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Items: 1 to 50 of 119

1.

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF.

JCI Insight. 2019 Sep 19;4(18). pii: 99271. doi: 10.1172/jci.insight.99271.

2.

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.

Chow BSM, Kocan M, Shen M, Wang Y, Han L, Chew JY, Wang C, Bosnyak S, Mirabito-Colafella KM, Barsha G, Wigg B, Johnstone EKM, Hossain MA, Pfleger KDG, Denton KM, Widdop RE, Summers RJ, Bathgate RAD, Hewitson TD, Samuel CS.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019060597. doi: 10.1681/ASN.2019060597. [Epub ahead of print]

PMID:
31511361
3.

"The more I learn, the more I realize how much I don't know." - The role of the renal nerves in hypertension.

Denton KM.

Hypertension. 2019 Oct;74(4):743-744. doi: 10.1161/HYPERTENSIONAHA.119.13561. Epub 2019 Aug 12. No abstract available.

PMID:
31401876
4.

Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.

Kiuchi MG, Esler MD, Fink GD, Osborn JW, Banek CT, Böhm M, Denton KM, DiBona GF, Everett TH 4th, Grassi G, Katholi RE, Knuepfer MM, Kopp UC, Lefer DJ, Lohmeier TE, May CN, Mahfoud F, Paton JFR, Schmieder RE, Pellegrino PR, Sharabi Y, Schlaich MP.

J Am Coll Cardiol. 2019 Jun 18;73(23):3006-3017. doi: 10.1016/j.jacc.2019.04.015. Review.

PMID:
31196459
5.

Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats.

Walton SL, Tjongue M, Tare M, Kwok E, Probyn M, Parkington HC, Bertram JF, Moritz KM, Denton KM.

Biol Sex Differ. 2019 Apr 22;10(1):21. doi: 10.1186/s13293-019-0235-9.

6.

Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation.

Singh RR, McArdle ZM, Iudica M, Easton LK, Booth LC, May CN, Parkington HC, Lombardo P, Head GA, Lambert G, Moritz KM, Schlaich MP, Denton KM.

Hypertension. 2019 Mar;73(3):718-727. doi: 10.1161/HYPERTENSIONAHA.118.12250.

PMID:
30661475
7.

Renal Denervation.

Singh RR, Denton KM.

Hypertension. 2018 Sep;72(3):528-536. doi: 10.1161/HYPERTENSIONAHA.118.10265. No abstract available.

PMID:
30354761
8.

Adenosine Receptors: A Tantalizing Target for the Treatment of Salt-Sensitive Hypertension.

Denton KM.

Hypertension. 2018 Aug;72(2):283-284. doi: 10.1161/HYPERTENSIONAHA.118.10842. Epub 2018 Jun 25. No abstract available.

PMID:
29941514
9.

Sex-specific differences in hypertension and associated cardiovascular disease.

Colafella KMM, Denton KM.

Nat Rev Nephrol. 2018 Mar;14(3):185-201. doi: 10.1038/nrneph.2017.189. Epub 2018 Jan 30. Review.

PMID:
29380817
10.

Relaxin contributes to the regulation of arterial pressure in adult female mice.

Mirabito Colafella KM, Samuel CS, Denton KM.

Clin Sci (Lond). 2017 Nov 28;131(23):2795-2805. doi: 10.1042/CS20171225. Print 2017 Dec 1.

PMID:
29101299
11.

New insights on glomerular hyperfiltration: a Japanese autopsy study.

Kanzaki G, Puelles VG, Cullen-McEwen LA, Hoy WE, Okabayashi Y, Tsuboi N, Shimizu A, Denton KM, Hughson MD, Yokoo T, Bertram JF.

JCI Insight. 2017 Oct 5;2(19). pii: 94334. doi: 10.1172/jci.insight.94334.

12.

Anti-fibrotic Potential of AT2 Receptor Agonists.

Wang Y, Del Borgo M, Lee HW, Baraldi D, Hirmiz B, Gaspari TA, Denton KM, Aguilar MI, Samuel CS, Widdop RE.

Front Pharmacol. 2017 Aug 31;8:564. doi: 10.3389/fphar.2017.00564. eCollection 2017. Review.

