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Items: 1 to 50 of 79

1.

CysLT1 receptor antagonists Pranlukast and Zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.

Figueroa EE, Kramer M, Strange K, Denton JS.

Am J Physiol Cell Physiol. 2019 Aug 7. doi: 10.1152/ajpcell.00281.2019. [Epub ahead of print]

PMID:
31390227
2.

DNA from Tooth Embedded in Man's Foot Resolves Quarter-Century-Old Shark Bite Mystery.

Yang L, Denton JSS, Corrigan S, Bowling TBT, Naylor GJP.

Wilderness Environ Med. 2019 Jul 1. pii: S1080-6032(19)30092-4. doi: 10.1016/j.wem.2019.04.008. [Epub ahead of print] No abstract available.

PMID:
31272893
3.

Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.

Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS.

J Pharmacol Exp Ther. 2019 Sep;370(3):350-359. doi: 10.1124/jpet.119.257204. Epub 2019 Jun 14.

PMID:
31201216
4.

Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.

Iwaki Y, Yashiro K, Kokubo M, Mori T, Wieting JM, McGowan KM, Bridges TM, Engers DW, Denton JS, Kurata H, Lindsley CW.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1601-1604. doi: 10.1016/j.bmcl.2019.04.048. Epub 2019 Apr 29.

PMID:
31072652
5.

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 ( AeKir1) Channel.

Aretz CD, Morwitzer MJ, Sanford AG, Hogan AM, Portillo MV, Kharade SV, Kramer M, McCarthey JB, Trigueros RR, Piermarini PM, Denton JS, Hopkins CR.

ACS Infect Dis. 2019 Jun 14;5(6):917-931. doi: 10.1021/acsinfecdis.8b00368. Epub 2019 Mar 15.

PMID:
30832472
6.

A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel.

Strange K, Yamada T, Denton JS.

J Gen Physiol. 2019 Feb 4;151(2):100-117. doi: 10.1085/jgp.201812138. Epub 2019 Jan 16. Review.

7.

Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti.

Rusconi Trigueros R, Hopkins CR, Denton JS, Piermarini PM.

Insects. 2018 Nov 15;9(4). pii: E163. doi: 10.3390/insects9040163.

8.

G protein-coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1.

Carrington SJ, Hernandez CC, Swale DR, Aluko OA, Denton JS, Cone RD.

J Biol Chem. 2018 Nov 16;293(46):17739-17753. doi: 10.1074/jbc.RA118.003238. Epub 2018 Sep 26.

PMID:
30257863
9.

Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology.

Piermarini PM, Inocente EA, Acosta N, Hopkins CR, Denton JS, Michel AP.

J Insect Physiol. 2018 Oct;110:57-65. doi: 10.1016/j.jinsphys.2018.09.001. Epub 2018 Sep 6.

PMID:
30196125
10.

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.

Kozek KA, Du Y, Sharma S, Prael FJ 3rd, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD.

ACS Chem Neurosci. 2019 Jan 16;10(1):358-370. doi: 10.1021/acschemneuro.8b00287. Epub 2018 Sep 13.

PMID:
30136838
11.

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.

Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS.

Mol Pharmacol. 2018 Aug;94(2):926-937. doi: 10.1124/mol.118.112359. Epub 2018 Jun 12.

12.

Cranial morphology in Mollisquama sp. (Squaliformes; Dalatiidae) and patterns of cranial evolution in dalatiid sharks.

Denton JSS, Maisey JG, Grace M, Pradel A, Doosey MH, Bart HL Jr, Naylor GJP.

J Anat. 2018 Jul;233(1):15-32. doi: 10.1111/joa.12823. Epub 2018 May 14.

PMID:
29761472
13.

Measuring inferential importance of taxa using taxon influence indices.

Denton JSS, Goolsby EW.

Ecol Evol. 2018 Apr 3;8(9):4484-4494. doi: 10.1002/ece3.3941. eCollection 2018 May.

14.

Diversification Patterns of Lanternfishes Reveal Multiple Rate Shifts in a Critical Mesopelagic Clade Targeted for Human Exploitation.

Denton JSS.

Curr Biol. 2018 Mar 19;28(6):933-940.e4. doi: 10.1016/j.cub.2018.01.082. Epub 2018 Mar 8.

15.

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

Sammons MF, Kharade SV, Filipski KJ, Boehm M, Smith AC, Shavnya A, Fernando DP, Dowling MS, Carpino PA, Castle NA, Zellmer SG, Antonio BM, Gosset JR, Carlo A, Denton JS.

ACS Med Chem Lett. 2018 Jan 19;9(2):125-130. doi: 10.1021/acsmedchemlett.7b00481. eCollection 2018 Feb 8.

