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Items: 1 to 50 of 166

1.

PGC-1a integrates a metabolism and growth network linked to caloric restriction.

Miller KN, Clark JP, Martin SA, Howell PR, Burhans MS, Haws SA, Johnson NB, Rhoads TW, Pavelec DM, Eliceiri KW, Roopra AS, Ntambi JM, Denu JM, Parks BW, Anderson RM.

Aging Cell. 2019 Jul 3:e12999. doi: 10.1111/acel.12999. [Epub ahead of print]

2.

Site-Specific Lysine Acetylation Stoichiometry Across Subcellular Compartments.

Lindahl AJ, Lawton AJ, Baeza J, Dowell JA, Denu JM.

Methods Mol Biol. 2019;1983:79-106. doi: 10.1007/978-1-4939-9434-2_6.

PMID:
31087294
3.

Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System.

Lozano GL, Park HB, Bravo JI, Armstrong EA, Denu JM, Stabb EV, Broderick NA, Crawford JM, Handelsman J.

Appl Environ Microbiol. 2019 May 2;85(10). pii: e03058-18. doi: 10.1128/AEM.03058-18. Print 2019 May 15.

4.

Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells.

Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ.

J Biol Chem. 2019 Mar 22;294(12):4656-4666. doi: 10.1074/jbc.RA118.006085. Epub 2019 Jan 30.

PMID:
30700550
5.

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model.

Kasahara K, Krautkramer KA, Org E, Romano KA, Kerby RL, Vivas EI, Mehrabian M, Denu JM, Bäckhed F, Lusis AJ, Rey FE.

Nat Microbiol. 2018 Dec;3(12):1461-1471. doi: 10.1038/s41564-018-0272-x. Epub 2018 Nov 5.

6.

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM.

Mol Cell. 2018 Sep 6;71(5):718-732.e9. doi: 10.1016/j.molcel.2018.07.031.

PMID:
30193097
7.

EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.

Yang Z, Qian S, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J, Zhong X.

Nat Genet. 2018 Sep;50(9):1247-1253. doi: 10.1038/s41588-018-0187-8. Epub 2018 Aug 6.

8.

Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity.

Zhang XS, Li J, Krautkramer KA, Badri M, Battaglia T, Borbet TC, Koh H, Ng S, Sibley RA, Li Y, Pathmasiri W, Jindal S, Shields-Cutler RR, Hillmann B, Al-Ghalith GA, Ruiz VE, Livanos A, van 't Wout AB, Nagalingam N, Rogers AB, Sumner SJ, Knights D, Denu JM, Li H, Ruggles KV, Bonneau R, Williamson RA, Rauch M, Blaser MJ.

Elife. 2018 Jul 25;7. pii: e37816. doi: 10.7554/eLife.37816.

9.

Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.

Qian S, Lv X, Scheid RN, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X, Du J.

Nat Commun. 2018 Jun 21;9(1):2425. doi: 10.1038/s41467-018-04836-y.

10.

General method for rapid purification of native chromatin fragments.

Kuznetsov VI, Haws SA, Fox CA, Denu JM.

J Biol Chem. 2018 Aug 3;293(31):12271-12282. doi: 10.1074/jbc.RA118.002984. Epub 2018 May 24.

PMID:
29794135
11.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R.

Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19.

12.

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.

Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM.

Cell Metab. 2018 Mar 6;27(3):677-688.e5. doi: 10.1016/j.cmet.2018.01.014.

13.

Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development.

Lee JH, Yang B, Lindahl AJ, Damaschke N, Boersma MD, Huang W, Corey E, Jarrard DF, Denu JM.

ACS Chem Biol. 2017 Nov 17;12(11):2804-2814. doi: 10.1021/acschembio.6b01035. Epub 2017 Oct 11.

14.

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.

Krautkramer KA, Dhillon RS, Denu JM, Carey HV.

Transl Res. 2017 Nov;189:30-50. doi: 10.1016/j.trsl.2017.08.005. Epub 2017 Sep 1. Review.

15.

Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?

Krautkramer KA, Rey FE, Denu JM.

J Biol Chem. 2017 May 26;292(21):8582-8593. doi: 10.1074/jbc.R116.761577. Epub 2017 Apr 7. Review.

16.

Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.

