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Items: 1 to 50 of 182

1.

Mining for natural product antileishmanials in a fungal extract library.

Mbekeani AJ, Jones RS, Bassas Llorens M, Elliot J, Regnault C, Barrett MP, Steele J, Kebede B, Wrigley SK, Evans L, Denny PW.

Int J Parasitol Drugs Drug Resist. 2019 Jun 11. pii: S2211-3207(19)30026-0. doi: 10.1016/j.ijpddr.2019.05.003. [Epub ahead of print]

2.

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

Pinneh EC, Mina JG, Stark MJR, Lindell SD, Luemmen P, Knight MR, Steel PG, Denny PW.

Sci Rep. 2019 May 30;9(1):8083. doi: 10.1038/s41598-019-44544-1.

3.

Expression levels of inositol phosphorylceramide synthase modulate plant responses to biotic and abiotic stress in Arabidopsis thaliana.

Pinneh EC, Stoppel R, Knight H, Knight MR, Steel PG, Denny PW.

PLoS One. 2019 May 23;14(5):e0217087. doi: 10.1371/journal.pone.0217087. eCollection 2019.

4.

Lytic reactions of drugs with lipid membranes.

Britt HM, García-Herrero CA, Denny PW, Mosely JA, Sanderson JM.

Chem Sci. 2018 Dec 3;10(3):674-680. doi: 10.1039/c8sc04831b. eCollection 2019 Jan 21.

5.

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania.

Trinconi CT, Miguel DC, Silber AM, Brown C, Mina JGM, Denny PW, Heise N, Uliana SRB.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):475-487. doi: 10.1016/j.ijpddr.2018.10.007. Epub 2018 Oct 24.

6.

Yeast: bridging the gap between phenotypic and biochemical assays for high-throughput screening.

Denny PW.

Expert Opin Drug Discov. 2018 Dec;13(12):1153-1160. doi: 10.1080/17460441.2018.1534826. Epub 2018 Oct 16.

PMID:
30326751
7.

Genenames.org: the HGNC and VGNC resources in 2019.

Braschi B, Denny P, Gray K, Jones T, Seal R, Tweedie S, Yates B, Bruford E.

Nucleic Acids Res. 2019 Jan 8;47(D1):D786-D792. doi: 10.1093/nar/gky930.

8.

Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.

Mbekeani AJ, Stanley WA, Kalel VC, Dahan N, Zalckvar E, Sheiner L, Schliebs W, Erdmann R, Pohl E, Denny PW.

Genes (Basel). 2018 Aug 29;9(9). pii: E434. doi: 10.3390/genes9090434.

9.

Improving large class performance and engagement through student-generated question banks.

Hancock D, Hare N, Denny P, Denyer G.

Biochem Mol Biol Educ. 2018 Jul;46(4):306-317. doi: 10.1002/bmb.21119. Epub 2018 Mar 12.

PMID:
29528559
10.

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.

Norcliffe JL, Mina JG, Alvarez E, Cantizani J, de Dios-Anton F, Colmenarejo G, Valle SG, Marco M, Fiandor JM, Martin JJ, Steel PG, Denny PW.

Sci Rep. 2018 Mar 2;8(1):3938. doi: 10.1038/s41598-018-22063-9.

11.

Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine.

Armitage EG, Alqaisi AQI, Godzien J, Peña I, Mbekeani AJ, Alonso-Herranz V, López-Gonzálvez Á, Martín J, Gabarro R, Denny PW, Barrett MP, Barbas C.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02095-17. doi: 10.1128/AAC.02095-17. Print 2018 May.

12.

Exploring autophagy with Gene Ontology.

Denny P, Feuermann M, Hill DP, Lovering RC, Plun-Favreau H, Roncaglia P.

Autophagy. 2018;14(3):419-436. doi: 10.1080/15548627.2017.1415189. Epub 2018 Feb 17. Review.

13.

Microbial protein targets: towards understanding and intervention.

Denny PW.

Parasitology. 2018 Feb;145(2):111-115. doi: 10.1017/S0031182017002037. Epub 2017 Nov 16.

14.

Formative student-authored question bank: perceptions, question quality and association with summative performance.

Walsh JL, Harris BHL, Denny P, Smith P.

