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Items: 1 to 50 of 78

1.

Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion.

Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MC.

J Biol Chem. 2018 May 11;293(19):7476-7485. doi: 10.1074/jbc.RA118.002233. Epub 2018 Mar 9.

2.

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes.

Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Lee Kraus W, Li W, Dent SYR.

BMC Genomics. 2018 Feb 20;19(1):150. doi: 10.1186/s12864-018-4533-0.

3.

Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.

Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL.

Genome Res. 2018 Feb;28(2):159-170. doi: 10.1101/gr.226019.117. Epub 2017 Dec 22.

4.

GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation.

Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYR.

Stem Cell Reports. 2018 Jan 9;10(1):287-299. doi: 10.1016/j.stemcr.2017.11.009. Epub 2017 Dec 14.

5.

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X.

Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4.

6.

The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.

Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, Kong Q, Zhao F, Wang CR, Dent SYR, Wang J, Xu X, Li HB, Fang D.

Cell Rep. 2017 Jul 18;20(3):600-612. doi: 10.1016/j.celrep.2017.06.065.

7.

The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.

Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D.

J Immunol. 2017 May 15;198(10):3927-3938. doi: 10.4049/jimmunol.1600312. Epub 2017 Apr 19.

8.

Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.

Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS.

J Allergy Clin Immunol. 2017 Dec;140(6):1651-1659.e1. doi: 10.1016/j.jaci.2016.12.974. Epub 2017 Feb 10.

PMID:
28192143
9.

Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.

Butler JS, Qiu YH, Zhang N, Yoo SY, Coombes KR, Dent SY, Kornblau SM.

Leuk Lymphoma. 2017 May;58(5):1207-1218. doi: 10.1080/10428194.2016.1235272. Epub 2016 Oct 13.

10.

Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.

Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA.

J Neurosci. 2017 Mar 8;37(10):2565-2579. doi: 10.1523/JNEUROSCI.2121-16.2017. Epub 2017 Feb 2.

11.

TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.

Li J, Xi Y, Li W, McCarthy RL, Stratton SA, Zou W, Li W, Dent SY, Jain AK, Barton MC.

Oncogene. 2017 May 25;36(21):2991-3001. doi: 10.1038/onc.2016.453. Epub 2017 Jan 9.

12.

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.

Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR.

Cell Rep. 2016 Nov 22;17(9):2382-2393. doi: 10.1016/j.celrep.2016.10.076.

13.

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.

Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY.

Mol Cell Biol. 2016 Oct 28;36(22):2855-2866. Print 2016 Nov 15.

14.

KATapulting toward Pluripotency and Cancer.

Hirsch CL, Wrana JL, Dent SYR.

J Mol Biol. 2017 Jun 30;429(13):1958-1977. doi: 10.1016/j.jmb.2016.09.023. Epub 2016 Oct 6. Review.

15.

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.

Schibler A, Koutelou E, Tomida J, Wilson-Pham M, Wang L, Lu Y, Cabrera AP, Chosed RJ, Li W, Li B, Shi X, Wood RD, Dent SY.

Genes Dev. 2016 May 15;30(10):1187-97. doi: 10.1101/gad.278887.116. Epub 2016 May 19.

16.

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY.

Mol Cell. 2016 May 19;62(4):558-71. doi: 10.1016/j.molcel.2016.03.030. Epub 2016 Apr 28.

17.

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.

Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F.

J Invest Dermatol. 2015 Dec;135(12):3133-3143. doi: 10.1038/jid.2015.314. Epub 2015 Aug 19.

18.

Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY.

Genes Dev. 2015 Jun 15;29(12):1341. doi: 10.1101/gad.266601.115. No abstract available.

19.

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY.

Genes Dev. 2015 Apr 15;29(8):803-16. doi: 10.1101/gad.255109.114. Epub 2015 Apr 15. Erratum in: Genes Dev. 2015 Jun 15;29(12):1341.

20.

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.

Li Y, Polak U, Bhalla AD, Rozwadowska N, Butler JS, Lynch DR, Dent SYR, Napierala M.

Mol Ther. 2015 Jun;23(6):1055-1065. doi: 10.1038/mt.2015.41. Epub 2015 Mar 11.

21.

Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module.

Lan X, Koutelou E, Schibler AC, Chen YC, Grant PA, Dent SY.

Mol Cell Biol. 2015 May;35(10):1777-87. doi: 10.1128/MCB.01454-14. Epub 2015 Mar 9.

22.

KATs in cancer: functions and therapies.

Farria A, Li W, Dent SY.

Oncogene. 2015 Sep 17;34(38):4901-13. doi: 10.1038/onc.2014.453. Epub 2015 Feb 9. Review.

23.

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.

Tomida J, Takata K, Lange SS, Schibler AC, Yousefzadeh MJ, Bhetawal S, Dent SY, Wood RD.

Nucleic Acids Res. 2015 Jan;43(2):1000-11. doi: 10.1093/nar/gku1385. Epub 2015 Jan 7.

24.

AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.

Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X.

Cell. 2014 Oct 23;159(3):558-71. doi: 10.1016/j.cell.2014.09.049.

25.

Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.

Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K.

EMBO Rep. 2014 Nov;15(11):1192-201. doi: 10.15252/embr.201438990. Epub 2014 Sep 30.

26.

Functions of SAGA in development and disease.

Wang L, Dent SY.

Epigenomics. 2014 Jun;6(3):329-39. doi: 10.2217/epi.14.22. Review.