Deota S, Chattopadhyay T, Ramachandran D, Armstrong E, Camacho B, Maniyadath B, Fulzele A, Gonzalez-de-Peredo A, Denu JM, Kolthur-Seetharam U.

Cell Rep. 2017 Mar 28;18(13):3069-3077. doi: 10.1016/j.celrep.2017.03.012.

17.

Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy.

Sanders D, Qian S, Fieweger R, Lu L, Dowell JA, Denu JM, Zhong X.

Plant Physiol. 2017 Apr;173(4):2243-2252. doi: 10.1104/pp.16.01499. Epub 2017 Feb 15.

18.

Using comparative biology to understand how aging affects mitochondrial metabolism.

Dhillon RS, Denu JM.

Mol Cell Endocrinol. 2017 Nov 5;455:54-61. doi: 10.1016/j.mce.2016.12.020. Epub 2016 Dec 23. Review.

PMID:
28025033
19.

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues.

Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, Keller MP, Attie AD, Rey FE, Denu JM.

Mol Cell. 2016 Dec 1;64(5):982-992. doi: 10.1016/j.molcel.2016.10.025. Epub 2016 Nov 23.

20.

Reader domain specificity and lysine demethylase-4 family function.

Su Z, Wang F, Lee JH, Stephens KE, Papazyan R, Voronina E, Krautkramer KA, Raman A, Thorpe JJ, Boersma MD, Kuznetsov VI, Miller MD, Taverna SD, Phillips GN Jr, Denu JM.

Nat Commun. 2016 Nov 14;7:13387. doi: 10.1038/ncomms13387.

21.

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.

Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS, Aguirre-Ghiso JA, Castracane J, Denu JM, Keely PJ.

EBioMedicine. 2016 Nov;13:146-156. doi: 10.1016/j.ebiom.2016.10.012. Epub 2016 Oct 8.

22.

Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis.

Rensvold JW, Krautkramer KA, Dowell JA, Denu JM, Pagliarini DJ.

J Biol Chem. 2016 Sep 30;291(40):20827-20837. Epub 2016 Aug 5.

23.

Investigating Histone Acetylation Stoichiometry and Turnover Rate.

Fan J, Baeza J, Denu JM.

Methods Enzymol. 2016;574:125-148. doi: 10.1016/bs.mie.2016.01.007. Epub 2016 Mar 2.

PMID:
27423860
24.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ.

Diabetes. 2016 Sep;65(9):2700-10. doi: 10.2337/db16-0432. Epub 2016 Jun 9.

25.

Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation.

Hullinger R, Li M, Wang J, Peng Y, Dowell JA, Bomba-Warczak E, Mitchell HA, Burger C, Chapman ER, Denu JM, Li L, Puglielli L.

J Exp Med. 2016 Jun 27;213(7):1267-84. doi: 10.1084/jem.20151776. Epub 2016 May 30.

26.

A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics.

Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA.

Mol Cell Proteomics. 2016 Jul;15(7):2462-75. doi: 10.1074/mcp.O115.049627. Epub 2016 Apr 25.

27.

Mechanisms and Dynamics of Protein Acetylation in Mitochondria.

Baeza J, Smallegan MJ, Denu JM.

Trends Biochem Sci. 2016 Mar;41(3):231-244. doi: 10.1016/j.tibs.2015.12.006. Epub 2016 Jan 25. Review.

28.

Reading the Combinatorial Histone Language.

Su Z, Denu JM.

ACS Chem Biol. 2016 Mar 18;11(3):564-74. doi: 10.1021/acschembio.5b00864. Epub 2015 Dec 21. Review.

PMID:
26675328
29.

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.

Yu W, Denu RA, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM.

J Biol Chem. 2016 Feb 12;291(7):3268-79. doi: 10.1074/jbc.M115.702076. Epub 2015 Dec 2.

30.

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R.

Cell Rep. 2015 Oct 20;13(3):479-488. doi: 10.1016/j.celrep.2015.09.022. Epub 2015 Oct 8.

31.

MARCC (Matrix-Assisted Reader Chromatin Capture): An Antibody-Free Method to Enrich and Analyze Combinatorial Nucleosome Modifications.

Su Z, Denu JM.

