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Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch.

Miro C, Di Cicco E, Ambrosio R, Mancino G, Di Girolamo D, Cicatiello AG, Sagliocchi S, Nappi A, De Stefano MA, Luongo C, Antonini D, Visconte F, Varricchio S, Ilardi G, Del Vecchio L, Staibano S, Boelen A, Blanpain C, Missero C, Salvatore D, Dentice M.

Nat Commun. 2019 Nov 27;10(1):5410. doi: 10.1038/s41467-019-13140-2.


Deiodinases and their intricate role in thyroid hormone homeostasis.

Luongo C, Dentice M, Salvatore D.

Nat Rev Endocrinol. 2019 Aug;15(8):479-488. doi: 10.1038/s41574-019-0218-2. Review.


The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress.

Sagliocchi S, Cicatiello AG, Di Cicco E, Ambrosio R, Miro C, Di Girolamo D, Nappi A, Mancino G, De Stefano MA, Luongo C, Raia M, Ogawa-Wong AN, Zavacki AM, Paladino S, Salvatore D, Dentice M.

Redox Biol. 2019 Jun;24:101228. doi: 10.1016/j.redox.2019.101228. Epub 2019 May 22.


Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.

Di Rienzo M, Antonioli M, Fusco C, Liu Y, Mari M, Orhon I, Refolo G, Germani F, Corazzari M, Romagnoli A, Ciccosanti F, Mandriani B, Pellico MT, De La Torre R, Ding H, Dentice M, Neri M, Ferlini A, Reggiori F, Kulesz-Martin M, Piacentini M, Merla G, Fimia GM.

Sci Adv. 2019 May 8;5(5):eaau8857. doi: 10.1126/sciadv.aau8857. eCollection 2019 May.


Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats.

Nettore IC, Rocca C, Mancino G, Albano L, Amelio D, Grande F, Puoci F, Pasqua T, Desiderio S, Mazza R, Terracciano D, Colao A, Bèguinot F, Russo GL, Dentice M, Macchia PE, Sinicropi MS, Angelone T, Ungaro P.

J Nutr Biochem. 2019 Jul;69:151-162. doi: 10.1016/j.jnutbio.2019.03.019. Epub 2019 Apr 8.


A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.

Carmody C, Ogawa-Wong AN, Martin C, Luongo C, Zuidwijk M, Sager B, Petersen T, Roginski Guetter A, Janssen R, Wu EY, Bogaards S, Neumann NM, Hau K, Marsili A, Boelen A, Silva JE, Dentice M, Salvatore D, Wagers AJ, Larsen PR, Simonides WS, Zavacki AM.

Endocrinology. 2019 May 1;160(5):1205-1222. doi: 10.1210/en.2019-00088.


Local hyperthyroidism promotes pancreatic acinar cell proliferation during acute pancreatitis.

Malagola E, Chen R, Bombardo M, Saponara E, Dentice M, Salvatore D, Reding T, Myers S, Hills AP, Graf R, Sonda S.

J Pathol. 2019 Jun;248(2):217-229. doi: 10.1002/path.5247. Epub 2019 Apr 4.


A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells.

Sommella E, Badolati N, Riccio G, Salviati E, Bottone S, Dentice M, Campiglia P, Tenore GC, Stornaiuolo M, Novellino E.

Nutrients. 2019 Jan 14;11(1). pii: E163. doi: 10.3390/nu11010163.


Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation.

Riccio G, Sommella E, Badolati N, Salviati E, Bottone S, Campiglia P, Dentice M, Tenore GC, Stornaiuolo M, Novellino E.

Nutrients. 2018 Nov 20;10(11). pii: E1808. doi: 10.3390/nu10111808.


Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation.

Badolati N, Sommella E, Riccio G, Salviati E, Heintz D, Bottone S, Di Cicco E, Dentice M, Tenore G, Campiglia P, Stornaiuolo M, Novellino E.

Nutrients. 2018 Oct 2;10(10). pii: E1406. doi: 10.3390/nu10101406.


Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts.

Cicatiello AG, Di Girolamo D, Dentice M.

Front Endocrinol (Lausanne). 2018 Sep 11;9:474. doi: 10.3389/fendo.2018.00474. eCollection 2018. Review.


A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist.

Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E, Stornaiuolo M.

Biochemistry. 2018 Feb 6;57(5):839-851. doi: 10.1021/acs.biochem.7b01087. Epub 2018 Jan 19.


Thyroid hormone promotes differentiation of colon cancer stem cells.

Cicatiello AG, Ambrosio R, Dentice M.

Mol Cell Endocrinol. 2017 Dec 25;459:84-89. doi: 10.1016/j.mce.2017.03.017. Epub 2017 Mar 22. Review.


DIO2 Thr92Ala Reduces Deiodinase-2 Activity and Serum-T3 Levels in Thyroid-Deficient Patients.

Castagna MG, Dentice M, Cantara S, Ambrosio R, Maino F, Porcelli T, Marzocchi C, Garbi C, Pacini F, Salvatore D.