13.

Editorial: Function of Renal Sympathetic Nerves.

Wang Y, Lim K, Denton KM.

Front Physiol. 2017 Aug 28;8:642. doi: 10.3389/fphys.2017.00642. eCollection 2017. No abstract available.

14.

Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage.

Singh RR, Sajeesh V, Booth LC, McArdle Z, May CN, Head GA, Moritz KM, Schlaich MP, Denton KM.

J Am Coll Cardiol. 2017 Feb 28;69(8):951-964. doi: 10.1016/j.jacc.2016.12.014.

15.

Effect of renal denervation on kidney function in patients with chronic kidney disease.

Hering D, Marusic P, Duval J, Sata Y, Head GA, Denton KM, Burrows S, Walton AS, Esler MD, Schlaich MP.

Int J Cardiol. 2017 Apr 1;232:93-97. doi: 10.1016/j.ijcard.2017.01.047. Epub 2017 Jan 6.

PMID:
28089459
16.

Sex- and age-related differences in arterial pressure and albuminuria in mice.

Barsha G, Denton KM, Mirabito Colafella KM.

Biol Sex Differ. 2016 Nov 14;7:57. doi: 10.1186/s13293-016-0110-x. eCollection 2016.

17.

Chronic recurrent dehydration associated with periodic water intake exacerbates hypertension and promotes renal damage in male spontaneously hypertensive rats.

Hilliard LM, Colafella KM, Bulmer LL, Puelles VG, Singh RR, Ow CP, Gaspari T, Drummond GR, Evans RG, Vinh A, Denton KM.

Sci Rep. 2016 Sep 22;6:33855. doi: 10.1038/srep33855.

18.

"You are what you drink!" Focus on "Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury".

Denton KM.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R12-3. doi: 10.1152/ajpregu.00222.2016. Epub 2016 Jun 8. No abstract available.

19.

Anti-fibrotic actions of relaxin.

Samuel CS, Royce SG, Hewitson TD, Denton KM, Cooney TE, Bennett RG.

Br J Pharmacol. 2017 May;174(10):962-976. doi: 10.1111/bph.13529. Epub 2016 Jul 7. Review. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.

20.

Renal Nitric Oxide Deficiency and Chronic Kidney Disease in Young Sheep Born with a Solitary Functioning Kidney.

Singh RR, Easton LK, Booth LC, Schlaich MP, Head GA, Moritz KM, Denton KM.

Sci Rep. 2016 May 26;6:26777. doi: 10.1038/srep26777.

21.

Epochs in the depressor/pressor balance of the renin-angiotensin system.

Colafella KM, Hilliard LM, Denton KM.

Clin Sci (Lond). 2016 May 1;130(10):761-71. doi: 10.1042/CS20150939. Review.

PMID:
27128801
22.

Placental Growth Factor: A Step Forward in the Search for a Treatment for Preeclampsia.

Hilliard LM, Denton KM.

Hypertension. 2016 Jun;67(6):1114-6. doi: 10.1161/HYPERTENSIONAHA.116.07378. Epub 2016 Apr 18. No abstract available.

PMID:
27091897
23.

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice.

Schwengel K, Namsolleck P, Lucht K, Clausen BH, Lambertsen KL, Valero-Esquitino V, Thöne-Reineke C, Müller S, Widdop RE, Denton KM, Horiuchi M, Iwai M, Boato F, Dahlöf B, Hallberg A, Unger T, Steckelings UM.

J Mol Med (Berl). 2016 Aug;94(8):957-66. doi: 10.1007/s00109-016-1406-3. Epub 2016 Mar 16.

PMID:
26983606
24.

High-Dose Estradiol-Replacement Therapy Enhances the Renal Vascular Response to Angiotensin II via an AT2-Receptor Dependent Mechanism.

Safari T, Nematbakhsh M, Evans RG, Denton KM.

Adv Pharmacol Sci. 2015;2015:682745. doi: 10.1155/2015/682745. Epub 2015 Nov 23.

25.

Response to Letters Regarding Article, "Renal Dysfunction Is Associated With a Reduced Contribution of Nitric Oxide and Enhanced Vasoconstriction After a Congenital Renal Mass Reduction in Sheep".

