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Items: 50

1.

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC.

Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9.

PMID:
29440447
2.

Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.

Bhayana S, Song F, Jacob J, Fadda P, Denko NC, Xu-Welliver M, Chakravarti A, Jacob NK.

Radiat Res. 2017 Dec;188(6):626-635. doi: 10.1667/RR14828.1. Epub 2017 Oct 4.

PMID:
28977780
3.

Stress-responsive HILPDA is necessary for thermoregulation during fasting.

VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I.

J Endocrinol. 2017 Oct;235(1):27-38. doi: 10.1530/JOE-17-0289. Epub 2017 Jul 24.

PMID:
28739822
4.

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response.

Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC.

Sci Rep. 2016 Sep 16;6:33353. doi: 10.1038/srep33353.

5.

Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.

Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN, Denko NC.

Sci Rep. 2016 Aug 8;6:31146. doi: 10.1038/srep31146.

6.

Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells.

Sun RC, Koong A, Giaccia A, Denko NC.

Adv Exp Med Biol. 2016;899:113-20. doi: 10.1007/978-3-319-26666-4_7.

7.

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC.

Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15.

8.

Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models.

Bobko AA, Evans J, Denko NC, Khramtsov VV.

Cell Biochem Biophys. 2017 Jun;75(2):247-253. doi: 10.1007/s12013-016-0733-x. Epub 2016 May 18.

9.

Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy.

Papandreou I, Verras M, McNeil B, Koong AC, Denko NC.

Exp Cell Res. 2015 Nov 15;339(1):147-53. doi: 10.1016/j.yexcr.2015.10.014. Epub 2015 Oct 17.

10.
11.

Hypoxic regulation of metabolism offers new opportunities for anticancer therapy.

Denko NC.

Expert Rev Anticancer Ther. 2014 Sep;14(9):979-81. doi: 10.1586/14737140.2014.930345. Epub 2014 Jun 14.

12.
13.

β-Catenin regulates hepatic mitochondrial function and energy balance in mice.

Lehwald N, Tao GZ, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG.

Gastroenterology. 2012 Sep;143(3):754-764. doi: 10.1053/j.gastro.2012.05.048. Epub 2012 Jun 7.

PMID:
22684045
14.

Identification of a protein mediating respiratory supercomplex stability.

Chen YC, Taylor EB, Dephoure N, Heo JM, Tonhato A, Papandreou I, Nath N, Denko NC, Gygi SP, Rutter J.

Cell Metab. 2012 Mar 7;15(3):348-60. doi: 10.1016/j.cmet.2012.02.006.

15.

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.

Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow-Cordero DE, Bouley DM, Offner F, Niwa M, Koong AC.

Blood. 2011 Jan 27;117(4):1311-4. doi: 10.1182/blood-2010-08-303099. Epub 2010 Nov 16.

16.

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

Papandreou I, Goliasova T, Denko NC.

Int J Cancer. 2011 Mar 1;128(5):1001-8. doi: 10.1002/ijc.25728. Epub 2010 Dec 7.

17.

The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT.

PLoS One. 2010 Mar 10;5(3):e9633. doi: 10.1371/journal.pone.0009633.

18.

Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth.

Spiotto MT, Banh A, Papandreou I, Cao H, Galvez MG, Gurtner GC, Denko NC, Le QT, Koong AC.

Cancer Res. 2010 Jan 1;70(1):78-88. doi: 10.1158/0008-5472.CAN-09-2747. Epub 2009 Dec 22.

19.

Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.

Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC.

Clin Cancer Res. 2009 Dec 1;15(23):7170-4. doi: 10.1158/1078-0432.CCR-09-1676. Epub 2009 Nov 17.

20.

FoxO3 regulates neural stem cell homeostasis.

Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A.

Cell Stem Cell. 2009 Nov 6;5(5):527-39. doi: 10.1016/j.stem.2009.09.014.

21.

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

Chen Y, Cairns R, Papandreou I, Koong A, Denko NC.

PLoS One. 2009 Sep 15;4(9):e7033. doi: 10.1371/journal.pone.0007033.

22.

Hypoxia, HIF1 and glucose metabolism in the solid tumour.

Denko NC.

Nat Rev Cancer. 2008 Sep;8(9):705-13. doi: 10.1038/nrc2468. Review.

PMID:
19143055
23.

Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress.

Verras M, Papandreou I, Lim AL, Denko NC.

