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Items: 1 to 50 of 347

1.

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art.

Beddoe RH, Sneddon HF, Denton RM.

Org Biomol Chem. 2018 Oct 31;16(42):7774-7781. doi: 10.1039/c8ob01929k. Review.

PMID:
30306184
2.

Genome-specific histories of divergence and introgression between an allopolyploid unisexual salamander lineage and two ancestral sexual species.

Denton RD, Morales AE, Gibbs HL.

Evolution. 2018 Jun 21. doi: 10.1111/evo.13528. [Epub ahead of print]

PMID:
29926914
3.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, Gupta GVRKM, Kamble M, Mannoori R, Cheruku S, Jogi S, Gulia J, Bastia T, Sanmathi C, Aher J, Kallem R, Srikumar BN, Vijaya KK, Naidu PS, Paschapur M, Kalidindi N, Vikramadithyan R, Ramarao M, Denton R, Molski T, Shields E, Subramanian M, Zhuo X, Nophsker M, Simmermacher J, Sinz M, Albright C, Bristow LJ, Islam I, Bronson JJ, Olson RE, King D, Thompson LA, Macor JE.

ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. doi: 10.1021/acsmedchemlett.8b00080. eCollection 2018 May 10.

PMID:
29795762
4.

A pheromone by any other gene would smell as sweet.

Pelletier TA, Denton RD.

Mol Ecol. 2018 Jan;27(2):311-312. doi: 10.1111/mec.14412.

PMID:
29561075
5.

A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.

Andrews KG, Faizova R, Denton RM.

Nat Commun. 2017 Jun 26;8:15913. doi: 10.1038/ncomms15913.

6.

A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants.

Andrews KG, Denton RM.

Chem Commun (Camb). 2017 Jul 13;53(57):7982-7985. doi: 10.1039/c7cc03076b.

PMID:
28537280
7.

Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs.

Abraham MM, Denton RE, Harper RW, Scott WL, O'Donnell MJ, Durrant JD.

Chem Biol Drug Des. 2017 Nov;90(5):909-918. doi: 10.1111/cbdd.13012. Epub 2017 Jun 12.

8.

Genome expression balance in a triploid trihybrid vertebrate.

McElroy KE, Denton RD, Sharbrough J, Bankers L, Neiman M, Lisle Gibbs H.

Genome Biol Evol. 2017 Mar 22. doi: 10.1093/gbe/evx059. [Epub ahead of print]

9.

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.

King D, Iwuagwu C, Cook J, McDonald IM, Mate R, Zusi FC, Hill MD, Fang H, Zhao R, Wang B, Easton AE, Miller R, Post-Munson D, Knox RJ, Gallagher L, Westphal R, Molski T, Fan J, Clarke W, Benitex Y, Lentz KA, Denton R, Morgan D, Zaczek R, Lodge NJ, Bristow LJ, Macor JE, Olson RE.

ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. doi: 10.1021/acsmedchemlett.7b00032. eCollection 2017 Mar 9.

10.

Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.

Hill MD, Fang H, King HD, Iwuagwu CI, McDonald IM, Cook J, Zusi FC, Mate RA, Knox RJ, Post-Munson D, Easton A, Miller R, Lentz K, Clarke W, Benitex Y, Lodge N, Zaczek R, Denton R, Morgan D, Bristow L, Macor JE, Olson R.

ACS Med Chem Lett. 2016 Dec 1;8(1):133-137. doi: 10.1021/acsmedchemlett.6b00471. eCollection 2017 Jan 12.

11.

Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.

Cook J, Zusi FC, McDonald IM, King D, Hill MD, Iwuagwu C, Mate RA, Fang H, Zhao R, Wang B, Cutrone J, Ma B, Gao Q, Knox RJ, Matchett M, Gallagher L, Ferrante M, Post-Munson D, Molski T, Easton A, Miller R, Jones K, Digavalli S, Healy F, Lentz K, Benitex Y, Clarke W, Natale J, Siuciak JA, Lodge N, Zaczek R, Denton R, Morgan D, Bristow LJ, Macor JE, Olson RE.