Denton KM, Lankadeva YR, Singh RR, Parkington HC, Tare M, Moritz KM.

Circulation. 2015 Oct 13;132(15):e195. doi: 10.1161/CIRCULATIONAHA.115.016790. No abstract available.

PMID:
26459085
26.

Accelerated age-related decline in renal and vascular function in female rats following early-life growth restriction.

Black MJ, Lim K, Zimanyi MA, Sampson AK, Bubb KJ, Flower RL, Parkington HC, Tare M, Denton KM.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1153-61. doi: 10.1152/ajpregu.00403.2014. Epub 2015 Sep 16.

27.

Angiotensin type 2 receptor: hidden partner.

Denton KM.

Hypertension. 2015 Aug;66(2):273-4. doi: 10.1161/HYPERTENSIONAHA.115.05383. Epub 2015 Jun 8. No abstract available.

PMID:
26056341
28.

Role of the kidney in the fetal programming of adult cardiovascular disease: an update.

Singh RR, Denton KM.

Curr Opin Pharmacol. 2015 Apr;21:53-9. doi: 10.1016/j.coph.2014.12.010. Epub 2015 Jan 12. Review.

PMID:
25588322
29.

Using stimulation of the diving reflex in humans to teach integrative physiology.

Choate JK, Denton KM, Evans RG, Hodgson Y.

Adv Physiol Educ. 2014 Dec;38(4):355-65. doi: 10.1152/advan.00125.2013.

30.

Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep.

Lankadeva YR, Singh RR, Moritz KM, Parkington HC, Denton KM, Tare M.

Circulation. 2015 Jan 20;131(3):280-8. doi: 10.1161/CIRCULATIONAHA.114.013930. Epub 2014 Nov 4.

PMID:
25369804
31.

Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor.

Mirabito KM, Hilliard LM, Kett MM, Brown RD, Booth SC, Widdop RE, Moritz KM, Evans RG, Denton KM.

Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F901-7. doi: 10.1152/ajprenal.00288.2014. Epub 2014 Aug 27.

32.

Reduced sensitivity of the renal vasculature to angiotensin II in young rats: the role of the angiotensin type 2 receptor.

Brown RD, Hilliard LM, Mirabito KM, Wirth LC, Moritz KM, Evans RG, Denton KM.

Pediatr Res. 2014 Nov;76(5):448-52. doi: 10.1038/pr.2014.121. Epub 2014 Aug 13. Erratum in: Pediatr Res. 2015 Apr;77(4):606. Firth, Laura C [corrected to Wirth, Laura C].

PMID:
25119338
33.

Role of inflammation and the angiotensin type 2 receptor in the regulation of arterial pressure during pregnancy in mice.

Mirabito KM, Hilliard LM, Wei Z, Tikellis C, Widdop RE, Vinh A, Denton KM.

Hypertension. 2014 Sep;64(3):626-31. doi: 10.1161/HYPERTENSIONAHA.114.03189. Epub 2014 Jun 16.

PMID:
24935937
34.

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats.

Hilliard LM, Chow CL, Mirabito KM, Steckelings UM, Unger T, Widdop RE, Denton KM.

Hypertension. 2014 Aug;64(2):378-83. doi: 10.1161/HYPERTENSIONAHA.113.02809. Epub 2014 May 19.

PMID:
24842923
35.

Impaired ability to modulate glomerular filtration rate in aged female sheep following fetal uninephrectomy.

Lankadeva YR, Singh RR, Hilliard LM, Moritz KM, Denton KM.

Physiol Rep. 2014 Jan 28;2(1):e00208. doi: 10.1002/phy2.208. eCollection 2014 Jan 1.

36.

Compensatory responses to nephron deficiency: adaptive or maladaptive?

Fong D, Denton KM, Moritz KM, Evans R, Singh RR.

Nephrology (Carlton). 2014 Mar;19(3):119-28. doi: 10.1111/nep.12198. Review.

PMID:
24533732
37.

Loss of a kidney during fetal life: long-term consequences and lessons learned.

