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Items: 12

1.

Isomerization of BRCA1-BARD1 promotes replication fork protection.

Daza-Martin M, Starowicz K, Jamshad M, Tye S, Ronson GE, MacKay HL, Chauhan AS, Walker AK, Stone HR, Beesley JFJ, Coles JL, Garvin AJ, Stewart GS, McCorvie TJ, Zhang X, Densham RM, Morris JR.

Nature. 2019 Jul;571(7766):521-527. doi: 10.1038/s41586-019-1363-4. Epub 2019 Jul 3.

PMID:
31270457
2.

The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.

Garvin AJ, Walker AK, Densham RM, Chauhan AS, Stone HR, Mackay HL, Jamshad M, Starowicz K, Daza-Martin M, Ronson GE, Lanz AJ, Beesley JF, Morris JR.

Genes Dev. 2019 Mar 1;33(5-6):333-347. doi: 10.1101/gad.321125.118. Epub 2019 Feb 22.

3.

Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11.

Spiliotopoulos A, Blokpoel Ferreras L, Densham RM, Caulton SG, Maddison BC, Morris JR, Dixon JE, Gough KC, Dreveny I.

J Biol Chem. 2019 Jan 11;294(2):424-436. doi: 10.1074/jbc.RA118.004469. Epub 2018 Oct 29.

4.

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

Uckelmann M, Densham RM, Baas R, Winterwerp HHK, Fish A, Sixma TK, Morris JR.

Nat Commun. 2018 Jan 15;9(1):229. doi: 10.1038/s41467-017-02653-3.

5.

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.

Densham RM, Morris JR.

Nucleus. 2017 Mar 4;8(2):116-125. doi: 10.1080/19491034.2016.1267092. Epub 2016 Dec 29. Review.

6.

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.

Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR.

Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30.

7.

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Garvin AJ, Densham RM, Blair-Reid SA, Pratt KM, Stone HR, Weekes D, Lawrence KJ, Morris JR.

EMBO Rep. 2013 Nov;14(11):975-83. doi: 10.1038/embor.2013.141. Epub 2013 Sep 10.

8.

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR.

EMBO J. 2012 Oct 3;31(19):3918-34. doi: 10.1038/emboj.2012.232. Epub 2012 Aug 21.

9.

MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability.

Densham RM, O'Neill E, Munro J, K├Ânig I, Anderson K, Kolch W, Olson MF.

Mol Cell Biol. 2009 Dec;29(24):6380-90. doi: 10.1128/MCB.00116-09. Epub 2009 Oct 12.

10.

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.

Densham RM, Todd DE, Balmanno K, Cook SJ.

Cell Signal. 2008 Nov;20(11):1986-94. doi: 10.1016/j.cellsig.2008.07.005. Epub 2008 Jul 10.

PMID:
18664382
11.

Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton.

Coleman ML, Densham RM, Croft DR, Olson MF.

Oncogene. 2006 May 4;25(19):2708-16.

PMID:
16407839
12.

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.

Todd DE, Densham RM, Molton SA, Balmanno K, Newson C, Weston CR, Garner AP, Scott L, Cook SJ.

Oncogene. 2004 Apr 22;23(19):3284-95.

PMID:
14981547

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