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Items: 1 to 50 of 349

1.

2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability.

Koutoulogenis GS, Kokotou MG, Hayashi D, Mouchlis VD, Dennis EA, Kokotos G.

Biomolecules. 2020 Mar 24;10(3). pii: E491. doi: 10.3390/biom10030491.

2.

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors.

Mouchlis VD, Mu C, Hammons R, Dennis EA.

Adv Biol Regul. 2020 Mar 10:100719. doi: 10.1016/j.jbior.2020.100719. [Epub ahead of print]

PMID:
32199750
3.

Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)".

Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G.

ACS Omega. 2019 Jun 20;4(6):10714. doi: 10.1021/acsomega.9b01662. eCollection 2019 Jun 30.

4.

Phospholipase A2 catalysis and lipid mediator lipidomics.

Mouchlis VD, Dennis EA.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):766-771. doi: 10.1016/j.bbalip.2018.08.010. Epub 2018 Aug 23. Review.

PMID:
30905345
5.

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice.

Declèves AE, Mathew AV, Armando AM, Han X, Dennis EA, Quehenberger O, Sharma K.

J Lipid Res. 2019 May;60(5):937-952. doi: 10.1194/jlr.M088690. Epub 2019 Mar 12.

6.

β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis.

Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G.

J Med Chem. 2019 Mar 28;62(6):2916-2927. doi: 10.1021/acs.jmedchem.8b01216. Epub 2019 Mar 12.

7.

Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis.

Feuerherm AJ, Dennis EA, Johansen B.

Arthritis Res Ther. 2019 Jan 21;21(1):29. doi: 10.1186/s13075-018-1794-6.

8.

Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.

Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M.

Cell Chem Biol. 2019 Mar 21;26(3):433-442.e4. doi: 10.1016/j.chembiol.2018.11.015. Epub 2019 Jan 17.

9.

LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training.

O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S.

Sci Signal. 2019 Jan 8;12(563). pii: eaaw2964. doi: 10.1126/scisignal.aaw2964. Review.

10.

Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics.

Mouchlis VD, Armando A, Dennis EA.

J Med Chem. 2019 Feb 28;62(4):1999-2007. doi: 10.1021/acs.jmedchem.8b01568. Epub 2019 Feb 4.

11.

Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis.

Quehenberger O, Dahlberg-Wright S, Jiang J, Armando AM, Dennis EA.

J Lipid Res. 2018 Dec;59(12):2436-2445. doi: 10.1194/jlr.D089516. Epub 2018 Oct 15.

12.

Hyperencapsulated mucoid pneumococcal isolates from patients with cystic fibrosis have increased biofilm density and persistence in vivo.

Dennis EA, Coats MT, Griffin S, Pang B, Briles DE, Crain MJ, Swords WE.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty073.

PMID:
30265307
13.

Female Pelvic Floor Immersive Simulation: A Randomized Trial to Test the Effectiveness of a Virtual Reality Anatomic Model on Resident Knowledge of Female Pelvic Anatomy.

Ellington DR, Shum PC, Dennis EA, Willis HL, Szychowski JM, Richter HE.

J Minim Invasive Gynecol. 2019 Jul - Aug;26(5):897-901. doi: 10.1016/j.jmig.2018.09.003. Epub 2018 Sep 12.

PMID:
30218709
14.

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2).

Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G.

ACS Omega. 2018 Aug 31;3(8):8843-8853. doi: 10.1021/acsomega.8b01214. Epub 2018 Aug 9. Erratum in: ACS Omega. 2019 Jun 20;4(6):10714.

15.

Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL.

Pain. 2018 Dec;159(12):2620-2629. doi: 10.1097/j.pain.0000000000001373.

16.

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR.

J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163. Epub 2018 Aug 16.

17.

Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7.

Dennis EA, Smythies LE, Grabski R, Li M, Ballestas ME, Shimamura M, Sun JJ, Grams J, Stahl R, Niederweis ME, Britt WJ, Smith PD.

