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Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.

Al-Shahi Salman R, Minks DP, Mitra D, Rodrigues MA, Bhatnagar P, du Plessis JC, Joshi Y, Dennis MS, Murray GD, Newby DE, Sandercock PAG, Sprigg N, Stephen J, Sudlow CLM, Werring DJ, Whiteley WN, Wardlaw JM, White PM; RESTART Collaboration.

Lancet Neurol. 2019 Jul;18(7):643-652. doi: 10.1016/S1474-4422(19)30184-X. Epub 2019 May 22.


The impact of early-life intelligence quotient on post stroke cognitive impairment.

Makin SD, Doubal FN, Shuler K, Chappell FM, Staals J, Dennis MS, Wardlaw JM.

Eur Stroke J. 2018 Jun;3(2):145-156. doi: 10.1177/2396987317750517. Epub 2018 Jan 8.


The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial.

Al-Shahi Salman R, Murray GD, Dennis MS, Newby DE, Sandercock PAG, Sprigg N, Sudlow CLM, Werring DJ, White PM, Whiteley WN.

Trials. 2019 Mar 25;20(1):183. doi: 10.1186/s13063-019-3270-2.


Treating anxiety after stroke (TASK): the feasibility phase of a novel web-enabled randomised controlled trial.

Chun HY, Carson AJ, Dennis MS, Mead GE, Whiteley WN.

Pilot Feasibility Stud. 2018 Aug 14;4:139. doi: 10.1186/s40814-018-0329-x. eCollection 2018.


Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM.

J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30.


Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Loos CMJ, Makin SDJ, Staals J, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Stroke. 2018 May;49(5):1183-1188. doi: 10.1161/STROKEAHA.117.020495. Epub 2018 Mar 22.


The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, Drever J, Dinsmore L, Williams C, White PM, Whiteley WN, Sandercock PAG, Sudlow CLM, Newby DE, Sprigg N, Werring DJ; RESTART collaborators.

Trials. 2018 Mar 5;19(1):162. doi: 10.1186/s13063-018-2542-6.


Anxiety After Stroke: The Importance of Subtyping.

Chun HY, Whiteley WN, Dennis MS, Mead GE, Carson AJ.

Stroke. 2018 Mar;49(3):556-564. doi: 10.1161/STROKEAHA.117.020078. Epub 2018 Feb 6.


Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model.

Mandikian D, Takahashi N, Lo AA, Li J, Eastham-Anderson J, Slaga D, Ho J, Hristopoulos M, Clark R, Totpal K, Lin K, Joseph SB, Dennis MS, Prabhu S, Junttila TT, Boswell CA.

Mol Cancer Ther. 2018 Apr;17(4):776-785. doi: 10.1158/1535-7163.MCT-17-0657. Epub 2018 Jan 16.


An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.

Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR.

Mol Cancer Ther. 2018 Mar;17(3):638-649. doi: 10.1158/1535-7163.MCT-17-0813. Epub 2017 Dec 27.


The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke.

Loos CM, McHutchison C, Cvoro V, Makin SD, Staals J, Chappell F, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):518-524. doi: 10.1177/1747493017730780. Epub 2017 Sep 14.


Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review.

Makin SDJ, Mubki GF, Doubal FN, Shuler K, Staals J, Dennis MS, Wardlaw JM.

J Stroke Cerebrovasc Dis. 2017 Dec;26(12):3020-3028. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.004. Epub 2017 Sep 8. Review.


White matter hyperintensity reduction and outcomes after minor stroke.

Wardlaw JM, Chappell FM, Valdés Hernández MDC, Makin SDJ, Staals J, Shuler K, Thrippleton MJ, Armitage PA, Muñoz-Maniega S, Heye AK, Sakka E, Dennis MS.

Neurology. 2017 Sep 5;89(10):1003-1010. doi: 10.1212/WNL.0000000000004328. Epub 2017 Aug 9.


The nature, characteristics and associations of care home staff stress and wellbeing: a national survey.

Islam MS, Baker C, Huxley P, Russell IT, Dennis MS.

BMC Nurs. 2017 May 8;16:22. doi: 10.1186/s12912-017-0216-4. eCollection 2017.


Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study.

Chappell FM, Del Carmen Valdés Hernández M, Makin SD, Shuler K, Sakka E, Dennis MS, Armitage PA, Muñoz Maniega S, Wardlaw JM.

Trials. 2017 Feb 21;18(1):78. doi: 10.1186/s13063-017-1825-7.


Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.

Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ, Watts RJ, Couch JA, Meng YG, Atwal JK, Brezski RJ, Spiess C, Ernst JA.

J Biol Chem. 2017 Mar 3;292(9):3900-3908. doi: 10.1074/jbc.M116.767749. Epub 2017 Jan 11.


An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.