J Clin Endocrinol Metab. 2017 May 1;102(5):1623-1630. doi: 10.1210/jc.2016-2587.


The Concerted Action of Type 2 and Type 3 Deiodinases Regulates the Cell Cycle and Survival of Basal Cell Carcinoma Cells.

Miro C, Ambrosio R, De Stefano MA, Di Girolamo D, Di Cicco E, Cicatiello AG, Mancino G, Porcelli T, Raia M, Del Vecchio L, Salvatore D, Dentice M.

Thyroid. 2017 Apr;27(4):567-576. doi: 10.1089/thy.2016.0532. Epub 2017 Feb 22.


The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils.

van der Spek AH, Bloise FF, Tigchelaar W, Dentice M, Salvatore D, van der Wel NN, Fliers E, Boelen A.

Endocrinology. 2016 Aug;157(8):3293-305. doi: 10.1210/en.2016-1103. Epub 2016 Jun 29.


Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis.

Di Girolamo D, Ambrosio R, De Stefano MA, Mancino G, Porcelli T, Luongo C, Di Cicco E, Scalia G, Vecchio LD, Colao A, Dlugosz AA, Missero C, Salvatore D, Dentice M.

J Clin Invest. 2016 Jun 1;126(6):2308-20. doi: 10.1172/JCI84465. Epub 2016 May 9.


Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling.

Catalano V, Dentice M, Ambrosio R, Luongo C, Carollo R, Benfante A, Todaro M, Stassi G, Salvatore D.

Cancer Res. 2016 Mar 1;76(5):1237-44. doi: 10.1158/0008-5472.CAN-15-1542. Epub 2015 Dec 16.


Pharmacological folding chaperones act as allosteric ligands of Frizzled4.

Generoso SF, Giustiniano M, La Regina G, Bottone S, Passacantilli S, Di Maro S, Cassese H, Bruno A, Mallardo M, Dentice M, Silvestri R, Marinelli L, Sarnataro D, Bonatti S, Novellino E, Stornaiuolo M.

Nat Chem Biol. 2015 Apr;11(4):280-6. doi: 10.1038/nchembio.1770. Epub 2015 Mar 9.


Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression.

Dentice M, Ambrosio R, Damiano V, Sibilio A, Luongo C, Guardiola O, Yennek S, Zordan P, Minchiotti G, Colao A, Marsili A, Brunelli S, Del Vecchio L, Larsen PR, Tajbakhsh S, Salvatore D.

Cell Metab. 2014 Dec 2;20(6):1038-48. doi: 10.1016/j.cmet.2014.10.009. Epub 2014 Nov 13.


The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism.

Luongo C, Martin C, Vella K, Marsili A, Ambrosio R, Dentice M, Harney JW, Salvatore D, Zavacki AM, Larsen PR.

Endocrinology. 2015 Feb;156(2):745-54. doi: 10.1210/en.2014-1698. Epub 2014 Dec 2.


Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.

Castroneves LA, Jugo RH, Maynard MA, Lee JS, Wassner AJ, Dorfman D, Bronson RT, Ukomadu C, Agoston AT, Ding L, Luongo C, Guo C, Song H, Demchev V, Lee NY, Feldman HA, Vella KR, Peake RW, Hartigan C, Kellogg MD, Desai A, Salvatore D, Dentice M, Huang SA.

Endocrinology. 2014 Oct;155(10):4061-8. doi: 10.1210/en.2013-2028. Epub 2014 Jul 8.


The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.

Luongo C, Ambrosio R, Salzano S, Dlugosz AA, Missero C, Dentice M.

Endocrinology. 2014 Jun;155(6):2077-88. doi: 10.1210/en.2013-2108. Epub 2014 Apr 2.


Thyroid hormones and skeletal muscle--new insights and potential implications.

Salvatore D, Simonides WS, Dentice M, Zavacki AM, Larsen PR.

Nat Rev Endocrinol. 2014 Apr;10(4):206-14. doi: 10.1038/nrendo.2013.238. Epub 2013 Dec 10. Review.


Type 3 deiodinase and solid tumors: an intriguing pair.

Dentice M, Antonini D, Salvatore D.

Expert Opin Ther Targets. 2013 Nov;17(11):1369-79. doi: 10.1517/14728222.2013.833189. Epub 2013 Aug 30. Review.


An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression.

Antonini D, Sibilio A, Dentice M, Missero C.

Front Endocrinol (Lausanne). 2013 Aug 22;4:104. doi: 10.3389/fendo.2013.00104. eCollection 2013.


Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3.

Ambrosio R, Damiano V, Sibilio A, De Stefano MA, Avvedimento VE, Salvatore D, Dentice M.

Nucleic Acids Res. 2013 Apr 1;41(6):3551-62. doi: 10.1093/nar/gkt065. Epub 2013 Feb 8.


Deiodination in cancer growth: the role of type III deiodinase.

Sibilio A, Ambrosio R, Bonelli C, De Stefano MA, Torre V, Dentice M, Salvatore D.

Minerva Endocrinol. 2012 Dec;37(4):315-27. Review.


