Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 352

1.

A mid-Cretaceous tyrannosauroid and the origin of North American end-Cretaceous dinosaur assemblages.

Nesbitt SJ, Denton RK Jr, Loewen MA, Brusatte SL, Smith ND, Turner AH, Kirkland JI, McDonald AT, Wolfe DG.

Nat Ecol Evol. 2019 Jun;3(6):892-899. doi: 10.1038/s41559-019-0888-0. Epub 2019 May 6.

PMID:
31061476
2.

Structure of the Current Sheet in the 11 July 2017 Electron Diffusion Region Event.

Nakamura R, Genestreti KJ, Nakamura T, Baumjohann W, Varsani A, Nagai T, Bessho N, Burch JL, Denton RE, Eastwood JP, Ergun RE, Gershman DJ, Giles BL, Hasegawa H, Hesse M, Lindqvist PA, Russell CT, Stawarz JE, Strangeway RJ, Torbert RB.

J Geophys Res Space Phys. 2019 Feb;124(2):1173-1186. doi: 10.1029/2018JA026028. Epub 2019 Feb 27.

3.

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.

Boy KM, Guernon JM, Zuev DS, Xu L, Zhang Y, Shi J, Marcin LR, Higgins MA, Wu YJ, Krishnananthan S, Li J, Trehan A, Smith D, Toyn JH, Meredith JE, Burton CR, Kimura SR, Zvyaga T, Zhuo X, Lentz KA, Grace JE, Denton R, Morrison JS, Mathur A, Albright CF, Ahlijanian MK, Olson RE, Thompson LA, Macor JE.

ACS Med Chem Lett. 2019 Feb 17;10(3):312-317. doi: 10.1021/acsmedchemlett.8b00541. eCollection 2019 Mar 14.

4.

How Accurately Can We Measure the Reconnection Rate E M for the MMS Diffusion Region Event of 11 July 2017?

Genestreti KJ, Nakamura TKM, Nakamura R, Denton RE, Torbert RB, Burch JL, Plaschke F, Fuselier SA, Ergun RE, Giles BL, Russell CT.

J Geophys Res Space Phys. 2018 Nov;123(11):9130-9149. doi: 10.1029/2018JA025711. Epub 2018 Nov 10.

5.

Activation of the Bile Acid Pathway and No Observed Antimicrobial Peptide Sequences in the Skin of a Poison Frog.

Civitello ML, Denton R, Zasloff MA, Malone JH.

G3 (Bethesda). 2019 Feb 7;9(2):581-589. doi: 10.1534/g3.118.200880.

6.

The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art.

Beddoe RH, Sneddon HF, Denton RM.

Org Biomol Chem. 2018 Oct 31;16(42):7774-7781. doi: 10.1039/c8ob01929k. Review.

PMID:
30306184
7.

Genome-specific histories of divergence and introgression between an allopolyploid unisexual salamander lineage and two ancestral sexual species.

Denton RD, Morales AE, Gibbs HL.

Evolution. 2018 Jun 21. doi: 10.1111/evo.13528. [Epub ahead of print]

PMID:
29926914
8.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

Marcin LR, Warrier J, Thangathirupathy S, Shi J, Karageorge GN, Pearce BC, Ng A, Park H, Kempson J, Li J, Zhang H, Mathur A, Reddy AB, Nagaraju G, Tonukunuru G, Gupta GVRKM, Kamble M, Mannoori R, Cheruku S, Jogi S, Gulia J, Bastia T, Sanmathi C, Aher J, Kallem R, Srikumar BN, Vijaya KK, Naidu PS, Paschapur M, Kalidindi N, Vikramadithyan R, Ramarao M, Denton R, Molski T, Shields E, Subramanian M, Zhuo X, Nophsker M, Simmermacher J, Sinz M, Albright C, Bristow LJ, Islam I, Bronson JJ, Olson RE, King D, Thompson LA, Macor JE.

ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. doi: 10.1021/acsmedchemlett.8b00080. eCollection 2018 May 10.

9.

A pheromone by any other gene would smell as sweet.

Pelletier TA, Denton RD.

Mol Ecol. 2018 Jan;27(2):311-312. doi: 10.1111/mec.14412.

PMID:
29561075
10.

A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid.

Andrews KG, Faizova R, Denton RM.

Nat Commun. 2017 Jun 26;8:15913. doi: 10.1038/ncomms15913.