Leong SR, Sukumaran S, Hristopoulos M, Totpal K, Stainton S, Lu E, Wong A, Tam L, Newman R, Vuillemenot BR, Ellerman D, Gu C, Mathieu M, Dennis MS, Nguyen A, Zheng B, Zhang C, Lee G, Chu YW, Prell RA, Lin K, Laing ST, Polson AG.

Blood. 2017 Feb 2;129(5):609-618. doi: 10.1182/blood-2016-08-735365. Epub 2016 Dec 1.


Recent trends in primary-care antidepressant prescribing to children and young people: an e-cohort study.

John A, Marchant AL, Fone DL, McGregor JI, Dennis MS, Tan JO, Lloyd K.

Psychol Med. 2016 Dec;46(16):3315-3327.


Cognitive Outcomes following Thrombolysis in Acute Ischemic Stroke: A Systematic Review.

Broome LJ, Battle CE, Lawrence M, Evans PA, Dennis MS.

J Stroke Cerebrovasc Dis. 2016 Dec;25(12):2868-2875. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.048. Epub 2016 Aug 25. Review.


Newspaper Reporting on a Cluster of Suicides in the UK.

John A, Hawton K, Gunnell D, Lloyd K, Scourfield J, Jones PA, Luce A, Marchant A, Platt S, Price S, Dennis MS.

Crisis. 2017 Jan;38(1):17-25. doi: 10.1027/0227-5910/a000410. Epub 2016 Jul 22.


Author Response.

Wardlaw JM, Brazzelli M, Chappell F, Dennis MS, Sandercock PA.

Neurology. 2016 Feb 16;86(7):697. No abstract available.


Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S.

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17.


Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke.

Sim J, Teece L, Dennis MS, Roffe C; SOࠢS Study Team.

PLoS One. 2016 May 26;11(5):e0153527. doi: 10.1371/journal.pone.0153527. eCollection 2016.


Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease.

Muñoz Maniega S, Chappell FM, Valdés Hernández MC, Armitage PA, Makin SD, Heye AK, Thrippleton MJ, Sakka E, Shuler K, Dennis MS, Wardlaw JM.

J Cereb Blood Flow Metab. 2017 Feb;37(2):644-656. doi: 10.1177/0271678X16635657. Epub 2016 Jul 21.


Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S.

Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25.


National stroke registries for monitoring and improving the quality of hospital care: A systematic review.

Cadilhac DA, Kim J, Lannin NA, Kapral MK, Schwamm LH, Dennis MS, Norrving B, Meretoja A.

Int J Stroke. 2016 Jan;11(1):28-40. doi: 10.1177/1747493015607523. Review.


Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ.

Neuron. 2016 Jan 6;89(1):70-82. doi: 10.1016/j.neuron.2015.11.024. Epub 2015 Dec 10.


Thrombectomy for Acute Ischemic Stroke.

Wardlaw JM, Dennis MS.

JAMA. 2015 Nov 3;314(17):1803-5. doi: 10.1001/jama.2015.14674. No abstract available.


Nurse-Led Medicines' Monitoring for Patients with Dementia in Care Homes: A Pragmatic Cohort Stepped Wedge Cluster Randomised Trial.

Jordan S, Gabe-Walters ME, Watkins A, Humphreys I, Newson L, Snelgrove S, Dennis MS.

PLoS One. 2015 Oct 13;10(10):e0140203. doi: 10.1371/journal.pone.0140203. eCollection 2015.


Clinically Confirmed Stroke With Negative Diffusion-Weighted Imaging Magnetic Resonance Imaging: Longitudinal Study of Clinical Outcomes, Stroke Recurrence, and Systematic Review.

Makin SD, Doubal FN, Dennis MS, Wardlaw JM.

Stroke. 2015 Nov;46(11):3142-8. doi: 10.1161/STROKEAHA.115.010665. Epub 2015 Sep 29.


Plasma Biomarkers of Inflammation, Endothelial Function and Hemostasis in Cerebral Small Vessel Disease.

Wiseman SJ, Doubal FN, Chappell FM, Valdés-Hernández MC, Wang X, Rumley A, Lowe GD, Dennis MS, Wardlaw JM.

Cerebrovasc Dis. 2015;40(3-4):157-64. doi: 10.1159/000438494. Epub 2015 Aug 8.


ABCD2 score and secondary stroke prevention: meta-analysis and effect per 1,000 patients triaged.

Wardlaw JM, Brazzelli M, Chappell FM, Miranda H, Shuler K, Sandercock PA, Dennis MS.

Neurology. 2015 Jul 28;85(4):373-80. doi: 10.1212/WNL.0000000000001780. Epub 2015 Jul 1. Review.


A comparison of location of acute symptomatic vs. 'silent' small vessel lesions.

Valdés Hernández Mdel C, Maconick LC, Muñoz Maniega S, Wang X, Wiseman S, Armitage PA, Doubal FN, Makin S, Sudlow CL, Dennis MS, Deary IJ, Bastin M, Wardlaw JM.

Int J Stroke. 2015 Oct;10(7):1044-50. doi: 10.1111/ijs.12558. Epub 2015 Jun 29.


