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Items: 1 to 50 of 210

1.

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art.

Beddoe RH, Sneddon HF, Denton RM.

Org Biomol Chem. 2018 Oct 31;16(42):7774-7781. doi: 10.1039/c8ob01929k. Review.

PMID:
30306184
2.

A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.

Andrews KG, Faizova R, Denton RM.

Nat Commun. 2017 Jun 26;8:15913. doi: 10.1038/ncomms15913.

3.

A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants.

Andrews KG, Denton RM.

Chem Commun (Camb). 2017 Jul 13;53(57):7982-7985. doi: 10.1039/c7cc03076b.

PMID:
28537280
4.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Denton RM, Pullen TJ, Armstrong CT, Heesom KJ, Rutter GA.

Biochem J. 2016 May 1;473(9):1165-78. doi: 10.1042/BCJ20160135. Epub 2016 Mar 2.

5.

Synthesis of quaternary aryl phosphonium salts: photoredox-mediated phosphine arylation.

Fearnley AF, An J, Jackson M, Lindovska P, Denton RM.

Chem Commun (Camb). 2016 Apr 11;52(28):4987-90. doi: 10.1039/c6cc00556j. Epub 2016 Feb 22.

PMID:
26898992
6.

Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions.

Saska J, Lewis W, Paton RS, Denton RM.

Chem Sci. 2016 Dec 11;7(12):7040-7049. doi: 10.1039/c6sc03012b. Epub 2016 Aug 2.

7.

Catalytic reductive N-alkylation of amines using carboxylic acids.

Andrews KG, Summers DM, Donnelly LJ, Denton RM.

Chem Commun (Camb). 2016 Jan 31;52(9):1855-8. doi: 10.1039/c5cc08881j.

PMID:
26669845
8.

The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions.

An J, Denton RM, Lambert TH, Nacsa ED.

Org Biomol Chem. 2014 May 21;12(19):2993-3003. doi: 10.1039/c4ob00032c.

PMID:
24699913
9.

Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.

Armstrong CT, Anderson JL, Denton RM.

Biochem J. 2014 Apr 15;459(2):369-81. doi: 10.1042/BJ20131664.

PMID:
24495017
10.

A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core.

Denton RM, Scragg JT.

Org Biomol Chem. 2012 Aug 7;10(29):5629-35. doi: 10.1039/c2ob25489a. Epub 2012 Jun 21.

PMID:
22717521
11.

Cell biology. Pyro-technic control of metabolism.

Irvine RF, Denton RM.

Science. 2011 Nov 11;334(6057):770-1. doi: 10.1126/science.1214727. No abstract available.

PMID:
22076369
12.

Catalytic phosphorus(V)-mediated nucleophilic substitution reactions: development of a catalytic Appel reaction.

Denton RM, An J, Adeniran B, Blake AJ, Lewis W, Poulton AM.

J Org Chem. 2011 Aug 19;76(16):6749-67. doi: 10.1021/jo201085r. Epub 2011 Jul 28.

PMID:
21744876
13.

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme.

Lupo G, Gestri G, O'Brien M, Denton RM, Chandraratna RA, Ley SV, Harris WA, Wilson SW.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8698-703. doi: 10.1073/pnas.1103802108. Epub 2011 May 9.

14.

Catalysis of phosphorus(V)-mediated transformations: dichlorination reactions of epoxides under Appel conditions.

Denton RM, Tang X, Przeslak A.

Org Lett. 2010 Oct 15;12(20):4678-81. doi: 10.1021/ol102010h.

PMID:
20845932
15.

Phosphine oxide-catalysed chlorination reactions of alcohols under Appel conditions.

Denton RM, An J, Adeniran B.

Chem Commun (Camb). 2010 May 7;46(17):3025-7. doi: 10.1039/c002825h. Epub 2010 Mar 26.

PMID:
20386856
16.

Total synthesis of atrochamins F, H, I, and J through cascade reactions.

Nicolaou KC, Lister T, Denton RM, Gelin CF.

Tetrahedron. 2008 May 19;64(21):4736-4757.

17.

Regulation of mitochondrial dehydrogenases by calcium ions.

Denton RM.

Biochim Biophys Acta. 2009 Nov;1787(11):1309-16. doi: 10.1016/j.bbabio.2009.01.005. Epub 2009 Jan 20. Review.

18.

The synthesis of azadirachtin: a potent insect antifeedant.

Ley SV, Abad-Somovilla A, Anderson JC, Ayats C, Bänteli R, Beckmann E, Boyer A, Brasca MG, Brice A, Broughton HB, Burke BJ, Cleator E, Craig D, Denholm AA, Denton RM, Durand-Reville T, Gobbi LB, Göbel M, Gray BL, Grossmann RB, Gutteridge CE, Hahn N, Harding SL, Jennens DC, Jennens L, Lovell PJ, Lovell HJ, de la Puente ML, Kolb HC, Koot WJ, Maslen SL, McCusker CF, Mattes A, Pape AR, Pinto A, Santafianos D, Scott JS, Smith SC, Somers AQ, Spilling CD, Stelzer F, Toogood PL, Turner RM, Veitch GE, Wood A, Zumbrunn C.

Chemistry. 2008;14(34):10683-704. doi: 10.1002/chem.200801103.

PMID:
18821532
19.

