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Items: 1 to 50 of 61

1.

Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice.

Luissint AC, Williams HC, Kim W, Flemming S, Azcutia V, Hilgarth RS, Leary MNO, Denning TL, Nusrat A, Parkos CA.

Mucosal Immunol. 2019 Feb 11. doi: 10.1038/s41385-019-0143-7. [Epub ahead of print]

PMID:
30745566
2.

Epithelial Traffic Control: IL22 Gives TA Cells the Green Light.

Abo H, Denning TL.

Cell Mol Gastroenterol Hepatol. 2018 Oct 30;7(2):409-410. doi: 10.1016/j.jcmgh.2018.10.004. [Epub ahead of print] No abstract available.

3.

Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.

Lin S, Haque A, Raeman R, Guo L, He P, Denning TL, El-Rayes B, Moolenaar WH, Yun CC.

FASEB J. 2018 Nov 27:fj201801415RR. doi: 10.1096/fj.201801415RR. [Epub ahead of print]

PMID:
30481488
4.

IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication.

Wein AN, Dunbar PR, McMaster SR, Li ZT, Denning TL, Kohlmeier JE.

J Immunol. 2018 Jul 15;201(2):573-582. doi: 10.4049/jimmunol.1701796. Epub 2018 May 30.

PMID:
29848754
5.

Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity.

Flannigan KL, Denning TL.

Immunology. 2018 May 17. doi: 10.1111/imm.12950. [Epub ahead of print] Review.

PMID:
29771448
6.

A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.

Ngo VL, Abo H, Maxim E, Harusato A, Geem D, Medina-Contreras O, Merlin D, Gewirtz AT, Nusrat A, Denning TL.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085. doi: 10.1073/pnas.1718902115. Epub 2018 May 14.

7.

Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma.

McMaster SR, Wein AN, Dunbar PR, Hayward SL, Cartwright EK, Denning TL, Kohlmeier JE.

Mucosal Immunol. 2018 Jul;11(4):1071-1078. doi: 10.1038/s41385-018-0003-x. Epub 2018 Feb 16.

8.

Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer.

Pujada A, Walter L, Patel A, Bui TA, Zhang Z, Zhang Y, Denning TL, Garg P.

Oncotarget. 2017 Oct 17;8(55):94650-94665. doi: 10.18632/oncotarget.21841. eCollection 2017 Nov 7.

9.

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.

Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, Hilgarth R, O'Leary MN, Garcia-Hernandez V, Leoni G, Feng M, Bernal G, Williams H, Dedhia PH, Gerner-Smidt C, Spence J, Parkos CA, Denning TL, Nusrat A.

J Clin Invest. 2017 Sep 1;127(9):3510-3520. doi: 10.1172/JCI90229. Epub 2017 Aug 7.

10.

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment.

Weinstein AM, Chen L, Brzana EA, Patil PR, Taylor JL, Fabian KL, Wallace CT, Jones SD, Watkins SC, Lu B, Stroncek DF, Denning TL, Fu YX, Cohen PA, Storkus WJ.

Oncoimmunology. 2017 Apr 28;6(6):e1322238. doi: 10.1080/2162402X.2017.1322238. eCollection 2017.

11.

IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.

Harusato A, Abo H, Ngo VL, Yi SW, Mitsutake K, Osuka S, Kohlmeier JE, Li JD, Gewirtz AT, Nusrat A, Denning TL.

Mucosal Immunol. 2017 Nov;10(6):1455-1467. doi: 10.1038/mi.2017.21. Epub 2017 Mar 22.

12.

Pathogenesis of NEC: Role of the innate and adaptive immune response.

Denning TL, Bhatia AM, Kane AF, Patel RM, Denning PW.

Semin Perinatol. 2017 Feb;41(1):15-28. doi: 10.1053/j.semperi.2016.09.014. Epub 2016 Dec 9. Review.

13.

CD98 siRNA-loaded nanoparticles decrease hepatic steatosis in mice.

Canup BS, Song H, Le Ngo V, Meng X, Denning TL, Garg P, Laroui H.

Dig Liver Dis. 2017 Feb;49(2):188-196. doi: 10.1016/j.dld.2016.11.008. Epub 2016 Nov 17.

PMID:
27939923
14.

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.

15.

Contribution of Mesenteric Lymph Nodes and GALT to the Intestinal Foxp3+ Regulatory T-Cell Compartment.

Geem D, Ngo V, Harusato A, Chassaing B, Gewirtz AT, Newberry RD, Denning TL.

Cell Mol Gastroenterol Hepatol. 2016 May;2(3):274-280.

16.

Macrophage Isolation from the Mouse Small and Large Intestine.

