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Items: 1 to 50 of 163

1.

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL.

Nat Commun. 2019 Sep 20;10(1):4325. doi: 10.1038/s41467-019-12354-8.

2.

Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?

de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C.

Annu Rev Pharmacol Toxicol. 2019 Sep 10. doi: 10.1146/annurev-pharmtox-010919-023309. [Epub ahead of print]

PMID:
31506008
3.

Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function.

Alvarez-Paino M, Amer MH, Nasir A, Cuzzucoli Crucitti V, Thorpe J, Burroughs L, Needham D, Denning C, Alexander MR, Alexander C, Rose FRAJ.

ACS Appl Mater Interfaces. 2019 Sep 25;11(38):34560-34574. doi: 10.1021/acsami.9b04769. Epub 2019 Sep 10.

PMID:
31502820
4.

Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention.

Mosqueira D, Smith JGW, Bhagwan JR, Denning C.

Trends Mol Med. 2019 Sep;25(9):775-790. doi: 10.1016/j.molmed.2019.06.005. Epub 2019 Jul 17. Review.

5.

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.

Zhou X, Bueno-Orovio A, Schilling RJ, Kirkby C, Denning C, Rajamohan D, Burrage K, Tinker A, Rodriguez B, Harmer SC.

Front Physiol. 2019 Mar 18;10:259. doi: 10.3389/fphys.2019.00259. eCollection 2019.

6.

Surface plasmon resonance imaging of excitable cells.

Howe CL, Webb KF, Abayzeed SA, Anderson DJ, Denning C, Russell NA.

J Phys D Appl Phys. 2019 Mar 6;52(10):104001. doi: 10.1088/1361-6463/aaf849. Epub 2019 Jan 4.

7.

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.

Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C.

Stem Cell Reports. 2018 Nov 13;11(5):1226-1243. doi: 10.1016/j.stemcr.2018.10.006. Epub 2018 Nov 1.

8.

Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing.

Harrison R, Lugo Leija HA, Strohbuecker S, Crutchley J, Marsh S, Denning C, El Haj A, Sottile V.

Stem Cell Res Ther. 2018 Sep 26;9(1):248. doi: 10.1186/s13287-018-0968-0.

9.

Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450BM3 Variant.

Geronimo I, Denning CA, Heidary DK, Glazer EC, Payne CM.

Biophys J. 2018 Oct 2;115(7):1251-1263. doi: 10.1016/j.bpj.2018.08.026. Epub 2018 Aug 27.

10.

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C.

Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249.

11.

Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells.

Kondrashov A, Duc Hoang M, Smith JGW, Bhagwan JR, Duncan G, Mosqueira D, Munoz MB, Vo NTN, Denning C.

Stem Cells Dev. 2018 Mar 15;27(6):391-404. doi: 10.1089/scd.2017.0268. Epub 2018 Mar 12.

12.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

13.

Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Duncan G, Firth K, George V, Hoang MD, Staniforth A, Smith G, Denning C.

Stem Cells Dev. 2017 Dec 1;26(23):1695-1705. doi: 10.1089/scd.2017.0172. Epub 2017 Oct 9.

14.

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.

Lewis LC, Lo PC, Foster JM, Dai N, Corrêa IR, Durczak PM, Duncan G, Ramsawhook A, Aithal GP, Denning C, Hannan NR, Ruzov A.

Epigenetics. 2017 Apr 3;12(4):277-286. doi: 10.1080/15592294.2017.1292189. Epub 2017 Mar 7.

15.

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage.

Zamora A, Denning CA, Heidary DK, Wachter E, Nease LA, Ruiz J, Glazer EC.

Dalton Trans. 2017 Feb 14;46(7):2165-2173. doi: 10.1039/c6dt04405k.

PMID:
28121322
16.

Small molecule absorption by PDMS in the context of drug response bioassays.

van Meer BJ, de Vries H, Firth KSA, van Weerd J, Tertoolen LGJ, Karperien HBJ, Jonkheijm P, Denning C, IJzerman AP, Mummery CL.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):323-328. doi: 10.1016/j.bbrc.2016.11.062. Epub 2016 Nov 14.

