

Brauner J, Hallin M, Deplano A, De Mendonça R, Nonhoff C, De Ryck R, Roisin S, Struelens MJ, Denis O.

Eur J Clin Microbiol Infect Dis. 2013 May;32(5):613-20. doi: 10.1007/s10096-012-1784-6. Epub 2012 Dec 13.


Sequence-based typing of Legionella pneumophila serogroup 1 clinical isolates from Belgium between 2000 and 2010.

Vekens E, Soetens O, De Mendonça R, Echahidi F, Roisin S, Deplano A, Eeckhout L, Achtergael W, Piérard D, Denis O, Wybo I.

Euro Surveill. 2012 Oct 25;17(43):20302.


Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae.

Bogaerts P, Bebrone C, Huang TD, Bouchahrouf W, Degheldre Y, Deplano A, Hoffmann K, Glupczynski Y.

Antimicrob Agents Chemother. 2012 Jun;56(6):3283-7. doi: 10.1128/AAC.06249-11. Epub 2012 Mar 5.


Previous healthcare exposure is the main antecedent for methicillin-resistant Staphylococcus aureus carriage on hospital admission in Belgium.

Vandendriessche S, Hallin M, Catry B, Jans B, Deplano A, Nonhoff C, Roisin S, De Mendonça R, Struelens MJ, Denis O.

Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2283-92. doi: 10.1007/s10096-012-1567-0. Epub 2012 Mar 1.


Emergence of NDM-1-producing Acinetobacter baumannii in Belgium.

Bogaerts P, Rezende de Castro R, Roisin S, Deplano A, Huang TD, Hallin M, Denis O, Glupczynski Y.

J Antimicrob Chemother. 2012 Jun;67(6):1552-3. doi: 10.1093/jac/dks041. Epub 2012 Feb 16. No abstract available.


Pseudo-outbreak of extremely drug-resistant pseudomonas aeruginosa urinary tract infections due to contamination of an automated urine analyzer.

Hallin M, Deplano A, Roisin S, Boyart V, De Ryck R, Nonhoff C, Byl B, Glupczynski Y, Denis O.

J Clin Microbiol. 2012 Mar;50(3):580-2. doi: 10.1128/JCM.06268-11. Epub 2012 Jan 4.

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