Asymmetric synthesis of 6'-hydroxyarenarol: the proposed biosynthetic precursor to popolohuanone E.

Munday RH, Denton RM, Anderson JC.

J Org Chem. 2008 Oct 17;73(20):8033-8. doi: 10.1021/jo801404u. Epub 2008 Sep 18.

PMID:
18798670
20.

Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.

Nicolaou KC, Stepan AF, Lister T, Li A, Montero A, Tria GS, Turner CI, Tang Y, Wang J, Denton RM, Edmonds DJ.

J Am Chem Soc. 2008 Oct 1;130(39):13110-9. doi: 10.1021/ja8044376. Epub 2008 Sep 5.

21.

Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin.

Nicolaou KC, Frederick MO, Burtoloso AC, Denton RM, Rivas F, Cole KP, Aversa RJ, Gibe R, Umezawa T, Suzuki T.

J Am Chem Soc. 2008 Jun 11;130(23):7466-76. doi: 10.1021/ja801139f. Epub 2008 May 16.

PMID:
18481856
22.

Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin.

Nicolaou KC, Cole KP, Frederick MO, Aversa RJ, Denton RM.

Angew Chem Int Ed Engl. 2007;46(46):8875-9. No abstract available.

PMID:
17943950
23.

Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J.

Nicolaou KC, Lister T, Denton RM, Gelin CF.

Angew Chem Int Ed Engl. 2007;46(39):7501-5. No abstract available.

PMID:
17768746
24.

Adamantaplatensimycin: a bioactive analogue of platensimycin.

Nicolaou KC, Lister T, Denton RM, Montero A, Edmonds DJ.

Angew Chem Int Ed Engl. 2007;46(25):4712-4. No abstract available.

PMID:
17514775
25.

A tribute to the life and work of Philip Randle.

Denton RM, Ashcroft SJ.

Diabetologia. 2007 Jul;50(7):1359-61. No abstract available.

PMID:
17473914
26.

Stereocontrolled synthesis of model core systems of lomaiviticins A and B.

Nicolaou KC, Denton RM, Lenzen A, Edmonds DJ, Li A, Milburn RR, Harrison ST.

Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2076-81. No abstract available.

PMID:
16496276
27.

A biomimetic strategy for the synthesis of the tricyclic dibenzofuran-1,4-dione core of popolohuanone E.

Anderson JC, Denton RM, Wilson C.

Org Lett. 2005 Jan 6;7(1):123-5.

PMID:
15624993
28.
29.
30.

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1).

Heesom KJ, Gampel A, Mellor H, Denton RM.

Curr Biol. 2001 Sep 4;11(17):1374-9.

33.
34.

Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes.

Diggle TA, Redpath NT, Heesom KJ, Denton RM.

Biochem J. 1998 Dec 15;336 ( Pt 3):525-9.

36.

Integrating cytosolic calcium signals into mitochondrial metabolic responses.

Robb-Gaspers LD, Burnett P, Rutter GA, Denton RM, Rizzuto R, Thomas AP.

EMBO J. 1998 Sep 1;17(17):4987-5000.

37.

Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism.

Robb-Gaspers LD, Rutter GA, Burnett P, Hajnóczky G, Denton RM, Thomas AP.

Biochim Biophys Acta. 1998 Aug 10;1366(1-2):17-32.

38.
39.

Signalling pathways involved in the stimulation of fatty acid synthesis by insulin.

Denton RM, Heesom KJ, Moule SK, Edgell NJ, Burnett P.

Biochem Soc Trans. 1997 Nov;25(4):1238-42. Review. No abstract available.

PMID:
9449983
40.

Heat shock increases the association of binding protein-1 with initiation factor 4E.

Vries RG, Flynn A, Patel JC, Wang X, Denton RM, Proud CG.

J Biol Chem. 1997 Dec 26;272(52):32779-84.

41.

Molecular mechanisms for the control of translation by insulin.

Proud CG, Denton RM.

Biochem J. 1997 Dec 1;328 ( Pt 2):329-41. Review.

42.

Insulin action on metabolism.

Heesom KJ, Harbeck M, Kahn CR, Denton RM.

Diabetologia. 1997 Oct;40 Suppl 3:B3-9. No abstract available.

PMID:
9345638
43.

Multiple signaling pathways involved in the metabolic effects of insulin.

Moule SK, Denton RM.

Am J Cardiol. 1997 Aug 4;80(3A):41A-49A. Review.

PMID:
9293955
45.
46.

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

Rutter GA, Burnett P, Rizzuto R, Brini M, Murgia M, Pozzan T, Tavaré JM, Denton RM.

Proc Natl Acad Sci U S A. 1996 May 28;93(11):5489-94.

47.

Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.

Gilligan M, Welsh GI, Flynn A, Bujalska I, Diggle TA, Denton RM, Proud CG, Docherty K.

J Biol Chem. 1996 Jan 26;271(4):2121-5.

48.

The hormonal regulation of pyruvate dehydrogenase complex.

Denton RM, McCormack JG, Rutter GA, Burnett P, Edgell NJ, Moule SK, Diggle TA.

Adv Enzyme Regul. 1996;36:183-98.

PMID:
8869747
49.

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

Moule SK, Edgell NJ, Welsh GI, Diggle TA, Foulstone EJ, Heesom KJ, Proud CG, Denton RM.

Biochem J. 1995 Oct 15;311 ( Pt 2):595-601.

50.

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