Postgrad Med J. 2018 Feb;94(1108):97-103. doi: 10.1136/postgradmedj-2017-135018. Epub 2017 Sep 2.

15.

Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.

Charlton RL, Rossi-Bergmann B, Denny PW, Steel PG.

Parasitology. 2018 Feb;145(2):219-236. doi: 10.1017/S0031182017000993. Epub 2017 Aug 14. Review.

16.

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis.

Mina JGM, Denny PW.

Parasitology. 2018 Feb;145(2):134-147. doi: 10.1017/S0031182017001081. Epub 2017 Jun 22. Review.

17.

The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis - Corrigendum.

Alqaisi AQI, Mbekeani AJ, Llorens MB, Elhammer AP, Denny PW.

Parasitology. 2018 Feb;145(2):156. doi: 10.1017/S0031182017000877. Epub 2017 Jun 9. No abstract available.

18.

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.

Mina JG, Thye JK, Alqaisi AQI, Bird LE, Dods RH, Grøftehauge MK, Mosely JA, Pratt S, Shams-Eldin H, Schwarz RT, Pohl E, Denny PW.

J Biol Chem. 2017 Jul 21;292(29):12208-12219. doi: 10.1074/jbc.M117.792374. Epub 2017 Jun 2.

19.

The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis.

Alqaisi AQI, Mbekeani AJ, Llorens MB, Elhammer AP, Denny PW.

Parasitology. 2018 Feb;145(2):148-155. doi: 10.1017/S0031182017000506. Epub 2017 May 10. Erratum in: Parasitology. 2018 Feb;145(2):156.

21.

An expanded evaluation of protein function prediction methods shows an improvement in accuracy.

Jiang Y, Oron TR, Clark WT, Bankapur AR, D'Andrea D, Lepore R, Funk CS, Kahanda I, Verspoor KM, Ben-Hur A, Koo da CE, Penfold-Brown D, Shasha D, Youngs N, Bonneau R, Lin A, Sahraeian SM, Martelli PL, Profiti G, Casadio R, Cao R, Zhong Z, Cheng J, Altenhoff A, Skunca N, Dessimoz C, Dogan T, Hakala K, Kaewphan S, Mehryary F, Salakoski T, Ginter F, Fang H, Smithers B, Oates M, Gough J, Törönen P, Koskinen P, Holm L, Chen CT, Hsu WL, Bryson K, Cozzetto D, Minneci F, Jones DT, Chapman S, Bkc D, Khan IK, Kihara D, Ofer D, Rappoport N, Stern A, Cibrian-Uhalte E, Denny P, Foulger RE, Hieta R, Legge D, Lovering RC, Magrane M, Melidoni AN, Mutowo-Meullenet P, Pichler K, Shypitsyna A, Li B, Zakeri P, ElShal S, Tranchevent LC, Das S, Dawson NL, Lee D, Lees JG, Sillitoe I, Bhat P, Nepusz T, Romero AE, Sasidharan R, Yang H, Paccanaro A, Gillis J, Sedeño-Cortés AE, Pavlidis P, Feng S, Cejuela JM, Goldberg T, Hamp T, Richter L, Salamov A, Gabaldon T, Marcet-Houben M, Supek F, Gong Q, Ning W, Zhou Y, Tian W, Falda M, Fontana P, Lavezzo E, Toppo S, Ferrari C, Giollo M, Piovesan D, Tosatto SC, Del Pozo A, Fernández JM, Maietta P, Valencia A, Tress ML, Benso A, Di Carlo S, Politano G, Savino A, Rehman HU, Re M, Mesiti M, Valentini G, Bargsten JW, van Dijk AD, Gemovic B, Glisic S, Perovic V, Veljkovic V, Veljkovic N, Almeida-E-Silva DC, Vencio RZ, Sharan M, Vogel J, Kansakar L, Zhang S, Vucetic S, Wang Z, Sternberg MJ, Wass MN, Huntley RP, Martin MJ, O'Donovan C, Robinson PN, Moreau Y, Tramontano A, Babbitt PC, Brenner SE, Linial M, Orengo CA, Rost B, Greene CS, Mooney SD, Friedberg I, Radivojac P.

Genome Biol. 2016 Sep 7;17(1):184. doi: 10.1186/s13059-016-1037-6.

22.

