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Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (TH1)/TH17 responses and autoimmunity.

Lee SU, Li CF, Mortales CL, Pawling J, Dennis JW, Grigorian A, Demetriou M.

PLoS One. 2019 Mar 26;14(3):e0214253. doi: 10.1371/journal.pone.0214253. eCollection 2019.


Identification of unique characteristics and the management of blunt traumatic aortic injuries occurring at unusual locations in the descending thoracic aorta.

Sabra MJ, Dennis JW, Allmon JC, Gautam S, Habib J.

J Vasc Surg. 2019 Jan;69(1):40-46. doi: 10.1016/j.jvs.2018.06.208.


N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.

Lai JD, Swystun LL, Cartier D, Nesbitt K, Zhang C, Hough C, Dennis JW, Lillicrap D.

Haematologica. 2018 Nov;103(11):1925-1936. doi: 10.3324/haematol.2018.188219. Epub 2018 Jul 12.


Novel application of an old technique: the use of external to internal carotid artery transposition in trauma.

Jensen AM, Dennis JW, Allmon JC, Habib JH, Skarupa DJ.

Trauma Surg Acute Care Open. 2018 Apr 25;3(1):e000182. doi: 10.1136/tsaco-2018-000182. eCollection 2018. No abstract available.


The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.

Chitturi J, Hung W, Rahman AMA, Wu M, Lim MA, Calarco J, Baran R, Huang X, Dennis JW, Zhen M.

PLoS Genet. 2018 Apr 12;14(4):e1007303. doi: 10.1371/journal.pgen.1007303. eCollection 2018 Apr.


Reassessing the utility of CT angiograms in penetrating injuries to the extremities.

Gurien LA, Kerwin AJ, Yorkgitis BK, Renkosik J, Allmon JC, Habib JH, Dennis JW.

Surgery. 2018 Feb;163(2):419-422. doi: 10.1016/j.surg.2017.09.019. Epub 2017 Nov 20.


N-acetylglucosamine: more than a silent partner in insulin resistance.

Hesketh GG, Dennis JW.

Glycobiology. 2017 Jul 1;27(7):595-598. doi: 10.1093/glycob/cwx035.


Genetic code asymmetry supports diversity through experimentation with posttranslational modifications.

Dennis JW.

Curr Opin Chem Biol. 2017 Dec;41:1-11. doi: 10.1016/j.cbpa.2017.08.012. Epub 2017 Sep 15. Review.


The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme.

Veyhl J, Dunn RJ, Johnston WL, Bennett A, Zhang LW, Dennis JW, Schachter H, Culotti JG.

PLoS One. 2017 Aug 17;12(8):e0183049. doi: 10.1371/journal.pone.0183049. eCollection 2017.


C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.

Johnston WL, Krizus A, Ramani AK, Dunham W, Youn JY, Fraser AG, Gingras AC, Dennis JW.

BMC Biol. 2017 Jul 17;15(1):61. doi: 10.1186/s12915-017-0398-y.


Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.

Kazazian K, Go C, Wu H, Brashavitskaya O, Xu R, Dennis JW, Gingras AC, Swallow CJ.

Cancer Res. 2017 Jan 15;77(2):434-447. doi: 10.1158/0008-5472.CAN-16-2060. Epub 2016 Nov 21.


Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.

Feldcamp L, Doucet JS, Pawling J, Fadel MP, Fletcher PJ, Maunder R, Dennis JW, Wong AH.

Behav Brain Res. 2016 Oct 1;312:253-64. doi: 10.1016/j.bbr.2016.06.033. Epub 2016 Jun 18.


PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.

Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20.


Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.

Ryczko MC, Pawling J, Chen R, Abdel Rahman AM, Yau K, Copeland JK, Zhang C, Surendra A, Guttman DS, Figeys D, Dennis JW.

Sci Rep. 2016 Mar 14;6:23043. doi: 10.1038/srep23043.


Many Light Touches Convey the Message.

Dennis JW.

Trends Biochem Sci. 2015 Nov;40(11):673-686. doi: 10.1016/j.tibs.2015.08.010. Epub 2015 Oct 1. Review.


The galectin lattice at a glance.