Mucosal Immunol. 2018 Nov;11(6):1694-1704. doi: 10.1038/s41385-018-0041-4. Epub 2018 Aug 3.

PMID:
30076393
18.

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.

Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA.

Hepatol Commun. 2017 Oct 30;1(10):1043-1057. doi: 10.1002/hep4.1115. eCollection 2017 Dec.

19.

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.

Mouchlis VD, Chen Y, McCammon JA, Dennis EA.

J Am Chem Soc. 2018 Mar 7;140(9):3285-3291. doi: 10.1021/jacs.7b12045. Epub 2018 Feb 26.

20.

Review of four major distinct types of human phospholipase A2.

Vasquez AM, Mouchlis VD, Dennis EA.

Adv Biol Regul. 2018 Jan;67:212-218. doi: 10.1016/j.jbior.2017.10.009. Epub 2017 Oct 23. Review.

21.

Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo.

Navratil AR, Shchepinov MS, Dennis EA.

J Am Chem Soc. 2018 Jan 10;140(1):235-243. doi: 10.1021/jacs.7b09493. Epub 2017 Dec 19.

22.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

23.

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.

Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G.

Sci Rep. 2017 Aug 1;7(1):7025. doi: 10.1038/s41598-017-07330-5.

24.

Characterization of Human Blood Monocytes and Intestinal Macrophages.

Dennis EA, Robinson TO, Smythies LE, Smith PD.

Curr Protoc Immunol. 2017 Aug 1;118:14.3.1-14.3.14. doi: 10.1002/cpim.30.

PMID:
28762485
25.

Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis.

Brown CR, Dennis EA.

Biochimie. 2017 Oct;141:86-90. doi: 10.1016/j.biochi.2017.06.010. Epub 2017 Jun 16.

26.

2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors.

Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V.

Bioorg Med Chem. 2017 Feb 1;25(3):926-940. doi: 10.1016/j.bmc.2016.12.007. Epub 2016 Dec 8.

27.

Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma.

Sokolowska M, Chen LY, Liu Y, Martinez-Anton A, Logun C, Alsaaty S, Cuento RA, Cai R, Sun J, Quehenberger O, Armando AM, Dennis EA, Levine SJ, Shelhamer JH.

J Allergy Clin Immunol. 2017 Apr;139(4):1379-1383. doi: 10.1016/j.jaci.2016.09.031. Epub 2016 Nov 5. No abstract available.

28.

Distance-of-Flight Mass Spectrometry: What, Why, and How?

Dennis EA, Gundlach-Graham AW, Ray SJ, Enke CG, Hieftje GM.

J Am Soc Mass Spectrom. 2016 Nov;27(11):1772-1786. Epub 2016 Aug 25.

PMID:
27562501
29.

Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.

Dennis EA.

J Biol Chem. 2016 Nov 18;291(47):24431-24448. Epub 2016 Aug 23. Review.

30.

2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.

Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G.

Bioorg Med Chem. 2016 Oct 1;24(19):4544-4554. doi: 10.1016/j.bmc.2016.07.057. Epub 2016 Jul 27.

31.

Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.

Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA.

Bioorg Med Chem. 2016 Oct 15;24(20):4801-4811. doi: 10.1016/j.bmc.2016.05.009. Epub 2016 May 10.

32.

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.

Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA.

J Med Chem. 2016 May 12;59(9):4403-14. doi: 10.1021/acs.jmedchem.6b00377. Epub 2016 Apr 28.

33.

Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.

Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S.

J Phys Chem B. 2016 Aug 25;120(33):8346-53. doi: 10.1021/acs.jpcb.6b02036. Epub 2016 Apr 26.

34.

Membrane and inhibitor interactions of intracellular phospholipases A2.

Mouchlis VD, Dennis EA.

Adv Biol Regul. 2016 May;61:17-24. doi: 10.1016/j.jbior.2015.11.011. Epub 2015 Dec 19. Review.

35.

Inductively Coupled Plasma Zoom-Time-of-Flight Mass Spectrometry.

Dennis EA, Ray SJ, Enke CG, Hieftje GM.

