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Items: 48


Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine.

Wang P, Huo CX, Lang S, Caution K, Nick ST, Dubey P, Deora R, Huang X.

Angew Chem Int Ed Engl. 2020 Jan 17. doi: 10.1002/anie.201915913. [Epub ahead of print]


Structural mechanism for regulation of DNA binding of BpsR, a Bordetella regulator of biofilm formation, by 6-hydroxynicotinic acid.

Booth WT, Davis RR, Deora R, Hollis T.

PLoS One. 2019 Nov 7;14(11):e0223387. doi: 10.1371/journal.pone.0223387. eCollection 2019.


A porcine xenograft-derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha-Gal epitope.

Bracey DN, Seyler TM, Jinnah AH, Smith TL, Ornelles DA, Deora R, Parks GD, Van Dyke ME, Whitlock PW.

Xenotransplantation. 2019 Sep;26(5):e12534. doi: 10.1111/xen.12534. Epub 2019 Jul 25.


Bordetella Colonization Factor A (BcfA) Elicits Protective Immunity against Bordetella bronchiseptica in the Absence of an Additional Adjuvant.

Yount KS, Jennings-Gee J, Caution K, Fullen AR, Corps KN, Quataert S, Deora R, Dubey P.

Infect Immun. 2019 Sep 19;87(10). pii: e00506-19. doi: 10.1128/IAI.00506-19. Print 2019 Oct.


Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice.

Caution K, Yount K, Deora R, Dubey P.

J Vis Exp. 2019 Feb 22;(144). doi: 10.3791/58930.


Structural Analysis of Bordetella pertussis Biofilms by Confocal Laser Scanning Microscopy

Cattelan N, Yantorno OM, Deora R.

Bio Protoc. 2018 Aug 5;8(15). pii: e2953. doi: 10.21769/BioProtoc.2953. No abstract available.


PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL.

PLoS Pathog. 2018 Apr 23;14(4):e1006998. doi: 10.1371/journal.ppat.1006998. eCollection 2018 Apr.


The Transcriptional Regulator BpsR Controls the Growth of Bordetella bronchiseptica by Repressing Genes Involved in Nicotinic Acid Degradation.

Guragain M, Jennings-Gee J, Cattelan N, Finger M, Conover MS, Hollis T, Deora R.

J Bacteriol. 2018 May 24;200(12). pii: e00712-17. doi: 10.1128/JB.00712-17. Print 2018 Jun 15.


The Adjuvant Bordetella Colonization Factor A Attenuates Alum-Induced Th2 Responses and Enhances Bordetella pertussis Clearance from Mouse Lungs.

Jennings-Gee J, Quataert S, Ganguly T, D'Agostino R Jr, Deora R, Dubey P.

Infect Immun. 2018 May 22;86(6). pii: e00935-17. doi: 10.1128/IAI.00935-17. Print 2018 Jun.


Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.

Dorji D, Mooi F, Yantorno O, Deora R, Graham RM, Mukkur TK.

Med Microbiol Immunol. 2018 Feb;207(1):3-26. doi: 10.1007/s00430-017-0524-z. Epub 2017 Nov 21. Review.


Hyperbiofilm Formation by Bordetella pertussis Strains Correlates with Enhanced Virulence Traits.

Cattelan N, Jennings-Gee J, Dubey P, Yantorno OM, Deora R.

Infect Immun. 2017 Nov 17;85(12). pii: e00373-17. doi: 10.1128/IAI.00373-17. Print 2017 Dec.


The Bordetella Bps Polysaccharide Is Required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine.

Nicholson TL, Brockmeier SL, Sukumar N, Paharik AE, Lister JL, Horswill AR, Kehrli ME Jr, Loving CL, Shore SM, Deora R.

Infect Immun. 2017 Jul 19;85(8). pii: e00261-17. doi: 10.1128/IAI.00261-17. Print 2017 Aug.


Erratum for Carbonetti et al., "Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development".

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00071-17. doi: 10.1128/CVI.00071-17. Print 2017 May. No abstract available.


Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development.

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME.