J Med Chem. 2016 Dec 22;59(24):11171-11181. doi: 10.1021/acs.jmedchem.6b01506. Epub 2016 Dec 13.

PMID:
27958732
12.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.

13.

Nitrogen dioxide reducing ascorbic acid technologies in the ventilator circuit leads to uniform NO concentration during inspiration.

Pezone MJ, Wakim MG, Denton RJ, Gamero LG, Roscigno RF, Gilbert RJ, Lovich MA.

Nitric Oxide. 2016 Aug 31;58:42-50. doi: 10.1016/j.niox.2016.06.001. Epub 2016 Jun 2.

PMID:
27264784
14.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Toyn JH, Boy KM, Raybon J, Meredith JE Jr, Robertson AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, Grace J, Berisha F, Furlong M, Wang JS, Lentz KA, Padmanabha R, Cook L, Wei C, Drexler DM, Macor JE, Albright CF, Gasior M, Olson RE, Hong Q, Soares HD, AbuTarif M, Ahlijanian MK.

J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. doi: 10.1124/jpet.116.232249. Epub 2016 Apr 20.

15.

No safety in the trees: Local and species-level adaptation of an arboreal squirrel to the venom of sympatric rattlesnakes.

Pomento AM, Perry BW, Denton RD, Gibbs HL, Holding ML.

Toxicon. 2016 Aug;118:149-55. doi: 10.1016/j.toxicon.2016.05.003. Epub 2016 May 5.

PMID:
27158112
16.

Cryptic sex? Estimates of genome exchange in unisexual mole salamanders (Ambystoma sp.).

Gibbs HL, Denton RD.

Mol Ecol. 2016 Jun;25(12):2805-15. doi: 10.1111/mec.13662. Epub 2016 May 21.

PMID:
27100619
17.

The assessment of developmental trauma in children and adolescents: A systematic review.

Denton R, Frogley C, Jackson S, John M, Querstret D.

Clin Child Psychol Psychiatry. 2017 Apr;22(2):260-287. doi: 10.1177/1359104516631607. Epub 2016 Mar 2. Review.

PMID:
26940119
18.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Denton RM, Pullen TJ, Armstrong CT, Heesom KJ, Rutter GA.

Biochem J. 2016 May 1;473(9):1165-78. doi: 10.1042/BCJ20160135. Epub 2016 Mar 2.

19.

Synthesis of quaternary aryl phosphonium salts: photoredox-mediated phosphine arylation.

Fearnley AF, An J, Jackson M, Lindovska P, Denton RM.

Chem Commun (Camb). 2016 Apr 11;52(28):4987-90. doi: 10.1039/c6cc00556j. Epub 2016 Feb 22.

PMID:
26898992
20.

Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions.

Saska J, Lewis W, Paton RS, Denton RM.

Chem Sci. 2016 Dec 11;7(12):7040-7049. doi: 10.1039/c6sc03012b. Epub 2016 Aug 2.

21.

Catalytic reductive N-alkylation of amines using carboxylic acids.

Andrews KG, Summers DM, Donnelly LJ, Denton RM.

Chem Commun (Camb). 2016 Jan 31;52(9):1855-8. doi: 10.1039/c5cc08881j.

PMID:
26669845
22.

Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure.

Lovich MA, Pezone MJ, Wakim MG, Denton RJ, Maslov MY, Murray MR, Tsukada H, Agnihotri AK, Roscigno RF, Gamero LG, Gilbert RJ.

ASAIO J. 2015 Jul-Aug;61(4):379-85. doi: 10.1097/MAT.0000000000000211.

PMID:
25710771
23.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858. Epub 2014 Jul 8.

24.

Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes.

Tang X, Chapman C, Whiting M, Denton R.