Recent trends in the incidence of anxiety and prescription of anxiolytics and hypnotics in children and young people: An e-cohort study.

John A, Marchant AL, McGregor JI, Tan JO, Hutchings HA, Kovess V, Choppin S, Macleod J, Dennis MS, Lloyd K.

J Affect Disord. 2015 Sep 1;183:134-41. doi: 10.1016/j.jad.2015.05.002. Epub 2015 May 12.


Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.

Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E, Mai E, Young J, Johnson C, Huseni M, Wang X, Chen Y, Wang P, Wang H, Dybdal N, Chu YW, Chiorazzi N, Scheer JM, Junttila T, Totpal K, Dennis MS, Ebens AJ.

Sci Transl Med. 2015 May 13;7(287):287ra70. doi: 10.1126/scitranslmed.aaa4802.


Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease.

Heye AK, Thrippleton MJ, Chappell FM, Hernández Mdel C, Armitage PA, Makin SD, Maniega SM, Sakka E, Flatman PW, Dennis MS, Wardlaw JM.

J Cereb Blood Flow Metab. 2016 Jan;36(1):264-74.


Comparing computer adaptive and curriculum-based measures of math in progress monitoring.

Shapiro ES, Dennis MS, Fu Q.

Sch Psychol Q. 2015 Dec;30(4):470-487. doi: 10.1037/spq0000116. Epub 2015 Mar 16.


Exploratory longitudinal cohort study of associations of fatigue after stroke.

Duncan F, Lewis SJ, Greig CA, Dennis MS, Sharpe M, MacLullich AM, Mead GE.

Stroke. 2015 Apr;46(4):1052-8. doi: 10.1161/STROKEAHA.114.008079. Epub 2015 Feb 12.


Cerebral small vessel disease and renal function: systematic review and meta-analysis.

Makin SD, Cook FA, Dennis MS, Wardlaw JM.

Cerebrovasc Dis. 2015;39(1):39-52. doi: 10.1159/000369777. Epub 2014 Dec 24. Review.


Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ.

Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.


Erratum to: Feelings of loneliness among adults with mental disorder.

Meltzer H, Bebbington P, Dennis MS, Jenkins R, McManus S, Brugha TS.

Soc Psychiatry Psychiatr Epidemiol. 2015 Mar;50(3):503-4. doi: 10.1007/s00127-014-0977-y. No abstract available.


An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models.

Scales SJ, Gupta N, Pacheco G, Firestein R, French DM, Koeppen H, Rangell L, Barry-Hamilton V, Luis E, Chuh J, Zhang Y, Ingle GS, Fourie-O'Donohue A, Kozak KR, Ross S, Dennis MS, Spencer SD.

Mol Cancer Ther. 2014 Nov;13(11):2630-40. doi: 10.1158/1535-7163.MCT-14-0487-T. Epub 2014 Sep 23.


PRINTQUAL - a measure for assessing the quality of newspaper reporting of suicide.

John A, Hawton K, Lloyd K, Luce A, Platt S, Scourfield J, Marchant AL, Jones PA, Dennis MS.

Crisis. 2014;35(6):431-5. doi: 10.1027/0227-5910/a000276.


Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells.

Junttila TT, Li J, Johnston J, Hristopoulos M, Clark R, Ellerman D, Wang BE, Li Y, Mathieu M, Li G, Young J, Luis E, Lewis Phillips G, Stefanich E, Spiess C, Polson A, Irving B, Scheer JM, Junttila MR, Dennis MS, Kelley R, Totpal K, Ebens A.

Cancer Res. 2014 Oct 1;74(19):5561-71. doi: 10.1158/0008-5472.CAN-13-3622-T. Epub 2014 Sep 16.


Antiplatelet therapy may be continued after intracerebral hemorrhage.

Al-Shahi Salman R, Dennis MS.

Stroke. 2014 Oct;45(10):3149-50. doi: 10.1161/STROKEAHA.114.005786. Epub 2014 Sep 9. No abstract available.


Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden.

Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM.

Neurology. 2014 Sep 30;83(14):1228-34. doi: 10.1212/WNL.0000000000000837. Epub 2014 Aug 27.


The Effects of a Tier 3 Intervention on the Mathematics Performance of Second Grade Students With Severe Mathematics Difficulties.

Bryant BR, Bryant DP, Porterfield J, Dennis MS, Falcomata T, Valentine C, Brewer C, Bell K.

J Learn Disabil. 2016 Mar-Apr;49(2):176-88. doi: 10.1177/0022219414538516. Epub 2014 Jun 26.


Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities.

Wardlaw JM, Allerhand M, Doubal FN, Valdes Hernandez M, Morris Z, Gow AJ, Bastin M, Starr JM, Dennis MS, Deary IJ.

Neurology. 2014 Apr 15;82(15):1331-8. doi: 10.1212/WNL.0000000000000312. Epub 2014 Mar 12.

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