Clin Vaccine Immunol. 2016 Nov 4;23(11):842-850. Print 2016 Nov. Erratum in: Clin Vaccine Immunol. 2017 May 5;24(5):.


Bordetella biofilms: a lifestyle leading to persistent infections.

Cattelan N, Dubey P, Arnal L, Yantorno OM, Deora R.

Pathog Dis. 2016 Feb;74(1):ftv108. doi: 10.1093/femspd/ftv108. Epub 2015 Nov 19. Review.


The protein BpsB is a poly-β-1,6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica.

Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, Deora R, Howell PL.

J Biol Chem. 2015 Sep 11;290(37):22827-40. doi: 10.1074/jbc.M115.672469. Epub 2015 Jul 22.


Comparative analyses of a cystic fibrosis isolate of Bordetella bronchiseptica reveal differences in important pathogenic phenotypes.

Sukumar N, Nicholson TL, Conover MS, Ganguly T, Deora R.

Infect Immun. 2014 Apr;82(4):1627-37. doi: 10.1128/IAI.01453-13. Epub 2014 Jan 27.


The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing.

Ganguly T, Johnson JB, Kock ND, Parks GD, Deora R.

Cell Microbiol. 2014 Jul;16(7):1105-18. doi: 10.1111/cmi.12264. Epub 2014 Feb 13.


D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing.

Taneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora R.

J Bacteriol. 2013 Nov;195(22):5102-11. doi: 10.1128/JB.00510-13. Epub 2013 Sep 6.


The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease.

Knight J, Deora R, Assimos DG, Holmes RP.

Urolithiasis. 2013 Jun;41(3):187-96. doi: 10.1007/s00240-013-0566-7. Epub 2013 Apr 30. Review.


Transcriptome profiling reveals stage-specific production and requirement of flagella during biofilm development in Bordetella bronchiseptica.

Nicholson TL, Conover MS, Deora R.

PLoS One. 2012;7(11):e49166. doi: 10.1371/journal.pone.0049166. Epub 2012 Nov 12.


Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines.

Tang S, Mishra M, Frazier DP, Moore ML, Inoue K, Deora R, Sui G, Dubey P.

PLoS One. 2012;7(4):e35570. doi: 10.1371/journal.pone.0035570. Epub 2012 Apr 19.


FHA-mediated cell-substrate and cell-cell adhesions are critical for Bordetella pertussis biofilm formation on abiotic surfaces and in the mouse nose and the trachea.

Serra DO, Conover MS, Arnal L, Sloan GP, Rodriguez ME, Yantorno OM, Deora R.

PLoS One. 2011;6(12):e28811. doi: 10.1371/journal.pone.0028811. Epub 2011 Dec 22.


Bordetella bronchiseptica in a paediatric cystic fibrosis patient: possible transmission from a household cat.

Register KB, Sukumar N, Palavecino EL, Rubin BK, Deora R.

Zoonoses Public Health. 2012 Jun;59(4):246-50. doi: 10.1111/j.1863-2378.2011.01446.x. Epub 2012 Jan 2.


BpsR modulates Bordetella biofilm formation by negatively regulating the expression of the Bps polysaccharide.

Conover MS, Redfern CJ, Ganguly T, Sukumar N, Sloan G, Mishra M, Deora R.

J Bacteriol. 2012 Jan;194(2):233-42. doi: 10.1128/JB.06020-11. Epub 2011 Nov 4.


Extracellular DNA is essential for maintaining Bordetella biofilm integrity on abiotic surfaces and in the upper respiratory tract of mice.

Conover MS, Mishra M, Deora R.

PLoS One. 2011 Feb 11;6(2):e16861. doi: 10.1371/journal.pone.0016861.


AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.

Waligora EA, Ramsey DM, Pryor EE Jr, Lu H, Hollis T, Sloan GP, Deora R, Wozniak DJ.

J Bacteriol. 2010 Oct;192(20):5390-401. doi: 10.1128/JB.00711-10. Epub 2010 Aug 13.


The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin.

Conover MS, Sloan GP, Love CF, Sukumar N, Deora R.