Nabi IR, Shankar J, Dennis JW.

J Cell Sci. 2015 Jul 1;128(13):2213-9. doi: 10.1242/jcs.151159. Epub 2015 Jun 19. Review.


Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.


Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.

Abdel Rahman AM, Ryczko M, Nakano M, Pawling J, Rodrigues T, Johswich A, Taniguchi N, Dennis JW.

Glycobiology. 2015 Feb;25(2):225-40. doi: 10.1093/glycob/cwu105. Epub 2014 Oct 1.


Targeted metabolomics in cultured cells and tissues by mass spectrometry: method development and validation.

Abdel Rahman AM, Pawling J, Ryczko M, Caudy AA, Dennis JW.

Anal Chim Acta. 2014 Oct 3;845:53-61. doi: 10.1016/j.aca.2014.06.012. Epub 2014 Jun 12.


A novel role for Plk4 in regulating cell spreading and motility.

Rosario CO, Kazazian K, Zih FS, Brashavitskaya O, Haffani Y, Xu RS, George A, Dennis JW, Swallow CJ.

Oncogene. 2015 Jun;34(26):3441-51. doi: 10.1038/onc.2014.275. Epub 2014 Sep 1.


Sodalis glossinidius prevalence and trypanosome presence in tsetse from Luambe National Park, Zambia.

Dennis JW, Durkin SM, Horsley Downie JE, Hamill LC, Anderson NE, MacLeod ET.

Parasit Vectors. 2014 Aug 19;7:378. doi: 10.1186/1756-3305-7-378.


N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway.

Johswich A, Longuet C, Pawling J, Abdel Rahman A, Ryczko M, Drucker DJ, Dennis JW.

J Biol Chem. 2014 Jun 6;289(23):15927-41. doi: 10.1074/jbc.M114.563734. Epub 2014 Apr 17.


The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].


Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution.

Williams R, Ma X, Schott RK, Mohammad N, Ho CY, Li CF, Chang BS, Demetriou M, Dennis JW.

PLoS One. 2014 Jan 24;9(1):e86088. doi: 10.1371/journal.pone.0086088. eCollection 2014.


Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry.

Abdel Rahman AM, Ryczko M, Pawling J, Dennis JW.

ACS Chem Biol. 2013 Sep 20;8(9):2053-62. doi: 10.1021/cb4004173. Epub 2013 Jul 22.


Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T.

Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308.


Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications.

Dennis JW, Brewer CF.

Mol Cell Proteomics. 2013 Apr;12(4):913-20. doi: 10.1074/mcp.R112.026989. Epub 2013 Feb 1.


Suppression of cancer progression by MGAT1 shRNA knockdown.

Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW.

PLoS One. 2012;7(9):e43721. doi: 10.1371/journal.pone.0043721. Epub 2012 Sep 5.


Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells.

Boscher C, Zheng YZ, Lakshminarayan R, Johannes L, Dennis JW, Foster LJ, Nabi IR.

J Biol Chem. 2012 Sep 21;287(39):32940-52. Epub 2012 Jul 30.


A prospective randomized study comparing fibrin sealant to manual compression for the treatment of anastomotic suture-hole bleeding in expanded polytetrafluoroethylene grafts.

Saha SP, Muluk S, Schenk W 3rd, Dennis JW, Ploder B, Grigorian A, Presch I, Goppelt A.

J Vasc Surg. 2012 Jul;56(1):134-41. doi: 10.1016/j.jvs.2012.01.009. Epub 2012 May 25.


Diagnosis and management of evacuated casualties with cervical vascular injuries resulting from combat-related explosive blasts.

Meghoo CA, Dennis JW, Tuman C, Fang R.

J Vasc Surg. 2012 May;55(5):1329-36; discussion 1336-7. doi: 10.1016/j.jvs.2011.11.125. Epub 2012 Feb 9.


High-throughput lectin magnetic bead array-coupled tandem mass spectrometry for glycoprotein biomarker discovery.

Choi E, Loo D, Dennis JW, O'Leary CA, Hill MM.

Electrophoresis. 2011 Dec;32(24):3564-75. doi: 10.1002/elps.201100341.


The eggshell in the C. elegans oocyte-to-embryo transition.