Curr Protoc Mol Biol. 2015 Jul 1;111:21.32.1-21. doi: 10.1002/0471142727.mb2132s111.

32.

Quantification of SAHA-Dependent Changes in Histone Modifications Using Data-Independent Acquisition Mass Spectrometry.

Krautkramer KA, Reiter L, Denu JM, Dowell JA.

J Proteome Res. 2015 Aug 7;14(8):3252-62. doi: 10.1021/acs.jproteome.5b00245. Epub 2015 Jul 13.

33.

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Feldman JL, Dittenhafer-Reed KE, Kudo N, Thelen JN, Ito A, Yoshida M, Denu JM.

Biochemistry. 2015 May 19;54(19):3037-3050. doi: 10.1021/acs.biochem.5b00150. Epub 2015 May 4.

34.

SIRT3 mediates multi-tissue coupling for metabolic fuel switching.

Dittenhafer-Reed KE, Richards AL, Fan J, Smallegan MJ, Fotuhi Siahpirani A, Kemmerer ZA, Prolla TA, Roy S, Coon JJ, Denu JM.

Cell Metab. 2015 Apr 7;21(4):637-46. doi: 10.1016/j.cmet.2015.03.007.

35.

Metabolic regulation of histone post-translational modifications.

Fan J, Krautkramer KA, Feldman JL, Denu JM.

ACS Chem Biol. 2015 Jan 16;10(1):95-108. doi: 10.1021/cb500846u. Review.

36.

Site-specific reactivity of nonenzymatic lysine acetylation.

Baeza J, Smallegan MJ, Denu JM.

ACS Chem Biol. 2015 Jan 16;10(1):122-8. doi: 10.1021/cb500848p.

37.

Stoichiometry of site-specific lysine acetylation in an entire proteome.

Baeza J, Dowell JA, Smallegan MJ, Fan J, Amador-Noguez D, Khan Z, Denu JM.

J Biol Chem. 2014 Aug 1;289(31):21326-38. doi: 10.1074/jbc.M114.581843. Epub 2014 Jun 10.

38.

ChIP-less analysis of chromatin states.

Su Z, Boersma MD, Lee JH, Oliver SS, Liu S, Garcia BA, Denu JM.

Epigenetics Chromatin. 2014 Apr 24;7:7. doi: 10.1186/1756-8935-7-7. eCollection 2014.

39.

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD.

Cancer Discov. 2014 May;4(5):564-77. doi: 10.1158/2159-8290.CD-13-0419. Epub 2014 Feb 17.

40.

NAD+ deficiency in age-related mitochondrial dysfunction.

Prolla TA, Denu JM.

Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.

41.

Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.

Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P.

J Biol Chem. 2014 Feb 28;289(9):6091-7. doi: 10.1074/jbc.M113.537191. Epub 2014 Jan 14.

42.

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

Feldman JL, Baeza J, Denu JM.

J Biol Chem. 2013 Oct 25;288(43):31350-6. doi: 10.1074/jbc.C113.511261. Epub 2013 Sep 18.

43.

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.

Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J.

Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19.

44.

Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.

Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.

J Biol Chem. 2013 Sep 6;288(36):26209-19. doi: 10.1074/jbc.M113.483396. Epub 2013 Jul 17.

45.

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.

Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X.

J Clin Invest. 2013 Jul;123(7):3084-98. doi: 10.1172/JCI64401. Epub 2013 Jun 17.

46.

The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation.

Wickert LE, Blanchette JB, Waldschmidt NV, Bertics PJ, Denu JM, Denlinger LC, Lenertz LY.

PLoS One. 2013 May 14;8(5):e63789. doi: 10.1371/journal.pone.0063789. Print 2013.

47.

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.

Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.

Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29.

48.

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P.

Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8.

49.

Sirtuin catalysis and regulation.

Feldman JL, Dittenhafer-Reed KE, Denu JM.

J Biol Chem. 2012 Dec 14;287(51):42419-27. doi: 10.1074/jbc.R112.378877. Epub 2012 Oct 18. Review.

50.

Minireview series on sirtuins: from biochemistry to health and disease.

Denu JM, Gottesfeld JM.

J Biol Chem. 2012 Dec 14;287(51):42417-8. doi: 10.1074/jbc.R112.428862. Epub 2012 Oct 18. No abstract available.

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