Mol Cell Biol. 2008 Dec;28(23):7212-24. doi: 10.1128/MCB.00947-08. Epub 2008 Sep 29.

24.

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

Papandreou I, Lim AL, Laderoute K, Denko NC.

Cell Death Differ. 2008 Oct;15(10):1572-81. doi: 10.1038/cdd.2008.84. Epub 2008 Jun 13.

25.

HIF-1alpha in endurance training: suppression of oxidative metabolism.

Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS.

Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2059-69. Epub 2007 Sep 12.

26.

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.

Cairns RA, Papandreou I, Sutphin PD, Denko NC.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9445-50. Epub 2007 May 15.

27.

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC.

Cell Metab. 2006 Mar;3(3):187-97.

28.

Histology-based expression profiling yields novel prognostic markers in human glioblastoma.

Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN.

J Neuropathol Exp Neurol. 2005 Nov;64(11):948-55.

29.

Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment.

Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC.

Cancer Res. 2005 Apr 15;65(8):3171-8.

30.

Editorial comment: mutation research special issue on stress responses.

Denko NC, Fornace AJ Jr.

Mutat Res. 2005 Jan 6;569(1-2):1-2. No abstract available.

PMID:
15603748
31.

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC.

Cancer Res. 2004 Sep 1;64(17):5943-7.

32.

The hypoxic tumor microenvironment and gene expression.

Leo C, Giaccia AJ, Denko NC.

Semin Radiat Oncol. 2004 Jul;14(3):207-14. Review.

PMID:
15254863
33.

Hypoxic gene expression and metastasis.

Le QT, Denko NC, Giaccia AJ.

Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):293-310. Review.

PMID:
15197330
35.

Investigating hypoxic tumor physiology through gene expression patterns.

Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ.

Oncogene. 2003 Sep 1;22(37):5907-14. Review.

PMID:
12947397
36.

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.

Chan DA, Sutphin PD, Denko NC, Giaccia AJ.

J Biol Chem. 2002 Oct 18;277(42):40112-7. Epub 2002 Aug 16.

37.

Hypoxia links ATR and p53 through replication arrest.

Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ.

Mol Cell Biol. 2002 Mar;22(6):1834-43.

38.

Genetic determinants that influence hypoxia-induced apoptosis.

Alarcon RM, Denko NC, Giaccia AJ.

Novartis Found Symp. 2001;240:115-28; discussion 128-32.

PMID:
11727925
39.

Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis.

Denko NC, Giaccia AJ.

Cancer Res. 2001 Feb 1;61(3):795-8. Review. No abstract available.

40.

Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.

Laderoute KR, Alarcon RM, Brody MD, Calaoagan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ.

Clin Cancer Res. 2000 Jul;6(7):2941-50.

41.

p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia.

Denko NC, Green SL, Edwards D, Giaccia AJ.

Exp Cell Res. 2000 Jul 10;258(1):82-91.

PMID:
10912790
42.

Candidate genes for the hypoxic tumor phenotype.

Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ.

Cancer Res. 2000 Feb 15;60(4):883-7.

43.

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy.

Wouters BG, Denko NC, Giaccia AJ, Brown JM.

Oncogene. 1999 Nov 11;18(47):6540-5.

44.

Highly conserved RNA sequences that are sensors of environmental stress.

Spicher A, Guicherit OM, Duret L, Aslanian A, Sanjines EM, Denko NC, Giaccia AJ, Blau HM.

Mol Cell Biol. 1998 Dec;18(12):7371-82.

45.

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.

Wouters BG, Giaccia AJ, Denko NC, Brown JM.

Cancer Res. 1997 Nov 1;57(21):4703-6.

46.

Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.

Wani MA, Denko NC, Stambrook PJ.

Somat Cell Mol Genet. 1997 Mar;23(2):123-33.

PMID:
9330640
47.

Megakaryocytic cell line-specific hyperploidy by cytotoxic necrotizing factor bacterial toxins.

Hudson KM, Denko NC, Schwab E, Oswald E, Weiss A, Lieberman MA.

Blood. 1996 Nov 1;88(9):3465-73.

48.

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ.

Cancer Res. 1994 Oct 15;54(20):5273-9.

49.

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

Denko NC, Giaccia AJ, Stringer JR, Stambrook PJ.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):5124-8.

50.

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

Giaccia AJ, Lewis AD, Denko NC, Cholon A, Evans JW, Waldren CA, Stamato TD, Brown JM.

Cancer Res. 1991 Aug 15;51(16):4463-9.

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