Harusato A, Geem D, Denning TL.

Methods Mol Biol. 2016;1422:171-80. doi: 10.1007/978-1-4939-3603-8_16.

17.

Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T Cells.

Ko EJ, Lee YT, Kim KH, Jung YJ, Lee Y, Denning TL, Kang SM.

J Virol. 2016 Jul 11;90(15):6976-6988. doi: 10.1128/JVI.00339-16. Print 2016 Aug 1.

18.

Moving Beyond the Mouse: Key New Insight Into Human Colonic Dendritic Cells.

Denning TL.

Cell Mol Gastroenterol Hepatol. 2015 Nov 25;2(1):3-4. doi: 10.1016/j.jcmgh.2015.11.004. eCollection 2016 Jan. No abstract available.

19.

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.

20.

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses.

Wang X, Zhao X, Feng C, Weinstein A, Xia R, Wen W, Lv Q, Zuo S, Tang P, Yang X, Chen X, Wang H, Zang S, Stollings L, Denning TL, Jiang J, Fan J, Zhang G, Zhang X, Zhu Y, Storkus W, Lu B.

Cancer Cell. 2015 Sep 14;28(3):296-306. doi: 10.1016/j.ccell.2015.07.014. Epub 2015 Aug 27.

21.

Wound repair: role of immune-epithelial interactions.

Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A.

Mucosal Immunol. 2015 Sep;8(5):959-68. doi: 10.1038/mi.2015.63. Epub 2015 Jul 15. Review.

22.

Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.

Flannigan KL, Geem D, Harusato A, Denning TL.

Am J Pathol. 2015 Jul;185(7):1809-19. doi: 10.1016/j.ajpath.2015.02.024. Epub 2015 May 11. Review.

23.

Phenotypic and functional profiling of mouse intestinal antigen presenting cells.

Harusato A, Flannigan KL, Geem D, Denning TL.

J Immunol Methods. 2015 Jun;421:20-26. doi: 10.1016/j.jim.2015.03.023. Epub 2015 Apr 17. Review.

24.

Harnessing regulatory T cells for the treatment of inflammatory bowel disease.

Geem D, Harusato A, Flannigan K, Denning TL.

Inflamm Bowel Dis. 2015 Jun;21(6):1409-18. doi: 10.1097/MIB.0000000000000343. Review.

25.

Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.

Koutsonanos DG, Esser ES, McMaster SR, Kalluri P, Lee JW, Prausnitz MR, Skountzou I, Denning TL, Kohlmeier JE, Compans RW.

Vaccine. 2015 Sep 8;33(37):4675-82. doi: 10.1016/j.vaccine.2015.01.086. Epub 2015 Mar 3.

26.

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT.

Science. 2014 Nov 14;346(6211):861-5. doi: 10.1126/science.1256999.

27.

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ.

Nava P, Kamekura R, Quirós M, Medina-Contreras O, Hamilton RW, Kolegraff KN, Koch S, Candelario A, Romo-Parra H, Laur O, Hilgarth RS, Denning TL, Parkos CA, Nusrat A.

Mol Biol Cell. 2014 Oct 1;25(19):2894-904. doi: 10.1091/mbc.E13-09-0512. Epub 2014 Jul 30.

28.

Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis.

Weitkamp JH, Rosen MJ, Zhao Z, Koyama T, Geem D, Denning TL, Rock MT, Moore DJ, Halpern MD, Matta P, Denning PW.

PLoS One. 2014 Jun 6;9(6):e99042. doi: 10.1371/journal.pone.0099042. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105487.

29.

Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes.

Geem D, Medina-Contreras O, McBride M, Newberry RD, Koni PA, Denning TL.

J Immunol. 2014 Jul 1;193(1):431-8. doi: 10.4049/jimmunol.1303167. Epub 2014 Jun 4.

30.

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis.

Laroui H, Viennois E, Xiao B, Canup BS, Geem D, Denning TL, Merlin D.

J Control Release. 2014 Jul 28;186:41-53. doi: 10.1016/j.jconrel.2014.04.046. Epub 2014 May 5.

31.

Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation.

Weber DA, Sumagin R, McCall IC, Leoni G, Neumann PA, Andargachew R, Brazil JC, Medina-Contreras O, Denning TL, Nusrat A, Parkos CA.

Mucosal Immunol. 2014 Sep;7(5):1221-32. doi: 10.1038/mi.2014.12. Epub 2014 Mar 12.

32.

Neutrophils enlist IL-22 to restore order in the gut.

Denning TL, Parkos CA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12509-10. doi: 10.1073/pnas.1310907110. Epub 2013 Jul 19. No abstract available.