Using the Gene Ontology to Annotate Key Players in Parkinson's Disease.

Foulger RE, Denny P, Hardy J, Martin MJ, Sawford T, Lovering RC.

Neuroinformatics. 2016 Jul;14(3):297-304. doi: 10.1007/s12021-015-9293-2.

23.

Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct.

Grøftehauge MK, Truan D, Vasil A, Denny PW, Vasil ML, Pohl E.

Int J Mol Sci. 2015 Jul 14;16(7):15971-84. doi: 10.3390/ijms160715971.

24.

Encouraging maximal learning with minimal effort using PeerWise.

Walsh JL, Denny P, Smith PE.

Med Educ. 2015 May;49(5):521-2. doi: 10.1111/medu.12720. No abstract available.

PMID:
25924138
25.

Computational analysis of the LRRK2 interactome.

Manzoni C, Denny P, Lovering RC, Lewis PA.

PeerJ. 2015 Feb 19;3:e778. doi: 10.7717/peerj.778. eCollection 2015.

26.

The role of phosphoglycans in the susceptibility of Leishmania mexicana to the temporin family of anti-microbial peptides.

Eggimann GA, Sweeney K, Bolt HL, Rozatian N, Cobb SL, Denny PW.

Molecules. 2015 Feb 6;20(2):2775-85. doi: 10.3390/molecules20022775.

27.

Investigating the anti-leishmanial effects of linear peptoids.

Eggimann GA, Bolt HL, Denny PW, Cobb SL.

ChemMedChem. 2015 Feb;10(2):233-7. doi: 10.1002/cmdc.201402416. Epub 2014 Dec 15.

PMID:
25512204
28.

Yeast as a potential vehicle for neglected tropical disease drug discovery.

Denny PW, Steel PG.

J Biomol Screen. 2015 Jan;20(1):56-63. doi: 10.1177/1087057114546552. Epub 2014 Aug 13. Review.

PMID:
25121554
29.

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection.

Jonczyk MS, Simon M, Kumar S, Fernandes VE, Sylvius N, Mallon AM, Denny P, Andrew PW.

PLoS One. 2014 Mar 3;9(3):e89831. doi: 10.1371/journal.pone.0089831. eCollection 2014.

30.

The utility of yeast as a tool for cell-based, target-directed high-throughput screening.

Norcliffe JL, Alvarez-Ruiz E, Martin-Plaza JJ, Steel PG, Denny PW.

Parasitology. 2014 Jan;141(1):8-16. doi: 10.1017/S0031182013000425. Epub 2013 Apr 24. Review.

PMID:
23611102
31.

Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.

Wisby L, Fernandes VE, Neill DR, Kadioglu A, Andrew PW, Denny P.

BMC Genomics. 2013 Apr 11;14:242. doi: 10.1186/1471-2164-14-242.

32.

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

Trmčić M, Chadbourne FL, Brear PM, Denny PW, Cobb SL, Hodgson DR.

Org Biomol Chem. 2013 Apr 28;11(16):2660-75. doi: 10.1039/c3ob27448a.

PMID:
23467665
33.

Mechanistic basis of infertility of mouse intersubspecific hybrids.

Bhattacharyya T, Gregorova S, Mihola O, Anger M, Sebestova J, Denny P, Simecek P, Forejt J.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E468-77. doi: 10.1073/pnas.1219126110. Epub 2013 Jan 17.

34.

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii.

Pratt S, Wansadhipathi-Kannangara NK, Bruce CR, Mina JG, Shams-Eldin H, Casas J, Hanada K, Schwarz RT, Sonda S, Denny PW.

Mol Biochem Parasitol. 2013 Jan;187(1):43-51. doi: 10.1016/j.molbiopara.2012.11.007. Epub 2012 Dec 16.

35.

Lipid metabolism as a therapeutic target.

Smith TK, Reynolds TB, Denny PW.

Biochem Res Int. 2012;2012:158139. doi: 10.1155/2012/158139. Epub 2012 Apr 12. No abstract available.

36.

T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.

Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, Strickland N, Gordon SB, Denny P, Kadioglu A, Andrew PW.

PLoS Pathog. 2012;8(4):e1002660. doi: 10.1371/journal.ppat.1002660. Epub 2012 Apr 19.

37.