Lankadeva YR, Singh RR, Tare M, Moritz KM, Denton KM.

Am J Physiol Renal Physiol. 2014 Apr 15;306(8):F791-800. doi: 10.1152/ajprenal.00666.2013. Epub 2014 Feb 5. Review.

38.

Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor.

Mirabito KM, Hilliard LM, Head GA, Widdop RE, Denton KM.

Biol Sex Differ. 2014 Sep 16;5:13. doi: 10.1186/s13293-014-0013-7. eCollection 2014.

39.

Sex-related differences in hypertension: seek and ye shall find.

Denton KM, Hilliard LM, Tare M.

Hypertension. 2013 Oct;62(4):674-7. doi: 10.1161/HYPERTENSIONAHA.113.00922. Epub 2013 Aug 26. No abstract available.

PMID:
23980069
40.

Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation.

Wang Y, Denton KM, Golledge J.

Hypertens Res. 2013 Nov;36(11):1006-7. doi: 10.1038/hr.2013.82. Epub 2013 Aug 15. No abstract available.

PMID:
23945966
41.

Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats.

Gallo LA, Tran M, Cullen-McEwen LA, Denton KM, Jefferies AJ, Moritz KM, Wlodek ME.

Reprod Fertil Dev. 2014 Aug;26(7):1032-43. doi: 10.1071/RD13133.

PMID:
23910917
42.

Maternal obesity: bad for baby's future.

Kett MM, Denton KM.

Hypertension. 2013 Sep;62(3):457-8. doi: 10.1161/HYPERTENSIONAHA.113.01650. Epub 2013 Jul 22. No abstract available.

PMID:
23876473
43.

Improvement in renal hemodynamics following combined angiotensin II infusion and AT1R blockade in aged female sheep following fetal unilateral nephrectomy.

Singh RR, Lankadeva YR, Denton KM, Moritz KM.

PLoS One. 2013 Jul 1;8(7):e68036. doi: 10.1371/journal.pone.0068036. Print 2013.

44.

Unmasking the potential of the angiotensin AT2 receptor as a therapeutic target in hypertension in men and women: what we know and what we still need to find out.

Hilliard LM, Mirabito KM, Denton KM.

Clin Exp Pharmacol Physiol. 2013 Aug;40(8):542-50. doi: 10.1111/1440-1681.12067. Review.

PMID:
23406015
45.

Update on the angiotensin AT(2) receptor.

McCarthy CA, Widdop RE, Denton KM, Jones ES.

Curr Hypertens Rep. 2013 Feb;15(1):25-30. doi: 10.1007/s11906-012-0321-4. Review.

PMID:
23224511
46.

The "his and hers" of the renin-angiotensin system.

Hilliard LM, Sampson AK, Brown RD, Denton KM.

Curr Hypertens Rep. 2013 Feb;15(1):71-9. doi: 10.1007/s11906-012-0319-y. Review.

PMID:
23180053
47.

Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy.

Lankadeva YR, Singh RR, Hilliard LM, Moritz KM, Denton KM.

PLoS One. 2012;7(10):e47528. doi: 10.1371/journal.pone.0047528. Epub 2012 Oct 15.

48.

Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy.

Singh RR, Jefferies AJ, Lankadeva YR, Lombardo P, Schneider-Kolsky M, Hilliard L, Denton KM, Moritz KM.

PLoS One. 2012;7(8):e42400. doi: 10.1371/journal.pone.0042400. Epub 2012 Aug 3.

49.

Sex differences in the renal vascular response to angiotensin II involves the Mas receptor.

Safari T, Nematbakhsh M, Hilliard LM, Evans RG, Denton KM.

Acta Physiol (Oxf). 2012 Oct;206(2):150-6. doi: 10.1111/j.1748-1716.2012.02468.x. Epub 2012 Aug 11.

PMID:
22775972
50.

Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats.

Gallo LA, Denton KM, Moritz KM, Tare M, Parkington HC, Davies M, Tran M, Jefferies AJ, Wlodek ME.

Hypertension. 2012 Jul;60(1):206-13. doi: 10.1161/HYPERTENSIONAHA.112.195578. Epub 2012 May 14.

PMID:
22585946

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