Mol Microbiol. 2010 Sep;77(6):1439-55. doi: 10.1111/j.1365-2958.2010.07297.x. Epub 2010 Jul 30.


Cross-species protection mediated by a Bordetella bronchiseptica strain lacking antigenic homologs present in acellular pertussis vaccines.

Sukumar N, Sloan GP, Conover MS, Love CF, Mattoo S, Kock ND, Deora R.

Infect Immun. 2010 May;78(5):2008-16. doi: 10.1128/IAI.01142-09. Epub 2010 Feb 22.


Active and passive immunizations with Bordetella colonization factor A protect mice against respiratory challenge with Bordetella bronchiseptica.

Sukumar N, Love CF, Conover MS, Kock ND, Dubey P, Deora R.

Infect Immun. 2009 Feb;77(2):885-95. doi: 10.1128/IAI.01076-08. Epub 2008 Dec 8.


The Bordetella Bps polysaccharide is critical for biofilm development in the mouse respiratory tract.

Sloan GP, Love CF, Sukumar N, Mishra M, Deora R.

J Bacteriol. 2007 Nov;189(22):8270-6. Epub 2007 Jun 22.


Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues.

Huigens RW 3rd, Richards JJ, Parise G, Ballard TE, Zeng W, Deora R, Melander C.

J Am Chem Soc. 2007 Jun 6;129(22):6966-7. Epub 2007 May 15. No abstract available.


Differential Bvg phase-dependent regulation and combinatorial role in pathogenesis of two Bordetella paralogs, BipA and BcfA.

Sukumar N, Mishra M, Sloan GP, Ogi T, Deora R.

J Bacteriol. 2007 May;189(10):3695-704. Epub 2007 Mar 9.


Role of a putative polysaccharide locus in Bordetella biofilm development.

Parise G, Mishra M, Itoh Y, Romeo T, Deora R.

J Bacteriol. 2007 Feb;189(3):750-60. Epub 2006 Nov 17.


Bordetella bronchiseptica flagellin is a proinflammatory determinant for airway epithelial cells.

López-Boado YS, Cobb LM, Deora R.

Infect Immun. 2005 Nov;73(11):7525-34.


The BvgAS signal transduction system regulates biofilm development in Bordetella.

Mishra M, Parise G, Jackson KD, Wozniak DJ, Deora R.

J Bacteriol. 2005 Feb;187(4):1474-84.


Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements.

Doulatov S, Hodes A, Dai L, Mandhana N, Liu M, Deora R, Simons RW, Zimmerly S, Miller JF.

Nature. 2004 Sep 23;431(7007):476-81.


A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.

Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14180-5. Epub 2004 Sep 16.


Multiple mechanisms of bipA gene regulation by the Bordetella BvgAS phosphorelay system.

Deora R.

Trends Microbiol. 2004 Feb;12(2):63-5. No abstract available.


Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.

Liu M, Deora R, Doulatov SR, Gingery M, Eiserling FA, Preston A, Maskell DJ, Simons RW, Cotter PA, Parkhill J, Miller JF.

Science. 2002 Mar 15;295(5562):2091-4.


Diversity in the Bordetella virulence regulon: transcriptional control of a Bvg-intermediate phase gene.

Deora R, Bootsma HJ, Miller JF, Cotter PA.

Mol Microbiol. 2001 May;40(3):669-83.


ZntR is an autoregulatory protein and negatively regulates the chromosomal zinc resistance operon znt of Staphylococcus aureus.

Singh VK, Xiong A, Usgaard TR, Chakrabarti S, Deora R, Misra TK, Jayaswal RK.

Mol Microbiol. 1999 Jul;33(1):200-7.


Characterization of the primary sigma factor of Staphylococcus aureus.

Deora R, Misra TK.

J Biol Chem. 1996 Sep 6;271(36):21828-34.


Purification and characterization of DNA dependent RNA polymerase from Staphylococcus aureus.

Deora R, Misra TK.

Biochem Biophys Res Commun. 1995 Mar 17;208(2):610-6.


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