17.

Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?

Kalra S, Montanaro F, Denning C.

J Neuromuscul Dis. 2016 Aug 30;3(3):309-332. Review.

18.

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.

Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK.

Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Review.

19.

Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion.

Hammad M, Rao W, Smith JG, Anderson DG, Langer R, Young LE, Barrett DA, Davies MC, Denning C, Alexander MR.

Biomater Sci. 2016 Aug 16;4(9):1381-91. doi: 10.1039/c6bm00214e.

20.

Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants.

Geronimo I, Denning CA, Rogers WE, Othman T, Huxford T, Heidary DK, Glazer EC, Payne CM.

Biochemistry. 2016 Jun 28;55(25):3594-606. doi: 10.1021/acs.biochem.6b00183. Epub 2016 Jun 16.

PMID:
27267136
21.

Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Rajamohan D, Kalra S, Duc Hoang M, George V, Staniforth A, Russell H, Yang X, Denning C.

Stem Cells Dev. 2016 Mar 15;25(6):439-52. doi: 10.1089/scd.2015.0253. Epub 2016 Feb 23.

22.

Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides.

Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E291-9. doi: 10.1073/pnas.1518634113. Epub 2016 Jan 5. Erratum in: Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4112-E4114.

23.

Scaling human pluripotent stem cell expansion and differentiation: are cell factories becoming a reality?

Smith JG, Celiz AD, Patel AK, Short RD, Alexander MR, Denning C.

Regen Med. 2015 Nov;10(8):925-30. doi: 10.2217/rme.15.65. Epub 2015 Nov 6. No abstract available.

PMID:
26542310
24.

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1728-48. doi: 10.1016/j.bbamcr.2015.10.014. Epub 2015 Oct 31.

25.

Applications of Raman micro-spectroscopy to stem cell technology: label-free molecular discrimination and monitoring cell differentiation.

Ghita A, Pascut FC, Sottile V, Denning C, Notingher I.

EPJ Tech Instrum. 2015;2(1):6. Epub 2015 Mar 24.

26.

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.

Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR.

Adv Mater. 2015 Jul 15;27(27):4006-12. doi: 10.1002/adma.201501351. Epub 2015 Jun 1.

27.

A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays.

Patel AK, Celiz AD, Rajamohan D, Anderson DG, Langer R, Davies MC, Alexander MR, Denning C.

Biomaterials. 2015 Aug;61:257-65. doi: 10.1016/j.biomaterials.2015.05.019. Epub 2015 May 15.

28.

Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy.

Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L.

Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19.

29.

Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells.

Földes G, Matsa E, Kriston-Vizi J, Leja T, Amisten S, Kolker L, Kodagoda T, Dolatshad NF, Mioulane M, Vauchez K, Arányi T, Ketteler R, Schneider MD, Denning C, Harding SE.

Stem Cell Reports. 2014 Nov 11;3(5):905-14. doi: 10.1016/j.stemcr.2014.09.002. Epub 2014 Oct 11.

30.
31.

The effect of speed of processing training on microsaccade amplitude.

Layfield S, Burge W, Mitchell W, Ross L, Denning C, Amthor F, Visscher K.

PLoS One. 2014 Sep 23;9(9):e107808. doi: 10.1371/journal.pone.0107808. eCollection 2014.

32.

Materials for stem cell factories of the future.

Celiz AD, Smith JG, Langer R, Anderson DG, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR.

Nat Mater. 2014 Jun;13(6):570-9. doi: 10.1038/nmat3972. Review.

PMID:
24845996
33.

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation.

Dixon JE, Shah DA, Rogers C, Hall S, Weston N, Parmenter CD, McNally D, Denning C, Shakesheff KM.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5580-5. doi: 10.1073/pnas.1319685111. Epub 2014 Mar 27. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8940-E8942.

34.

Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations.

Dick E, Kalra S, Anderson D, George V, Ritso M, Laval SH, Barresi R, Aartsma-Rus A, Lochmüller H, Denning C.