β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells.

Dentice M, Luongo C, Ambrosio R, Sibilio A, Casillo A, Iaccarino A, Troncone G, Fenzi G, Larsen PR, Salvatore D.

Gastroenterology. 2012 Oct;143(4):1037-47. doi: 10.1053/j.gastro.2012.06.042. Epub 2012 Jul 3.


The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation.

Dentice M, Marsili A, Zavacki A, Larsen PR, Salvatore D.

Biochim Biophys Acta. 2013 Jul;1830(7):3937-45. doi: 10.1016/j.bbagen.2012.05.007. Epub 2012 May 25. Review.


Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle.

Marsili A, Tang D, Harney JW, Singh P, Zavacki AM, Dentice M, Salvatore D, Larsen PR.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E818-24. doi: 10.1152/ajpendo.00292.2011. Epub 2011 Jul 19.


Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation.

Dentice M, Salvatore D.

J Endocrinol. 2011 Jun;209(3):273-82. doi: 10.1530/JOE-11-0002. Epub 2011 Mar 11. Review.


Hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases.

Dentice M.

Expert Opin Ther Targets. 2011 Apr;15(4):493-504. doi: 10.1517/14728222.2011.553607. Epub 2011 Jan 25. Review.


The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.

Dentice M, Marsili A, Ambrosio R, Guardiola O, Sibilio A, Paik JH, Minchiotti G, DePinho RA, Fenzi G, Larsen PR, Salvatore D.

J Clin Invest. 2010 Nov;120(11):4021-30. doi: 10.1172/JCI43670. Epub 2010 Oct 11.


Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.

Marsili A, Ramadan W, Harney JW, Mulcahey M, Castroneves LA, Goemann IM, Wajner SM, Huang SA, Zavacki AM, Maia AL, Dentice M, Salvatore D, Silva JE, Larsen PR.

Endocrinology. 2010 Dec;151(12):5952-60. doi: 10.1210/en.2010-0631. Epub 2010 Sep 29.


Role of type 3 deiodinase in cancer.

Dentice M, Ambrosio R, Salvatore D.

Expert Opin Ther Targets. 2009 Nov;13(11):1363-73. doi: 10.1517/14728220903339122. Review.


Dual dichotomies--when thyroid dysfunction and thyroid hormones get into the skin.

Dentice M, Monfrecola G.

Thyroid. 2008 Aug;18(8):823-4. doi: 10.1089/thy.2008.1542. No abstract available.


Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63.

Antonini D, Dentice M, Mahtani P, De Rosa L, Della Gatta G, Mandinova A, Salvatore D, Stupka E, Missero C.

J Invest Dermatol. 2008 Jul;128(7):1676-85. doi: 10.1038/jid.2008.12. Epub 2008 Feb 7.


Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.

Gereben B, Zeöld A, Dentice M, Salvatore D, Bianco AC.

Cell Mol Life Sci. 2008 Feb;65(4):570-90. Review.


Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.

Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14466-71. Epub 2007 Aug 24.


Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.

Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeöld A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BC, Harney JW, Zavacki AM, Bianco AC.

Mol Cell Biol. 2007 Jul;27(13):4774-83. Epub 2007 Apr 23.


Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.

Zeöld A, Pormüller L, Dentice M, Harney JW, Curcio-Morelli C, Tente SM, Bianco AC, Gereben B.

J Biol Chem. 2006 Oct 20;281(42):31538-43. Epub 2006 Aug 23.


The cost of antibiotic treatment for priority infectious syndromes in Paraguay, 2004.

Baez E, Dentice MA, Heitmann I.

Epidemiol Bull. 2005 Jun;26(2):8-11. No abstract available.


Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis.

Dentice M, Cordeddu V, Rosica A, Ferrara AM, Santarpia L, Salvatore D, Chiovato L, Perri A, Moschini L, Fazzini C, Olivieri A, Costa P, Stoppioni V, Baserga M, De Felice M, Sorcini M, Fenzi G, Di Lauro R, Tartaglia M, Macchia PE.

J Clin Endocrinol Metab. 2006 Apr;91(4):1428-33. Epub 2006 Jan 17.


Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.

Dentice M, Luongo C, Elefante A, Ambrosio R, Salzano S, Zannini M, Nitsch R, Di Lauro R, Rossi G, Fenzi G, Salvatore D.

Mol Cell Biol. 2005 Nov;25(22):10171-82.


The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.

Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Zeöld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC.

Nat Cell Biol. 2005 Jul;7(7):698-705. Epub 2005 Jun 19.


Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells.

Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R, Vitale M, Rossi G, Fenzi G, Salvatore D.

Mol Cell Biol. 2004 Sep;24(18):7863-77.


Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2.

Pentimalli F, Dentice M, Fedele M, Pierantoni GM, Cito L, Pallante P, Santoro M, Viglietto G, Dal Cin P, Fusco A.

Cancer Res. 2003 Nov 1;63(21):7423-7.


Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC.

Mol Endocrinol. 2003 Dec;17(12):2603-12. Epub 2003 Aug 21.


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