Chem Commun (Camb). 2014 Jul 14;50(55):7340-3. doi: 10.1039/c4cc02171a.

PMID:
24871529
25.

Evolutionary basis of mitonuclear discordance between sister species of mole salamanders (Ambystoma sp.).

Denton RD, Kenyon LJ, Greenwald KR, Gibbs HL.

Mol Ecol. 2014 Jun;23(11):2811-24. doi: 10.1111/mec.12775. Epub 2014 May 17.

PMID:
24787951
26.

The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions.

An J, Denton RM, Lambert TH, Nacsa ED.

Org Biomol Chem. 2014 May 21;12(19):2993-3003. doi: 10.1039/c4ob00032c.

PMID:
24699913
27.

Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine.

Lovich MA, Fine DH, Denton RJ, Wakim MG, Wei AE, Maslov MY, Gamero LG, Vasquez GB, Johnson BJ, Roscigno RF, Gilbert RJ.

Nitric Oxide. 2014 Feb 15;37:66-72. doi: 10.1016/j.niox.2014.02.001. Epub 2014 Feb 7.

PMID:
24513304
28.

Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.

Armstrong CT, Anderson JL, Denton RM.

Biochem J. 2014 Apr 15;459(2):369-81. doi: 10.1042/BJ20131664.

PMID:
24495017
29.

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.

Chaturvedula PV, Mercer SE, Pin SS, Thalody G, Xu C, Conway CM, Keavy D, Signor L, Cantor GH, Mathias N, Moench P, Denton R, Macci R, Schartman R, Whiterock V, Davis C, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3157-61. doi: 10.1016/j.bmcl.2013.04.012. Epub 2013 Apr 12.

PMID:
23632269
30.

Halide and proton binding kinetics of yellow fluorescent protein variants.

Seward HE, Basran J, Denton R, Pfuhl M, Muskett FW, Bagshaw CR.

Biochemistry. 2013 Apr 9;52(14):2482-91. doi: 10.1021/bi3016839. Epub 2013 Apr 2.

PMID:
23514090
31.

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

Albright CF, Dockens RC, Meredith JE Jr, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE Jr, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G.

J Pharmacol Exp Ther. 2013 Mar;344(3):686-95. doi: 10.1124/jpet.112.199356. Epub 2012 Dec 28.

32.

Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R, Browning M, Tong G, Houston JG, Dubowchik GM, Macor JE.

J Med Chem. 2012 Dec 13;55(23):10644-51. doi: 10.1021/jm3013147. Epub 2012 Nov 15.

PMID:
23153230
33.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7702-6. doi: 10.1016/j.bmcl.2012.09.113. Epub 2012 Oct 23.

PMID:
23142617
34.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7707-10. doi: 10.1016/j.bmcl.2012.09.112. Epub 2012 Oct 10.

PMID:
23116889
35.

Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.

Bahl A, Barton P, Bowers K, Caffrey MV, Denton R, Gilmour P, Hawley S, Linannen T, Luckhurst CA, Mochel T, Perry MW, Riley RJ, Roe E, Springthorpe B, Stein L, Webborn P.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. doi: 10.1016/j.bmcl.2012.08.103. Epub 2012 Sep 11.

PMID:
23021991
36.

Cloning, expression and characterization of lepidopteran isopentenyl diphosphate isomerase.

Sen SE, Tomasello A, Grasso M, Denton R, Macor J, Béliveau C, Cusson M, Crowell DN.

Insect Biochem Mol Biol. 2012 Oct;42(10):739-50. doi: 10.1016/j.ibmb.2012.07.001. Epub 2012 Jul 20.

PMID:
22820710
37.

Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Britton RG, Horner-Glister E, Pomenya OA, Smith EE, Denton R, Jenkins PR, Steward WP, Brown K, Gescher A, Sale S.

Eur J Med Chem. 2012 Aug;54:952-8. doi: 10.1016/j.ejmech.2012.06.031. Epub 2012 Jun 22.