27.

Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.

Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY.

Mol Cell Biol. 2014 Oct 1;34(19):3746-53. doi: 10.1128/MCB.00622-14. Epub 2014 Jul 28.

28.

K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

Stilling RM, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, Bahari-Javan S, Barth J, Sananbenesi F, Schütz AL, Dyczkowski J, Martinez-Hernandez A, Kerimoglu C, Dent SY, Bonn S, Reymann KG, Fischer A.

EMBO J. 2014 Sep 1;33(17):1912-27. doi: 10.15252/embj.201487870. Epub 2014 Jul 14.

29.

Chromatin modifiers and remodellers: regulators of cellular differentiation.

Chen T, Dent SY.

Nat Rev Genet. 2014 Feb;15(2):93-106. doi: 10.1038/nrg3607. Epub 2013 Dec 24. Review.

30.

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M.

J Clin Invest. 2013 Oct;123(10):4318-28. doi: 10.1172/JCI69035. Epub 2013 Sep 24.

31.

The lasting influence of LSD1 in the blood.

Dent SY, Chandra J.

Elife. 2013 Jun 18;2:e00963. doi: 10.7554/eLife.00963.

32.

Chromatin: receiver and quarterback for cellular signals.

Johnson DG, Dent SY.

Cell. 2013 Feb 14;152(4):685-9. doi: 10.1016/j.cell.2013.01.017. Epub 2013 Jan 31. Review.

33.

The role of chromatin modifiers in normal and malignant hematopoiesis.

Butler JS, Dent SY.

Blood. 2013 Apr 18;121(16):3076-84. doi: 10.1182/blood-2012-10-451237. Epub 2013 Jan 2. Review.

34.

Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.

McCullough SD, Xu X, Dent SY, Bekiranov S, Roeder RG, Grant PA.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21319-24. doi: 10.1073/pnas.1218331110. Epub 2012 Dec 10.

35.

Expanded complexity of unstable repeat diseases.

Polak U, McIvor E, Dent SY, Wells RD, Napierala M.

Biofactors. 2013 Mar-Apr;39(2):164-75. doi: 10.1002/biof.1060. Epub 2012 Dec 11. Review.

36.

Stabilization of the promoter nucleosomes in nucleosome-free regions by the yeast Cyc8-Tup1 corepressor.

Chen K, Wilson MA, Hirsch C, Watson A, Liang S, Lu Y, Li W, Dent SY.

Genome Res. 2013 Feb;23(2):312-22. doi: 10.1101/gr.141952.112. Epub 2012 Nov 2.

37.

Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36.

Butler JS, Dent SY.

Nat Struct Mol Biol. 2012 Sep;19(9):863-4. doi: 10.1038/nsmb.2370. No abstract available.

38.

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.

Butler JS, Koutelou E, Schibler AC, Dent SY.

Epigenomics. 2012 Apr;4(2):163-77. doi: 10.2217/epi.12.3. Review.

39.

Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts.

Polak U, Hirsch C, Ku S, Gottesfeld J, Dent SY, Napierala M.

J Vis Exp. 2012 Feb 20;(60). pii: 3416. doi: 10.3791/3416.

40.

Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.

Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SY.

Hum Mol Genet. 2012 Jan 15;21(2):394-405. doi: 10.1093/hmg/ddr474. Epub 2011 Oct 14.

41.

Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.

Latham JA, Chosed RJ, Wang S, Dent SY.

Cell. 2011 Sep 2;146(5):709-19. doi: 10.1016/j.cell.2011.07.025.

42.

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.

Atanassov BS, Dent SY.

EMBO Rep. 2011 Sep 1;12(9):924-30. doi: 10.1038/embor.2011.140.

43.

Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia.

Kim E, Napierala M, Dent SY.

Nucleic Acids Res. 2011 Oct;39(19):8366-77. doi: 10.1093/nar/gkr542. Epub 2011 Jul 10.

44.

Ubp8 and SAGA regulate Snf1 AMP kinase activity.

Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY.

Mol Cell Biol. 2011 Aug;31(15):3126-35. doi: 10.1128/MCB.01350-10. Epub 2011 May 31.

45.

Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.

Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY.

J Biol Chem. 2011 Apr 8;286(14):12234-44. doi: 10.1074/jbc.M110.202416. Epub 2011 Feb 1.

46.

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K.

EMBO J. 2011 Jan 19;30(2):249-62. doi: 10.1038/emboj.2010.318. Epub 2010 Dec 3.

47.

The role of deubiquitinating enzymes in chromatin regulation.

Atanassov BS, Koutelou E, Dent SY.

FEBS Lett. 2011 Jul 7;585(13):2016-23. doi: 10.1016/j.febslet.2010.10.042. Epub 2010 Oct 26. Review.

48.

Multiple faces of the SAGA complex.

Koutelou E, Hirsch CL, Dent SY.

Curr Opin Cell Biol. 2010 Jun;22(3):374-82. doi: 10.1016/j.ceb.2010.03.005. Epub 2010 Apr 2.

49.

R loops stimulate genetic instability of CTG.CAG repeats.

Lin Y, Dent SY, Wilson JH, Wells RD, Napierala M.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):692-7. doi: 10.1073/pnas.0909740107. Epub 2009 Dec 22.

50.

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.

Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B.

EMBO J. 2010 Jan 6;29(1):68-79. doi: 10.1038/emboj.2009.332. Epub 2009 Nov 19.

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