33.

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota.

Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, Bry L, Kraj P, Kisielow P, Ignatowicz L.

Nature. 2013 May 9;497(7448):258-62. doi: 10.1038/nature12079. Epub 2013 Apr 28.

34.

The role of the vascular dendritic cell network in atherosclerosis.

Alberts-Grill N, Denning TL, Rezvan A, Jo H.

Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C1-21. doi: 10.1152/ajpcell.00017.2013. Epub 2013 Apr 3. Review.

35.

Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.

Dunham RM, Thapa M, Velazquez VM, Elrod EJ, Denning TL, Pulendran B, Grakoui A.

J Immunol. 2013 Mar 1;190(5):2009-16. doi: 10.4049/jimmunol.1201937. Epub 2013 Jan 28.

36.

Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.

Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA.

PLoS One. 2012;7(12):e51955. doi: 10.1371/journal.pone.0051955. Epub 2012 Dec 18.

37.

Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.

Khounlotham M, Kim W, Peatman E, Nava P, Medina-Contreras O, Addis C, Koch S, Fournier B, Nusrat A, Denning TL, Parkos CA.

Immunity. 2012 Sep 21;37(3):563-73. doi: 10.1016/j.immuni.2012.06.017. Epub 2012 Sep 13.

38.

A(₂B)AR expression in non-immune cells plays an important role in the development of murine colitis.

Ingersoll SA, Laroui H, Kolachala VL, Wang L, Garg P, Denning TL, Gewirtz AT, Merlin D, Sitaraman SV.

Dig Liver Dis. 2012 Oct;44(10):819-26. doi: 10.1016/j.dld.2012.05.013. Epub 2012 Jun 19.

39.

Isolation and characterization of dendritic cells and macrophages from the mouse intestine.

Geem D, Medina-Contreras O, Kim W, Huang CS, Denning TL.

J Vis Exp. 2012 May 21;(63):e4040. doi: 10.3791/4040.

40.

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

Medina-Contreras O, Geem D, Laur O, Williams IR, Lira SA, Nusrat A, Parkos CA, Denning TL.

J Clin Invest. 2011 Dec;121(12):4787-95. doi: 10.1172/JCI59150.

41.

Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.

Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B.

J Immunol. 2011 Jul 15;187(2):733-47. doi: 10.4049/jimmunol.1002701. Epub 2011 Jun 10.

42.

The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

Koch S, Nava P, Addis C, Kim W, Denning TL, Li L, Parkos CA, Nusrat A.

Gastroenterology. 2011 Jul;141(1):259-68, 268.e1-8. doi: 10.1053/j.gastro.2011.03.043. Epub 2011 Mar 25.

43.

Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses.

Neish AS, Denning TL.

F1000 Biol Rep. 2010 Apr 12;2. pii: 27. doi: 10.3410/B2-27.

44.

Segmented filamentous bacteria shape intestinal immunity.

Denning TL, Sitaraman SV.

Gastroenterology. 2010 Jul;139(1):351-3. doi: 10.1053/j.gastro.2010.05.032. Epub 2010 May 25. No abstract available.

PMID:
20510226
45.

Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

Manicassamy S, Ravindran R, Deng J, Oluoch H, Denning TL, Kasturi SP, Rosenthal KM, Evavold BD, Pulendran B.

Nat Med. 2009 Apr;15(4):401-9. doi: 10.1038/nm.1925. Epub 2009 Mar 1.

46.

Adenosine triphosphate energizes intestinal T(H)17 cells.

Denning TL, Sitaraman SV.

Gastroenterology. 2009 Mar;136(3):1107-9. doi: 10.1053/j.gastro.2009.01.028. Epub 2009 Jan 22. No abstract available.

PMID:
19167397
47.

Division of labor, plasticity, and crosstalk between dendritic cell subsets.

Pulendran B, Tang H, Denning TL.

Curr Opin Immunol. 2008 Feb;20(1):61-7. Epub 2007 Dec 21. Review.

48.

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.

Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B.

Nat Immunol. 2007 Oct;8(10):1086-94. Epub 2007 Sep 16.

PMID:
17873879
49.

Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses.

Denning TL, Granger SW, Mucida D, Graddy R, Leclercq G, Zhang W, Honey K, Rasmussen JP, Cheroutre H, Rudensky AY, Kronenberg M.

J Immunol. 2007 Apr 1;178(7):4230-9. Erratum in: J Immunol. 2007 May 15;178(10):6654. Granger, Steve [corrected to Granger, Steve W].

50.

ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

Agrawal A, Dillon S, Denning TL, Pulendran B.

J Immunol. 2006 May 15;176(10):5788-96.

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