11.

A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants.

Andrews KG, Denton RM.

Chem Commun (Camb). 2017 Jul 13;53(57):7982-7985. doi: 10.1039/c7cc03076b.

PMID:
28537280
12.

Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs.

Abraham MM, Denton RE, Harper RW, Scott WL, O'Donnell MJ, Durrant JD.

Chem Biol Drug Des. 2017 Nov;90(5):909-918. doi: 10.1111/cbdd.13012. Epub 2017 Jun 12.

13.

Genome expression balance in a triploid trihybrid vertebrate.

McElroy KE, Denton RD, Sharbrough J, Bankers L, Neiman M, Lisle Gibbs H.

Genome Biol Evol. 2017 Mar 22. doi: 10.1093/gbe/evx059. [Epub ahead of print]

14.

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.

King D, Iwuagwu C, Cook J, McDonald IM, Mate R, Zusi FC, Hill MD, Fang H, Zhao R, Wang B, Easton AE, Miller R, Post-Munson D, Knox RJ, Gallagher L, Westphal R, Molski T, Fan J, Clarke W, Benitex Y, Lentz KA, Denton R, Morgan D, Zaczek R, Lodge NJ, Bristow LJ, Macor JE, Olson RE.

ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. doi: 10.1021/acsmedchemlett.7b00032. eCollection 2017 Mar 9.

15.

Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.

Hill MD, Fang H, King HD, Iwuagwu CI, McDonald IM, Cook J, Zusi FC, Mate RA, Knox RJ, Post-Munson D, Easton A, Miller R, Lentz K, Clarke W, Benitex Y, Lodge N, Zaczek R, Denton R, Morgan D, Bristow L, Macor JE, Olson R.

ACS Med Chem Lett. 2016 Dec 1;8(1):133-137. doi: 10.1021/acsmedchemlett.6b00471. eCollection 2017 Jan 12.

16.

Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.

Cook J, Zusi FC, McDonald IM, King D, Hill MD, Iwuagwu C, Mate RA, Fang H, Zhao R, Wang B, Cutrone J, Ma B, Gao Q, Knox RJ, Matchett M, Gallagher L, Ferrante M, Post-Munson D, Molski T, Easton A, Miller R, Jones K, Digavalli S, Healy F, Lentz K, Benitex Y, Clarke W, Natale J, Siuciak JA, Lodge N, Zaczek R, Denton R, Morgan D, Bristow LJ, Macor JE, Olson RE.

J Med Chem. 2016 Dec 22;59(24):11171-11181. doi: 10.1021/acs.jmedchem.6b01506. Epub 2016 Dec 13.

PMID:
27958732
17.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.

18.

Nitrogen dioxide reducing ascorbic acid technologies in the ventilator circuit leads to uniform NO concentration during inspiration.

Pezone MJ, Wakim MG, Denton RJ, Gamero LG, Roscigno RF, Gilbert RJ, Lovich MA.

Nitric Oxide. 2016 Aug 31;58:42-50. doi: 10.1016/j.niox.2016.06.001. Epub 2016 Jun 2.

PMID:
27264784
19.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Toyn JH, Boy KM, Raybon J, Meredith JE Jr, Robertson AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, Grace J, Berisha F, Furlong M, Wang JS, Lentz KA, Padmanabha R, Cook L, Wei C, Drexler DM, Macor JE, Albright CF, Gasior M, Olson RE, Hong Q, Soares HD, AbuTarif M, Ahlijanian MK.

J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. doi: 10.1124/jpet.116.232249. Epub 2016 Apr 20.

20.

No safety in the trees: Local and species-level adaptation of an arboreal squirrel to the venom of sympatric rattlesnakes.

Pomento AM, Perry BW, Denton RD, Gibbs HL, Holding ML.

Toxicon. 2016 Aug;118:149-55. doi: 10.1016/j.toxicon.2016.05.003. Epub 2016 May 5.

PMID:
27158112
21.

Cryptic sex? Estimates of genome exchange in unisexual mole salamanders (Ambystoma sp.).

Gibbs HL, Denton RD.

Mol Ecol. 2016 Jun;25(12):2805-15. doi: 10.1111/mec.13662. Epub 2016 May 21.

PMID:
27100619
22.

The assessment of developmental trauma in children and adolescents: A systematic review.