Stem Cells Dev. 2013 Oct 15;22(20):2714-24. doi: 10.1089/scd.2013.0135. Epub 2013 Jul 5.

35.

Exon skipping and gene transfer restore dystrophin expression in hiPSC-cardiomyocytes harbouring DMD mutations.

Dick E, Kalra S, Anderson D, George V, Ritson M, Laval S, Barresi R, Aartsma-Rus A, Lochmuller H, Denning C.

Stem Cells Dev. 2013 Jun 21. [Epub ahead of print]

PMID:
23786351
36.

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C.

Eur Heart J. 2014 Apr;35(16):1078-87. doi: 10.1093/eurheartj/eht067. Epub 2013 Mar 6.

37.

Non-invasive label-free monitoring the cardiac differentiation of human embryonic stem cells in-vitro by Raman spectroscopy.

Pascut FC, Kalra S, George V, Welch N, Denning C, Notingher I.

Biochim Biophys Acta. 2013 Jun;1830(6):3517-24. doi: 10.1016/j.bbagen.2013.01.030. Epub 2013 Feb 9.

PMID:
23403134
38.

Selenium dioxide-mediated synthesis of α-ketoamides from arylglyoxals and secondary amines.

Shaw AY, Denning CR, Hulme C.

Tetrahedron Lett. 2012 Aug 8;53(32):4151-4153. Epub 2012 Jun 6.

39.

Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL.

Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7.

40.

Current status of drug screening and disease modelling in human pluripotent stem cells.

Rajamohan D, Matsa E, Kalra S, Crutchley J, Patel A, George V, Denning C.

Bioessays. 2013 Mar;35(3):281-98. doi: 10.1002/bies.201200053. Epub 2012 Aug 8. Review.

41.

In vitro uses of human pluripotent stem cell-derived cardiomyocytes.

Matsa E, Denning C.

J Cardiovasc Transl Res. 2012 Oct;5(5):581-92. Epub 2012 May 26. Review.

PMID:
22639342
42.

Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes.

Paik I, Scurr DJ, Morris B, Hall G, Denning C, Alexander MR, Shakesheff KM, Dixon JE.

Biotechnol Bioeng. 2012 Oct;109(10):2630-41. doi: 10.1002/bit.24529. Epub 2012 Apr 24.

PMID:
22511037
43.

5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development.

Almeida RD, Loose M, Sottile V, Matsa E, Denning C, Young L, Johnson AD, Gering M, Ruzov A.

Epigenetics. 2012 Apr;7(4):383-9. doi: 10.4161/epi.19375. Epub 2012 Apr 1.

PMID:
22419071
44.

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.

Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.

45.

Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network.

Dixon JE, Dick E, Rajamohan D, Shakesheff KM, Denning C.

Mol Ther. 2011 Sep;19(9):1695-703. doi: 10.1038/mt.2011.125. Epub 2011 Jun 21.

46.

Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection.

Dick E, Matsa E, Young LE, Darling D, Denning C.

Nat Protoc. 2011 Jun;6(6):701-14. doi: 10.1038/nprot.2011.320. Epub 2011 May 5.

PMID:
21637193
47.

Toward label-free Raman-activated cell sorting of cardiomyocytes derived from human embryonic stem cells.

Pascut FC, Goh HT, George V, Denning C, Notingher I.

J Biomed Opt. 2011 Apr;16(4):045002. doi: 10.1117/1.3570302.

48.

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C.

Eur Heart J. 2011 Apr;32(8):952-62. doi: 10.1093/eurheartj/ehr073. Epub 2011 Mar 2.

49.

Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells.

Pascut FC, Goh HT, Welch N, Buttery LD, Denning C, Notingher I.

Biophys J. 2011 Jan 5;100(1):251-9. doi: 10.1016/j.bpj.2010.11.043.

50.

Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines.

Dick E, Matsa E, Bispham J, Reza M, Guglieri M, Staniforth A, Watson S, Kumari R, Lochmüller H, Young L, Darling D, Denning C.

Stem Cell Res. 2011 Mar;6(2):158-67. doi: 10.1016/j.scr.2010.10.002. Epub 2010 Nov 20.

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