PMID:
22789812
38.

A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core.

Denton RM, Scragg JT.

Org Biomol Chem. 2012 Aug 7;10(29):5629-35. doi: 10.1039/c2ob25489a. Epub 2012 Jun 21.

PMID:
22717521
39.

The fear of others: a qualitative analysis of interpersonal threat in social phobia and paranoia.

Stopa L, Denton R, Wingfield M, Taylor KN.

Behav Cogn Psychother. 2013 Mar;41(2):188-209. doi: 10.1017/S1352465812000422. Epub 2012 Jun 13.

PMID:
22691440
40.

Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Gulianello M, Huang Y, Kostich W, Lentz KA, Mercer SE, Schartman R, Signor L, Browning M, Macor JE, Dubowchik GM.

ACS Med Chem Lett. 2012 Feb 27;3(4):337-41. doi: 10.1021/ml300021s. eCollection 2012 Apr 12.

41.

Cell biology. Pyro-technic control of metabolism.

Irvine RF, Denton RM.

Science. 2011 Nov 11;334(6057):770-1. doi: 10.1126/science.1214727. No abstract available.

PMID:
22076369
42.

Catalytic phosphorus(V)-mediated nucleophilic substitution reactions: development of a catalytic Appel reaction.

Denton RM, An J, Adeniran B, Blake AJ, Lewis W, Poulton AM.

J Org Chem. 2011 Aug 19;76(16):6749-67. doi: 10.1021/jo201085r. Epub 2011 Jul 28.

PMID:
21744876
43.

Primary care of adults with developmental disabilities: Canadian consensus guidelines.

Sullivan WF, Berg JM, Bradley E, Cheetham T, Denton R, Heng J, Hennen B, Joyce D, Kelly M, Korossy M, Lunsky Y, McMillan S; Colloquium on Guidelines for the Primary Health Care of Adults with Developmental Disabilities.

Can Fam Physician. 2011 May;57(5):541-53, e154-68. English, French.

44.

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme.

Lupo G, Gestri G, O'Brien M, Denton RM, Chandraratna RA, Ley SV, Harris WA, Wilson SW.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8698-703. doi: 10.1073/pnas.1103802108. Epub 2011 May 9.

45.

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.

Paine SW, Ménochet K, Denton R, McGinnity DF, Riley RJ.

Drug Metab Dispos. 2011 Jun;39(6):1008-13. doi: 10.1124/dmd.110.037267. Epub 2011 Feb 28.

46.

A rapid computational filter for predicting the rate of human renal clearance.

Paine SW, Barton P, Bird J, Denton R, Menochet K, Smith A, Tomkinson NP, Chohan KK.

J Mol Graph Model. 2010 Dec;29(4):529-37. doi: 10.1016/j.jmgm.2010.10.003. Epub 2010 Oct 20.

PMID:
21075652
47.

Catalysis of phosphorus(V)-mediated transformations: dichlorination reactions of epoxides under Appel conditions.

Denton RM, Tang X, Przeslak A.

Org Lett. 2010 Oct 15;12(20):4678-81. doi: 10.1021/ol102010h.

PMID:
20845932
48.

Phosphine oxide-catalysed chlorination reactions of alcohols under Appel conditions.

Denton RM, An J, Adeniran B.

Chem Commun (Camb). 2010 May 7;46(17):3025-7. doi: 10.1039/c002825h. Epub 2010 Mar 26.

PMID:
20386856
49.

Focused practices, special interests.

Denton R.

Can Fam Physician. 2010 Mar;56(3):223-4. No abstract available.

50.

Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.

Huizinga DH, Denton R, Koehler KG, Tomasello A, Wood L, Sen SE, Crowell DN.

Mol Plant. 2010 Jan;3(1):143-55. doi: 10.1093/mp/ssp091. Epub 2009 Nov 10.

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