Denton R, Frogley C, Jackson S, John M, Querstret D.

Clin Child Psychol Psychiatry. 2017 Apr;22(2):260-287. doi: 10.1177/1359104516631607. Epub 2016 Mar 2. Review.

PMID:
26940119
23.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Denton RM, Pullen TJ, Armstrong CT, Heesom KJ, Rutter GA.

Biochem J. 2016 May 1;473(9):1165-78. doi: 10.1042/BCJ20160135. Epub 2016 Mar 2.

24.

Synthesis of quaternary aryl phosphonium salts: photoredox-mediated phosphine arylation.

Fearnley AF, An J, Jackson M, Lindovska P, Denton RM.

Chem Commun (Camb). 2016 Apr 11;52(28):4987-90. doi: 10.1039/c6cc00556j. Epub 2016 Feb 22.

PMID:
26898992
25.

Synthesis of malhamensilipin A exploiting iterative epoxidation/chlorination: experimental and computational analysis of epoxide-derived chloronium ions.

Saska J, Lewis W, Paton RS, Denton RM.

Chem Sci. 2016 Dec 11;7(12):7040-7049. doi: 10.1039/c6sc03012b. Epub 2016 Aug 2.

26.

Catalytic reductive N-alkylation of amines using carboxylic acids.

Andrews KG, Summers DM, Donnelly LJ, Denton RM.

Chem Commun (Camb). 2016 Jan 31;52(9):1855-8. doi: 10.1039/c5cc08881j.

PMID:
26669845
27.

Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure.

Lovich MA, Pezone MJ, Wakim MG, Denton RJ, Maslov MY, Murray MR, Tsukada H, Agnihotri AK, Roscigno RF, Gamero LG, Gilbert RJ.

ASAIO J. 2015 Jul-Aug;61(4):379-85. doi: 10.1097/MAT.0000000000000211.

PMID:
25710771
28.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858. Epub 2014 Jul 8.

29.

Development of a redox-free Mitsunobu reaction exploiting phosphine oxides as precursors to dioxyphosphoranes.

Tang X, Chapman C, Whiting M, Denton R.

Chem Commun (Camb). 2014 Jul 14;50(55):7340-3. doi: 10.1039/c4cc02171a.

PMID:
24871529
30.

Evolutionary basis of mitonuclear discordance between sister species of mole salamanders (Ambystoma sp.).

Denton RD, Kenyon LJ, Greenwald KR, Gibbs HL.

Mol Ecol. 2014 Jun;23(11):2811-24. doi: 10.1111/mec.12775. Epub 2014 May 17.

PMID:
24787951
31.

The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions.

An J, Denton RM, Lambert TH, Nacsa ED.

Org Biomol Chem. 2014 May 21;12(19):2993-3003. doi: 10.1039/c4ob00032c.

PMID:
24699913
32.

Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine.

Lovich MA, Fine DH, Denton RJ, Wakim MG, Wei AE, Maslov MY, Gamero LG, Vasquez GB, Johnson BJ, Roscigno RF, Gilbert RJ.

Nitric Oxide. 2014 Feb 15;37:66-72. doi: 10.1016/j.niox.2014.02.001. Epub 2014 Feb 7.

PMID:
24513304
33.

Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.

Armstrong CT, Anderson JL, Denton RM.

Biochem J. 2014 Apr 15;459(2):369-81. doi: 10.1042/BJ20131664.

PMID:
24495017
34.

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.

Chaturvedula PV, Mercer SE, Pin SS, Thalody G, Xu C, Conway CM, Keavy D, Signor L, Cantor GH, Mathias N, Moench P, Denton R, Macci R, Schartman R, Whiterock V, Davis C, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3157-61. doi: 10.1016/j.bmcl.2013.04.012. Epub 2013 Apr 12.

PMID:
23632269
35.

Halide and proton binding kinetics of yellow fluorescent protein variants.

Seward HE, Basran J, Denton R, Pfuhl M, Muskett FW, Bagshaw CR.

Biochemistry. 2013 Apr 9;52(14):2482-91. doi: 10.1021/bi3016839. Epub 2013 Apr 2.

PMID:
23514090
36.

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

Albright CF, Dockens RC, Meredith JE Jr, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE Jr, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G.

J Pharmacol Exp Ther. 2013 Mar;344(3):686-95. doi: 10.1124/jpet.112.199356. Epub 2012 Dec 28.