Johnston WL, Dennis JW.

Genesis. 2012 Apr;50(4):333-49. doi: 10.1002/dvg.20823. Epub 2011 Dec 27. Review.


Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M.

Nat Commun. 2011;2:334. doi: 10.1038/ncomms1333.


Glycosylation, galectins and cellular signaling.

Boscher C, Dennis JW, Nabi IR.

Curr Opin Cell Biol. 2011 Aug;23(4):383-92. doi: 10.1016/ Epub 2011 May 26. Review.


The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.

Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB.

Genes Dev. 2010 Dec 15;24(24):2784-99. doi: 10.1101/gad.1985910. Epub 2010 Nov 24.


Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans.

Johnston WL, Krizus A, Dennis JW.

Curr Biol. 2010 Nov 9;20(21):1932-7. doi: 10.1016/j.cub.2010.09.059. Epub 2010 Oct 28.


Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia.

Shi Y, Tomic J, Wen F, Shaha S, Bahlo A, Harrison R, Dennis JW, Williams R, Gross BJ, Walker S, Zuccolo J, Deans JP, Hart GW, Spaner DE.

Leukemia. 2010 Sep;24(9):1588-98. doi: 10.1038/leu.2010.152. Epub 2010 Jul 29.


Plk4 is required for cytokinesis and maintenance of chromosomal stability.

Rosario CO, Ko MA, Haffani YZ, Gladdy RA, Paderova J, Pollett A, Squire JA, Dennis JW, Swallow CJ.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6888-93. doi: 10.1073/pnas.0910941107. Epub 2010 Mar 26.


Metabolism, cell surface organization, and disease.

Dennis JW, Nabi IR, Demetriou M.

Cell. 2009 Dec 24;139(7):1229-41. doi: 10.1016/j.cell.2009.12.008. Review.


Adaptive regulation at the cell surface by N-glycosylation.

Dennis JW, Lau KS, Demetriou M, Nabi IR.

Traffic. 2009 Nov;10(11):1569-78. doi: 10.1111/j.1600-0854.2009.00981.x. Epub 2009 Sep 2. Review.


Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae.

Lajoie P, Kojic LD, Nim S, Li L, Dennis JW, Nabi IR.

J Cell Mol Med. 2009 Sep;13(9B):3218-25. doi: 10.1111/j.1582-4934.2009.00732.x. Epub 2009 Mar 6.


Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane.

Lajoie P, Goetz JG, Dennis JW, Nabi IR.

J Cell Biol. 2009 May 4;185(3):381-5. doi: 10.1083/jcb.200811059. Epub 2009 Apr 27. Review.


N-Glycans in cancer progression.

Lau KS, Dennis JW.

Glycobiology. 2008 Oct;18(10):750-60. doi: 10.1093/glycob/cwn071. Epub 2008 Aug 13. Review.


Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.

Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD.

Cancer Res. 2008 Aug 15;68(16):6688-97. doi: 10.1158/0008-5472.CAN-07-6833. Erratum in: Cancer Res. 2008 Sep 15;68(18):7692.


Genome-scale identification of UDP-GlcNAc-dependent pathways.

Lau KS, Khan S, Dennis JW.

Proteomics. 2008 Aug;8(16):3294-302. doi: 10.1002/pmic.200800208.


A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.

Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, Wrana JL, Dennis JW, Schimmer AD.

Apoptosis. 2008 Mar;13(3):413-22. doi: 10.1007/s10495-007-0175-4.


Complex N-glycan and metabolic control in tumor cells.

Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A, Pawling J, Dennis JW.

Cancer Res. 2007 Oct 15;67(20):9771-80.


Plasma membrane domain organization regulates EGFR signaling in tumor cells.

Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, Lagana A, Joshi B, Dennis JW, Nabi IR.

J Cell Biol. 2007 Oct 22;179(2):341-56. Epub 2007 Oct 15.


Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.

Martindill DM, Risebro CA, Smart N, Franco-Viseras Mdel M, Rosario CO, Swallow CJ, Dennis JW, Riley PR.

Nat Cell Biol. 2007 Oct;9(10):1131-41. Epub 2007 Sep 23.


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