J Am Soc Mass Spectrom. 2016 Mar;27(3):380-7. doi: 10.1007/s13361-015-1309-5. Epub 2015 Dec 3.

PMID:
26634932
36.

Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source.

Dennis EA, Ray SJ, Enke CG, Gundlach-Graham AW, Barinaga CJ, Koppenaal DW, Hieftje GM.

J Am Soc Mass Spectrom. 2016 Mar;27(3):371-9. doi: 10.1007/s13361-015-1295-7. Epub 2015 Nov 9.

PMID:
26552388
37.

The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.

Dennis EA, Coats MT, Griffin SE, Hale JY, Novak L, Briles DE, Crain MJ.

PLoS One. 2015 Oct 15;10(10):e0140335. doi: 10.1371/journal.pone.0140335. eCollection 2015.

38.

Eicosanoid storm in infection and inflammation.

Dennis EA, Norris PC.

Nat Rev Immunol. 2015 Aug;15(8):511-23. doi: 10.1038/nri3859. Epub 2015 Jul 3. Review. Erratum in: Nat Rev Immunol. 2015 Nov;15(11):724.

39.

Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease.

Dennis EA.

J Lipid Res. 2015 Jul;56(7):1245-7. doi: 10.1194/jlr.E061101. Epub 2015 Jun 1. No abstract available.

40.

Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates.

Mouchlis VD, Bucher D, McCammon JA, Dennis EA.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E516-25. doi: 10.1073/pnas.1424651112. Epub 2015 Jan 26.

41.

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.

Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH Jr, Russell DW, Subramaniam S, Brown HA.

J Lipid Res. 2015 Mar;56(3):722-36. doi: 10.1194/jlr.P056002. Epub 2015 Jan 17.

42.

Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids.

Astarita G, Kendall AC, Dennis EA, Nicolaou A.

Biochim Biophys Acta. 2015 Apr;1851(4):456-68. doi: 10.1016/j.bbalip.2014.11.012. Epub 2014 Dec 5. Review.

43.

Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis.

Loomba R, Quehenberger O, Armando A, Dennis EA.

J Lipid Res. 2015 Jan;56(1):185-92. doi: 10.1194/jlr.P055640. Epub 2014 Nov 17.

44.

Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses.

Smith PD, Shimamura M, Musgrove LC, Dennis EA, Bimczok D, Novak L, Ballestas M, Fenton A, Dandekar S, Britt WJ, Smythies LE.

J Immunol. 2014 Dec 1;193(11):5604-12. doi: 10.4049/jimmunol.1302608. Epub 2014 Oct 29.

45.

Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies.

Baker PR, Armando AM, Campbell JL, Quehenberger O, Dennis EA.

J Lipid Res. 2014 Nov;55(11):2432-42. doi: 10.1194/jlr.D051581. Epub 2014 Sep 15.

46.

Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo.

Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B.

J Med Chem. 2014 Sep 25;57(18):7523-35. doi: 10.1021/jm500192s. Epub 2014 Sep 3.

PMID:
25152071
47.

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation.

Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12746-51. doi: 10.1073/pnas.1404372111. Epub 2014 Aug 19.

48.

Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples.

Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA.

J Chromatogr A. 2014 Sep 12;1359:60-9. doi: 10.1016/j.chroma.2014.07.006. Epub 2014 Jul 12.

49.

Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer.

Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR.

Mol Cancer Res. 2014 Nov;12(11):1677-88. doi: 10.1158/1541-7786.MCR-14-0397-T. Epub 2014 Jul 25.

50.

Zoom-TOFMS: addition of a constant-momentum-acceleration "zoom" mode to time-of-flight mass spectrometry.

Dennis EA, Gundlach-Graham AW, Ray SJ, Enke CG, Barinaga CJ, Koppenaal DW, Hieftje GM.

Anal Bioanal Chem. 2014 Nov;406(29):7419-30. doi: 10.1007/s00216-014-7875-8. Epub 2014 May 28.

PMID:
24866712

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