PMID:
23275065
37.

Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R, Browning M, Tong G, Houston JG, Dubowchik GM, Macor JE.

J Med Chem. 2012 Dec 13;55(23):10644-51. doi: 10.1021/jm3013147. Epub 2012 Nov 15.

PMID:
23153230
38.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7702-6. doi: 10.1016/j.bmcl.2012.09.113. Epub 2012 Oct 23.

PMID:
23142617
39.

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7707-10. doi: 10.1016/j.bmcl.2012.09.112. Epub 2012 Oct 10.

PMID:
23116889
40.

Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.

Bahl A, Barton P, Bowers K, Caffrey MV, Denton R, Gilmour P, Hawley S, Linannen T, Luckhurst CA, Mochel T, Perry MW, Riley RJ, Roe E, Springthorpe B, Stein L, Webborn P.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. doi: 10.1016/j.bmcl.2012.08.103. Epub 2012 Sep 11.

PMID:
23021991
41.

Cloning, expression and characterization of lepidopteran isopentenyl diphosphate isomerase.

Sen SE, Tomasello A, Grasso M, Denton R, Macor J, Béliveau C, Cusson M, Crowell DN.

Insect Biochem Mol Biol. 2012 Oct;42(10):739-50. doi: 10.1016/j.ibmb.2012.07.001. Epub 2012 Jul 20.

PMID:
22820710
42.

Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Britton RG, Horner-Glister E, Pomenya OA, Smith EE, Denton R, Jenkins PR, Steward WP, Brown K, Gescher A, Sale S.

Eur J Med Chem. 2012 Aug;54:952-8. doi: 10.1016/j.ejmech.2012.06.031. Epub 2012 Jun 22.

PMID:
22789812
43.

A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core.

Denton RM, Scragg JT.

Org Biomol Chem. 2012 Aug 7;10(29):5629-35. doi: 10.1039/c2ob25489a. Epub 2012 Jun 21.

PMID:
22717521
44.

The fear of others: a qualitative analysis of interpersonal threat in social phobia and paranoia.

Stopa L, Denton R, Wingfield M, Taylor KN.

Behav Cogn Psychother. 2013 Mar;41(2):188-209. doi: 10.1017/S1352465812000422. Epub 2012 Jun 13.

PMID:
22691440
45.

Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.

Luo G, Chen L, Conway CM, Denton R, Keavy D, Gulianello M, Huang Y, Kostich W, Lentz KA, Mercer SE, Schartman R, Signor L, Browning M, Macor JE, Dubowchik GM.

ACS Med Chem Lett. 2012 Feb 27;3(4):337-41. doi: 10.1021/ml300021s. eCollection 2012 Apr 12.

46.

Cell biology. Pyro-technic control of metabolism.

Irvine RF, Denton RM.

Science. 2011 Nov 11;334(6057):770-1. doi: 10.1126/science.1214727. No abstract available.

PMID:
22076369
47.

Catalytic phosphorus(V)-mediated nucleophilic substitution reactions: development of a catalytic Appel reaction.

Denton RM, An J, Adeniran B, Blake AJ, Lewis W, Poulton AM.

J Org Chem. 2011 Aug 19;76(16):6749-67. doi: 10.1021/jo201085r. Epub 2011 Jul 28.

PMID:
21744876
48.

Primary care of adults with developmental disabilities: Canadian consensus guidelines.

Sullivan WF, Berg JM, Bradley E, Cheetham T, Denton R, Heng J, Hennen B, Joyce D, Kelly M, Korossy M, Lunsky Y, McMillan S; Colloquium on Guidelines for the Primary Health Care of Adults with Developmental Disabilities.

Can Fam Physician. 2011 May;57(5):541-53, e154-68. English, French.

49.

Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme.

Lupo G, Gestri G, O'Brien M, Denton RM, Chandraratna RA, Ley SV, Harris WA, Wilson SW.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8698-703. doi: 10.1073/pnas.1103802108. Epub 2011 May 9.

50.

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.

Paine SW, Ménochet K, Denton R, McGinnity DF, Riley RJ.

Drug Metab Dispos. 2011 Jun;39(6):1008-13. doi: 10.1124/dmd.110.037267. Epub 2011 Feb 28.

PMID:
21357702

Supplemental Content

Loading ...
Support Center