16.

Plight of the pore polar bar(rier).

Denton JS, Kharade SV.

Channels (Austin). 2017 Nov 2;11(6):502-503. doi: 10.1080/19336950.2017.1367234. Epub 2017 Aug 25. No abstract available.

17.

Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590.

Kharade SV, Sheehan JH, Figueroa EE, Meiler J, Denton JS.

Mol Pharmacol. 2017 Sep;92(3):338-346. doi: 10.1124/mol.117.108472. Epub 2017 Jun 15.

18.

Malpighian Tubules as Novel Targets for Mosquito Control.

Piermarini PM, Esquivel CJ, Denton JS.

Int J Environ Res Public Health. 2017 Jan 24;14(2). pii: E111. doi: 10.3390/ijerph14020111. Review.

19.

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria.

Swale DR, Engers DW, Bollinger SR, Gross A, Inocente EA, Days E, Kanga F, Johnson RM, Yang L, Bloomquist JR, Hopkins CR, Piermarini PM, Denton JS.

Sci Rep. 2016 Nov 16;6:36954. doi: 10.1038/srep36954.

20.

Dynamic expression of genes encoding subunits of inward rectifier potassium (Kir) channels in the yellow fever mosquito Aedes aegypti.

Yang Z, Statler BM, Calkins TL, Alfaro E, Esquivel CJ, Rouhier MF, Denton JS, Piermarini PM.

Comp Biochem Physiol B Biochem Mol Biol. 2017 Feb;204:35-44. doi: 10.1016/j.cbpb.2016.11.003. Epub 2016 Nov 9.

PMID:
27836744
21.

Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations.

Martin GM, Rex EA, Devaraneni P, Denton JS, Boodhansingh KE, DeLeon DD, Stanley CA, Shyng SL.

J Biol Chem. 2016 Oct 14;291(42):21971-21983. Epub 2016 Aug 29.

22.

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

Swale DR, Kurata H, Kharade SV, Sheehan J, Raphemot R, Voigtritter KR, Figueroa EE, Meiler J, Blobaum AL, Lindsley CW, Hopkins CR, Denton JS.

ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. doi: 10.1021/acschemneuro.6b00111. Epub 2016 May 24.

23.

The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.

Kharade SV, Nichols C, Denton JS.

Future Med Chem. 2016 May;8(7):789-802. doi: 10.4155/fmc-2016-0005. Epub 2016 May 10. Review.

24.

ROMK inhibitor actions in the nephron probed with diuretics.

Kharade SV, Flores D, Lindsley CW, Satlin LM, Denton JS.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F732-F737. doi: 10.1152/ajprenal.00423.2015. Epub 2015 Dec 9.

25.

High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.

Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J.

PLoS One. 2015 Nov 24;10(11):e0143243. doi: 10.1371/journal.pone.0143243. eCollection 2015.

27.

Localization and role of inward rectifier K(+) channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti.

Piermarini PM, Dunemann SM, Rouhier MF, Calkins TL, Raphemot R, Denton JS, Hine RM, Beyenbach KW.

Insect Biochem Mol Biol. 2015 Dec;67:59-73. doi: 10.1016/j.ibmb.2015.06.006. Epub 2015 Jun 12.

PMID:
26079629
28.

ROMK (Kir1.1) pharmacology comes of age.

Kharade SV, Swale DR, Denton JS.

Channels (Austin). 2015;9(3):119-20. doi: 10.1080/19336950.2015.1046733. No abstract available.

29.

Computational and functional analyses of a small-molecule binding site in ROMK.

Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS.

Biophys J. 2015 Mar 10;108(5):1094-103. doi: 10.1016/j.bpj.2015.01.022.

30.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.

Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD.

Nature. 2015 Apr 2;520(7545):94-8. doi: 10.1038/nature14051. Epub 2015 Jan 19.

31.

Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels.

Raphemot R, Rouhier MF, Swale DR, Days E, Weaver CD, Lovell KM, Konkel LC, Engers DW, Bollinger SR, Hopkins C, Piermarini PM, Denton JS.

PLoS One. 2014 Nov 6;9(11):e110772. doi: 10.1371/journal.pone.0110772. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119883. Bollinger, Sean F [corrected to Bollinger, Sean R].

32.

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.

McCloskey C, Rada C, Bailey E, McCavera S, van den Berg HA, Atia J, Rand DA, Shmygol A, Chan YW, Quenby S, Brosens JJ, Vatish M, Zhang J, Denton JS, Taggart MJ, Kettleborough C, Tickle D, Jerman J, Wright P, Dale T, Kanumilli S, Trezise DJ, Thornton S, Brown P, Catalano R, Lin N, England SK, Blanks AM.