Sphingolipid and ceramide homeostasis: potential therapeutic targets.

Young SA, Mina JG, Denny PW, Smith TK.

Biochem Res Int. 2012;2012:248135. doi: 10.1155/2012/248135. Epub 2012 Feb 9.

38.

Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb.

Kurapati R, McKenna C, Lindqvist J, Williams D, Simon M, LeProust E, Baker J, Cheeseman M, Carroll N, Denny P, Laval S, Lochmüller H, Ochala J, Blanco G.

Hum Mol Genet. 2012 Apr 15;21(8):1706-24. doi: 10.1093/hmg/ddr605. Epub 2011 Dec 23.

PMID:
22199023
39.

Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene.

McKeone R, Vieira H, Gregory-Evans K, Gregory-Evans CY, Denny P.

PLoS One. 2011;6(10):e25489. doi: 10.1371/journal.pone.0025489. Epub 2011 Oct 13.

40.

A participatory learning approach to biochemistry using student authored and evaluated multiple-choice questions.

Bottomley S, Denny P.

Biochem Mol Biol Educ. 2011 Sep-Oct;39(5):352-61. doi: 10.1002/bmb.20526.

41.

Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes.

Ali HZ, Harding CR, Denny PW.

Biochem Res Int. 2012;2012:691363. doi: 10.1155/2012/691363. Epub 2011 Sep 21.

42.

Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa.

Chadbourne FL, Raleigh C, Ali HZ, Denny PW, Cobb SL.

J Pept Sci. 2011 Nov;17(11):751-5. doi: 10.1002/psc.1398. Epub 2011 Aug 1.

PMID:
21805542
43.

Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain.

Mina JG, Mosely JA, Ali HZ, Denny PW, Steel PG.

Org Biomol Chem. 2011 Mar 21;9(6):1823-30. doi: 10.1039/c0ob00871k. Epub 2011 Jan 26.

PMID:
21267500
44.

Equidistant fish-eye calibration and rectification by vanishing point extraction.

Hughes C, Denny P, Glavin M, Jones E.

IEEE Trans Pattern Anal Mach Intell. 2010 Dec;32(12):2289-96. doi: 10.1109/TPAMI.2010.159.

PMID:
20733225
45.

Antimicrobial peptides for leishmaniasis.

Cobb SL, Denny PW.

Curr Opin Investig Drugs. 2010 Aug;11(8):868-75. Review.

PMID:
20721829
46.

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.

Ashrafian H, Docherty L, Leo V, Towlson C, Neilan M, Steeples V, Lygate CA, Hough T, Townsend S, Williams D, Wells S, Norris D, Glyn-Jones S, Land J, Barbaric I, Lalanne Z, Denny P, Szumska D, Bhattacharya S, Griffin JL, Hargreaves I, Fernandez-Fuentes N, Cheeseman M, Watkins H, Dear TN.

PLoS Genet. 2010 Jun 24;6(6):e1001000. doi: 10.1371/journal.pgen.1001000.

47.

A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase.

Mina JG, Mosely JA, Ali HZ, Shams-Eldin H, Schwarz RT, Steel PG, Denny PW.

Int J Biochem Cell Biol. 2010 Sep;42(9):1553-61. doi: 10.1016/j.biocel.2010.06.008. Epub 2010 Jun 16.

PMID:
20561598
48.

Accuracy of fish-eye lens models.

Hughes C, Denny P, Jones E, Glavin M.

Appl Opt. 2010 Jun 10;49(17):3338-47. doi: 10.1364/AO.49.003338.

PMID:
20539353
49.

Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase.

Mina JG, Okada Y, Wansadhipathi-Kannangara NK, Pratt S, Shams-Eldin H, Schwarz RT, Steel PG, Fawcett T, Denny PW.

Plant Mol Biol. 2010 Jul;73(4-5):399-407. doi: 10.1007/s11103-010-9626-3. Epub 2010 Mar 23.

PMID:
20309609
50.

ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.

Miller G, Neilan M, Chia R, Gheryani N, Holt N, Charbit A, Wells S, Tucci V, Lalanne Z, Denny P, Fisher EM, Cheeseman M, Askew GN, Dear TN.

PLoS One. 2010 Feb 9;5(2):e9137. doi: 10.1371/journal.pone.0009137.

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