EMBO Mol Med. 2014 Sep;6(9):1161-74. doi: 10.15252/emmm.201403944.

33.

Pharmacological validation of an inward-rectifier potassium (Kir) channel as an insecticide target in the yellow fever mosquito Aedes aegypti.

Rouhier MF, Raphemot R, Denton JS, Piermarini PM.

PLoS One. 2014 Jun 24;9(6):e100700. doi: 10.1371/journal.pone.0100700. eCollection 2014.

34.

Molecular and functional characterization of Anopheles gambiae inward rectifier potassium (Kir1) channels: a novel role in egg production.

Raphemot R, Estévez-Lao TY, Rouhier MF, Piermarini PM, Denton JS, Hillyer JF.

Insect Biochem Mol Biol. 2014 Aug;51:10-9. doi: 10.1016/j.ibmb.2014.05.002. Epub 2014 May 20.

35.

Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.

Swale DR, Kharade SV, Denton JS.

Curr Opin Pharmacol. 2014 Apr;15:7-15. doi: 10.1016/j.coph.2013.11.002. Epub 2013 Nov 26. Review.

36.

Direct activation of β-cell KATP channels with a novel xanthine derivative.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS.

Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19.

37.

Seven-locus molecular phylogeny of Myctophiformes (Teleostei; Scopelomorpha) highlights the utility of the order for studies of deep-sea evolution.

Denton JS.

Mol Phylogenet Evol. 2014 Jul;76:270-92. doi: 10.1016/j.ympev.2014.02.009. Epub 2014 Feb 28.

PMID:
24583290
38.

Druggability of the inward rectifier family: a hope for rare channelopathies?

Denton JS.

Future Med Chem. 2014 Jun;6(9):971-3. doi: 10.4155/fmc.14.12. Epub 2014 Feb 18. No abstract available.

39.

Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.

Raphemot R, Kadakia RJ, Olsen ML, Banerjee S, Days E, Smith SS, Weaver CD, Denton JS.

Assay Drug Dev Technol. 2013 Nov-Dec;11(9-10):532-43. doi: 10.1089/adt.2013.544. Epub 2013 Nov 22.

40.

Are characiform fishes Gondwanan in origin? Insights from a time-scaled molecular phylogeny of the Citharinoidei (Ostariophysi: Characiformes).

Arroyave J, Denton JS, Stiassny ML.

PLoS One. 2013 Oct 8;8(10):e77269. doi: 10.1371/journal.pone.0077269. eCollection 2013.

41.

Evaluation of new geological reference materials for uranium-series measurements: Chinese Geological Standard Glasses (CGSG) and macusanite obsidian.

Denton JS, Murrell MT, Goldstein SJ, Nunn AJ, Amato RS, Hinrichs KA.

Anal Chem. 2013 Oct 15;85(20):9975-81. doi: 10.1021/ac4017117. Epub 2013 Oct 3.

PMID:
24004454
42.

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA.

Pain. 2013 Dec;154(12):2853-9. doi: 10.1016/j.pain.2013.08.026. Epub 2013 Aug 28.

43.

Novel diuretic targets.

Denton JS, Pao AC, Maduke M.

Am J Physiol Renal Physiol. 2013 Oct 1;305(7):F931-42. doi: 10.1152/ajprenal.00230.2013. Epub 2013 Jul 17. Review.

44.

Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels.

Raphemot R, Rouhier MF, Hopkins CR, Gogliotti RD, Lovell KM, Hine RM, Ghosalkar D, Longo A, Beyenbach KW, Denton JS, Piermarini PM.

PLoS One. 2013 May 29;8(5):e64905. doi: 10.1371/journal.pone.0064905. Print 2013.

45.

High-throughput screening for small-molecule modulators of inward rectifier potassium channels.

Raphemot R, Weaver CD, Denton JS.

J Vis Exp. 2013 Jan 27;(71). pii: 4209. doi: 10.3791/4209.

47.

Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.

Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS.

Front Pharmacol. 2011 Nov 30;2:75. doi: 10.3389/fphar.2011.00075. eCollection 2011.

48.

Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.

Denton JS, Jacobson DA.

Trends Endocrinol Metab. 2012 Jan;23(1):41-8. doi: 10.1016/j.tem.2011.09.004. Epub 2011 Nov 29. Review.

49.

Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity.

Denton JS, Weaver CD, Chauder BA, Lindsley CW.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Sep 1 [updated 2010 Oct 20].

50.

Discovery of a small molecule inhibitor of ROMK and Kir7.1.

Denton JS, Weaver CD, Lewis LM, Chauder BA, Lindsley CW.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Sep 1 [updated 2010 Oct 20].

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